Articles tagged with Weight Loss
A Mayo Clinic study found that laparoscopic sleeve gastrectomy can improve the health and eligibility of patients with advanced chronic kidney disease and obesity. The procedure reduced cardiovascular risks, including diabetes and hypertension, and improved access to kidney transplantation.
A study published in PLOS ONE found that combining time-restricted eating with high-intensity functional training improves body composition and cardiometabolic health more than either alone. The research, conducted on inactive women with obesity, showed significant weight loss and favorable changes in lipid and glucose levels.
Neotame has been shown to cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to irritable bowel syndrome and sepsis. The study also found a breakdown of the epithelial barrier, which forms part of the gut wall.
The American College of Physicians recommends adding SGLT-2 and GLP-1 agonists to metformin in adults with Type 2 diabetes for improved cardiovascular outcomes. The guidelines prioritize shared decision-making, considering individual patient characteristics and values.
Endoscopic sleeve gastroplasty is a cost-saving option compared to semaglutide for treating class II obesity. A study found that achieving price parity with semaglutide requires a significant discount of at least 3-fold.
A Finnish study found that only 10% of newly diagnosed type 2 diabetics lost weight, while 3% gained weight, highlighting the challenges of achieving weight loss in these patients. The study also showed a strong association between weight gain and increased risk of microvascular and macrovascular complications.
Researchers have identified two plant compounds with potential as GLP-1 agonist weight loss pills, derived from common plants and potentially offering fewer side effects than current medications. The discovery was made using high-performance artificial intelligence techniques to analyze over 10,000 compounds.
A new study evaluates the use of tirzepatide in overweight/obese adults with type 1 diabetes, showing significant weight loss and improved glucose control. Tirzepatide also reduces insulin dose and increases time-in-range on continuous glucose monitoring.
A European randomized controlled trial found that replacing sugar with sweeteners improved weight loss control for at least one year after rapid weight loss in adults. The study also showed greater diet satisfaction and lower cravings for sweet foods among participants who consumed low/no-energy sweetened products.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
Researchers found that people who limited their eating to less than 8 hours per day were more likely to die from cardiovascular disease compared to those who ate for 12-16 hours. This contradicts previous research suggesting short-term benefits of time-restricted eating.
A Stanford Medicine study found that metformin stimulates production of lac-phe, an anti-hunger molecule abundant after exercise, leading to moderate weight loss in mice and humans. Understanding how metformin works through this pathway may lead to new strategies for lowering body mass and improving health.
A new synthesis method for semaglutide developed by an international team of researchers may help alleviate the global shortage of the drug, which is used to treat diabetes and aid in weight loss. The method uses glycosylation, resulting in ten-fold higher yields compared to existing processes.
A new study found that short-term very low calorie diets are safe and acceptable for teenagers with moderate to severe obesity, with most experiencing rapid weight loss and some reporting side effects. The diets were closely monitored by an experienced dietitian and included meal replacements to ensure essential nutrient requirements.
According to a new study published in JAMA, at least 1 in 5 US state Medicaid programs cover one or more anti-obesity medications. The high cost of these medications has raised concerns about affordability, but the trend shows an increase in recent years.
A new study published in the Journal of the Endocrine Society found significant cardiometabolic improvements in patients who underwent bariatric surgery, including lower blood pressure and cholesterol levels. The study analyzed over 7,800 patients and showed that younger females and whites experienced greater post-surgery cardiometabol...
A collaborative study found that patients with end-stage renal disease who undergo weight loss surgery can experience significant improvements in BMI, hypertension, and diabetes management. This enhancement of overall health and transplant viability offers hope for previously ineligible patients.
A study published in JAMA Surgery found that 56% of patients using GLP-1 RAs had significant gastric contents on ultrasound before elective procedures, despite adequate fasting. The study suggests that conventional fasting times may need to be reexamined for this patient subset.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
Researchers followed 12 healthy volunteers taking part in a seven-day water-only fast, measuring thousands of proteins in their blood. The study showed that the body undergoes significant changes across multiple organs after three days without food, with potential health benefits visible only after this period.
A 12-year study published in JAMA found that bariatric surgery significantly improved blood glucose control and type 2 diabetes remission compared to medical management alone. Participants who underwent bariatric surgery experienced greater weight loss, reduced medication use, and higher rates of diabetes remission.
