A study found that physicians who presented treatments for obesity as good news and an opportunity were more successful in helping patients lose weight. Patients who received counseling with a positive and optimistic tone had significantly higher weight loss outcomes compared to those who received neutral or negative advice.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateNov 6, 2023
A new study published in JAMA Network Open found time-restricted eating to be safe and effective for people with Type 2 diabetes, helping them lose weight and control blood sugar levels. Participants who followed the time-restricted eating plan had an easier time sticking to it than those on a calorie-reduced diet.
SourceUniversity of Illinois Chicago·JournalJAMA Network Open·DateOct 27, 2023
A large-scale study found that metformin can reduce weight gain and increase adherence to treatment in youth with bipolar disorder. The medication, typically used for Type 2 diabetes, was effective in preventing weight gain and showed promise as a potential solution to this common side effect of SGAs.
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A six-month randomized clinical trial involving 75 adults with type 2 diabetes found that time-restricted eating was effective for weight loss. This novel dietary approach lowered hemoglobin A1c levels without calorie counting, offering potential for improved blood sugar management and overall health.
SourceJAMA Network·JournalJAMA Network Open·DateOct 27, 2023
The SURMOUNT-3 study demonstrated a significant weight loss of 24.3% in participants administered tirzepatide, compared to 2.5% for placebo. The study also showed improvements in multiple health measures, including waist circumference and blood sugar levels.
SourceThe Obesity Society·JournalNature Medicine·DateOct 15, 2023
A new UConn study examined the effect of couples on each other's 'grit' and self-control, key ingredients for weight management. Researchers found that couples did not influence each other's self-control or grit levels, but rather these traits were malleable through behavioral interventions.
SourceUniversity of Connecticut·JournalJournal of Behavioral Medicine·TypeObservational study·DateOct 13, 2023
A study found that the host's immune response to Trypanosoma brucei infection triggers lipolysis, leading to weight loss and a protective effect against disease progression. This discovery opens up new treatment strategies targeting the infection in adipose tissue.
SourceInstituto de Medicina Molecular·JournalNature Microbiology·TypeExperimental study·DateOct 12, 2023
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study found that pre-pregnancy obesity is a primary driver of future cardiovascular disease risk, rather than pregnancy complications. The research followed 4,216 individuals from early pregnancy to postpartum and found those with overweight or obese BMI had a higher risk of developing hypertensive disorders during pregnancy.
SourceNorthwestern University·JournalCirculation Research·DateOct 10, 2023
Research reveals that low muscle mass is associated with a two-fold risk of death from cardiovascular disease in individuals with diabetes. The study found that body composition, not just weight loss, plays a crucial role in managing weight in people with diabetes.
The study found that glucagon-like peptide-1 agonists are associated with a higher risk of pancreatitis, gastroparesis, and bowel obstruction compared to bupropion-naltrexone. Patients considering weight loss medication should be aware of these potential risks due to the drugs' wide use.
A large epidemiological study found a higher incidence of stomach paralysis, pancreatitis, and bowel obstruction in patients taking GLP-1 agonist medications for weight loss. The study, published in JAMA, highlights the need for updated warning labels to inform patients of these potential risks.
SourceUniversity of British Columbia·JournalJournal of the American Medical Association·TypeData/statistical analysis·DateOct 5, 2023
A UCLA-led team has discovered the nerve supply that activates brown adipose tissue, a potential key to treating obesity. The study found nerve branches in all eight cadavers dissected, which may lead to using nerves to stimulate BAT activity for weight loss.
SourceUniversity of California - Los Angeles Health Sciences·JournalPLOS ONE·TypeObservational study·DateOct 4, 2023
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A recent study demonstrated that lasting remission of type 2 diabetes is feasible in the real-world setting through a low-calorie diet and weight loss maintenance. The DiRECT trial showed significant weight loss and remission rates, even after five years, with participants who maintained their weight losing type 2 diabetes permanently.
Researchers at the University of Birmingham found that individuals with fatty liver disease are three times more likely to have a personality disorder than those without. Lifestyle modifications, such as changes in diet and exercise, can prevent disease progression but often fail to be implemented due to mental health factors.
SourceUniversity of Birmingham·JournalBMC Gastroenterology·TypeData/statistical analysis·DateOct 2, 2023
A real-world study of over 23,000 adults with type 2 diabetes found that semaglutide significantly improved blood sugar control and weight loss for up to 3 years. The study showed that patients who had never taken a GLP-1 RA or those with higher adherence achieved more pronounced reductions in blood sugar levels and weight loss.
