Articles tagged with Weight Loss
A USC study found that prescription fills for semaglutide increased by over 400% between 2021 and 2023, with most prescriptions going to privately insured patients. The study suggests that this may worsen disparities in diabetes and obesity outcomes among Medicaid and Medicare recipients.
The number of semaglutide prescriptions filled reached 2.6 million in 2023, with Wegovy accounting for most fills since its approval in June 2021. Most Wegovy fills were among commercially insured populations, despite the disproportionate burden of obesity in Medicaid and Medicare Part D.
Experts advocate for incorporating normalization of blood sugar regulation into diabetes prevention strategies. Studies show that weight loss-induced prediabetes remission can significantly reduce the risk of developing type 2 diabetes, especially when combined with lifestyle changes.
A recent study published in JAMA Pediatrics found that meal-replacement therapy paired with financial incentives resulted in a greater reduction in body mass index compared to MRT alone. The study enrolled 126 adolescents and found that the combination treatment led to a significant decrease in BMI and total body fat mass.
A special issue of the Journal of the Academy of Nutrition and Dietetics explores the effects of various fasting regimens on body weight, cardiometabolic disease risk, and sleep. The study found that time-restricted eating can result in clinically meaningful weight loss and reduction in liver enzymes in adolescents with type 2 diabetes.
Researchers analyzed fecal samples from fat cats undergoing different dietary changes and found striking similarities to human studies, particularly in the presence of short-chain fatty acids. The study suggests that feline gut microbiome shifts may correlate with metabolic outcomes and provide valuable insights for obesity treatment.
Severe obesity can alter metabolism and psyche, leading to impulsive behavior and a willingness to take risks. A study found that massive weight loss improved glucose metabolism and mood, allowing for more metabolically driven decision-making.
A new study found that low energy availability among female athletes impairs performance by up to 18% in short-term tests and increases systemic stress, compromising immune function. Athletes who restrict their food intake experience muscle loss and decreased physical performance.
A review article by Uppsala University researchers highlights the global issue of malnutrition in the sick and elderly, affecting up to 50% of hospital patients in Sweden. Simple measures such as counselling, dietitian collaboration, and nutritional drinks can reverse malnutrition and improve quality of life.
A new study found that surgical weight loss significantly reduces widespread pain in Black and Hispanic patients, with the greatest benefit seen within the first three months after surgery. However, disparities persist, with these groups still experiencing a higher pain burden than the general population.
Researchers found that mice lacking certain signal molecules produced during exercise had reduced oxygen consumption and fat burning, leading to increased susceptibility to weight gain. In humans, those producing more of these alternative versions consumed less oxygen and had lower body fat.
Tirzepatide was associated with significantly greater weight loss than semaglutide in adults with overweight or obesity. Future studies are needed to explore differences in other outcomes.
A new study found that patients prescribed semaglutide for diabetes or weight loss have a higher risk of developing NAION, a potentially blinding eye condition. The study revealed a significant risk increase in diabetic and overweight/obesity patients taking semaglutide.
A new mouse study suggests that elenolic acid can lower blood sugar levels and promote weight loss in obese mice with diabetes. The compound was found to induce the release of metabolic hormones GLP-1 and PYY, leading to improved glucose regulation and insulin sensitivity.
Researchers found that people who achieved weight loss and prediabetes remission had a 76% lower risk of developing type 2 diabetes compared to those who only lost weight. This suggests that normalization of blood sugar levels should be included as a therapeutic goal in guidelines to improve diabetes prevention.
A randomized clinical trial found that combining exercise with glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment was the most effective weight loss strategy while preserving bone health. In contrast, GLP-1RA treatment alone reduced bone mineral density at clinically relevant sites.
Research debunks four common myths about intermittent fasting: it does not lead to a poor diet, cause eating disorders, excessive lean muscle mass loss, or affect sex hormones. Studies show both types of intermittent fasting (alternate-day and time-restricted) are safe despite popular misconceptions.
Research reveals close relationship between midlife diet and healthy aging; Limiting ultra-processed foods may not improve diet quality. Baby-led weaning meets nutritional needs for healthy growth, while whole grains retain more nutrients during milling.
Women with obesity-related heart failure experienced greater weight loss and improved HF symptoms compared to men. Semaglutide improved HF-related symptoms, physical limitations, exercise function, reduced inflammation, and lower blood pressure across both sexes.
