Articles tagged with Cellular Senescence
Extracellular vesicles (EVs) are key players in the pathogenesis of chronic lung diseases, modulating cellular senescence and immune-inflammatory responses. EVs facilitate aberrant intercellular communication, deliver pathogenic miRNAs and proteins, and promote chronic inflammation.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
A study by Penn State researchers found that people who aged faster during midlife were more likely to experience memory lapses a decade later. The study, which analyzed data from 232 individuals, found that those who were aging rapidly were 18% more likely to experience a prospective memory lapse on any given day.
Researchers at Memorial Sloan Kettering Cancer Center have developed nanoparticles that can selectively eliminate a small population of immune cells found to drive fibrosis, potentially paving the way for new approaches against immunotherapy-resistant tumors and fibrotic diseases. The approach could make immunotherapy work for more pat...
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
Emerging evidence suggests that the aging brain microenvironment may shape brain tumor progression, treatment resistance, and cognitive outcomes. The review highlights interconnected processes associated with brain aging, including cellular senescence, neuroinflammation, and altered neural signaling.
The Starr Healthspan Innovation Alliance will bridge the gap between scientific discovery and life-changing treatments for age-related diseases. The partnership will expand clinical trials and support groundbreaking laboratory research to extend healthy lifespan.
Cyclin D1, a protein linked to cancer, paradoxically promotes chronic inflammation in non-proliferating senescent cells, which can lead to age-related disease. Research suggests that targeting cyclin D1 may be a promising strategy to reduce inflammation and promote healthier aging.
Researchers from the University of Osaka have found a rare type of immune cell that expands in supercentenarians, potentially helping protect against cancer and other age-related threats. The cells, known as CD4 CTLs, have been shown to be highly active and may help the body cope with persistent threats that increase with age.
A new hypothesis proposes that women's reproductive resilience is key to understanding longevity, with menopause representing an important inflection point in the loss of reproductive resilience. This framework challenges traditional views on aging and fertility, highlighting the importance of studying women in longevity research.
Researchers develop SenMayo gene set to identify senescent cells across different tissues and experimental models. Several studies evaluate approaches to reduce the burden or harmful effects of senescent cells in preclinical models.
Researchers found that long-term systemic treatment with senolytic PROTAC 753b slowed several features of age-related intervertebral disc degeneration in male mice, preserving extracellular matrix protein aggrecan and reducing inflammatory markers. However, female mice showed little improvement, suggesting a sex-specific response.
Aging cells become more susceptible to ferroptosis due to elevated levels of acid ceramidase, a previously targeted therapeutic candidate. This vulnerability can be passed to neighboring cells, impacting overall tissue health. The discovery offers new hope for supporting healthy aging and treating age-related diseases.
A new study reveals that macrophages, a key immune cell type, age differently across tissues and between sexes. The researchers found that aging macrophages become more focused on responding to stress and cellular damage, but lose some molecular programs involved in maintaining healthy tissue structure.
Research reveals multifloral honey's protective effects on human skin cells from UV radiation, promoting cell recovery and preventing aging. The study found that honey increased stemness-related markers and reduced aging-associated genes in skin stem cells and fibroblasts.
Cellular senescence is a stable form of cell-cycle arrest induced by intrinsic and extrinsic stimuli. The review highlights the importance of understanding how different initiating events shape distinct senescent cell phenotypes, contributing to chronic inflammation, tissue dysfunction, cancer, and age-related diseases.
Recent research suggests that senescence often limits stem cell activity in normal tissues but can also promote tumor progression in cancer. Understanding the dynamic interplay between these two biological processes is crucial for developing safer regenerative therapies and more effective cancer treatments.
A recent study published in Cell has revealed that senescent cells, often associated with aging and disease, play a previously unrecognized role in building the brain's protective barriers. These cells contribute to the formation of two critical barrier systems: the blood-brain and blood-CSF barriers.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Senescent cells that stop dividing but don't die can become abnormally active, causing inflammation and instability in blood vessel plaques. The study found that losing key regulatory proteins activates the CD38 enzyme, leading to a higher risk of blood clots and cardiovascular events.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
New review highlights emerging complexity of senescent cell populations playing both protective and harmful roles in aging. Precision geroprotection aims to selectively eliminate maladaptive senescent cells while preserving beneficial ones.
