Articles tagged with Metabolism
Researchers reverse-engineered a primordial protein and inserted it into a living bacterium, successfully powering its metabolism, growth, and reproduction. The discovery sheds light on the origins of metabolism and has implications for synthetic biology and bioelectronics.
A new study by University of Arizona researchers suggests that ALS patients may benefit from more glucose, as it can help increase energy production and improve cellular function. The findings, published in eLife, reveal that when ALS-affected neurons are given more glucose, they are able to survive longer and function better.
A study of thousands of patients found that statin users had more than double the risk of developing type 2 diabetes. The analysis revealed a dose-dependent relationship between statin use and diabetes diagnosis.
Coral and algal symbiotic relationships are crucial for reef construction. Researchers analyzed cellular processes in anemones hosting native and non-native dinoflagellate algae to understand preferential relationships and potential for revival of bleached coral communities. They found elevated protein expression associated with nutrie...
Researchers at Houston Methodist have identified a new regulatory mechanism in zebrafish models that leads to high levels of LDL cholesterol, increasing the risk of cardiovascular disease. The study suggests targeting this protein using its antagonist could reduce white blood cell counts and bring down the risk of heart disease.
Researchers at Binghamton University are developing a new power source from human sweat, aiming to create self-powered electronic skins. The project uses metabolisms of sweat-eating bacteria to transform chemical energy into electrical power.
Researchers have developed a biosynthetic dual-core cell computer using CRISPR-Cas9 components, enabling scalable and flexible computing. This biological system can process up to 100,000 different metabolic molecules per second, far surpassing previous cell computers.
Researchers developed DASH materials that exhibit metabolism, self-assembly, and organization - key traits of life. The biomaterial autonomously emerges from nanoscale building blocks, grows, and decays, allowing it to perpetuate dynamic processes.
Researchers create green fluorescent protein-based biosensors to probe energy metabolism in living cells, enabling multicolor imaging and visualization of multiple molecules. The sensors achieve up to a seven-fold increase in fluorescent brightness in response to glucose concentrations.
A systematic review suggests that vitamin C administration can decrease ICU length of stay by an average of 7.8%, with higher doses reducing duration by up to 8.6%. Vitamin C's role in energy metabolism and cardiovascular system makes it a promising intervention for critically ill patients.
Researchers at Ohio State University College of Medicine have identified a metabolic process in the heart that, if treated, could prevent or slow the progression of heart failure. By normalizing a reactive fat compound called acyl-CoA, the hearts retained their ability to burn fat and generate energy.
Researchers identified 727 genes in fat tissue that express their own circadian rhythm, many carrying out key metabolic functions. Morning-peaking transcripts regulate gene expression and nucleic acid biology, while evening-peaking transcripts are associated with redox activity and organic acid metabolism.
Researchers at The Wistar Institute have discovered a novel role of NAD+ metabolism in promoting tumor growth and progression in preclinical models of pancreatic cancer. Cellular senescence, a process that stops cells from dividing, can also produce proinflammatory molecules that promote tumor growth.
Researchers at Joslin Diabetes Center found that exercise causes dramatic changes to fat, releasing factors into the bloodstream that improve glucose tolerance. The study identified transforming growth factor beta 2 as an adipokine released from fat that has positive effects on health.
PET scans reveal female brains are metabolically 3-4 years younger than males, affecting resilience to neurodegeneration. Sex differences in metabolic brain aging may influence later life outcomes.
Scientists at Helmholtz Munich found a transcription factor called Tbx3 that plays a pivotal role in maintaining energy and sugar metabolism. Its absence leads to an identity crisis of satiety neurons, resulting in obesity.
Researchers discovered that specific gut cells, intraepithelial T lymphocytes, limit the availability of hormones that speed up metabolism, leading to slowed metabolic rates and increased risk of obesity and cardiovascular disease. The study's findings could pave the way for new therapeutic avenues to treat related conditions.
A recent study from Arizona State University uses breath and hair analysis to understand metabolism and calories burned during exercise. The results show that people burn fat in the morning and switch to burning carbohydrates during moderate exercise, regardless of their diet.
Researchers found that participants who completed mindfulness training lost an average of 3 kilograms more than those who did not attend the course. The study suggests that mindfulness techniques can help improve eating behavior and facilitate successful weight loss in individuals with obesity.
Researchers found that mitochondrial DNA influences cellular metabolism and susceptibility to metabolic diseases. Switching mitochondrial genetic backgrounds in mice showed significant impacts on adiposity, whole body metabolism, and nuclear gene expression.
