Articles tagged with Weight Loss
Early-phase clinical trials of a new weight management medication amycretin have confirmed its safety and tolerability. The medication targets two specific receptors to help control blood sugar and appetite, showing promise in treating overweight, obesity, and type 2 diabetes.
The American College of Cardiology has issued a Concise Clinical Guidance document to inform clinicians about medication for weight management in patients with cardiovascular benefit. Modern obesity medications, such as semaglutide and tirzepatide, have been proven effective in reducing overall cardiovascular disease risk.
A new study found that weighted vests and resistance training did not prevent bone loss in older adults undergoing intentional weight loss. The researchers call for alternative strategies to protect skeletal health in aging populations with obesity.
A new study found that self-esteem scores doubled within one year of weight-loss surgery, with the highest increases seen among those who lost the most weight. The study also highlighted the importance of understanding and addressing weight stigma in obesity treatment.
A University of Oxford study found that an intensive low-energy diet programme significantly improved eating disorder symptoms in people with type 2 diabetes and excess weight at risk of developing eating disorders. The programme showed benefits persisting six months after completion.
Researchers at Tufts University have designed a new compound that incorporates structural elements of four hormones - GLP-1, GIP, glucagon, and PYY - to create a single weight loss drug. This chimera peptide aims to address the drawbacks of current weight loss drugs, such as nausea and limited efficacy.
A Cleveland Clinic study found that patients taking injectable GLP-1 medications for obesity lost an average of 3.6% body weight, significantly lower than the 11.9% seen in non-discontinuers. Treatment discontinuation negatively impacted blood sugar control in those with prediabetes.
A new study found that nearly one-third of individuals adopting healthy diets didn't lose weight but still experienced significant improvements in cardiometabolic markers, including increased HDL cholesterol and reduced visceral fat. The research suggests a healthy diet can have benefits beyond weight loss.
Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.
New research shows that weight stigma and not weight itself have the biggest impact on mental health and healthy behaviors in patients after weight-loss surgery. This reduction in weight stigma is linked to improvements in both mental and physical health, including lower levels of anxiety and depression.
A Virginia Tech professor has received a proof-of-concept grant to further develop a chemical compound that could help promote weight loss by increasing mitochondrial activity. The compound, named BAM15, shows promise in preclinical studies without affecting food intake or muscle mass.
Researchers at University of Gothenburg identified a group of nerve cells controlling semaglutide's appetite-suppressing effects without causing nausea. The discovery may lead to improved treatments for obesity and type 2 diabetes.
This novel treatment approach yields better weight loss maintenance and cardiovascular risk outcomes compared to standard-of-care treatment. Patient-delivered lifestyle intervention combined with peer support significantly improves weight loss and reduces cardiovascular risk.
Sustained midlife weight loss was associated with lower chronic disease incidence and decreased all-cause mortality. The study's findings suggest that maintaining a healthy weight during middle age can have long-term health benefits.
Bariatric surgery, a critical tool for combating obesity, is under threat in Australia due to skyrocketing indemnity insurance premiums. The study found that surgeons are being penalized by rising premiums, forcing some to reconsider their future in the field.
A new study from the University of Bath found that regular, moderate-intensity exercise preserves vitamin D levels in overweight and obese individuals. The study showed that exercise completely maintained the body's active form of vitamin D, which plays a key role in supporting bone health and the immune system.
A new study by York University suggests that the broad ethnic categories used in clinical settings may mask differences in sub-ethnic groups. The findings indicate that socio-economic factors play a significant role in weight loss disparities among Black, Middle Eastern, Latin, and South Asian communities.
SYNT-101 successfully redirects nutrient absorption to the lower intestine, promoting satiety and metabolic balance. The study demonstrated strong safety and tolerability profiles, as well as control of hunger and weight loss.
Researchers found that tirzepatide increases energy expenditure directly after treatment, while semaglutide reduces it. Both drugs aid weight loss by decreasing food intake and enhancing fat oxidation.
A new analysis of 100 top TikTok videos about food noise found that half reference the use of medications, mainly anti-obesity drugs, to manage constant thoughts about food and eating. The study highlights the potential risks of misinformation on social media platforms like TikTok.
A study published in Molecular Motabolism found that prolonged water-fasting can increase inflammation and stress on the body, potentially exacerbating existing heart and vascular conditions. However, some benefits were observed, including a reduction in amyloid beta proteins associated with Alzheimer's disease.
