Articles tagged with Tumor Tissue
A study found associations between genetic markers on chromosomes 11, 1, 2, 5, 18, 20, and 22 in tumor stroma and clinicopathological features. These findings support a model where genetic changes occur in both stromal and epithelial compartments during tumorigenesis.
Researchers have developed a new contrast agent that selectively targets and highlights malignant micro-calcifications in the breast, while ignoring similar calcifications found in benign breast conditions. This technique has the potential to improve breast cancer diagnosis by reducing false positives and increasing detection rates.
Researchers found DNA methylation in normal-appearing areas of the breast near tumors, suggesting a potential marker for early cancer detection. Abnormal methylation levels were also identified in three other genes, which may help estimate a woman's risk of cancer recurrence.
Researchers have identified a unique pattern of microRNAs in pancreatic tumor tissue, suggesting a new way to diagnose and treat the disease. The findings may lead to more effective early detection and treatment of pancreatic cancer.
University of Michigan researchers use gas bubbles to block blood flow to tumors, offering a promising new technique in embolotherapy. The method allows for precise control over bubble formation, minimizing damage to surrounding tissue.
Researchers have developed a new microbeam radiation therapy (MRT) technique that can deliver more lethal doses to tumors while sparing healthy tissue. The improved method uses significantly thicker microbeams and interlaces them within a well-defined target volume to increase killing potential.
Researchers used terahertz light to examine excised breast tissue and determine if removed margins were clear of cancer, with promising results. This technology has the potential to eliminate the need for multiple surgeries and tissue samples.
Tissue stiffness influences cell growth and changes in function by modulating cell contractility, leading to the activation of key growth signaling pathways and increase in cell tension. This study highlights the importance of mechanical forces in tumor development and could lead to the development of new tumor therapies or targets.
A study published in Cancer Cell found that increased tissue rigidity promotes the malignant behavior of tumor cells by inducing Rho-generated cytoskeletal tension and focal adhesions. This discovery may lead to new therapeutic strategies for treating cancers.
Researchers found that Bcl-xL, a protein that prevents cell death, can encourage tumor growth in mice. Higher levels of Bcl-xL were linked to increased tumor development and tissue injury in studies on lung and liver damage.
Researchers at Georgetown University Medical Center have developed a cutting-edge matrix assembly technology to analyze large numbers of tumors. The new method allows scientists to discover and detect unique biomarkers of disease in patients, leading to more accurate patient diagnosis and treatment.
A study found that DCIS tumours tend to occur in areas of mammographically dense breast tissue, with locations correlating strongly with the area of highest average percent density. The findings suggest that some aspect of dense tissue directly influences the carcinogenic process.
A new fluorescence device using time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) has been developed to detect atherosclerotic plaque and brain tumors. The technique shows promising results in distinguishing between inflamed and stable plaque areas, as well as detecting tumor cells left behind after surgery.
A new protein targets tumor vasculature by inducing coagulation when administered systemically, delaying tumor growth and producing some tumor regressions. The treatment shows promise for cancer therapy, adding a powerful punch to the fight against cancer.
The researchers found that activating the Oct4 gene in adult tissue causes tumors by preventing stem cells from differentiating. This discovery may allow scientists to multiply adult stem cells in the lab without forming mature tissue.
Researchers at Ohio State University have identified a new protein, Pirh2, that diminishes the activity of p53, a powerful tumor suppressor. Overexpression of Pirh2 was found in 84% of human lung cancers and 93% of mouse tumors, suggesting its potential role in cancer development.
Researchers have discovered an inactive form of scatter factor protein that effectively suppresses tumor growth and dissemination in mice. The study provides promising insights into the development of new cancer therapies.
Researchers engineered human mesenchymal stem cells to target tumors, delivering a therapeutic gene that inhibits cancer growth. The approach significantly improved survival of mice with breast and melanoma cancers.
Fluorescence spectroscopy can quickly and accurately discriminate between brain tumor and normal tissue, according to researchers at Cedars-Sinai Medical Center. The technique analyzes biochemical and functional changes in cells, providing high diagnostic specificity.
Thermal ablation, utilizing ultrasound or MRI imaging, effectively destroys breast tumors by applying heat or freezing abnormal tissue. The procedure has been successfully performed on over 50 patients, with no scarring and no cosmetic deformity remaining after treatment.
Researchers identified 671 genes with altered expression in prostate cancer tissue, revealing a high degree of similarity between benign adjacent tissue and cancerous tissue. The study found that genetic alterations occur throughout the gland, even in seemingly benign areas, providing new insights into prostate cancer progression.
Researchers have developed a technique called 2D CSI MRS that uses chemical signatures to distinguish between tumor recurrence, normal tissue, and treatment-related changes in the brain. This method has shown significant differences in chemical ratios for recurrent tumors versus treatment-altered tissue.
A research team led by Dr. Howard Lipshitz discovered that a protein linked to mammalian embryo implantation also plays a role in tumour metastasis in fruit fly development. The study found a surprising level of similarity between the proteins in flies and mammals, with potential implications for understanding human disease.
Research suggests that cutting off blood vessels to starve tumors of oxygen may not always be effective, as it can also make them harder to treat. Instead, feeding the tumor with oxygen may be a more viable option to kill cancer cells.
A combined approach of photodynamic therapy (PDT) and radiation shows promise in treating mouse tumors, with increased oxygenation improving the effectiveness of both treatments. The study used verteporfin, a light-activated drug that targets tumor tissue, leading to improved outcomes.
