Articles tagged with Tumor Tissue
A new software toolkit combines deformable anthropomorphic models with precision dosimetry to determine the most effective cancer-killing dose for every patient. This approach enables personalized radionuclide drug therapies, leading to improved outcomes and better survival rates.
Scientists have designed nanoparticles that can flip from a sphere to a net-like structure in response to tumor signals, accumulating at the site of cancer. This new approach aims to target treatments specifically to diseased cells, overcoming current limitations.
The new system uses micro-robotics to provide surgeons with a better view of bladder tumors, allowing for more accurate diagnoses and easier tumor removal. The device can operate in challenging environments and has been shown to have sub-millimeter precision.
Researchers discovered a calcified ovarian teratoma in a Roman-age skeleton, shedding light on the presence of this tumour in antiquity. The tumour contained four anomalous teeth and a small bone fragment, providing valuable information for the study of ancient diseases.
A University of Colorado Cancer Center study found that SPARC acts as an anti-inflammatory drug, reducing tumor growth and metastasis in bladder cancer. The protein is produced by healthy tissue to mute tumors, but aggressive cancers suppress its production, leading to faster disease progression.
Genetic sequencing technology is altering cancer diagnosis and treatment, but traditional specimen handling methods slow progress. Scripps physicians propose freezing tumor tissue to preserve DNA coding, potentially leading to better diagnoses and treatments.
A survey of women with dense breasts found that many would pursue additional screening if notified of their breast density. The study highlights the need for patient education regarding breast density and available alternative technologies to aid in screening.
A new study found that EMR before RFA is a safe and effective treatment option for patients with nodular Barrett's esophagus and advanced neoplasia. The performance of EMR before RFA was not associated with a diminished likelihood of success or increased stricture rate compared to RFA alone.
Chemists at UMass Amherst have developed a sensor array system using gold nanoparticles and proteins that can rapidly detect and identify different cancer types in living tissue. The technology uses a 'nose' strategy similar to how humans recognize odors, allowing for precise detection of metastatic cells with high accuracy.
Professor Ming Su at UCF's NanoScience Technology Center has been awarded a $2 million NIH New Innovator Award to use nanoparticles to improve radiation therapy. The goal is to reduce damage to surrounding healthy cells while killing cancerous tumors.
A new imaging technique called near-field thermoacoustics has the potential to benefit medical practitioners and biology researchers. The technique uses harmless electromagnetic radiation to create high-contrast images of normal tissues, tumors, and other pathological changes.
Researchers at Queen's University Belfast have discovered a new protein that plays a crucial role in regulating the spread of cancer cells. By targeting this protein, new therapies may be developed to prevent cancer from spreading.
A novel procedure in JoVE enables scientists to study the effects of interstitial fluid flow on tumor cells, promoting a better understanding of tumor growth and metastasis. The technique mimics in vivo conditions, allowing researchers to evaluate potential new therapies.
A new probe developed at Norris Cotton Cancer Center and Dartmouth College helps surgeons differentiate between cancerous tissue and normal tissue in low-grade tumors. The probe reads how light travels through tissue, producing a straightforward answer as to whether the tissue is cancerous.
Researchers developed a new imaging device that uses photoacoustics to detect breast tumors, revealing high-contrast images of malignant tissue. The technology combines light-based system with ultrasound, providing superior targeting ability and potentially clinically useful for making breast cancer diagnoses.
Researchers at Stanford University developed nanoparticles that can be imaged three ways at once and highlighted brain tumors, precisely delineating their boundaries. The technique could improve prognosis for patients with glioblastomas, the most aggressive form of brain tumor.
Researchers have developed a new endoscope technology that uses Cerenkov Luminescence to guide surgeons in removing more of cancerous tumors than possible. The technology has shown promise in laboratory experiments and may be suitable for human use, potentially improving cancer treatment outcomes.
A randomised controlled trial found ultrasound-guided surgery excises all cancerous tissue with minimal healthy tissue removal, reducing re-excisions and radiotherapy. The technique enables precise tumour localisation and assessment of surgical margins.
Researchers found that Pannexin1 helps closely pack together tumor cells, forming large multicellular tissues. The protein sets off a chain reaction involving ATP and receptors, ultimately remodeling the actin network to increase forces between cells, driving them to bind more tightly.
Researchers identified a biochemical chain of events leading to activation of a protein-cleaving enzyme called hepsin on the surface of breast tumor cells. Hepsin breaks down basement membrane proteins, allowing tumor cells to escape and invade surrounding tissues.
