Researchers discovered a protein called activated protein C (aPC) that helps blood stem cells remain in a protected state, reducing premature differentiation and improving transplantability. This approach shows promise for improving the success of stem cell transplantations and gene therapies for treating blood disorders.
Researchers at NIH have discovered key intracellular signaling processes involved in the weight-loss effects of semaglutide, a GLP-1 drug. The findings may help extend treatment duration and reduce plateaus experienced by patients.
The study reveals fundamental physical principles underlying bacterial FM signal processing, demonstrating that FM decoding mechanisms increase information entropy by approximately 2 bits compared to traditional AM. A simplified cAMP signaling pathway was reconstructed using a light-controlled system, enabling precise monitoring of fre...
Scientists create synthetic diacylglycerols that can be controlled by UV light, revealing new insights into cellular signaling networks. The findings enable precise regulation of metabolic processes such as insulin secretion and nerve signal transmission.
Researchers at UCSD School of Medicine discovered a novel PLC-epsilon enzyme subtype that activates a second signaling pathway for cell proliferation. This finding may enable targeting the enzyme's second function to prevent pathological responses while preserving its critical physiological roles.