Researchers at Chonnam National University discovered a century-old solvent, dichloromethane, can efficiently synthesize amide bonds. The breakthrough method enables scalable and cost-effective amide synthesis, reducing waste and using benign byproducts.
Researchers have developed a new catalysis method that can generate a diverse array of valuable compounds, including six distinct molecular scaffolds, using reprogrammed biocatalysts and sunlight-harvesting catalysts. The method opens up new possibilities for medicinal chemistry and accelerates combinatorial synthesis of novel molecules.
Researchers at ETH Zurich have developed a new method to produce billions of pharmaceutically active substances using DNA-encoded chemical libraries. The new method can synthesize and test much larger drug molecules, including ring-shaped peptides, and reduces contamination in the molecular library.
A new statistical-modeling workflow can quickly identify molecular structures of products formed by chemical reactions, accelerating drug discovery and synthetic chemistry. The workflow also enables the analysis of unpurified reaction mixtures, reducing time spent on purification and characterization.
Researchers at Swiss Federal Laboratories for Materials Science and Technology have discovered a new chemical synthesis method that forms stable benzene rings on a gold surface. This method, called the 'dry' method, avoids toxic byproducts and allows for the observation of molecular reactions in real-time.
Researchers at NC State University have developed a 'self-driving lab' that uses artificial intelligence and fluidic systems to advance our understanding of metal halide perovskite nanocrystals. The technology can autonomously dope MHP nanocrystals, adding manganese atoms on demand, allowing for faster control over properties.