A study has identified a protein called hepsin that may trigger the spread of breast cancer in certain cases. Hepsin, a protease enzyme, was found to free tumor cells from their native tissue matrix, allowing them to invade other tissues and grow into aggressive tumors.
Researchers at Penn developed a new MRI contrast agent that targets acidic environments of tumors, improving diagnosis accuracy. The coating technology allows the particles to be neutral near healthy tissue but become ionized in low pH, attracting them to tumor sites.
A Wayne State University study shows that soybean compounds can make radiation treatment of lung cancer more effective while helping to preserve normal tissue. The compounds, known as isoflavones, block DNA repair mechanisms and molecular survival pathways in cancer cells, making them more vulnerable to ionizing radiation.
Researchers identified a key protein mutation that enables brain tumors to invade healthy brain tissue. Excessive epidermal growth factor receptor (EGFR) signals trigger the production of GBP1, rendering tumors more invasive and allowing them to spread into surrounding tissue.
Scientists have developed a new smart polymer that breaks apart into small pieces in response to harmless levels of irradiation, paving the way for safe medical applications of tissue-penetrating light. The material has potential for use in diagnosing diseases and engineering new human tissues in the lab.
Scientists developed a new tool to identify cancerous and healthy brain tissue, allowing for more precise tumor removal and reduced risk of recurrence. The tool, combining an ultrasonic aspirator with a mass spectrometer, proved successful on human brain samples in half the time previously needed.
Researchers at Imperial College London and the University of Oxford used 'optical' laser tweezers and a super-resolution microscope to observe the inner workings of white blood cells, including Natural Killer cells. The study provides new insights into how these cells deliver deadly enzyme-filled granules to kill diseased tissue.
A new hybrid imaging device combining photoacoustic imaging, optical coherence tomography, and pulse-echo ultrasound has been developed to diagnose early-stage ovarian cancer. The device was tested on both pig and human ovarian tissue, correctly identifying malignant tumors in initial tests.
Researchers at Boston University School of Medicine found flexible-fiber CO2 lasers to be safe and effective in endoscopic assisted transsphenoidal craniotomies, with low complication rates. The study demonstrated the utility of this technology for treating pituitary tumors and other sellar lesions.
A study found that women with dense breasts are at higher risk of certain breast cancers and their tumors are more likely to be aggressive. Breast density was also linked to specific tumor characteristics, including ductal carcinoma in situ (DCIS) and estrogen receptor-negative tumors.
A Johns Hopkins team discovered that cancer cells exhibit a universal 'chaotic' pattern of methylation, leading to unpredictable gene function and increased randomness. This finding may require a new approach to cancer therapy, focusing on helping cancer cells return to normal instead of just killing them.
A new study confirms that genetic differences exist in breast tissue across racial groups, which may explain disparities in breast cancer morbidity and mortality. The research found varying levels of genes related to the DNA repair pathway, a known mechanism in cancer.
Researchers at the University of Illinois developed a new microscopy technique that can identify cancer cells with over 99% confidence in under five minutes. The technique uses nonlinear interferometric vibrational imaging to analyze molecular composition and produce color-coded images, providing clear tumor boundaries.
Researchers have developed a new method to target and destroy cancerous cells using hyperthermia, which elevates the temperature of tumor cells while keeping surrounding healthy tissue at a lower degree of body heat. The technique uses ferrofluids to induce hyperthermia and has been shown to be biocompatible with iron oxide nanoparticles.
Researchers develop a new method to target cancer tumors using heat and magnets, reducing side effects and damage to healthy tissue. The innovative technique uses biomarkers attached to individual tumors and excites nano-particles with an external magnetic field, killing the tumor cells.
A Purdue University-led team has found a molecular compound that appears to be useful in identifying cancerous and precancerous tissue in the prostate. The compound, cholesterol sulfate, is absent in healthy prostate tissue but present in prostate cancer tumors, making it a potential marker for the disease.
A new study reveals that even slight reductions in PTEN expression can significantly increase cancer susceptibility in specific tissues, implying that environmental factors like diet and carcinogens may drive tumor development. This finding has implications for the development of diagnostic tests targeted to these gene alterations.
Researchers have discovered that blocking Mcl-1, a protein inhibiting Bak activation, enables TRAIL to activate Bak and kill resistant tumor cells. This strategy has potential for improving the efficacy of anti-cancer treatment.
Researchers have developed a new technique that combines electrosurgery with mass spectrometry to analyze tissue during surgery. This allows surgeons to distinguish between malignant tumor cells and healthy tissue in real-time, potentially sparing patients from unnecessary second surgeries.
Researchers have created a robot-controlled palpating device that detects tumors with 40% more accuracy than humans, reducing tissue damage by over 35%. The device applies consistent force in each step, producing a complete map of the tissue.
