Articles tagged with Respiration
Critically ill children on ventilator support can experience patient-ventilator asynchrony (PVA), which worsens outcomes. Researchers are using machine learning to develop a common set of definitions and measurements for PVA in pediatric patients, aiming to minimize risks and improve clinical outcomes.
A new study reveals how Aulacopleura, an ancient sea-dwelling trilobite, developed variable mid-section segments to tolerate dips in local oxygen levels. This adaptation allowed the species to thrive despite being preyed upon by larger predators.
A new study by UCSF found that half of participants with extensive tobacco exposure had persistently high respiratory symptoms, yet performed well in COPD tests. The study highlights a gap in effective care for tobacco-exposed individuals and emphasizes the need for broader definition of smoking-related lung disease.
Researchers found that human senescent fibroblasts trigger progressive lung fibrosis in immunodeficient mice by inducing paracrine senescence and pro-fibrotic activities. The study also suggests that senolytic compounds like navitoclax can ameliorate lung fibrosis induced by senescent human fibroblasts.
Researchers at Sahmyook University repurposed meclofenamate to treat abnormal respiratory mucus, reducing mucin secretion and characteristics of respiratory mucus. This study offers an alternative solution for patients with respiratory diseases, saving time and costs compared to conventional drug development strategies.
A new study suggests that bacterial testing in children with sinusitis could greatly reduce unnecessary antibiotic use. By identifying which children are likely to benefit from antibiotics, doctors can avoid prescribing medications to those who wouldn't see improvement in symptoms.
The July issue of CHEST journal features 49 articles on clinically relevant topics, including disability rights and life-sustaining treatment. The journal offers complementary web resources, such as visual abstracts, to expand the reach of its research.
Researchers at Vanderbilt University Medical Center will compare the effectiveness of ketamine and etomidate in critically ill adults undergoing tracheal intubation. The study aims to determine which medication helps patients survive or prevents symptoms of PTSD.
Researchers found that a triple combination therapy of elexacaftor, tezacaftor, and ivacaftor improves lung function and reduces inflammation in patients with cystic fibrosis. The treatment's positive effects last over 12 months, offering hope for better management of the disease.
A deep learning-based model developed in 7,105 patients predicted 30-day all-cause mortality in patients with CAP with AUCs ranging from 0.77 to 0.80. The model showed higher specificity than the CURB-65 score at the same sensitivity.
Researchers created a detailed analysis of the domestic cat's nasal airway, revealing two distinct regions of air flow during inhalation. The study suggests that the cat nose functions as an efficient dual-purposed gas chromatograph, capable of detecting and separating chemicals quickly and efficiently.
The study analyzed historical data on coal miners in China, revealing a strong correlation between raw coal production, mining technology, and CWP incidence. The researchers identified key turning points in disease incidence, linked to changes in diagnostic criteria and labor management, as well as coal industry policy reforms.
A study found that exposure to air pollution increased the risk of contracting Covid-19, being hospitalized, and dying from the disease. Long-term exposure to pollutants even at levels below EU limits was associated with a higher burden on healthcare systems.
UCF researcher Dr. Justine Tigno-Aranjuez has discovered a new receptor that recognizes house dust mite allergens, opening up potential for broad-spectrum therapy. The finding could lead to improved treatments for common allergies, including asthma.
Researchers have discovered that microplastics can accumulate in the nasal cavity and oropharynx, increasing the risk of respiratory diseases. The study's findings highlight the importance of awareness about microplastic exposure and its potential health impacts.
The new scientific statement highlights the importance of identifying the root cause of pediatric cardiomyopathy to develop effective treatment strategies. Genetic testing is recommended for all children with cardiomyopathy, which may lead to financial and emotional cost savings.
Two studies investigate long-term consequences of COVID-19, identifying potential drug targets for treating chronic disease. Researchers found novel pathways in the lungs and immune system that may lead to effective treatment options, including therapies targeting immune dysfunction and mucous cell differentiation.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
A new study found that race-neutral reference equations can incorrectly identify respiratory impairments in Black individuals, leading to increased severity of identified conditions. The findings highlight the need for more accurate and inclusive pulmonary function test interpretation methods.
A UC Riverside-led study reveals the Salton Sea environment is toxic, causing sulfuric smells, dust storms, chemicals, and fires that contribute to chronic health conditions like asthma and respiratory illnesses. The study's findings have important public health implications for vulnerable child populations.
A UNIGE team has identified how the influenza A virus manages to penetrate cells to infect them by hijacking the iron transport mechanism. By blocking this receptor, researchers were able to significantly reduce its ability to invade cells, highlighting a potential strategy for treating influenza virus infections.