Patients in an online obesity clinic achieved average weight loss of 16.7% after 64 weeks, similar to clinical trials of semaglutide, but using less than half the medication. The study found that personalized doses of semaglutide combined with behavioral therapy and support led to successful weight loss.
Researchers found that individuals who consumed collagen-enriched protein bars lost twice as much weight as a control group. The supplement also improved blood pressure, waist circumference, and liver health. Participants reported feeling less hungry and more full.
A new head-to-head study has shown that tirzepatide results in around 50% more weight loss than semaglutide in adults with obesity. The study found that tirzepatide led to an average weight loss of 20.2%, significantly higher than the 13.7% achieved with semaglutide.
A new analysis of the SELECT trial shows semaglutide reduces major cardiovascular events by 40% within 3-6 months, even before significant weight loss and full target dose. The study found that semaglutide's effects on reducing inflammation, blood sugar, and blood pressure may contribute to its early clinical benefits.
Researchers found that GLP-1 receptor agonists have a direct effect on reducing obesity-related cancer beyond weight-loss, with a 41% lower relative risk compared to bariatric surgery. The study also suggests that these medications work through multiple mechanisms, including reducing inflammation.
Researchers found that a 3-month program of time-restricted eating at any time of the day can result in significant weight loss for at least a year, regardless of eating window timing. The study suggests that restricting the eating window to 8 hours may be an effective long-term approach for sustaining weight loss.
A systematic review of available evidence found GLP-1 RAs lead to significant weight loss and improved blood sugar control in adults with severe mental illness. The analysis also showed that these medications were not associated with a worsening of mental state or suicidal behaviour.
Researchers found that silencing Mitch, a key regulator of mitochondrial fusion, increases cellular respiration and burns more fats and carbohydrates. In human cells, deleting Mitch leads to increased muscular endurance and a decrease in fat accumulation.
Researchers at Pennington Biomedical Research Center investigated tirzepatide's effects on weight loss and metabolic health. The study found that tirzepatide decreased calorie intake and increased fat oxidation, leading to significant weight loss. However, the drug did not decrease the slowing down of metabolic rate usually observed wi...
A study published by the European Association for the Study of Obesity found that women are significantly more aware of and have a better understanding of obesity drugs like semaglutide and tirzepatide. Understanding tolerable side effects, effectiveness, and ability to maintain weight loss is crucial for people commencing treatment.
A study of nearly 2 million people found that the use of GLP-1RA-based medications increased from 13% to 35% among those with type 2 diabetes, while traditional medications like metformin declined. Tirzepatide saw a steeper and more sustained rise in its use compared to other recently approved medications.
A new study found that tirzepatide can produce sustained weight loss of up to 31% in adults with overweight or obesity without diabetes, regardless of age or BMI. The study also identified patterns of weight loss trajectories and found that females and those without obesity-related complications may be more responsive to the medication.
A new analysis of the SURMOUNT-1 trial found that around two-thirds of participants regained only 5% or less of their lowest weight over three years. The study suggests that most patients receiving tirzepatide had a relatively stable weight journey, with limited weight regain after reaching their nadir weight.
A six-month study found that patients using GLP-1 and dual GLP-1/GIP receptor agonist therapy experienced minimal lean muscle mass loss as they lost weight. Regular resistance training, consistent protein intake, and close supervision by an expert obesity doctor were associated with better muscle retention.
Research found that people taking GLP-1s consume less processed foods, soda, refined grains, and beef, but still desire them. The study also showed an increase in consumption of fruits, leafy greens, and whole grains among GLP-1 users.
The Endocrine Society strongly disagrees with the administration's decision not to finalize a rule allowing Medicare and Medicaid to cover anti-obesity medications. This decision leaves millions of Americans with obesity without access to evidence-based treatment, exacerbating the country's growing obesity epidemic.
The American College of Physicians has awarded $260,000 in grants to support regional programs addressing equity challenges in obesity care. Thirteen grantees will implement collaborative outreach projects to train medical professionals and their patients to combat misinformation and improve clinical capacity for obesity care.
A new review of studies on percentage weight-based targets in obesity interventions found that these targets often result in a 'success or failure' outcome, leaving little room for improvement in obesity-related complications, quality of life, and overall physical and social functioning. The study recommends shifting focus towards more...
A new paper highlights emerging alternatives to traditional diabetes medicines, such as continuous glucose monitors and lifestyle interventions like GEM, which can improve patient adherence and long-term health outcomes.