A randomized clinical trial found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of meal replacement diet improved glycemic outcomes and weight loss in the short term compared to metformin or empagliflozin. The study suggests a promising initial intervention for type 2 diabetes management.
A list of evidence-based nutritional recommendations has been developed to assist clinicians in treating patients with anti-obesity medications. The recommendations aim to improve nutritional needs within the context of reduced food intake, and include ongoing monitoring of dietary intake and nutritional status.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
Research published in the Stroke journal found that teenage women who were overweight or obese had a higher risk of ischemic stroke before age 55. The study analyzed data from over 50 years and suggested that even temporary excess weight may have long-term health effects.
Research shows that GLP-1 receptor agonist drugs are highly effective for weight management and Type 2 diabetes treatment, but they come with complex considerations such as dosages, side effects, and comparisons between specific drugs. Experts caution against overusing these drugs or viewing them as a universal cure-all for obesity.
Current medical training neglects to educate future doctors on how to encourage healthier eating habits and focuses on weight loss and BMI. Researchers advocate for small changes in medical education to address anti-obesity bias and promote cardiometabolic health, a stronger predictor of overall well-being.
A study suggests that women who underwent sleeve gastrectomy before pregnancy had children who gained more weight per month in the first three years of life. In contrast, those born to mothers who had Roux-en-Y gastric bypass surgery experienced slower weight gain. Researchers found this difference after adjusting for various factors, ...
A recent study funded by tirzepatide maker Eli Lilly Inc. found that the medication resulted in significant weight loss regardless of the number of obesity-related complications patients had at the outset. The study combined data from four trials involving over 4,700 subjects with obesity or overweight conditions.
A new study found that tirzepatide significantly reduced weight in Chinese adults with obesity, with both 10mg and 15mg doses showing clinical benefits. The treatment also demonstrated an acceptable safety profile.
Wake Forest University School of Medicine has received a $1.5 million grant to study bone microarchitecture in patients following bariatric surgery. The researchers will use high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging to assess bone loss and muscle changes after weight-loss surgery.
A new study highlights the benefits of intermittent fasting and protein-pacing on gut health, weight loss, and metabolic responses. Participants showed improved diversity of the gut microbiota, decreased symptoms of gastrointestinal problems, and increased beneficial microbes linked to a lean body type.
Researchers at Pohang University of Science & Technology developed a hybrid porous structure using polyvinyl alcohol, enabling uniform lithium electrodeposition. The new design facilitated the transport of lithium ions, reducing 'dead Li' areas and internal short circuits, resulting in high stability after 200 charge-discharge cycles.
A national study found a significant increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) among adolescents and young adults in the US. Female adolescents showed a higher increase in GLP-1RA usage compared to males, highlighting the need for education on potential safety risks during pregnancy.
Research presented at Digestive Disease Week 2024 reveals the risks associated with weight-loss drugs and alpha-gal syndrome. Studies found that GLP-1 weight loss drugs may increase the risk of biliary disease and gastroparesis, while an alpha-gal syndrome diagnosis is linked to GI symptoms in females.
A new American Heart Association scientific statement reveals significant gaps in the application of obesity research to patient care, with widespread adoption varying by healthcare professional and institution. The statement emphasizes the need for better implementation of evidence-based treatments and strategies, such as lifestyle mo...
A new study led by UT Health San Antonio found that long-term ketogenic diets can induce senescence, or aged cells, in normal tissues, affecting heart and kidney function. However, an intermittent ketogenic diet regimen eliminated these pro-inflammatory effects.
Researchers have developed a new weight loss drug that combines GLP-1 with molecules blocking the NMDA receptor, exploiting its effects on appetite control and neuroplasticity. This approach shows promise for greater weight loss in mice than existing medications.
A study published in JAMA Surgery found that bariatric surgery significantly reduces the risk of breast cancer in women with obesity, particularly those with high blood insulin levels. The results show a 32% lower risk overall and a 52% lower risk for women with high insulin levels at the start of the study.
A wireless feedback system is comparable to a similar system with added coaching in achieving meaningful weight loss. The study suggests that technology alone may not produce clinically acceptable weight loss for most individuals, highlighting the need for stepped care with human coach support.
A new study shows that text messaging with financial incentives significantly improves weight loss in men with obesity compared to traditional methods. The intervention combines personalized text messages with cash rewards, resulting in a 5% weight loss threshold, and could be an effective low-cost solution for health services.
