Articles tagged with Biological Rhythms
Scientists found that mice lost 85% of their hair when treated with radiation in the morning, compared to a 17% loss in the evening. This discovery suggests that delivering cancer radiotherapy later in the day may reduce hair loss.
Scientists identify Gene Ataxin-2 as a key component of the circadian clock, which regulates sleep-wake cycles. The study found that Ataxin-2 helps activate translation of PER protein, keeping the clock on a 24-hour rhythm.
Researchers found that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression, suggesting a physical basis for many symptoms. The study provides clues for potential new classes of compounds to rapidly treat depression by resetting abnormal clock genes.
Research shows disrupted brain gene activity in depressed brains, out of sync with the usual daily cycle, offering a new target for diagnosis and treatment. The findings also reveal a previously unknown daily rhythm to gene activity across many areas of the brain.
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells, suggesting potential for improved cancer treatments. By promoting the expression of Rev-erbα and NAMPT, Myc upregulates genes that suppress circadian oscillations, leading to altered metabolism and potentially increased replication rates in cancer cells.
A study published in Current Biology found that roosters' crowing is entrained to a circadian rhythm, meaning it follows a natural daily cycle. The researchers used constant light conditions and recorders to observe the birds' behavior, confirming that predawn crowing depends on an internal clock.
The Proceedings of the National Academy of Sciences has selected six papers published in 2012 to receive the Cozzarelli Prize. The prize acknowledges papers that reflect scientific excellence and originality, particularly in physical and mathematical sciences.
Research at Vanderbilt University reveals a direct link between the body's circadian rhythm and insulin activity, which controls metabolism. The study found that disruption in the circadian clock can lead to increased risk of obesity, diabetes, and heart disease.
A team of researchers found that non-optimal codon usage slows translation of the genetic code into protein, allowing it to achieve its optimal structure. This discovery provides new insights into controlling the rates at which critically important proteins are synthesized and could lead to better understanding of cancers and diseases.
A study by Vanderbilt University researchers found that cells can alter their biological clocks by using different synonymous codons in the genetic code. This adaptation allows cells to survive in changing environments, such as varying temperatures, and potentially has applications in biotechnology like biofuel production.
Researchers from the Marine Biological Laboratory discovered that lancelets have melanopsin-producing cells, which are involved in non-visual light-dependent functions. Studying these cells provides insight into the evolutionary history of circadian receptors and their role in regulating biological clocks.
UCI-led studies reveal cellular mechanism governing day-night pattern, identifying novel compounds that control energy metabolism. The findings point to potential treatments for metabolic disorders, cancer and aging.
Researchers exposed fruit flies to daily temperature changes to understand how temperature affects the circadian clock. They found that different brain cells play a crucial role in synchronising the clock at warmer and cooler temperatures.
Women with premenstrual dysphoric disorder (PMDD) have altered body rhythms of the hormone melatonin, which may explain sleep disruptions. The study found decreased melatonin levels during night-time hours and symptomatic luteal phase, highlighting potential targets for treatment.
Researchers found that chromatin, a protein complex, regulates genes in the liver to sync with circadian cycles. The study suggests connections between dietary schedules and chronic diseases, such as high blood sugar and cholesterol.
Researchers study circadian clocks in cultured cells and find that the transcription factor BMAL1 must die for the DBP gene to function. This discovery offers a possible explanation for how different genes have distinct daily cycles of expression.
Researchers at NYU have uncovered the electrical activity of biological clock neurons that help regulate behavioral rhythms. The study highlights the importance of understanding the coordination between neuronal firing and gene expression to develop new pathways for treating sleep disorders.
Researchers at New York University have discovered how the biological clock drives daily rhythms in pacemaker neurons. The study found that a specific gene, Ir, plays a crucial role in linking the biological clock to neuronal activity.
Fruit flies exhibit a daily temperature preference rhythm that mirrors human body temperature rhythms, controlled by a circadian clock. The discovery opens up new avenues for studying human development and disease using fruit flies as models.
Research suggests that loss of daily rhythms can cause obesity, as our bodies struggle to stay in tune with irregular meal, sleep, and work schedules. Disrupted circadian desynchrony affects brain systems regulating metabolism, increasing the risk of developing obesity and diabetes.
A new study from Linköping University reveals that circadian rhythm disruptions can immediately inhibit blood vessel growth in zebrafish embryos. The research also shows that vascular endothelial growth factor (VEGF) production is key to normal circadian rhythm functioning.
