Articles tagged with Metabolism
A study of 14 high-risk children found that convalescent plasma provided expected antibody levels without safety concerns. The therapy's effectiveness declined over time, highlighting the need for early administration.
Researchers discovered multiple levels of torpor in hummingbirds, including shallow and deep states, as well as a transition stage between normal sleep and torpor. This flexible control allows hummingbirds to conserve energy while minimizing potential costs, such as increased vulnerability to disease or predation.
Researchers discovered that microbes capable of extracellular electron transfer (EET) are spread through horizontal gene transfer and exist in various environments worldwide. The genes, which enable EET, were found in a wide range of organisms, from deep-sea microbes to human gut bacteria.
A study by Michigan Medicine researchers found that people with diabetes have more macrophages in their fat tissue, particularly the anti-inflammatory CD206+ subtype. This subtype is unique in terms of gene expression and may play a role in the development of diabetes.
Research found that over 55,000 chemicals in everyday plastic products can reprogram precursor cells to become fat cells, leading to increased fat accumulation. The study suggests that previously unknown plastic chemicals may be contributing to overweight and obesity.
The Nutrition for Precision Health study will use data from 10,000 participants to develop algorithms predicting individual responses to food and dietary routines. The goal is to create more personalized nutrition recommendations and reduce health disparities.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
A recent study published in Scientific Reports found that chewing food thoroughly increases energy expenditure through diet-induced thermogenesis (DIT), which helps prevent obesity. The study involved participants who chewed liquid food for varying durations, revealing that prolonged chewing and tasting increased DIT, gas exchange, pro...
Researchers at Salk Institute have discovered a new molecular pathway that controls blood glucose levels independent of insulin, offering new avenues for treating diabetes and metabolic disorders. The hormone FGF1 suppresses lipolysis and regulates glucose production in the liver.
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
A bile acid derivative, TUDCA, reduced food intake and increased energy expenditure in mice with an Alzheimer's-like disorder. The treatment improved quality of life by mitigating metabolic abnormalities associated with the disease.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
Researchers at University of California - Riverside are studying the keto and intermittent fasting diets on a molecular level, finding that women may metabolize fat differently than men. The study aims to understand why keto diet may not be effective for women and how it affects their overall health.
Researchers discovered that wound macrophages undergo different metabolic programs to coordinate tissue repair, including the use of reactive oxygen radicals for blood vessel growth. Macrophages also utilize a different type of mitochondrial exchange for anti-inflammatory and reparative functions in late-stage wound healing.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
A study by the Technical University of Munich discovered that pungent substances from chili, ginger, and pepper are transferred to breast milk after consumption. These substances can be detectable in breast milk for several hours, with maximum concentrations being 70- to 350-fold below the taste perception threshold of an adult.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers discovered that ants pass proteins through mouth-to-mouth exchanges to share metabolic labor and adapt to colony needs. This discovery sheds light on how ants divide tasks between individuals and the colony's life cycle.
A new review in the Journal of Dairy Science explores the relationship between serotonin and calcium metabolism in dairy cows, highlighting its importance in maintaining calcium balance. Research shows that mammary serotonin drives hormone production that modulates mammary calcium transport.
A study found that D-glyceric acid treatment improved metabolism, blood parameters, and reduced low-grade inflammation in healthy volunteers aged 50-60 years. The compound's activation of mitochondrial metabolism may help interrupt the spiral of persistent systemic inflammation and improve liver function.
A study published in Nature Communications identified C-terminal binding protein 2 (CtBP2) as a global regulator of metabolism that balances sugar and fat levels in the liver. CtBP2 is crucial for controlling glucose and lipid balance, making it a promising drug target for treating symptoms associated with obesity.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
A new study from University of Wisconsin-Madison researchers reveals that fasting is essential for mice to derive full benefit from calorie restriction. Fasting alone improves insulin sensitivity and reprograms metabolism, reducing frailty in old age and extending lifespan.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Researchers identified five genes mutated in people with liver disease, affecting insulin sensitivity and fat metabolism. These mutations reduce the liver's ability to respond to dietary sugars and fats.
A clinical trial found that a green Mediterranean diet rich in leafy greens like Mankai and green tea can elevate fasting ghrelin levels, reducing belly fat and improving insulin sensitivity. This approach may also have additional cardiometabolic benefits.
Researchers at Trinity College Dublin have discovered that lactate can influence cells in the lung environment to support immune defenses against infection while limiting collateral damage. Lactate may hold therapeutic potential as a host-directed therapy for diseases like TB and COVID-19, which cause destruction of pulmonary tissue.
Dysfunction in mitochondrial respiration leads to imbalanced extracellular matrix (ECM) and tissue organization in cartilage. Research discovered the respiratory chain plays a key role in maintaining ECM balance.
Cachexia is characterized by weight loss and muscle tissue shrinkage, driven by the immune system's response to chronic infections and diseases. Researchers from CeMM emphasize the need for more research into cachexia, highlighting the importance of interplay between the immune system and metabolism.
MUSC researcher Haizhen Wang receives R37 grant to investigate CDK6's role in T-cell acute lymphoblastic leukemia, a aggressive cancer. The research aims to understand how the immune system can be used to reduce leukemia progression.
A new Stanford University study suggests that rising oxygen levels may have slowed down ancient ocean extinctions. The research found that oxygen levels beyond 40% of present atmospheric levels expanded viable ocean habitat and reduced extinction rates. This discovery has implications for understanding the fate of ocean creatures in to...
A study published in Cell Metabolism identified a protein called neurturin as crucial for muscle health, improving metabolic rates, motor function and exercise capacity. Mice genetically modified to produce more neurturin had increased resistance to degeneration in neurons associated with ALS.