A randomized clinical trial found that 4:3 intermittent fasting resulted in modestly greater weight loss over 12 months compared to daily caloric restriction. The study showed improved cardiometabolic outcomes, including lower blood pressure and cholesterol levels, suggesting that fasting may be a more effective approach for weight loss.
A four-year study presented at the American College of Cardiology's Annual Scientific Session found that oral semaglutide reduced cardiovascular death, heart attack, and stroke by 14% compared to a placebo. The drug's benefits are comparable to injectable forms and offer an alternative for patients who prefer not to take injections.
A new white paper finds that expanding access to anti-obesity medications can prevent or delay chronic disease by years, providing significant societal benefits. The study estimates a $10 trillion return on investment and 13% annual returns on investment for society.
A new study from the University of Mississippi finds that time-restricted eating combined with regular exercise leads to more significant fat loss and reduced body fat percentage compared to exercise alone. However, lean mass preservation was maintained in this study, contradicting previous concerns about potential muscle loss.
A high-fat diet reduces neurotensin, a brain peptide that interacts with the dopamine network, leading to reduced pleasure in eating. Boosting neurotensin levels restores pleasure and promotes weight loss in mice, offering new avenues for addressing obesity.
New research suggests that maintaining a healthy weight throughout life and losing weight later in life may reduce the risk of kidney cancer. Higher BMI at various ages across adulthood was associated with increased risks of developing different types of kidney cancer, including renal cell carcinoma, papillary RCC, and chromophobe RCC.
A new technology called in vivo antibody painting enables sustained weight loss and prolonged blood sugar management with a lower dose of GLP-1 receptor agonist. The system, developed by MIT professor Bradley Pentelute, attaches peptides directly to antibodies, overcoming the limitation of peptide degradation.
A Swedish study of over 1,300 participants found that losing a significant amount of weight still offers protection against health issues like cancer and cardiovascular disease, even if some weight is regained. However, regaining weight can increase the risk of microvascular disease and other health problems.
A new study from the University of Surrey found that healthcare professionals face difficulties in recognizing and addressing disordered eating in people with type 1 Diabetes due to lack of support and limited confidence. This can lead to delays in diagnosis and potentially life-threatening complications for patients.
A recent study published in Heart journal found that extreme weight fluctuations significantly increase the risk of death among obese individuals with cardiovascular disease. Both weight loss and gain above 10kg raise mortality risk, highlighting the importance of maintaining a stable weight even within the obese range.
Replacing animal products with plant-based foods, even highly processed ones, can lead to substantial weight loss due to reduced calorie and fat intake and increased fiber consumption. This is according to a new analysis of a randomized clinical trial published in Nutrition & Metabolism.
A pooled data analysis found that water aerobics can effectively reduce overall weight and trim waist circumference by 3 cm in obese or overweight participants. Exercise periods lasting more than 10 weeks significantly reduced body weight and waist circumference in women and those aged 45 and older.
A study of 350 patients found that taking semaglutide before bariatric surgery did not increase total weight loss and had similar health outcomes to surgery alone. Researchers suggest a surgery-first strategy may lead to better obesity treatment outcomes.
A new study found that the proportion of visceral fat, rather than the absolute amount, is a stronger predictor of high triglyceride levels and inflammation. Lowering visceral fat proportion during weight loss can lead to better metabolic health outcomes.
Researchers developed a novel approach using electrospun poly(Lactic-co-Glycolic Acid) membrane with autologous cells to treat oral mucositis, a painful side effect of chemotherapy. The study showed significant results, with ulcers healed completely within six days and reduced inflammation.
Complimentary press passes are available for NUTRITION 2025, exploring cutting-edge research on nutrition and public health. Media professionals can attend in person or access virtual newsroom materials before the meeting.
A two-month intervention targeting ultra-processed foods resulted in a significant reduction of UPF intake, with participants consuming almost half the amount initially. Participants also experienced weight loss, improved mood, and reduced sugar, saturated fat, and sodium consumption.
A cohort study found that patients with obesity undergoing joint replacement who experienced significant weight loss after initiating anti-obesity medications had a lower risk of 5-year and 10-year revision. This suggests that safe and sustainable weight loss may improve implant survivorship in obese patients.
A systematic review of 38 studies found that frequent use of health and fitness apps is associated with problematic habits related to food and exercise. The research highlights the need for app developers to consider the psychological impacts of these tools on users' mental health.
Researchers found that teens with obesity consumed more calories in the late afternoon and early evening compared to their peers of healthy weight. The study, published in PNAS, demonstrates that the body's biological clock directly impacts food intake throughout the day.