The study found that bariatric surgery improved blood sugar control and reduced diabetes medication use more effectively than medical and lifestyle modifications. Bariatric surgery also led to superior cholesterol and triglyceride levels, which can contribute to fewer heart attacks and strokes.
A new study in tens of thousands of people with obesity shows the impact of different weight management treatments on achieving a 5% weight loss. Effective treatment options include nutrition counseling, medically supervised meal replacements, anti-obesity medications, and bariatric surgery.
A new study published in LANCET eClinicalMedicine found that regular exercise can help individuals maintain weight loss after completing medical weight loss treatment. The study showed that exercising just two hours a week can lead to better quality of life, improved mental health, and reduced fatigue.
Weight loss treatments such as nutrition counseling and bariatric surgery increased the patient-level probability of achieving significant weight loss. Current treatment utilization rates are insufficient to impact the population level, highlighting a need for improved access.
A study published in the Journal of the American College of Surgeons found that gastric bypass surgery results in high rates of Type-2 diabetes remission five years after the operation, even after patients regain a significant amount of weight. In contrast, patients who underwent sleeve gastrectomy and regained their weight were five t...
A new study published in the American Heart Association journal Hypertension found that tirzepatide significantly lowered systolic blood pressure levels in nearly 500 adults with obesity. The results suggest treating obesity with this weight loss medication may be an effective strategy for preventing or treating high blood pressure.
A five-year study shows that bariatric surgery maintains normal blood pressure levels without medications, while reducing BMI compared to medical therapy alone. Participants who underwent bariatric surgery had fewer medications and lower blood pressure rates than those on medication alone.
A new study found that abdominal aortic calcification is associated with rapid weight loss in older women, leading to higher risks of falls, fractures, and mortality. The researchers hope this discovery will lead to changes in treatment approaches for rapid weight loss in older adults.
A new study led by University of Bristol researchers found that weight loss in people with type 2 diabetes can alter levels of cancer-related chemicals circulating in the blood. Nine cancer-related proteins were changed by the weight loss intervention, suggesting a potential reduction in cancer risk.
Researchers at Pennington Biomedical aim to investigate the effects of intermittent fasting and calorie counting on healthspan. Participants in the DiAL-Health study will be compensated up to $2,500 for their involvement.
A new study highlights the negative consequences of yo-yo dieting, including shame, body dissatisfaction, and stress. Participants reported engaging in disordered behaviors to lose weight, only to regain it and feel worse about themselves.
Researchers found that when participants had more self-compassionate responses to their lapse, they reported better mood and self-control over their eating and exercise behavior. Practicing self-compassion can help individuals become less demoralized by setbacks and quickly resume pursuing weight loss goals.
A recent study by University of Missouri researcher Mansoo Yu found that online weight loss interventions with counseling and social support are effective for middle-aged adults with obesity. The study identified two key features: professional health coaching and access to social support from other users, which led to significant long-...
A study of 157,000 participants found that those with recent weight loss were more likely to be diagnosed with cancer within the next 12 months. Cancer of the upper gastrointestinal tract was most commonly associated with recent weight loss.
A new study found that only 6% of people with type 2 diabetes achieved diabetes remission solely through weight loss by about eight years after diagnosis. People who initially lost a significant amount of weight in the first year were more likely to achieve sustained remission.
A study from Dana-Farber Cancer Institute found that unintentional weight loss is associated with an increased risk of cancer diagnosis within the coming year. The research suggests that patients experiencing unexpected weight loss should see their doctor to consider possible causes, including cancer. Healthy weight loss can come from ...
Researchers found that participants who achieved diabetes remission through weight loss had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease. The study, led by Professor Edward Gregg, monitored over 5,000 patients for 12 years.
Participants with diabetes remission had a 33% lower rate of CKD and a 40% lower rate of CVD compared to those without remission. The magnitude of risk reduction was greatest for participants with longer-term remission.
A recent meta-analysis published in PLOS ONE found that dancing is a highly effective intervention for reducing body fat in overweight and obese individuals. The study analyzed data from various dance interventions and concluded that they can lead to significant weight loss and fat reduction.
A meta-analysis of 90 studies found that adolescents use nonprescription weight-loss products excessively, with girls being more affected. The study highlights the need for interventions to reduce this behavior and mitigate potential long-term health consequences.
A review of over 90 studies found that 5.5% of adolescents globally have used non-prescription weight loss products, while 2% do so in the previous week. Ineffective treatments can lead to long-term health consequences, according to the study.