A new USC study found that artificial sweeteners like sucralose can trick the brain into feeling hungry, leading to increased calorie consumption. This study, one of the largest to-date on artificial sweeteners, suggests that females and people with obesity may be more sensitive to these sweeteners.
A systematic review presents evidence that environmental obesogens, such as hormone-disrupting chemicals, play a significant role in childhood and adult obesity. Dr. Leonardo Trasande recommends simple policies to reduce exposure and suggests economic benefits of limiting public exposure.
A recent study published in Cell Metabolism found that reducing naturally occurring errors in protein synthesis improves both health and lifespan. By engineering a mutation in ribosomes, researchers observed fewer protein mistakes and improved heat resistance, leading to longer lifespans in yeast, worms, and fruit flies.
The energy balance model fails to explain the biological causes of weight gain, whereas the carbohydrate-insulin model identifies excessive consumption of rapidly digestible carbohydrates as a key contributor to obesity. This perspective argues for a shift in focus from calorie restriction to dietary pattern change.
A recent study published in Scientific Reports found that individuals with inflexible metabolisms exhibit higher carbohydrate oxidation rates at night, indicating a reduced ability to burn fat during sleep. This discovery has the potential for practical use in disease prevention and early intervention.
Scientists at CIBFar have discovered the molecular mechanism of SARS-CoV-2's main protease, which enables the virus to replicate in host cells. The study provides valuable insights into the process and has immediate applications for developing antiviral drugs.
A new USC study found a link between 'forever chemicals' and changes in glucose metabolism in Latina girls, potentially increasing their risk of developing type 2 diabetes. Researchers measured the impact of PFAS on glucose metabolism over time among adolescents and young adults.
Researchers discovered that Neuropeptide F (NPF) in fruit flies controls sugar and fat metabolism through glucagon-like and insulin-like hormones. The study reveals similarities between insect and mammalian metabolic processes.
A new study by Salk scientists found that time-restricted eating (TRE) confers multiple health benefits, including reduced risk of type 2 diabetes, fatty liver disease, and sepsis, regardless of age and sex. TRE may also protect against infectious diseases like COVID-19 and improve insulin resistance.
The University of Maryland associate professor will use genetics, cell biology, and pharmacology to examine the mechanisms of copper transport and its connection to thermogenesis and fat burning. The research aims to improve human health by understanding how copper relates to hypothermia, obesity, and diabetes.
A new study reveals that metabolism increases rapidly during infancy, peaking at around one year old. After a gradual decline until the 20s, metabolism levels off and then slows down again after age 60, with older adults requiring fewer calories. The findings suggest that muscle loss and cellular changes contribute to this decline.
Researchers at the University of Basel developed a breath test to measure treatment success in epilepsy patients. The test provides immediate results without requiring a blood sample, allowing doctors to adjust medication quickly and precisely tailored to individual patients' needs.
A new study from the University of Sheffield reveals that vitamin D supplements do not reduce the severity of IBS symptoms or improve quality of life. Despite correcting deficiencies in those with poor vitamin D status, high-dose vitamin D supplementation did not alleviate symptoms.
Researchers predict two nicotine biomarkers, NMR and TNE, in smokers of multiple ethnicities using machine learning approaches. These models can estimate nicotine biomarker levels from DNA data or existing genomic information.
A study published in iScience has identified dozens of muscle proteins with decreased quantities in individuals with prediabetes and type 2 diabetes. The findings highlight the significance of mitochondrial energy metabolism in the progression from prediabetes to type 2 diabetes.
A new study from Aarhus University found that over 80% of participants have more than three genetic variants affecting medicinal product metabolism, increasing the risk of reduced effect or side effects. Genetic tests can provide personalized treatment plans by analyzing multiple genes and variants.
Researchers from Synapsy have identified lactate's key features, including NADH and neurogenesis, which contribute to its antidepressant effect. Lactate restores adult neurogenesis in the hippocampus, a region crucial for memory and depression.
Researchers have identified two subtypes of POMC neurons with distinct hormone sensing and appetite suppression profiles. The findings suggest that the diversity of these neurons is crucial for their function in regulating metabolism.
Research from University of Nebraska-Lincoln and Yale University suggests that temperature explains why tropical waters have a higher biodiversity. However, global warming could reduce this diversity as temperatures rise, potentially leading to extinctions.
A new study using 7T brain scans suggests that compromised energy metabolism may be an early indicator of mild cognitive impairment and Alzheimer's disease. The researchers found a correlation between the energy reserve index and cognition levels, providing new insights into the disease.
Experts and patients are urging medical textbooks to be rewritten due to the rare condition of unexplained low blood sugar. The new guidelines aim to diagnose and treat this condition as any other disease.
The US Preventive Services Task Force recommends against routine screening for vitamin D deficiency in healthy adults due to insufficient evidence. Individual requirements for vitamin D levels vary, making a one-size-fits-all approach challenging.
A study published in Nature Metabolism found that individuals who experience significant 'sugar dips' after eating tend to be hungrier and consume more calories throughout the day. Big dippers had a 9% increase in hunger and ate around 312 calories more than little dippers, potentially leading to weight gain over time.
The University of Arkansas has been awarded a $10.8 million NIH grant to establish an integrative metabolic research center, focusing on diseases like cancer, diabetes, and obesity. The center will combine expertise in advanced imaging, bioenergetics, and data science to explore the role of cell and tissue metabolism.
Researchers discovered that pregnancy-related hormones significantly increase concentrations of CYP3A4, a key enzyme in drug metabolism. This finding has significant implications for managing medications during pregnancy and may provide insights into the development of new ADME-tox models.