Articles tagged with Biological Rhythms
A team of researchers at Washington University in St. Louis has discovered that individual cells isolated from the biological clock can keep a 24-hour rhythm, but they are unreliable on their own. The cells must communicate with each other to establish a coherent daily cycle.
A study with hamsters shows that chronic alcohol consumption blunts the biological clock's ability to synchronize daily activities to light. The research suggests that this disruption can have long-lasting effects on the body's internal clock, even after withdrawal from alcohol.
A study found that chemotherapy impairs sleep-wake activity rhythms in breast cancer patients, leading to shorter days and disrupted biological clocks. The disruption worsens with repeated chemotherapy cycles, highlighting the need for routine screening and management of sleep disturbances.
Researchers discovered that insect circadian rhythms affect pesticide susceptibility, with defenses strongest during mid-day and weakest around dawn or dusk. This knowledge may lead to improved pest control strategies and reduced pesticide use.
A study published in Ecology Letters reveals that plants' circadian clocks can improve climate change scenarios by accurately predicting CO2 levels and photosynthesis. The internal clock enables plants to adapt to their environment, surviving and reproducing more efficiently.
Researchers found that Period 1 regulates expression of alpha-ENaC in mouse kidney, leading to decreased sodium loss in urine. The study suggests a link between the circadian rhythm and salt balance, with implications for blood pressure control.
Researchers have found that the circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice, leading to decreased sodium loss in urine. Additionally, a study on gene therapy revealed that TLR9-MyD88 pathway is critical for adaptive immune responses to AAV vectors. Another study on kidney repair ...
The Peter and Patricia Gruber Foundation awards $500,000 to Hall, Rosbash, and Young for their groundbreaking discoveries on the molecular mechanisms controlling circadian rhythms in the nervous system. Their research revealed a transcriptional feedback loop that oscillates during the 24-hour cycle, driving daily behavior.
Researchers at UT Southwestern Medical Center used the fungus Neurospora to study the biochemistry and genetics of body clocks. They found that a protein called FRQ marks time by a sequence of changes in its chemical structure, which controls many biological processes including cell division, hormonal release, and sleep/wake cycles.
A study by Ueli Schibler's team reveals that a specific microRNA called miR-122 plays a crucial role in regulating the expression of circadian genes in liver cells. The discovery sheds light on the molecular mechanisms controlling the internal clock and its potential connection to hepatitis C virus replication.
A team at Rensselaer Polytechnic Institute developed a wearable device that delivers blue light directly to the eyes to improve sleep quality in older adults. The study found that exposure to blue light levels of 50 lux and 10 lux for 90 minutes suppressed nocturnal melatonin levels, indicating stimulation of the circadian system.
Researchers have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes daily activities. Two studies published in Cell and Molecular Cell provide a complete view of the regulation of circadian clocks across a day, revealing the role of phosphorylation and temperature compensation.
Scientists at Queen Mary University of London have discovered a PER:PER protein pair required for circadian clock function in fruit flies. This finding may also apply to mammals, including humans, with implications for regulating our biological clocks.
Researchers found that mice with mutated or missing clock genes developed thick and inflexible blood vessels, a hallmark of vascular disease. This suggests that clocks may work normally in the brain but malfunction in blood vessels to bring on hypertension and vascular disease.
Researchers linked circadian clock to SIRT1 and NAD levels, revealing a biochemical mechanism that drives metabolic disorders. The study finds potential new avenues for treating age-related disorders and restoring healthy daily rhythms.
A study by Northwestern University researchers discovered the circadian clock genes strongly regulate NAD production, a critical cofactor involved in energy utilization. This discovery sheds light on how aging, metabolism, and the circadian clock are interconnected.
Researchers at UCI have found that circadian rhythms regulate energy levels in cells, with implications for treating diseases like cancer, diabetes, and obesity. The discovery opens a new window into understanding how the body's day-night patterns and metabolism work together to maintain cellular function.
Researchers found three factors governing circadian clock resetting: Cryptochrome, Jetlag, and Timeless. These proteins fine-tune light responses on a molecular level, ensuring the bodyclock stays synchronized with its environment.
A high-fat diet can affect circadian rhythms, leading to hormone imbalance, obesity, psychological disorders, and cancer. Fasting and a low-fat diet regulate adiponectin signaling pathways, while a high-fat diet disrupts these pathways, contributing to metabolic disorders.