Researchers at the Salk Institute found that a molecular link between circadian rhythm disturbances and an increased inflammatory response can lead to chronic diseases. The absence of cryptochrome leads to the activation of a signaling system that elevates levels of inflammatory molecules, causing low-grade, chronic inflammation.
Researchers at the virtual Helmholtz Institute PolarTime are studying the inner clock of Antarctic krill to understand its impact on the marine ecosystem under climate change. They will investigate the principles and evolution of endogenous biological rhythms and clocks in pelagic organisms.
Scientists have determined the three-dimensional structure of CLOCK and BMAL1 proteins, which regulate gene expression in response to daily cycles. The discovery provides new understanding into the intricacies of biological clocks and may lead to breakthroughs in treating circadian-related disorders.
Researchers have identified a key player in the mechanism that tells plants when to flower, involving a protein called FKF1 and the plant's circadian clock. This discovery may lead to improved crop yields and better understanding of plant biology.
Researchers at NYU have discovered a new role for non-master pacemaker neurons in regulating circadian rhythms. By studying fruit flies, they found that these neurons suppress signaling of master pacemaker neurons during the evening, allowing them to fire and wake up the fly.
A new study reveals that obesity is associated with disrupted biological rhythms and social jetlag. The research found that individuals who are overweight or obese are at increased risk for serious metabolic diseases, such as diabetes, due to a lack of sleep and an irregular body-mass index (BMI). The study suggests that lifestyle fact...
Researchers discovered that strong light can activate a protein called Period 2, which regulates heart metabolism and minimizes damage from heart attacks. This finding suggests that daylight exposure could reduce the risk of having a heart attack or suffering damage from one.
A new project led by University of Michigan math professor Daniel Forger aims to understand how the brain's daily clock controls mood in humans and animals. The study uses mathematical modeling and experiments involving mice to examine the relationship between abnormal circadian rhythms and bipolar disorder.
Research highlights the impact of inadequate sleep on pilots' cognitive performance, mood, and piloting skills. The author proposes fatigue prediction models, sleep hygiene education, and wearable technologies to mitigate the risks of pilot fatigue.
Researchers will investigate four cellular processes using Neurospora fungi to develop general principles of coupled network dynamics. The goal is to improve care for patients with abdominal trauma or gut pathogens exposure. The project aims to elucidate potential methods for enhanced disease treatment and trauma care.
Researchers have discovered that Rev-erb proteins play a crucial role in controlling the body's internal clock and fat metabolism. When both proteins are not functioning, the liver fills with fat, leading to metabolic disorders. The study highlights the importance of understanding the circadian rhythm of metabolism.
Researchers at UCI Center for Epigenetics & Metabolism discovered that circadian rhythms significantly impact liver metabolite production, with approximately 60% dependent on the body clock. This finding has implications for understanding obesity, high cholesterol, and metabolic diseases.
Researchers are deconstructing molecular and genetic rhythms to better understand biological timing mechanisms. By isolating genes and signals, they hope to control and repair broken clocks, leading to breakthroughs in fields like cancer research and communication signal improvement.
The project 'Clockwork Green' investigates the importance of circadian clocks in plants, exploring their role in survival and reproduction. By releasing transgenic tobacco plants with silenced clock genes in their natural habitat, researchers aim to uncover the functions of circadian-regulated genes and their impact on plant growth.
A study published in Nature found a link between the circadian clock and sudden cardiac death, revealing that the controller of the circadian clock, Klf15, affects potassium flow out of heart muscle cells. This can lead to abnormal heart rhythms and increased risk of deadly arrhythmias.
Researchers at Case Western Reserve University School of Medicine discovered a novel genetic factor linking the body's natural circadian rhythm to heart electrical activity. This discovery provides insights into day-night variation in arrhythmia susceptibility and may lead to innovative approaches for diagnosis, prognosis, and treatment.
Research reveals that a circadian clock controls the expression and function of TLR9, an immune system protein, leading to enhanced or impaired immune responses depending on the time of day. The study's findings have significant implications for sepsis treatment and prevention.
Plants use their internal clocks to anticipate and prepare for insect attacks, increasing production of defense hormones like jasmonate. This allows them to resist damage from caterpillars and other pests.
Research at Oregon State University found that disrupting circadian rhythms causes accelerated neurodegeneration, loss of motor function, and premature death. Disrupted clock mechanisms predispose the brain to neurodegeneration, which may cause more damage to the clock function.
