Articles tagged with Paracrine Signaling
Scientists found that tumor-promoting fibroblasts attract nerve fibers through a vicious cycle of signaling and neurotransmitter release. This cycle promotes pre-cancerous growth and pulls in more nerve fibers, leading to a self-reinforcing loop. Disrupting this cycle may lead to new therapies for pancreatic cancer.
A Korean research team discovered that High Mobility Group Box 1 (HMGB1) plays a critical role in transmitting senescence from aging cells to distant tissues through the bloodstream. Reduced HMGB1 circulates systemically, inducing senescence in remote tissues and impairing regenerative capacity.
UCSF researchers identified glioma's cellular source of recurrent disease, finding cells shift to mesenchymal, radiation-resistant phenotype in response to standard therapy. Paracrine signals from tumor microenvironment drive this transition through AP1 pathway, leading to therapy resistance and tumor recurrence.
Researchers at the University of Texas Medical Branch have gained new insight into the triggers for preterm birth. The study found that exosomes, a type of cell-to-cell communication, play a crucial role in labor and delivery timing.
Researchers observed paracrine signaling in Bacillus subtilis, a novel mechanism for maintaining two differentiated cell populations within a bacterial community. This discovery opens doors to developing strategies to reverse differentiation in antibiotic persister cells.