Research reveals that the immune system's phagocytic response is stronger at night and weaker during the day, with flies infected at night showing improved survival rates. The study suggests that circadian proteins play a crucial role in regulating immunity, particularly during restorative functions like sleep.
Researchers found that night-shift workers who use bright light exposure therapy and wear dark sunglasses can improve performance and alertness during night shifts. The study suggests a compromise circadian phase position can be achieved, allowing for better nighttime sleep on days off.
A study found that night shift workers who use bright light exposure therapy, dark sunglasses, and a strict sleep schedule can achieve a compromise circadian phase position, improving alertness and performance. This partial physiological adaptation allows for increased daytime sleep on days off.
A recent study suggests that seasonal affective disorder (SAD) may be linked to a genetic mutation in the eye's melanopsin gene. Individuals with this mutation are five times more likely to experience SAD symptoms, highlighting a potential genetic predisposition to the condition.
Scientists found that mussels alternate between eating and growing genes in response to changing environmental conditions. The study suggests that mussels use a survival strategy similar to circadian rhythms, allowing them to separate physiological processes and reduce damage from free radicals.
Stanford researchers found that a functioning circadian system is crucial to Siberian hamsters' ability to remember their environment. The study suggests that the circadian clock controls the daily cycle of sleep and wakefulness by inhibiting brain activity, which affects learning and memory.
Researchers found that melatonin rhythm abnormalities worsen as cirrhosis progresses, and abnormal pituitary hormone patterns can predict hepatic encephalopathy development. These findings suggest that melatonin circadian rhythm abnormalities may be an early indicator of liver disease severity.
Researchers identified genes controlling rhythmic plant growth, enabling bursts of growth at night and increasing competitiveness in shaded environments. These findings could lead to designing crops that grow faster and produce more food than current varieties.
Researchers at Oregon State University have identified the biological clock genes responsible for plant growth spurts, which occur at night. The study uses DNA microarrays and bioinformatics to analyze thousands of genes in a short period, revealing that most plant genes are expressed only at a particular time of day.
The Lighting Research Center (LRC) at Rensselaer Polytechnic Institute has received a $250,000 grant from the US Green Building Council to investigate the link between daylight design and student well-being. The project aims to quantify the impact of daylight on students' performance, sleep quality, and stress levels.
Research from University of Michigan sleep experts reveals that babies born to moms with depression are more prone to having chaotic sleep patterns in the first half-year of life. The study found that infants born to depressed mothers nap more during the day, take longer to settle down at night, and wake up more often during the night.
Research suggests that older adults require less sleep than younger individuals, with a decline in both the quality and quantity of sleep. This finding has implications for the treatment of insomnia in older adults, who may overestimate their need for sleep and use medications unnecessarily.
Two new studies found a connection between the circadian clock and metabolism through the protein SIRT1, which regulates energy levels throughout the day. The findings suggest that drugs targeting SIRT1 could help treat circadian sleep disturbances.
UC Irvine researchers found that CLOCK protein regulates body clock, working in balance with SIRT1 to modulate energy use. This balance is vital for proper metabolism, and disruption can lead to metabolic disorders. The study suggests that sleep and diet can help maintain this equilibrium.
A new approach by Rensselaer Polytechnic Institute researchers provides a framework for studying the effects of circadian disruption on various health problems. The device, called Daysimeter, measures daily rest and activity patterns, as well as exposure to circadian light, in both humans and rodents.
Researchers have identified a novel mechanism in plants that regulates circadian rhythms, which are integral to responses to light, temperature, and other environmental cues. The PRR gene family plays a crucial role in these mechanisms, with its members transcribed and translated at different times of day.
A newly discovered biological clock controls many metabolic functions and determines life span, operating on shorter time intervals for small mammals like rats and longer ones for larger animals like chimpanzees. The discovery was made by NYU dental professor Dr. Timothy Bromage while observing incremental growth lines in tooth enamel.
A newly discovered biological clock controls incremental growth in tooth enamel and skeletal bone tissue, affecting metabolic processes and lifespan. The rhythm varies across organisms, with humans having the most variation, and its impact on human behavior is being explored.
Researchers have discovered a novel circadian clock mechanism in monarch butterflies, involving two distinct cryptochrome proteins. This mechanism is similar to that found in mammals and plays a critical role in navigation during migration.
Researchers have identified a new clock gene, CRY2, that provides insight into the biology of monarch butterfly migration and evolution of circadian clocks. The discovery reveals a dual function of CRY2 as a core clock component and an output molecule linking the clock to the sun compass.