A new exercise-mimicking drug, SLU-PP-332, has shown promising results in obese mice, leading to weight loss and increased muscle activity without increasing physical activity. The drug works by boosting a natural metabolic pathway, making the body act like it is training for a marathon, resulting in faster metabolism of fat.
SourceUniversity of Florida·JournalJournal of Pharmacology and Experimental Therapeutics·TypeExperimental study·DateSep 25, 2023
Researchers found a 55% reduction in lymphoma risk and a 40% overall reduction in blood cancer risk among bariatric surgery patients. Women with high blood sugar at the start of the study benefited most from the surgery.
SourceUniversity of Gothenburg·JournalThe Lancet Healthy Longevity·TypeObservational study·DateSep 20, 2023
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Researchers found that almond-supplemented diets resulted in significant weight loss and improved cardiometabolic outcomes. The study demonstrated the benefits of nuts as part of a balanced weight loss diet, with almonds providing unsaturated fats that can improve blood cholesterol levels and contribute to a healthy heart.
SourceUniversity of South Australia·JournalObesity·TypeRandomized controlled/clinical trial·DateSep 18, 2023
A randomized controlled trial found that high-protein and normal-protein diets were both effective in improving glucose control, weight loss, and body composition in adults with Type 2 diabetes. The study suggests that individuals can choose a dietary pattern that suits their preferences while still achieving significant health benefits.
SourceUniversity of Alabama at Birmingham·JournalObesity·TypeRandomized controlled/clinical trial·DateSep 12, 2023
Women with polycystic ovary syndrome (PCOS) who follow a keto diet for at least 45 days may experience significant weight loss and improvements in reproductive hormone levels. Lower testosterone levels can also help reduce excess hair growth and other symptoms associated with PCOS.
SourceThe Endocrine Society·JournalJournal of the Endocrine Society·DateSep 7, 2023
Researchers have identified a cluster of neurons in the hypothalamus called GABRA5 that regulates energy expenditure. Astrocytes control this cluster, producing tonic GABA that inhibits it, leading to weight gain.
SourceInstitute for Basic Science·JournalNature Metabolism·TypeExperimental study·DateAug 31, 2023
Women who maintained a stable weight were 1.2 to 2 times more likely to achieve exceptional longevity compared to those who lost 5% or more, with a 51% lower survival rate at age 90. Stable weight is associated with increased longevity in older women.
SourceUniversity of California - San Diego·JournalJournal of Gerontology·TypeObservational study·DateAug 29, 2023
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Researchers developed a liver-targeting drug that reversed obesity and lowered cholesterol in obese mice by delivering the drug via nanogel. The treatment, which was administered intraperitoneally, effectively normalized weight and reduced cholesterol levels despite continued high-fat diet consumption.
SourceUniversity of Massachusetts Amherst·JournalPNAS Nexus·TypeExperimental study·DateAug 29, 2023
A new study from the University of Copenhagen reveals that GDF15 improves insulin sensitivity in rodents, particularly in their liver and fatty tissue. This finding raises interesting perspectives for treating type 2 diabetes and high blood pressure, as increased insulin sensitivity is a critical indicator of health.
SourceUniversity of Copenhagen - Faculty of Science·JournalCell Metabolism·DateAug 28, 2023
A pilot study led by George Mason University's Michael Bloom explores the impact of PFAS on weight loss in Hispanic children participating in a community-based weight loss intervention. The research aims to quantify associations between PFAS exposure and weight lost, as well as clinical biomarkers.
A new study from Lund University in Sweden found that the biggest metabolic changes following gastric bypass surgery occurred immediately after the procedure. However, one year later, the concentration of metabolites and fats had returned to nearly pre-surgery levels.
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Researchers found that both dietary weight loss strategies improved the diversity of the gut microbiome. The study suggests that individuals can choose a strategy that works for them, regardless of its impact on their microbiome. Changes in the microbiome may also affect other body functions.
SourceUniversity of Colorado Anschutz Medical Campus·JournalNutrients·DateAug 17, 2023
Researchers found that liraglutide improves associative learning in people with obesity by restoring brain activity to normal-weight levels. The study showed that participants with obesity had reduced ability to associate sensory stimuli and decreased brain activity compared to those with normal weight.
SourceMax Planck Institute for Biology of Ageing·JournalNature Metabolism·TypeExperimental study·DateAug 17, 2023
Neuroscientists at Scripps Research have identified a specific cluster of neurons that work as a 'switch' for cold-related food-seeking behavior in mice. The discovery could lead to potential therapeutics for metabolic health and weight loss by targeting this brain circuitry.
