Articles tagged with Messenger Rna
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A recent study by UChicago scientists reveals how the N6-methyladenosine (m6A) modification on mRNA affects the half-life of mRNA, regulating cellular protein quantities. This discovery could provide fundamental insights into healthy functioning and disorders such as obesity, diabetes, and infertility.
Researchers have discovered that neuronal RNA granules are highly heterogeneous and dynamic in their composition, containing proteins that repress protein synthesis. This uncoupling of mRNA transport from protein production is essential for learning and memory, and has implications for understanding neurodegenerative diseases.
Scientists have discovered that microRNA-128 plays a crucial role in regulating gene expression in neurons, leading to increased neuron activity and epilepsy. The study used mice experiments to demonstrate the effects of reducing microRNA-128 levels, which can help hamper muscle activation.
Researchers found that messenger RNA can take a two-way journey down the cell's cytoskeleton, delivering proteins to specific locations and avoiding diseases such as Alzheimer's, cancer, and Fragile X syndrome. This flexible navigation allows mRNA to bypass obstacles and reach its intended destination.
Researchers find RNA, not protein, catalyzes eukaryotic gene splicing, increasing complexity in higher organisms. This discovery enriches the 'RNA world' origin hypothesis, suggesting life on earth began with RNA-based systems.
A recent study published in PLOS Biology reveals that a majority of rhythmic proteins are produced during two intervals of the circadian cycle, with proteins required for metabolism showing peak production during the day and those required for cell growth at night. This discovery provides new insights into the regulation of protein pro...
Scientists at UMass Chan Medical School discovered that knocking out a gene important for mRNA translation restores memory deficits and reduces behavioral symptoms in a mouse model of Fragile X syndrome. The study suggests that the prime cause of the disease may be a translational imbalance, and restoration of this balance may be neces...
Scientists have discovered that protein translation in dendrites is complex and dictates by translational hotspots, not solely when RNA is present. This finding may inform neurological and psychiatric illness therapeutics.
Researchers analyzed the riboproteome to gain a better understanding of translation and its impact on cancer. The study uncovered dynamic components of the ribosome that can be altered in cancer, highlighting potential therapeutic targets.
A team of scientists has developed a synthetic mRNA that induces self-repair and regeneration of the infarcted heart in mice. The study shows that this approach can lead to long-term therapeutic effects, including improved survival following myocardial infarction.
Researchers from McGill University have confirmed a 50-year-old hypothesis on the RNA double helix structure, revealing its potential applications in biological nanomaterials and supramolecular chemistry. The discovery may lead to new possibilities for genetic information storage and treatment of diseases like HIV and AIDS.
A breakthrough discovery reveals that high levels of the eIF4E protein can promote cancer by unwinding complex mRNA knots, allowing ribosomes to translate genetic code into proteins that trigger tumor growth. This understanding may lead to highly specific cancer treatments targeting growth-promoting cells.
A study published in Cell has confirmed that non-coding DNA, previously considered 'junk', plays a crucial role in regulating cell development. The researchers found that certain white blood cells use introns to control the activity of genes involved in their function.
Researchers at University of Chicago Medical Center discovered a new layer of complexity in human gene expression, finding a single gene that encodes two separate proteins from the same mRNA sequence. This discovery could lead to a therapy for spinocerebellar ataxia type-6 (SCA6), a neurodegenerative disease.
Researchers at UC Santa Cruz have trapped the ribosome in a key transitional state, allowing them to see how it translates genetic code into proteins without mistakes. Understanding this process is crucial for developing new antibiotics and has significant implications for the origin of life.
Researchers at MIT have discovered a mechanism that allows cells to read their own DNA in the correct direction and prevents most of the so-called 'junk DNA' from copying into RNA. This process helps explain the existence of many recently discovered types of short strands of RNA whose function is unknown.
A team at Arizona State University has identified thousands of RNA sequences, known as Translation Enhancing Elements (TEEs), which initiate cap-independent translation in the human genome. These findings have significant implications for understanding protein synthesis and may hold potential for biomedical applications.
Researchers at University of Delaware and Woods Hole Oceanographic Institution found evidence of active bacteria, fungi and other microscopic organisms at depths deeper than a skyscraper is high. The microbes are reproducing, digesting food and moving around despite extreme conditions.
Researchers found evidence of actively metabolizing and proliferating bacteria, archaea, and fungi in the deep biosphere, with implications for global biogeochemical cycles. The study revealed diverse biochemical pathways and movement mechanisms, including flagellar-driven locomotion and gliding.
Researchers at EMBL discovered that each gene can be transcribed into dozens or hundreds of unique mRNA molecules with different boundaries, affecting gene function and protein production. This variation could equip cells to adapt to external challenges.