Research found that low oxygen levels in infants due to sleep apnea can lead to dysregulation of the autonomic nervous system, resulting in high blood pressure. The study's findings may contribute to the development of novel therapies for patients with hypertension who do not respond well to treatment.
A new study found that obstructive sleep apnea causes widespread changes in gene activity in mice, affecting up to 16% of genes, particularly in lung tissue. The findings may lead to diagnostic and therapeutic approaches, including blood tests tracking dysregulated gene products.
Researchers studied termite mounds to develop efficient ventilation systems for buildings. The 'egress complex' network enhances air flow, heat, and moisture exchange, maintaining a balanced temperature and humidity inside. This design enables wind-powered ventilation with minimal energy consumption.
A new study shows that masking and portable air cleaners significantly reduced the spread of SARS-CoV-2 in two Swiss schools during the Omicron wave. The researchers detected salivary and airborne virus concentrations in air samples and students, with a 70% decrease in viral transmission under mask mandates.
A new commentary from infectious disease experts emphasizes the importance of continued masking in healthcare settings due to low evidence of efficacy and high transmission risks. Despite recent conflicting views, the authors argue that mask-wearing remains a crucial strategy for infection prevention.
A study published by the European Respiratory Society found that around 20.2% of French adults are likely to have obstructive sleep apnoea (OSA), with only 3.5% being treated for the condition. OSA is more common in men, older adults, and those with cardiovascular disease.
A new immunotherapy treatment developed by UCF researchers uses targeted IL-2 to fight respiratory viral infections with improved outcomes in animal studies. The treatment promotes an antiviral inflammatory response and reduces bronchial inflammation.
A Chinese Medical Journal review highlights the health hazards of air pollution, particularly from fine particulate matter (PM2.5), which is associated with increased risks of cardiovascular disease, hospitalization, and respiratory mortality. The study suggests that reducing PM2.5 levels through government interventions and individual...
Researchers found that face masks significantly reduced the release of exhaled particles in children, which can help prevent the spread of respiratory infections. The study used cloth and surgical masks to test various activities, including breathing quietly, speaking, singing, coughing, and sneezing.
Researchers at the University of Missouri identified occludin protein as a mediator for cell-to-cell transmission of coronavirus. The study found that damaged occludin protein enables virus replication and spread to neighboring cells, worsening symptoms.
A new study found that inhaling low concentrations of ethanol vapor can inactivate the influenza A virus in mice without harmful side effects. The researchers believe this method could also treat similar viruses like Covid-19 and potentially stop pandemics. However, further evaluation is needed to ensure its efficacy and safety on humans.
Researchers at Anglia Ruskin University found that a portable breath test can detect changes in metabolism in response to diet. The study used the Lumen device to monitor metabolic fuel use at home and showed that it could detect acute changes in carbohydrate use, but was not sensitive on a day-to-day basis.
A Brazilian study found that prenatal exposure to cannabinoids increases the risk of sudden infant death syndrome, breathing difficulties, and impaired control of breathing. The study suggests that consumption of cannabis or derivatives during pregnancy can have severe effects on the fetus's neural and physiological functions.
A new study by Texas A&M University researchers shows that exposure to ultrafine particles during pregnancy enhances the risk for respiratory viral infections, including influenza. Pregnant women are already at increased risk for severe flu, and air pollution exacerbates this vulnerability.
A new study reveals that young children diagnosed with pulmonary tuberculosis are at an increased risk of subsequent wheezing, poor lung function, and reduced height and weight. The study found that children who developed PTB before six months old had more than double the risk of wheezing after 6 months.
Researchers from NUS Medicine discovered that specific CPS structures and sugar combinations help Streptococcus pneumoniae colonize the human respiratory tract. The study sheds light on the importance of CPS structure in bacterial survival, which will inform future vaccine development.
Experts recommend managing SARS-CoV-2 like other endemic respiratory viruses using Standard and Transmission-based Precautions. They also suggest reconsidering pandemic-era strategies such as asymptomatic testing and contact tracing in the endemic era.
A major UK study has discovered that disturbed sleep patterns in patients hospitalised with COVID-19 were likely a driver of breathlessness. The study found that 62% of participants experienced sleep disruption, which persisted for at least 12 months and was associated with anxiety and muscle weakness.
The primary COVID-19 vaccines provided adequate protection against transmission, hospitalization, and death, but their effectiveness waned in the face of the Omicron variant. The study found that vaccines developed prior to Omicron's emergence were 83% effective against infection at baseline, but this decreased to 47% by 40 weeks.