SourceScripps Research Institute·JournalNature·DateAug 16, 2023
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Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A recent study at UC Irvine found that semaglutide medication can lead to significant weight loss and reduce cardiovascular risk in 93 million U.S. adults. The medication may prevent up to 1.5 million heart attacks and strokes over 10 years, resulting in 43 million fewer obese people.
SourceUniversity of California - Irvine·JournalCardiovascular Drugs and Therapy·TypeData/statistical analysis·DateAug 15, 2023
The study of 18.4 million patients indicates a low annual probability of 5% or greater weight loss, but a higher likelihood of BMI reduction to the healthy weight category, especially among those with high initial BMIs.
SourceJAMA Network·JournalJAMA Network Open·DateAug 7, 2023
A randomized clinical trial found that telephone-based cognitive behavioral therapy (tele-CBT) significantly reduced binge eating, emotional eating, and depression/anxiety symptoms in individuals after bariatric surgery. However, short-term weight outcomes were unaffected by tele-CBT.
SourceJAMA Network·JournalJAMA Network Open·DateAug 3, 2023
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A world-first study from the University of South Australia exposes the real weight gains of everyday Australians, finding that weight fluctuates throughout the year. The study highlights the importance of targeting temporal hot spots to curb unhealthy weight fluctuations and prevent unwanted weight gain.
SourceUniversity of South Australia·JournalJAMA Network Open·TypeCase study·DateJul 27, 2023
A Northwestern University study found that only 60% of women with heart disease risk factors received counseling on optimizing their heart health during their six-week postpartum visit. The study highlights the need for improved access to care and increased awareness of maternal cardiovascular health monitoring.
A randomized controlled study found that participants who restricted their daily eating to between noon and 8 p.m. lost more weight and showed similar improvements in blood sugar levels compared to those on a calorie-restricted diet.
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Researchers developed a tailored approach to weight loss and cardiometabolic risk factors, showing significant improvement in targeted areas like abnormal fullness and emotional eating. The study suggests the need for an actionable, phenotype-based classification of patients in obesity treatment, moving beyond reliance on scales or bod...
A new study found that social media platforms like TikTok and Instagram are ideal spaces to educate and guide US youth of color on healthy weight management. Nearly 1 in 4 adolescents experienced obesity from 2017 to 2020, with youths of color experiencing disproportionately higher rates.
SourceBoston University School of Public Health·JournalJMIR Pediatrics and Parenting·TypeSurvey·DateJul 13, 2023
A recent international study of over 745,000 adolescents from 41 countries found a decrease in those who overestimate their weight and an increase in those who underestimate it. This shift could reduce the effectiveness of public health interventions aimed at weight reduction in young people, as they may make unhealthy lifestyle choices.
SourceTaylor & Francis Group·JournalChild and Adolescent Obesity·TypeObservational study·DateJul 3, 2023
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A new study from Aarhus University reveals that female athletes who consume too little energy through their diet in comparison to their training volume experience negatively impacted muscles' ability to respond to training. The study shows that insufficient energy intake can lead to changes in the hormonal system, including a decrease ...
SourceAarhus University·JournalThe Journal of Physiology·TypeRandomized controlled/clinical trial·DateJul 3, 2023
A new $7 million study at Wake Forest University is investigating the impact of resistance training, bone-loading exercises, and osteoporosis medication on bone health in older adults who are losing weight. The study aims to determine whether these interventions can help preserve bone mass and reduce fracture risk.
Research from University of Illinois Chicago found water fasts spur noticeable short-term weight loss, but metabolic benefits disappear soon after fast ends. Participants lost 4-10% of their weight during the fast, and some gained back the lost weight within three months.
SourceUniversity of Illinois Chicago·JournalNutrition Reviews·TypeLiterature review·DateJun 29, 2023
Researchers have uncovered a key mechanism for promoting weight loss and maintaining energy burn during dieting, thanks to the hormone GDF15. This discovery opens new possibilities for helping people maintain weight loss after dieting.
SourceMcMaster University·JournalNature·TypeExperimental study·DateJun 28, 2023
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A 12-year study by Pennington Biomedical researchers found that metabolic surgery provides better results, less regression, compared to medical or lifestyle intervention for patients with class 1 obesity. The study showed significant improvements in glycemic control and weight loss, with high rates of diabetes remission.