Research at the University of Colorado Anschutz Medical Campus reveals that hsa-miR-146a is overexpressed in most metastatic bladder cancer tumors. This tiny miRNA molecule plays a crucial role in making bladder cancer more aggressive.
Researchers at Drexel University have identified two key molecules involved in promoting nerve cell growth and branching after injury. By manipulating the expression of these molecules, they were able to induce longer and more branched axons, which is essential for restoring nerve function.
Scientists have identified a complex of three molecules that regulates the production of defective Huntingtin protein, a key contributor to Huntington's disease. By targeting this complex with pharmaceuticals, it may be possible to directly affect the production of defective proteins and treat the underlying causes of the disease.
A recent study published in PNAS reveals that DNA transcription produces mRNA and long noncoding RNA (lncRNA) pairs, which are transcribed coordinately as stem cells differentiate into other cell types. The finding could redefine our understanding of gene organization and regulation.
Researchers discover cancerous mRNA's poly(A) tails can evade the body's safeguards, allowing it to escape regulatory mechanisms. This discovery opens up a new avenue for understanding how genes are activated or inactivated without mutations.
Researchers find that certain RNAs can pause without being degraded, enabling protein production, and suggesting multiple proteins could be made from the same mRNA
Researchers from the University of Sheffield and Harvard Medical School have made a groundbreaking discovery on the TREX protein system, which acts as a passport for mRNA transport. This breakthrough could lead to new treatments for cancer, Motor Neuron Disease, and myotonic dystrophy.
Researchers at EMBL have determined the 3D structure of part of the flu virus' RNA polymerase, crucial for replication. This finding enables the design of innovative anti-flu drugs targeting all influenza strains.
Researchers at the University of Bonn have visualized the transport of messenger RNA from the cell nucleus to the cytoplasm using a highly sensitive light microscope. The study reveals that the process involves brief collisions with the nuclear membrane and quality control checks, resulting in only about every fourth successful export.
Researchers have discovered a vast new gene regulatory network in mammalian cells that could explain genetic variability in cancer. The mPR network allows mRNAs to communicate through small RNA molecules called microRNAs, influencing the expression of other genes.
Researchers at Brown University have developed a genetic biopsy technique to analyze the genes expressed by human eggs without harming them. By comparing the gene expression sequences in polar bodies and their host eggs, they found that more than 90% of detected genes were also present in the eggs.
Scientists discovered a previously unknown compensatory pathway that protects the brain and organs from genetic and environmental threats. The NMD pathway is vulnerable to insults, but human cells have evolved a way to overcome attacks by sending reinforcement molecules to compensate for losses.
Researchers have created a detailed map of gene expression in the mouse cerebral cortex, which shares 90% of its genes with humans. The atlas provides insight into how genes work in this complex region of the brain, including correlations between specific genes and human diseases such as Parkinson's and Alzheimer's.
Researchers have identified key mRNA molecules that the Fragile-X mental retardation protein binds to in brains of mice, suggesting new avenues for treating intellectual disability and autism. The study also proposes two possible treatment strategies: lowering specific protein activity or replacing FMRP's ability to regulate translation.
Researchers have discovered a new mechanism in regulating human genes by enabling pre-mRNA splicing. The U2AF protein plays a crucial role in this process, which involves the cooperation of different proteins to remove introns and form mature mRNA. This process is essential for genetic information flow from DNA to RNA to proteins.
Researchers discovered that microRNA levels increase or decrease in the zebra finch brain after hearing a new song. This finding suggests that microRNAs play a regulatory role in fine-tuning the brain's response to social information.
Researchers found that the lack of structure on messenger RNA facilitates protein synthesis, even without a Shine-Dalgarno sequence. The absence of secondary structures on these mRNAs makes it easier for ribosomes to access and identify the start codon.
Scientists uncover a highly conserved dual mechanism that regulates both brain development and function across diverse species. The discovery could lead to biomarkers for neurological diseases and potentially cure them with microRNA therapeutics.
Researchers at the Broad Institute have developed a method to measure how much messenger RNA is produced and degraded, revealing dynamic changes in RNA levels over time. The technique allows for high-resolution and comprehensive views of the RNA lifecycle, enabling scientists to investigate what happens when something goes wrong in cells.
Researchers at Albert Einstein College of Medicine observed the activity of a single gene in living yeast cells, tracking mRNA production and transcription initiation. The study provides new insights into how genes are regulated in single-celled organisms like yeast, which can inform our understanding of similar processes in humans.