Researchers at Sahlgrenska Academy discovered that gut microbiota in people with type 2 diabetes produces a substance impairing insulin response. This finding highlights the importance of diet and gut microbiota interaction in understanding metabolism in health and disease.
A new study by Cold Spring Harbor Laboratory has identified new regulators of nitrogen use in plants, which may lead to the development of crops better suited to thrive under different environmental conditions. The researchers found that eliminating certain genes can stunt plant growth and distort roots when nitrogen is scarce.
Researchers at UC Davis and Cold Spring Harbor Laboratory discovered a gene network that enables plant roots to efficiently take up and metabolize nitrogen. This breakthrough could lead to the development of crop varieties that need less fertilizer or make better use of it, reducing environmental impacts.
Research found that six weeks of endurance exercise altered the gut microbiota, decreasing inflammation-causing Proteobacteria and increasing Akkermansia, a genus linked to enhanced metabolism. Exercise also improved cardiometabolic health by reducing VLDL particles.
Researchers studied thermodynamics of small nanomachines and found that synchronizing their movements triggers significant synergy effects, leading to greater overall energy output. The findings could potentially be used to improve efficiency of any machine.
The University of Freiburg has been granted two Clusters of Excellence, CIBSS and livMatS, with funding of up to 100 million euros over seven years. The clusters will focus on biological signalling studies and bioinspired materials research.
A team at Princeton's Lewis-Sigler Institute for Integrative Genomics has produced new resources for studying the biology of multicellular organisms. The researchers analyzed gene activity patterns in four major tissues and developed a tool to predict gene expression across cell types.
Renewable biofuels have huge potential, but two main challenges need to be overcome: developing efficient microbial cell factories and converting biomass into sugars. The study suggests that improving these processes could make biomass-derived hydrocarbons a real alternative to fossil fuels.
Untreated gestational diabetes after pregnancy is associated with development of glucose metabolism disorders in mothers, but not childhood overweight/obesity. The study found that new criteria for gestational diabetes diagnosis may be relevant in assessing maternal risk.
Researchers have discovered a key role for O-GlcNAc modifications in enhancing neuronal regeneration after injury. Altering sugar levels on proteins can alter metabolism, leading to improved regeneration outcomes.
Researchers have identified elesclomol as a potential treatment for human copper metabolism disorders by restoring mitochondrial energy production. The study found that elesclomol can mimic the missing transporters of copper, providing a new opportunity to treat genetic disorders such as Menkes disease.
Prof. Doron Lancet and colleagues propose a new chemical model that supports the 'Lipid World' concept, where lipids can store and transmit information, leading to compositional reproduction and Darwinian evolution. The researchers argue that life could emerge before DNA and RNA.
A Salk Institute study found that depleting a mouse's microbiome with antibiotics reduces glucose levels and improves insulin sensitivity. The research suggests the microbiome plays a role in glucose regulation and may offer insights into treating type 2 diabetes.
Researchers discovered that free-living insects can copy and inject plant hormones into leaves to increase nutrient content. This strategy is similar to endophytic insect species and could aid in developing effective pest management strategies.
Researchers found that maintaining high levels of the protein vinculin in fruit flies' hearts reduced the effects of aging and improved their life span, quality of life, and metabolism. Flies bred with higher vinculin levels lived up to nine weeks, compared to six weeks for typical fruit flies.
A recent study from Johns Hopkins University reveals a flaw in the water treatment process that can create toxic transformation products, including 2-butene-1,4-dial. This compound has been linked to negative effects on human cells and may be responsible for toxicity in cigarette smoke and car exhaust.
A new study by Ohio State University reveals that a lipid released from brown fat, called lipokine, surges in the bloodstream after exercise. This finding suggests that burning of brown fat and this lipid play an important role in the metabolic benefits of exercise.
High-risk atherosclerotic plaque and cancer cells exhibit reprogrammed metabolism, which can be targeted with drugs to limit inflammation. The study proposes a novel approach for identifying dangerous plaque using PET cameras.
A new study found that fatty fish increases the size and lipid composition of beneficial HDL particles, while camelina oil decreases harmful IDL particle concentrations. Both changes can lower cardiovascular disease risk.
Arthur Grossman, a Carnegie scientist, has received a $300,000 Human Frontier Science Program grant to investigate how light and metabolic signals control photosynthetic processes in algae. This research aims to develop a holistic view of photosynthetic control, spanning metabolism to epigenetics and mathematical modeling.