SourcePennington Biomedical Research Center·JournalDiabetes Care·DateJun 27, 2023
Researchers found that restricting methionine intake via a low-methionine diet or oral administration of recombinant methioninase-producing E. coli reversed old-age-induced obesity in mice, leading to significant weight loss after just 14 days.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateJun 27, 2023
A randomized controlled trial found that time-restricted eating produced similar weight loss results to traditional calorie counting in a racially diverse population of adults with obesity. Participants who engaged in 8-hour time-restricted eating had improved insulin sensitivity compared to those in the control group.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateJun 26, 2023
A new study found that higher doses of oral semaglutide improved regulation of blood sugar levels and weight loss compared to lower doses. Participants who received the 25mg and 50mg doses lost an average of 17.5 pounds, nearly twice as much weight loss as those who took the lowest dose.
SourceUniversity of North Carolina Health Care·JournalThe Lancet·DateJun 26, 2023
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
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A study published in Radiology found that weight-loss surgery, specifically sleeve gastrectomy, has negative effects on bone health in adolescents and young adults. The procedure led to an increase in bone marrow fat and a decrease in bone density, suggesting potential long-term consequences for bone health and fracture risk.
SourceRadiological Society of North America·JournalRadiology·DateJun 13, 2023
A retrospective analysis of national data found that over 20 million Americans experienced loss of smell or taste after COVID infection, with a large portion never fully recovering these senses. The study estimated that almost 28 million Americans may be left with decreased sense of smell after COVID infection.
SourceMass Eye and Ear·JournalThe Laryngoscope·TypeMeta-analysis·DateJun 12, 2023
Researchers found that participants only need to track around 30% of the days to lose more than 3% weight and 40% of the days to lose more than 5% weight. A third group, called the low trackers, started tracking only three days a week, and dropped to zero by three months, where they stayed for the rest of the intervention.
SourceUniversity of Connecticut·JournalObesity·TypeData/statistical analysis·DateJun 8, 2023
A new study suggests that sabotage, collusion, and 'feeding' behaviors from loved ones can undermine weight loss attempts. Researchers found these negative social support mechanisms can erode confidence and self-esteem.
SourceUniversity of Surrey·JournalCurrent Obesity Reports·TypeLiterature review·DateJun 6, 2023
Researchers found that a reduction in body weight of 1% led to participants' brain age being almost 9 months younger than expected. This attenuation of brain aging was associated with changes in liver fat and enzymes, which can negatively affect brain health in Alzheimer's disease.
SourceBen-Gurion University of the Negev·JournaleLife·TypeRandomized controlled/clinical trial·DateJun 1, 2023
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A clinical trial found that a telephone-based weight loss program can help breast cancer patients with overweight or obesity lower their weight by a significant degree. Women who received the program lost an average of 4.8% of their baseline body weight, compared to a 0.9% increase in the control group.
A new weight loss tool called PATHWEIGH was developed to address clinician barriers in providing patient care that addresses weight. The tool has shown early success and has been implemented in a health system's primary care clinics, improving weight management efforts among patients with obesity.
SourceAmerican Academy of Family Physicians·JournalThe Annals of Family Medicine·DateMay 23, 2023
Researchers found that focusing on satiety and satiation through the consumption of fruits and vegetables can lead to better weight loss outcomes. Both diet programs increased levels of satiation and satiety among participants, as well as promoting better quality of life and emotional well-being.
SourceAmerican Academy of Family Physicians·JournalThe Annals of Family Medicine·DateMay 23, 2023
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Teenagers living with obesity who experience uncontrolled hunger are more likely to perceive their weight as negative, worried about its health effects, and actively trying to lose weight. They also report greater dissatisfaction with their body image and higher rates of bullying.
SourceEuropean Association for the Study of Obesity·DateMay 19, 2023
A multicentre, one-year real-world study found semaglutide effective for weight loss in patients with overweight and obesity, with 82% losing over 5% body weight. The medication also improved metabolic parameters, including blood pressure and cholesterol levels.
SourceEuropean Association for the Study of Obesity·DateMay 19, 2023
A new analysis of the SURMOUNT-1 study shows that tirzepatide improves body composition across a range of adult age groups, with significant reductions in fat mass. The treatment also results in a clinically meaningful improvement in body composition, with only one-quarter of weight lost being lean mass.
SourceEuropean Association for the Study of Obesity·DateMay 18, 2023
A Dutch study found that individuals who feel safe in their neighborhoods lose more weight during lifestyle interventions. Those with higher scores on a safety scale experienced greater decreases in weight and waist circumference, regardless of sex, age, or education level.
SourceEuropean Association for the Study of Obesity·DateMay 18, 2023
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Researchers at Koc University have identified a novel molecular mechanism that can slow down or block muscle wasting in cancer patients. The activation of EDA2R signalling promotes skeletal muscle atrophy, and deleting either EDA2R or NIK enzyme can protect the organism from muscle loss.