Scientists at University of Cambridge identified a signalling molecule governing plant circadian clock response to environmental changes. This discovery alters the current understanding of the circadian clock and may have significant implications for agriculture.
A University of California, Irvine study identifies a single amino acid that triggers circadian rhythms, opening up potential for new pharmaceuticals to treat sleep disorders and related ailments. The finding uncovers the most specific information about the body's internal clock to date.
Scientists at the University of Pennsylvania School of Medicine have found a protein called Rev-erb that coordinates the body's daily oxygen cycle to maintain correct metabolism. This discovery provides new pathways for treating metabolic disorders like obesity and diabetes.
Researchers found that high-fat diets can shift mice's activity patterns, causing them to eat more during the day and altering molecular components of the circadian clock. The study suggests that metabolic processes, like nutrient status, may influence the internal body clock.
Researchers at Harvard University have found that a simple circadian clock can maintain an accurate 24-hour cycle through the rhythmic addition and subtraction of phosphate groups on a single protein. This discovery builds upon previous research and has implications for understanding general feedback mechanisms in organisms.
Researchers found that mice lacking a critical component of the retinal clock exhibit abnormal gene activity and defective electrical responses, but their eyes appear normal. The study suggests that the retina's autonomous circadian clock plays a crucial role in visual processing.
The discovery explains how plants time their growth to take advantage of resources such as light and water. The researchers found that the circadian clock regulates nearly every step in the auxin signaling pathway, with activity peaking late at night when water is most available.
A study from Colorado State University reveals that circadian rhythms regulate the function of all genes in mammals, influencing metabolism and health. Researchers analyzed data from thousands of genes using advanced algorithms to identify patterns of oscillation.
Researchers found that sick flies lose their circadian rhythm patterns when infected with bacteria, leading to shorter periods of continuous sleep. This disruption affects the immune system, making infected flies more susceptible to infection and increasing their mortality rate.
A recent study by Scripps Research Institute scientists has identified intercellular mechanisms as essential to maintaining cellular circadian clocks. The research highlights the importance of networked electrical and neurochemical interactions in sustaining cellular rhythms, offering new insights into the circadian clock's operation.
Researchers at UT Southwestern Medical Center found that the Clock gene, regulating biological clocks, is involved in developing bipolar disorder in mice. The study reveals behaviors similar to humans with bipolar disorder, including hyperactivity and euphoria, which are restored by lithium treatment.
The stability of cellular oscillators depends on specific biochemical processes, reflecting recent association studies. The researchers' mathematical model identified the molecular parameters responsible for the stability of internal body clocks.
Researchers found a significant circadian rhythm in swim performance, with athletes performing better in the evening and worse in the morning. The study's results suggest that a circadian rhythm affects athletic performance, with peak performance occurring at 11pm.
Researchers found that human circadian clocks couple to local sun time, with chronotypes becoming later in densely populated areas. City dwellers experience decreased influence of local sun time relative to rural residents.
The honey bee's molecular structure of its biological clock is more similar to mammals than to flies, according to groundbreaking research. The key genes involved in the biological clock were identified and characterized, opening up new directions for understanding complex behaviors like sun-compass navigation and time sensing.
Researchers have elucidated the role of adrenal clocks in maintaining circadian rhythms. The adrenal gland contains a peripheral clock that defines a time window for responding to external stimuli, regulating corticosterone release and stabilizing physiological rhythms.
A study by UT Southwestern Medical Center found that the timing of food consumption can activate genes in a specific brain area, including the dorsomedial hypothalamic nucleus. This discovery may help explain why dysfunctional eating patterns contribute to human obesity.
Researchers found that Bmal1-deficient mice experience premature aging due to oxidative stress and genotoxic stress, leading to weight loss, organ shrinkage, and early death. The study suggests BMAL1 as a potential target for alleviating specific age-related pathologies.
Researchers found that genetic mutations cause the PERIOD protein to degrade more quickly, contradicting previous thinking. This discovery could lead to new treatments for sleep disorders and depression by manipulating the circadian rhythm.
Researchers found that patients taking ramelteon experienced a significant advancement of dim light melatonin secretion offset compared to placebo. The results suggest that ramelteon may help people adjust to time zone changes and shift their natural circadian rhythm.
Researchers at University of Pennsylvania School of Medicine discovered that Rev-erb is a critical component of the internal molecular clock in mammals and is sensitive to lithium. Lithium inhibits GSK3, preventing destruction of Rev-erb, which leads to activation of clock genes such as bmal1.