A new study by Karolinska Institutet reveals that enzyme FIH determines how muscles consume oxygen, with implications for elite athletes and potential new forms of metabolism-affecting drugs.
The study reveals that the circulating form of soluble a-Klotho can act as a co-receptor for FGF23, making every cell a potential target. This breakthrough challenges the long-held belief that only cell-attached a-Klotho can receive FGF23 signals.
Scientists at Princeton University have developed a method to control the metabolism of living cells using light, enabling the production of commercially valuable chemicals. This technique allows for the creation of biofuels like isobutanol, which could potentially replace gasoline as a vehicle fuel.
Scientists developed a method to predict how global warming affects disease severity, using the metabolic theory of ecology. The study showed that different processes have unique relationships with temperature, and that linking these theories can describe how disease interactions change with global warming.
Researchers have developed a new non-invasive method to measure the metabolic activity of brown adipose tissue, making it easier to verify its heat generation. The method uses multispectral optoacoustic tomography (MSOT) to visualize changes in oxygenated and deoxygenated hemoglobin, allowing scientists to study its effects on energy b...
Researchers discovered that the fission protein Drp1 is controlled by an internal biological clock, which determines the design of mitochondrial networks and their energy capacity. Impairing this rhythm leads to a decline in energy production, with potential therapeutic applications for diseases like Alzheimer's.
A new study from the University of Eastern Finland found that camelina oil reduces overall and LDL cholesterol levels in individuals with impaired glucose metabolism. Camelina oil, rich in alpha-linolenic acid, showed a positive effect on blood cholesterol levels but had no similar effects for fatty or lean fish.
Driftwood hoppers, also known as talitrids, have evolved to thrive in marine driftwood habitats. They are characterized by their small size and reliance on symbiotic microflora for digestive purposes. The species demonstrate dwarfism due to poor diet and slow metabolism, with the smallest species measuring less than 6 mm in length.
A research team led by Professor Jens Nielsen has mapped out the complex metabolism of yeast cells, enabling the efficient production of protein therapies for diseases like cancer. The breakthrough could lead to significantly cheaper treatments, potentially reducing costs by 10%.
New research finds that eating breakfast decreases genes involved in fat metabolism and increases sugar uptake in fat cells. This may lead to lower diabetes and cardiovascular risk in obese individuals.
A Russian researcher and his colleagues have determined the normal range of boron in human tissues, revealing its importance in metabolism. The study found that men and women have different dietary balances but similar boron functions, suggesting a gender-independent metabolism.
Researchers at Harvard T.H. Chan School of Public Health discovered Nrf1 protein's role in maintaining cholesterol balance within cells. The protein senses and responds to excess cholesterol, promoting protective countermeasures and potentially treating diseases where cholesterol metabolism is disrupted.
Researchers found a 10% decrease in serum zinc levels in women with prediabetes, highlighting the importance of zinc metabolism in diabetes pathogenesis. Zinc plays a crucial role in insulin synthesis and tissue susceptibility to hormones.
Apixaban is a predictable linear NOAC providing good bioavailability, fast onset and offset of action, and low drug-food interactions. Its safety benefits include lower major bleeding event incidence compared to traditional anticoagulants.
Researchers have discovered the first confirmed human case of 2,3-dioxygenase deficiency, a rare metabolic disorder characterized by excessive serotonin levels. The study, led by Aimin Liu at UTSA, uses advanced instrumentation techniques to document the patient's conditions.
Scientists have discovered two new classes of histone modifications that couple cellular metabolism to gene activity, providing a potential mechanism for environmental influences on gene expression. The novel marks, propionylation and butyrylation, are linked to fatty acid metabolism and can drive transcription in test tube experiments.
Researchers at the University of Wisconsin-Madison have identified a critical step in how cancer cells shift their metabolism, leading them down a cancerous path. By inhibiting a specific protein modification, the study reveals a potential therapeutic target to reverse several hallmarks of cancer.
Apixaban is a new oral anticoagulant with good bioavailability, independent of patient sex and age. The drug has a short half-life, wide therapeutic window, and low number of drug interactions, making it suitable for patients with bleeding or surgical conditions.
A study found that consuming high sugar diets increases fat levels in the blood and liver, raising cardiovascular health risks. Healthy men with low liver fat showed similar changes after consuming a high sugar diet, highlighting the importance of sugar intake regulation.
Researchers discover nerve-associated macrophages that become inflamed with age and disrupt fat cell function. Lowering inflammation in these cells restores normal fat metabolism in older mice.