A study of 25 obese Chinese individuals reveals that intermittent energy restriction (IER) alters the gut microbiome and brain activity, leading to significant weight loss and reductions in obesity-related comorbidities. The changes are coupled over time, suggesting a complex relationship between the gut microbiome and brain.
A diabetes drug called dulaglutide may significantly lower a woman's risk of substantial weight gain after giving up smoking. In contrast to men, women are five times as likely to experience substantial weight gain after stopping smoking, according to the study.
A new study finds that a hormone produced by the fetus and a mother's sensitivity to it are the causes behind nausea and vomiting during pregnancy. Lowering GDF15 levels or pre-exposing women to the hormone may mitigate symptoms, providing potential ways to prevent extreme forms of pregnancy sickness.
A BMJ investigation reveals lax regulation of prescription-only weight loss drug adverts in the UK, leaving patients vulnerable to potential harms. The Medicines and Healthcare products Regulatory Agency (MHRA) has not issued a single sanction for prescription drugs in five years.
A new poll found that 83% of older adults believe health insurers should cover medications to help people with obesity manage their weight. Nearly as many, 76%, also believe Medicare should cover these drugs, which are currently not covered under law.
A Northwestern University study found that nearly two-thirds of patients discontinue or change their medication within a year, highlighting the need for better understanding of barriers to treatment adherence. The high discontinuation rate for GLP-1 RAs may be due to gastrointestinal side effects.
Continued treatment with tirzepatide maintained and augmented initial weight reduction in adults with obesity. Withdrawing tirzepatide led to substantial regain of lost weight in a randomized clinical trial involving 670 participants.
A phase 3 trial found that tirzepatide promotes additional weight loss and preserves metabolic health when continued, but discontinuation leads to significant weight regain. Researchers suggest chronic treatment may be necessary for sustained weight loss and improved cardiometabolic risk factors.
Research suggests that anti-obesity medications can lower the risk of premature death in people with knee or hip osteoarthritis, particularly those who experience a slow-to-moderate rate of weight loss. Studies show a 28% lower risk of death for these individuals compared to those with no weight loss.
The UTHealth Houston School of Public Health offers a 12-month lifestyle program combining evidence-based nutrition education with culinary learning to support behavior change. Participants will attend in-person and virtual classes, including hands-on cooking lessons, physical activity guidance, and mindfulness education.
Women who underwent bariatric surgery had lower pregnancy weight gain compared to controls with similar early pregnancy characteristics. The study found no difference in weight gain based on surgical procedure or surgery-to-conception interval, but suggested a potential benefit for women with shorter intervals.
Replacing animal products with plant-based foods leads to significant weight loss, reduced cholesterol and fat intake, and increased fiber consumption among overweight adults. A new analysis found that a vegan diet rich in fruits, vegetables, grains, and beans results in an average weight loss of about 13 pounds.
Researchers aim to optimize digital weight-loss programs for rural populations by adding human components, such as weekly group video sessions and individual coaching calls. The goal is to help residents manage their weight and fight the obesity epidemic in areas with limited access to in-person programs.
A 20% reduction in major adverse cardiovascular events has been observed for patients with obesity but no history of diabetes taking semaglutide. This study marks a significant milestone, demonstrating the cardiovascular benefits of semaglutide beyond its weight loss effects.
Researchers found that people with overweight or obesity who took semaglutide for over 3 years had a 20% lower risk of heart attack, stroke, or death from cardiovascular disease. The study showed significant weight loss and improved cardiovascular outcomes in adults without diabetes.
A recent clinical trial found that semaglutide significantly reduced cardiovascular events in adults with overweight or obesity who do not have diabetes. The medication was shown to lower the risk of death from cardiovascular causes, nonfatal heart attacks, and strokes by 20% compared to placebo.
Researchers from Helmholtz Munich discovered that GIP decreases body weight by interacting with specific inhibitory neurons in the brain, offering a revolutionary approach to patients worldwide. The study reveals the underlying molecular mechanisms of GIPR:GLP-1R co-agonists and their potential as next-generation anti-obesity drugs.
The American Gastroenterological Association suggests a balanced approach when treating patients on GLP-1 RAs undergoing endoscopic procedures. AGA recommends proceeding with the procedure as planned for patients who followed standard pre-procedure fasting instructions and do not have symptoms suggesting retained gastric contents.