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Science News for December 3, 2001


Researchers distinguish new type of leukemia

Researchers distinguish a new type of leukemia called mixed-lineage leukemia (MLL) that is genetically different from acute lymphoblastic leukemia (ALL). The study used DNA microarrays to compare gene expression profiles and found clues about the origin of MLL, suggesting it is caused by arrested maturation of lymphocytes.

SourceHoward Hughes Medical Institute·JournalNature Genetics·DateDec 3, 2001

Smoking increases likelihood of impotency

A study by Northwestern University researchers found that men who smoke are more likely to experience erectile dysfunction due to the negative effects of smoking on blood vessels. The prevalence of erectile dysfunction in former smokers was similar to that of never-smokers, highlighting the long-term risks of tobacco use.

SourceNorthwestern University·JournalThe Journal of Urology·DateDec 3, 2001

7-day-on, 7-day-off regimen could reduce cost, toxicities of HIV therapy

Researchers suggest a structured intermittent therapy approach, where patients receive daily doses of HAART for seven days, followed by seven days off the medication. This regimen has shown significant reductions in certain side effects, including cholesterol and triglyceride levels, without compromising treatment efficacy.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalProceedings of the National Academy of Sciences·DateDec 3, 2001

Gatekeepers may not be essential to keep HMO costs down

A new study found that eliminating gatekeepers in health maintenance organizations (HMOs) does not necessarily increase costs. In contrast to traditional HMOs, point-of-service plans with open physician panels showed comparable spending on medical care expenditures, including physician services, hospital services, and prescription drugs.

SourceCenter for Advancing Health·JournalHealth Services Research·DateDec 3, 2001

Estrogen holds promise as preventive therapy for cardiovascular disease

A randomized controlled trial found that unopposed estrogen therapy reduced atherosclerosis progression by .0017 millimeters per year in postmenopausal women. The study also showed that cholesterol-lowering drugs had a similar effect when combined with estrogen, suggesting potential benefits for cardiovascular health in women at risk.

SourceUniversity of Southern California·JournalAnnals of Internal Medicine·DateDec 3, 2001