Researchers found that chrysanthemum plants adapted to irregular light periods, promoting rapid leaf development. The study's results suggest that these changes can be induced by low average light intensity, potentially reducing supplemental lighting costs in greenhouses.
A new study correlating circadian clocks with transplant success found that arteries of mice with dysfunctional internal clocks became diseased within weeks after transplantation. Transplanted blood vessels from healthy mice remained healthy in mutant mice, suggesting optimal organ function may be key to successful transplants.
Scientists have discovered a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning. This discovery may help explain the genetic underpinnings of sleeplessness, aging and chronic illnesses such as cancer and diabetes.
Researchers found that the body's internal clock regulates human platelet function, causing a peak in platelet activation corresponding to the morning peak in adverse cardiovascular events. This discovery has potential to address the morning peak in cardiovascular risk and decrease related mortality.
Researchers found that a species of cavefish, Phreatichthys andruzzii, has an unusual circadian clock that ticks at an extremely long period, unaffected by eye loss. The study suggests that the fish's clocks can be regulated by feeding behaviour, but not light exposure.
Researchers at Yale University have identified a crucial gene, DET1, that regulates the plant circadian clock. This finding could lead to engineering plants that can thrive in different seasons and locations. By understanding the circadian rhythm, farmers may be able to grow crops year-round, reducing seasonal limitations.
Researchers at UCLA found that the suprachiasmatic nucleus, or SCN, begins to decline in rhythmic neural activity by middle age. This decline may contribute to difficulties with sleep, adjusting to time changes, and performing shift-work in older adults.
Researchers have identified a key regulator of the plant's daily growth cycle, which shares similarities with human circadian rhythm genes. This discovery may lead to a better understanding of how clock genes regulate cell division in humans and provide new avenues for developing disease therapies.
A novel molecule, QUASIMODO (QSM), has been discovered as essential for relaying light-information to the circadian clocks of fruit flies. This molecule plays a crucial role in synchronizing the internal biological processes, such as sleep/wake cycles, with external time.
A new study by University of Notre Dame researchers reveals that the malaria mosquito Anopheles gambiae exhibits daily rhythms in gene expression, with nearly 16% of its genome showing time-of-day specific changes. This discovery highlights potential targets for novel malarial control strategies and optimization of existing approaches.
Researchers at University of Pennsylvania School of Medicine found that disrupting the circadian rhythms of fruit flies by feeding them at incorrect times led to reduced fertility. The study suggests a connection between diet and reproduction, highlighting the importance of timing in maintaining reproductive capacity.
A Northwestern University study found that people who go to bed late and sleep in eat more fast food, fewer fruits and vegetables, and weigh more than those with earlier sleep times. The extra calories consumed can lead to significant weight gain if not balanced by physical activity.
Researchers found that infants' brains develop the ability to determine light and dark cycles independently of visual stimuli. The study suggests that this innate ability is a hard-wired feature of development, allowing animals to synchronize their circadian rhythms with daily changes in light exposure.
A new study reveals that clock genes function in multiple areas of the human brain, affecting sleep patterns and cognitive function in Alzheimer's patients. The findings have significant implications for understanding and treating sleep disturbances associated with the disease.
Researchers at Michigan State University have identified the key role of circadian clocks in plant freezing tolerance. The study found that integrating cold-signaling pathways with the circadian clock is crucial for maximum freezing tolerance, paving the way for the development of stress-tolerant crops.
Researchers have found that obesity can impair the body's natural circadian rhythms, particularly in the cardiovascular system. The study suggests that this disruption can lead to a range of health problems, including impaired heart function and an increased risk of disease.
Researchers found that the 'twenty-four' gene is critical for producing a key clock protein in fruit flies. Without this gene, flies experience disrupted sleep-wake rhythms and have trouble waking up. The findings suggest a similar mechanism may be at play in humans.
Scientists have identified a 24-hour internal clock in red blood cells, which works independently of DNA and gene activity. This discovery sheds light on the ancient mechanism that controls daily and seasonal activities across all living organisms.
Researchers analyzed the air traffic controller's schedule and found he was performing at 71% of his effectiveness due to fatigue. The study suggests using mathematical models to predict fatigue and optimize schedules, leading to reduced risk of accidents in various 24/7 operations.
The Scripps Research Institute has been awarded $3.17 million over four years to develop compounds that counteract disruptions of the human biological clock, associated with sleep disorders and bipolar disease. The grant supports research on nuclear receptors, a promising drug target for various diseases.