Researchers used Diffusion-Weighted Magnetic Resonance Imaging (DWMRI) to visualize and measure water characteristics in mouse tumors before and after chemotherapy. They found a significant correlation between water diffusion properties prior to treatment and subsequent tumor growth rate.
Researchers discovered beta catenin's role in regulating cortical growth, which may be associated with brain diseases such as mental retardation. The study also found that overexpressing beta catenin in neural precursor cells caused the cerebral cortex to grow dramatically, leading to a wrinkled appearance similar to humans.
Researchers at the University of Illinois have developed a simple protein test to detect telomerase activity in cancerous cells of dogs and cats. The test has shown promising results in diagnosing malignant tumors in pets, with high accuracy rates compared to traditional diagnostic methods.
Scientists at the University of Illinois have developed microspheres that enhance contrast in optical coherence tomography, allowing for improved imaging of individual cells and early tumor detection. The microspheres can be targeted to specific tumors, enabling enhanced OCT imaging for surgical guidance.
Researchers at Yale University have developed a novel molecule that eradicates cancer by destroying tumor blood vessels. The icon targets the inner surface of tumors expressing tissue factor, allowing it to bind and activate an immune response against cancer cells.
Researchers at U-M discovered nearly 200 genes with varying expression profiles in normal and malignant prostate tissue. The study identified new clinical biomarkers, hepsin and pim-1, which were correlated with patient prognosis and could lead to new diagnostic tests.
A team of four researchers at Rensselaer Polytechnic Institute has received a $1 million grant to solve various problems using inverse problems, a branch of applied mathematics. They aim to develop algorithms for detecting tumors, locating submerged objects, and identifying cracks in airplanes using low-frequency elastic waves.
Scientists at Cedars-Sinai Medical Center used gene array technology to analyze thousands of genes in malignant brain tumor samples. They identified a critical step in the development of glioblastoma multiforme, which may improve patient prognosis and lead to effective therapies.
Scientists have identified small blood vessels as a key target of radiation therapy, allowing for higher doses with minimal side effects. The discovery could lead to improved treatment options for cancers treated with abdominal radiation therapy.
Researchers are developing microscopic chips called bioMEMS to monitor and treat serious diseases like heart disease and diabetes. These chips could contain stem cells, medication, or sensors to detect mutated genes or cancerous tissues.
A new womb surgery technique uses an IntraUterine Shaver to remove uterine tissue mechanically, reducing the risk of complications associated with current methods. The procedure is expected to cut substantially the number of hysterectomies and make minimal access surgery more accessible.
Vascugel, a perivascular tissue engineered implant, prevents intimal hyperplasia by regulating biochemical compounds involved in blood vessel repair. The study supports the potential use of Vascugel to enhance cardiovascular procedures and reduce costs associated with (re)stenosis.
Researchers aim to uncover molecular signatures of cancer initiation using gene expression profiles. They will compare genes in hereditary colon, breast, and kidney cancers with normal tissues to identify altered genes and target potential chemopreventive agents.
Researchers at Duke University Medical Center have successfully transplanted discarded thymus tissue into two infants with DiGeorge Syndrome, restoring their immune systems and providing long-term treatment. The children's new gland has provided a normally functioning immune system that requires no long-term drug support.
Researchers have successfully delivered beta-endorphin genes into the sheath of tissue surrounding the spinal cord, reducing hyperalgesic pain sensation in animal models. The study's simplified approach and selective therapeutic effect suggest potential applications for treating various spinal cord and brain disorders.
A new scanner, the T-Scan 2000, can detect tumors in breast tissue using a tiny electric current, allowing doctors to avoid biopsies. This device has the potential to reduce negative biopsies and increase early biopsy referrals for women with suspect lesions.
Researchers at Osiris Therapeutics confirmed the existence and capability of human adult stem cells to form multiple normal human tissues. These cells can undergo substantial expansion and differentiation into bone, cartilage, or fat, forming healthy connective tissue.
A new imaging device, Hall Effect Imaging (HEI), uses ultrasonic emissions to highlight variations in electrical conductivity between healthy and diseased tissue, offering a faster alternative to painful biopsies. HEI has high specificity, ruling out false positives, and could complement MRI technology.
Purdue University researchers have developed a new way to preserve species by transplanting ovarian tissue from one animal into another, enabling the production of viable eggs in a wide variety of female mammals. The breakthrough could boost breeding programs for endangered species and address fertility problems in humans.
Researchers at the University of Illinois have developed a novel optical biopsy technique using near-infrared light to detect hidden growths in breast tissue. The method shows strong correlation between infrared signatures and tumor types, potentially eliminating painful needle biopsies or expensive MRI procedures.
A new X-ray technique called defraction-enhanced imaging (DEI) produces sharper images of breast tissue, potentially diagnosing tumors earlier and reducing cancer deaths. The method uses a single-energy X-ray source to reduce scatter and improve contrast, highlighting the edges of structures in cancerous tumors.
Researchers developed a non-invasive method to detect early signs of cancer and heart attacks using optical coherence tomography (OCT). OCT produces a clear picture of tissue without damaging it, allowing visualization of individual cells.
Mohs surgery has shown promise in preventing melanoma recurrence, particularly in patients with lentigo-maligna tumors. The technique's precision and ability to check surgical margins may provide a better chance of getting rid of tumors and preventing recurrences while conserving tissue.