Dr. Marcus Ruscetti receives the prize to study senescence and its impact on immune responses in cancer metastasis. The funding will help him develop novel treatments targeting senescent cells.
Researchers have discovered a new vulnerability in senescent cells, which can be targeted to kill them and treat cancers. The approach could complement existing treatments, leading to improved outcomes for patients.
Scientists discovered a weak spot in cancer cells' editing room, which can be targeted by new treatments for aggressive cancers. By blocking the spliceosome, researchers found selectively killed RAS-expressing cells and caused mouse tumors to shrink.
A new study by the Barcelona Supercomputing Center reveals that women's immune systems undergo more pronounced changes with age, leading to a greater susceptibility to autoimmune diseases. In contrast, men experience less extensive immune system changes, but are at higher risk for certain blood cancers.
Researchers at NYU School of Global Public Health found that people living in neighborhoods with fewer social and economic opportunities have higher levels of CDKN2A RNA, a measure of cellular aging. This suggests that structural conditions may be biologically embedded and influence aging processes over time.
A study published in Cell Chemical Biology reveals that an impaired transport protein and ceramide buildup can trigger replicative senescence, a state where cells remain alive but no longer divide. Ceramides accumulate inside the endoplasmic reticulum, triggering stress signals that lead to cellular limbo.
A new study from the University of Minnesota Medical School has identified certain naturally occurring polyunsaturated lipids that selectively induce death in senescent cells, which are old and damaged cells that accumulate with age. These lipids trigger a process called ferroptosis, which can be used as a potential treatment for age-r...
Researchers at OIST identified 80 plasma membrane repair proteins in budding yeast, revealing a coordinated sequence of molecular events. The study provides a foundation for investigating plasma membrane repair mechanisms in higher eukaryotes, including human cells.
Researchers found that perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA) accelerate biological aging in middle-aged men, with effects being strongest in this age group due to lifestyle factors. PFAS pollution has been linked to human cancers, obesity, infertility, and hormonal imbalances.
A study reveals that senescence plays a paradoxical role in postpartum breast cancer, promoting tumor formation while also aiding tissue repair. Targeting senescent cells during mammary gland involution could potentially reduce the risk of this form of cancer.
Researchers highlight polyploidy-induced senescence as a coordinated biological program that may drive aging, tissue repair, and cancer risk. Polyploidization in healthy tissues could help maintain organ structure and barrier integrity, but its instability can promote chromosomal instability and malignant transformation.
Researchers focus on system-level resilience and long-term biological coordination to understand aging as a loss of coordination between biological systems. Studies show how mitochondrial signaling influences inflammation in senescence and microbiota–brain interactions shape aging trajectories.
Researchers have characterized the association between cellular senescence and human brain structure in both development and late life. The study found that senescence-related gene expression is linked to brain volume and cortical organization, with distinct roles depending on cell type and stage of life.
Researchers found that mitochondrial RNA can leak into healthy tissue, triggering inflammation and scarring. Inhibiting certain proteins enables mitochondrial RNA to escape, leading to less inflammation and healthier liver tissue.
Researchers found that glycation stress, caused by methylglyoxal, promotes aortic stiffening and cellular senescence. Natural compound Gly-Low, containing nicotinamide and alpha-lipoic acid, reversed these effects and reduced stiffness in aging mice.
Researchers at Cold Spring Harbor Laboratory have devised a new approach to stimulate cell growth and repair in the intestine using CAR T-cell therapy. This therapy has shown promising results in improving gut health in both young and old mice, with significant reductions in inflammation and improved nutrient absorption.
Researchers explore the link between senescent cells and metabolic diseases, highlighting potential treatments known as senotherapeutics. Senolytics, senomorphics, and senosensitizers are interventions aimed at eliminating or suppressing senescent cells to mitigate metabolic disease.