A new UK-based trial found that text messages with financial incentives can help men with obesity lose weight, with an average of 4.8% body weight loss over 12 months. The study, which involved 585 men living with obesity, suggests that text messaging alone may not be as effective in promoting weight loss.
A new Northwestern University study found that technology alone resulted in worse weight loss compared to a combination of tech and telehealth coaching for obesity treatment. The study suggests that while technology has its benefits, it cannot replace the human touch for meaningful weight loss.
A new study quantifies the impact of childhood obesity on long-term health and life expectancy. Childhood obesity was found to have a profound effect, with a child living with severe obesity at age 4 having a life expectancy of just 39 years. Weight loss can give back decades of life.
Two studies based on the SELECT trial show semaglutide leads to sustained weight loss of 10% body weight and 7cm waist reduction after 4 years, regardless of starting weight or BMI. The medication also delivers cardiovascular benefits, with a lower risk of heart attack, stroke, or death.
Researchers found that Kallistatin expression increases after weight loss in individuals with overweight and obesity. Additionally, human Kallistatin improves hepatic insulin sensitivity in diet-induced obese mice. The study suggests that Kallistatin may be an interesting therapeutic target for people with obesity and type 2 diabetes.
A Danish study found that patients who tapered off semaglutide slowly and focused on lifestyle changes maintained their weight loss for at least 6 months. Lower doses of the drug were as effective as higher ones, with a tailored approach minimising side-effects.
A new endoscopic procedure has been developed to reduce production of ghrelin, a key hunger hormone, by ablating the stomach lining. This process resulted in a 7.7% body weight loss and a 40% reduction in fasting ghrelin levels in a six-month trial involving 10 female patients with obesity.
A 5:2 diet has been shown to protect against chronic liver inflammation and liver cancer in mice. The study identified two proteins, PPARα and PCK1, that are jointly responsible for the protective effect of fasting.
A Mayo Clinic study found that laparoscopic sleeve gastrectomy can improve the health and eligibility of patients with advanced chronic kidney disease and obesity. The procedure reduced cardiovascular risks, including diabetes and hypertension, and improved access to kidney transplantation.
A study published in PLOS ONE found that combining time-restricted eating with high-intensity functional training improves body composition and cardiometabolic health more than either alone. The research, conducted on inactive women with obesity, showed significant weight loss and favorable changes in lipid and glucose levels.
Neotame has been shown to cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to irritable bowel syndrome and sepsis. The study also found a breakdown of the epithelial barrier, which forms part of the gut wall.
The American College of Physicians recommends adding SGLT-2 and GLP-1 agonists to metformin in adults with Type 2 diabetes for improved cardiovascular outcomes. The guidelines prioritize shared decision-making, considering individual patient characteristics and values.
Endoscopic sleeve gastroplasty is a cost-saving option compared to semaglutide for treating class II obesity. A study found that achieving price parity with semaglutide requires a significant discount of at least 3-fold.
A Finnish study found that only 10% of newly diagnosed type 2 diabetics lost weight, while 3% gained weight, highlighting the challenges of achieving weight loss in these patients. The study also showed a strong association between weight gain and increased risk of microvascular and macrovascular complications.
Researchers have identified two plant compounds with potential as GLP-1 agonist weight loss pills, derived from common plants and potentially offering fewer side effects than current medications. The discovery was made using high-performance artificial intelligence techniques to analyze over 10,000 compounds.
A new study evaluates the use of tirzepatide in overweight/obese adults with type 1 diabetes, showing significant weight loss and improved glucose control. Tirzepatide also reduces insulin dose and increases time-in-range on continuous glucose monitoring.
A European randomized controlled trial found that replacing sugar with sweeteners improved weight loss control for at least one year after rapid weight loss in adults. The study also showed greater diet satisfaction and lower cravings for sweet foods among participants who consumed low/no-energy sweetened products.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
Researchers found that people who limited their eating to less than 8 hours per day were more likely to die from cardiovascular disease compared to those who ate for 12-16 hours. This contradicts previous research suggesting short-term benefits of time-restricted eating.
A Stanford Medicine study found that metformin stimulates production of lac-phe, an anti-hunger molecule abundant after exercise, leading to moderate weight loss in mice and humans. Understanding how metformin works through this pathway may lead to new strategies for lowering body mass and improving health.
A new synthesis method for semaglutide developed by an international team of researchers may help alleviate the global shortage of the drug, which is used to treat diabetes and aid in weight loss. The method uses glycosylation, resulting in ten-fold higher yields compared to existing processes.