Researchers have uncovered how yeast cells recognize and assemble cargo mRNA for transport, a process critical for cell function. The discovery sheds new light on the mechanisms underlying molecular transport in both simple and complex organisms.
A recent study by Ohio State University researchers has identified a gene mutation that causes microcephalic osteodysplastic primoridal dwarfism type 1 (MOPD1), a rare developmental disorder. The defect, triggered by a tiny gene mutation, greatly slows growth in the uterus and causes severe brain and organ abnormalities.
A Johns Hopkins Medicine study found that human endogenous retrovirus K (HERV-K) may be responsible for some cases of ALS, a neurodegenerative disease. Researchers identified HERV-K mRNA transcripts in the brains of ALS patients and found that they were present in areas surrounding the motor cortex.
Researchers describe the mechanism of blockade and reactivation in molecular detail, revealing TFIIS's role in facilitating mRNA excision. This process is essential for cell survival and regulates gene activity in stem and tumor cells.
Researchers have identified a new way genes are regulated that is unique to primates, involving Alu elements and long noncoding RNAs. This mechanism could prove to be a valuable treatment target as researchers seek to manipulate gene expression to improve human health.
Researchers have developed a new method for treating genetic diseases using modified mRNAs, which can be administered repeatedly without increasing the risk of cancer or severe immune reactions. In mouse models, this technique successfully restored lung function in mice with a congenital lung defect.
Scientists at Albert Einstein College of Medicine successfully visualized single molecules of naturally-occurring messenger RNA (mRNA) transcribed in living mammalian cells. This breakthrough technique has important consequences for human disease like cancer, as mRNA localization within tumor cells correlates with metastasis.
Researchers have discovered a new function of interferons, which inhibit the production of IL-1beta protein and suppress inflammation. This finding has significant implications for treating autoimmune and inflammatory diseases.
Researchers at Albert Einstein College of Medicine have developed a microscope apparatus that achieves unprecedented resolution in living cells, allowing them to visualize the dynamic mechanism by which messenger RNA molecules pass through nuclear pores. This breakthrough could lead to treatments for disorders such as myotonic dystrophy.
Researchers at MIT have created a new technique using RNA to reprogram human skin cells into an immature state that can develop into any cell type. This approach holds promise for treating diseases by transforming patients' own cells into replacements, while eliminating the risks associated with current DNA-based methods.
Scientists are studying microRNAs as potential therapeutics for a range of applications due to their role in various cellular processes. Investigations have shed light on the role of miRNAs in cancer, particularly in controlling developmental events and cell growth.
Scientists have identified a molecular master switch that catalyzes the transition of precursor cells to mature oligodendrocytes in the brain. The molecule miR-219 plays a crucial role in this process, which has implications for treating diseases such as multiple sclerosis and gliomas.
Researchers found that random fluctuations in gene expression can cause some individuals to express a trait even if they have the mutated gene. This phenomenon is controlled by specific fluctuations in mRNA production and appears to be influenced by environmental factors.
Scientists at EMBL have visualized the molecular mechanism responsible for oskar mRNA transport in Drosophila. By combining immunofluorescence with electron microscopy imaging, they defined a hierarchy of RNA particle assembly. This breakthrough sheds light on development and neuronal function, including synaptic plasticity and learnin...
Researchers at Texas A&M University have found that PatA inhibits nonsense-mediated mRNA decay (NMD), a mechanism that degrades damaged mRNA. This inhibition may lead to cancer cell apoptosis. The study also reveals the potential of a simplified derivative of PatA, DMDAPatA, as an anti-cancer agent.
Researchers determine the three-dimensional structure of Pur-alpha protein, essential for normal neural function, and gain insights into its molecular function. The findings provide a possible basis for developing an effective therapy for Fragile X tremor/ataxia syndrome.
Researchers from UNC Health Care have discovered a crucial link between the synthesis of histone messenger RNA and apoptosis, a normal biochemical response to cell damage. The study identifies FLASH protein as essential for producing histone proteins, which regulate gene expression.
Scientists have found that the ends of mRNAs may play a role in preventing normal cells from becoming cancerous. In normal cells, long 3'UTRs regulate gene expression, but in cancer cells, these regulatory sequences are often lost, leading to overproduction of proteins and uncontrolled cell growth.
University of Wisconsin-Madison researchers found a new site for RNA degradation initiation, challenging existing assumptions about the process. The discovery involves CRD-BP, a protein that prevents RNA from degrading in this location.
A single genetic event explains the short legs of all short-legged dog breeds, including dachshunds and corgis. The discovery provides new insights into human developmental disorders and may lead to a better understanding of hypochondroplasia, a growth disorder affecting some people.