Researchers at Mayo Clinic have developed a new technique to identify senescent cells using aptamers, which can potentially lead to targeted therapies. The study found several rare aptamers that bind specifically to fibronectin on the surface of mouse cells, offering a promising approach for characterizing and treating senescent cells.
Researchers found that overactive Runx1 gene accelerates age-related degeneration of intervertebral discs, causing premature cellular aging and unhealthy tissue changes. Targeting Runx1 may be a promising strategy to prevent or slow disc aging.
Researchers have discovered that activating lysosome biogenesis alleviates senescence in Hutchinson-Gilford progeria syndrome. By promoting progerin clearance, this approach shows promise as a potential therapeutic avenue for HGPS and other age-related disorders.
A groundbreaking study by Florida Atlantic University researchers found that working with service dogs can slow cellular aging in female veterans. The study, which involved female veterans with post-traumatic stress disorder, revealed promising biological benefits associated with service dog training.
Researchers found that cells exiting the cell cycle show stronger signs of senescence and are more sensitive to senolytic drugs. DNA content plays a crucial role in how aging cells function and respond to treatment.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
A keto diet may have different effects on males and females, with estrogen found to promote protection against adverse effects such as cellular senescence. The study found that male mice on a keto diet showed increased markers of oxidative stress and cellular senescence, but these effects were reversed by estrogen treatment.
Cancer cells with abundant circular DNA elements (ecDNA) carrying oncogenes like MYCN are resistant to chemotherapy. Combining standard chemotherapy with a secondary therapy targeting these senescent cells leads to improved outcomes in mouse models of neuroblastoma and medulloblastoma.
The Aging (Aging-US) meeting will bring together researchers and clinicians to explore the latest advances in cellular senescence and its translation into therapies for age-related diseases. The event will provide a unique platform for discussing both basic research and its clinical applications.
The UT Health San Antonio research team, led by Blake Rasmussen, has been selected as a semifinalist in the XPRIZE Healthspan competition. They will use a low-frequency ultrasound spa to develop a non-invasive treatment that helps renew cells and tissues, potentially improving overall health and longevity.
A new study reveals an AI-assisted technique that can measure and track aging cells, which are known to play a key role in wound repair and aging-related diseases. The tool uses nuclear morphometrics to analyze cell characteristics and distinguish between healthy and senescent cells.
Researchers induced senescence in worms by manipulating transcription factor TFEB, mimicking mammalian aging. Key growth factors insulin and TGFbeta were identified as crucial signaling molecules in circumventing senescence.
Researchers at the University of Oklahoma investigate the overlap between cognitive decline caused by chemotherapy and aging, discovering decreased blood flow, disrupted blood-brain barriers, and senescent cells. Removing these cells with senolytics can improve cerebral blood flow, cognition, and overall brain health.
A Korean research team discovered that High Mobility Group Box 1 (HMGB1) plays a critical role in transmitting senescence from aging cells to distant tissues through the bloodstream. Reduced HMGB1 circulates systemically, inducing senescence in remote tissues and impairing regenerative capacity.
Scientists have created a novel method to distinguish between healthy and senescent cells using electric fields, marking a fresh start in ageing research. The frequency-modulated dielectrophoresis (FM-DEP) technique is label-free, rapid, and easy to apply, allowing for the characterization of cell type by measuring the cutoff frequency.
Scientists at San Raffaele Telethon Institute for Gene Therapy discovered that CRISPR-Cas9 gene editing can cause inflammation and senescence-like responses in blood stem cells. This reduces the cells' ability to regenerate blood cells after transplantation, limiting the long-term success of gene therapy.
Researchers found that surgery induces accumulation of senescent cells in the hippocampal region of aged mice, leading to neuroinflammation. Dosing with a combination of Dasatinib and Quercetin reduced surgery-induced inflammation.
Researchers will examine the link between cellular senescence and Parkinson's disease onset and progression. The team aims to find new ways to slow disease progression and establish senescence as a novel target for treatment.
Research highlights the interconnected relationship between aging, circadian rhythms, and cancer, with shared mechanisms including genomic instability, cellular senescence, and chronic inflammation. Modulating circadian rhythms may serve as a novel strategy to intervene in age-related functional decline and treat cancer.