The CHEST journal April issue features cutting-edge research on asthma, chronic obstructive pulmonary disease (COPD), and sarcoidosis. Key findings include the potential of efzofitimod as a treatment for managing sarcoidosis. The journal also showcases innovative approaches to clinical practice and education in chest medicine.
Researchers have identified a new cell state in embryonic airway development, which may lead to new approaches for treating chronic respiratory diseases. The discovery highlights the crucial role of cellular heterogeneity in shaping airway biology.
Researchers developed a biologically inspired 'vaping robot' to mimic human breathing patterns and tested commercially available e-liquids containing menthol. The study found that menthol vapers took shallower breaths and had poorer lung function compared to non-menthol smokers, regardless of age or smoking history.
A national-level analysis found substantial adverse maternal outcomes among pregnant patients with COVID-19 infection during the early pandemic period. The study highlights increased odds of severe respiratory complications among these patients at delivery.
The MATISSE study found that administering the Pfizer Bivalent Prefusion F Vaccine in pregnancy reduces severe RSV-associated lower respiratory tract infection by 82% in infants aged six months old. This vaccine is particularly important in low- and middle-income countries where the burden of RSV illness is highest.
Researchers found that obstructive sleep apnea (OSA) can cause premature cognitive decline in middle-aged men, including poorer executive functioning and social cognition. The study suggests that OSA itself is sufficient to cause these deficits, rather than being solely attributed to co-morbidities.
A study published in Annals of the American Thoracic Society has identified disparities in patients receiving extracorporeal membrane oxygenation (ECMO) treatment for severe respiratory illness. Men and those with private health insurance are more likely to receive ECMO, while women and Medicaid recipients are less likely.
Researchers used transcranial stimulation to regulate Autonomic Nervous System responses and increase oxygen saturation in hospitalized patients with Covid-19. The treatment improved ANS regulation and reduced symptoms without adverse effects.
A new Rutgers study finds that childhood asthma diagnoses decreased by 52% in the US during the first year of the pandemic compared to previous years. Researchers attribute this decline to fewer colds and the practice of wearing masks, which may have reduced the risk of asthma triggers.
A recent study found an unusual peak in RSV hospital admissions in the third quarter of 2021, nearly doubling typical annual numbers. The surge in cases was unexpected, with low hospitalizations reported in 2020 due to the COVID-19 pandemic.
Researchers examine how chronological and biological age impact vaccine effectiveness, finding that both factors influence immune system capacity to mount responses. The study highlights the need for further research into 'immune aging' risk and departures from healthy aging.
A WVU researcher is working on a biopsychosocial intervention to help people with chronic hip pain move and regain mobility. The intervention, called HIPS, combines mindfulness techniques like self-compassion and progressive relaxation with goal-setting and diaphragmatic breathing to reduce pain and increase physical activity.
The study resolves a long-standing question about the structure of respiratory supercomplexes in unicellular eukaryotic organisms. Complex II is found to be part of the supercomplex in these organisms, optimizing ATP formation and revealing a surprising variety in supercomplex construction.
The American College of Chest Physicians released a clinical practice guideline on respiratory management for patients with neuromuscular weakness, providing evidence-based recommendations for mouthpiece ventilation and airway clearance therapies. The guideline aims to improve care for this vulnerable population.
Researchers at the University of Cincinnati developed an innovative breathing device called PEP Buddy, which improves symptoms of breathlessness, quality of life, and oxygen levels in people with COPD. The study found significant reductions in shortness of breath and improvements in quality of life among participants.
The March issue of CHEST journal features 44 articles on topics such as asthma, critical care, and sleep medicine. The journal also includes complementary web resources, including visual abstracts.
Researchers at Anglia Ruskin University found that consuming a hydroxytyrosol-rich, olive-derived phytocomplex improved respiratory parameters, oxygen consumption, and running economy during aerobic exercise. The study also showed reduced perceived exertion and enhanced acute recovery.
Contracting a lower respiratory tract infection in early childhood is associated with a higher risk of dying from respiratory disease as an adult. Children who had a LRTI by age two were almost twice as likely to die prematurely in adulthood.
A new study published in The Lancet found that contracting a respiratory infection in early childhood is associated with a higher risk of dying from respiratory disease as an adult. Children who had a lower respiratory tract infection (LRTI) before the age of two were 93% more likely to die prematurely from respiratory disease, account...
A Chinese Medical Journal study found that smoking, alcohol consumption, and lack of work-related injury insurance are significant risk factors for developing pulmonary tuberculosis in patients with pneumoconiosis. The study also identified rural birth, household exposure to patients with PTB, and hospitalization history as relevant ri...