Researchers found that estrogen suppresses p53 after stroke, preventing cell death and reducing damage. The study used female rats treated with estrogen versus placebo to induce global cerebral ischemia, a common type of ischemic stroke.
Researchers found that a shorter form of the protein AIB1 alters breast tissue, making it more fibrous and potentially increasing tumor growth. The study suggests that this change may be related to dense breast tissue, a known risk factor for breast cancer.
Researchers at Stanford University School of Medicine identified beta-1 integrin as a key molecule involved in tumor development and invasion. Inhibiting this molecule slowed the growth of tumors and improved tissue separation, offering new potential targets for cancer treatment.
Scientists at Heidelberg University Hospital have identified a previously unknown protein called SCAI that inhibits the movement and spread of tumor cells. The study suggests that SCAI could be an interesting starting point for research into new mechanisms for fighting cancer.
AVEO scientists have developed a novel human-in-mouse (HIM) cancer model system, which allows for the creation of invasive human tumors that mimic human tumor behaviors and response. The models provide a more realistic genetic context for evaluating new anti-tumor therapies.
Rice University scientists have developed a method to optimize the attack on cancer cells using laser-nanoparticles. By adjusting the size and composition of nanoparticles, researchers can create more uniform temperature profiles within tumors.
Researchers propose a new model explaining how cancer cells grow and spread, attributing inefficiency to pressure differences between tumor cells and host tissues. Understanding this process is crucial for developing effective treatments for metastatic cancer.
Researchers have developed a new technique to determine tumor methylation status in archived tissue samples, providing a potential biomarker for early cancer diagnosis and risk assessment. The technique uses high-resolution melting analysis and has been validated on archival and fresh tissues.
Researchers used PHIFU with short duty cycle and high intensity combined with ultrasound contrast agent (UCA) to damage rabbit liver VX2 tumour by non-thermal effect. The study found that PHIFU combination with UCA can enhance non-thermal effects of ultrasound, promoting tumor cell apoptosis and inhibiting proliferation.
The new device would deliver more precise and less costly proton radiation to cancerous tumors with minimal damage to surrounding healthy tissue. The Brookhaven scientists are seeking industrial partners to license and commercialize the technology.
HER2-positive breast cancer can be more aggressive due to the suppression of its own regulator gene Lig-1. Researchers found that when Lig-1 levels are low, cancer cells grow faster.
Researchers have developed a new imaging system that highlights cancerous tissue, allowing surgeons to visualize and remove diseased tissue with greater precision. The FLARE system uses special chemical dyes and near-infrared light to 'cutting by color' tumors more easily.
A new method developed by Murali Krishna and colleagues at the National Institutes of Health uses low-field paramagnetic resonance imaging to image tumors and surrounding organs in mice. This approach has shown promise for determining the best treatment approach for tumors and other diseases, as well as monitoring responses to treatment.
Researchers discovered a key molecule that normalizes tumor vasculature, allowing immune cells to colonize cancer tissue in large numbers. This finding led to improved survival rates in mice with disrupted Rgs5 gene, highlighting the potential of vascular normalization for enhancing immune therapy.
Researchers developed a tumor-targeting viral therapy that slowed the growth of neuroblastoma and peripheral nerve sheath tumors by inhibiting tissue growth and reducing blood vessel formation. The treatment, called rQT3, showed promise in laboratory studies and improved life spans in mice with these types of tumors.
Researchers have developed an anti-cancer therapy using eIF4E-specific antisense oligonucleotides (ASOs), which effectively knock down the protein's expression in human tumors. The treatment has been shown to inhibit tumor growth without compromising normal tissue function, suggesting a promising approach for cancer treatment.
Scientists have developed a novel method for capturing and genome-wide screening of blood vessel cells in their actual disease state, advancing potential for genetic research. The technique allows for precise cell-specific information and has implications for diseases such as cancer and chronic wounds.
A Mayo Clinic-led collaborative study finds that focused ultrasound treatment of uterine fibroids offers sustained symptom relief and durable outcomes. The more complete destruction of tumors by focused ultrasound results in improved quality of life and lower incidence of severe side effects.
A new technique called Fluorescence Diffuse Optical Tomography has been developed to image breast cancer in patients with high contrast. The method uses fluorophore molecules that re-radiate fluorescent light, providing richer information about tumor physiology.
A new imaging technique using Indocyanine Green (ICG) dye helps surgeons precisely remove cancerous tumors from the kidney while sparing as much healthy tissue as possible. This innovation allows for more effective treatment and better patient outcomes.