Articles tagged with Molecular Structure
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Ural Federal University developed a simple method to produce fluorine-containing heterocycles, which are promising building blocks for medicinal chemistry and agrochemistry. The new compounds were found to be highly chemically active and selectively entered into various reactions.
Researchers highlight the potential of covalent organic frameworks (COFs) in solar-to-fuel production, converting sunlight into hydrogen and other fuels. COF-based photocatalysts have shown promising properties, including improved catalysis and electron delocalization, making them a viable solution for future energy needs.
A new system developed at Stanford University and SLAC National Accelerator Laboratory determines the 3D structures of RNA-only molecules with high resolution, applying it to a ribozyme from pond scum and a piece of viral RNA from SARS-CoV-2. The study reveals tiny pockets in the viral RNA that could be targeted for COVID-19 treatments.
A team of researchers from Tokyo Institute of Technology developed a novel imaging method using metal-atom tracers in HAADF-STEM to determine the conformational structures of complex polynuclear coordination compounds. The technique achieves accurate visualization of highly branched molecules, filling a gap in structural analysis.
Researchers have successfully characterized a new form of toxic Aβ42 fibrils in Alzheimer's disease using sensitivity-enhanced solid-state NMR spectroscopy. The study paves the way for novel therapeutic strategies targeting these aggregates that drive AD progression.
Researchers have mapped the structure of CRISPR-Cas12j3 from bacteriophages, a discovery that reveals how it works and solves packaging problems for genome editing. The new system has vast potential for precise genome editing with improved efficiencies and alternative targeting mechanisms.
Olfactory receptors respond to a variety of odors by binding to large numbers of different molecules, rather than specific chemical features. The team discovered that the amino acids lining the pocket don't form strong chemical bonds with odorants, but instead recognize their general chemical nature.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
Researchers using ALMA data have observed gas re-accreting onto galaxies affected by ram pressure stripping, potentially slowing down their demise. This process creates unique structures resistant to ram pressure's effects, with mass and a sticky nature that holds onto material more tightly.
Researchers at Waseda University have developed a novel mechanism for inducing high-speed bending in thick crystals using the photothermal effect, enabling rapid actuation and simulation. This breakthrough has significant implications for flexible robotics, actuators, and soft robotics.
Researchers at Penn State create a material that can capture and purify water by forming a film with fluorinated amino acids. The film is able to hold PFAS substances for up to 24 hours, making it a potential tool for contaminant removal in drinking water.
Researchers at RUDN University designed a novel metal-containing compound with an unusual planar architecture, exhibiting spin glass behavior. This unexpected structure is promising for creating high-capacity memory storage devices.
Researchers successfully synthesized crenarchaeol, a complex organic lipid found in archaea membranes. The correct structure reveals 22 chiral centers and an uncommon cyclohexane group, with implications for understanding oceanic nitrogen cycles and reconstructing past sea temperatures.
RUDN University chemists have created molecules that can assemble into complex structures using chlorine and bromine halogen atoms. These substances will help to create supramolecules with catalytic, luminescent, conducting properties.
Researchers have developed a new approach to create stable and ordered single molecule layers on silicon surfaces through self-assembly. They use N-heterocyclic carbenes, which can form strong covalent bonds with silicon while maintaining mobility to arrange into regular molecular structures.
Researchers studied DUT-8, a switchable MOF structure that changes shape in response to guest molecules. The findings improve understanding of switching processes and gas exchange reactions in MOFs, paving the way for targeted development of functional materials.
Scientists have successfully synthesized the first conjoined bismacrocycle with all phenylene units, a complex material that has potential in photoelectric and supramolecular applications. The molecule's unique structure allows it to form a peanut-shaped host-guest complex with fullerene derivatives.
Researchers from TU Graz and FSU Jena discovered three opposing driving forces controlling the self-assembly of functionalized molecules at interfaces. A design principle using machine learning was established to predict structures and properties. This breakthrough enables the easy assembly of desired interfacial properties on demand.
A team of scientists developed a machine learning method that optimizes antibody properties, identifying potential candidates for therapeutic use. The new approach increased the candidate pool from thousands to millions, leading to improved drug efficacy and stability.
Insilico Medicine will present its latest results in modern and next-generation AI for generative chemistry at ACS Spring 2021. The company's Chemistry42 platform facilitates the discovery of novel small molecule leads in several therapeutic areas, integrating AI techniques with computational and medicinal chemistry methods.
Chemists have developed a method to synthesize complex, three-dimensional molecules using light energy transfer, expanding the range of molecules for new drug development. The novel approach uses commercially available starting materials and demonstrates broad applicability.
The eukaryotic cell nucleus has an organized layout, similar to a superstore, with DNA-packed into compact structures and molecules moving efficiently through channels. The chromatin fibers work like shelves, holding genetic information, while proteins move randomly within the channels according to Brownian motion rules.
Researchers at the University of Groningen found that introducing a molecule that attacks self-replicating fibres allows for the emergence of more complex structures. This discovery solves Spiegelman's monster, which previously hindered the origin of complexity in life.
Scientists successfully applied novel approach to imaging gas-phased molecule Carbonyl Sulfide, revealing a significantly bent and asymmetrically stretched configuration of the ionized OCS+ structure. The ZCP-LIED technique retrieves accurate and precise information about atomic structure without exact knowledge over the laser field.
Researchers at Peter the Great Saint-Petersburg Polytechnic University are developing thin films made from biological macromolecules such as proteins and amino acids. These unique materials exhibit self-organization ability and can be assembled into certain structures, potentially solving energy efficiency limitations in modern electro...
Polaritons form structures behaving like molecules, with properties such as new energy states and optical properties. Artificial polariton molecules have potential uses in quantum information systems, including dissipating less power and operating faster than traditional methods.
Scientists have developed a method to visualize and quantify alternative structures of RNA molecules, identifying a conserved structural switch in the SARS-CoV-2 virus. This technique has implications for understanding viral replication and potential targets for antiviral therapy.
Researchers at Bielefeld University have successfully arranged individual metal atoms on an insulator surface at room temperature. The ordered structure is created because the molybdenum acetate molecules align precisely with the charge distribution on the calcite surface, firmly anchoring them in place.
Researchers at Tokyo Institute of Technology produced and characterized novel organic molecules with a long helical structure, revealing special interactions between coils that can exhibit interesting optical and chemical properties. The longer compounds also displayed face-to-face stabilizing interactions between different helical lay...
ModMol is an augmented reality app that allows users to visualize and edit molecules in 3D. The app currently supports 115 molecules, including organic and inorganic systems, biomolecules, polymers, and proteins. It enables users to customize molecules using the period table and standard fragments, and save edited structures for export.
Researchers at UC Santa Barbara have developed a new approach to boost NMR signal detection in previously 'invisible' regions. By using dynamic nuclear polarization with transition metal vanadium, they have created hyperfine DNP spectroscopy, which offers a broader frequency range and can analyze local chemistry around transition metals.
A new computer algorithm improves the quality of 3D molecular structure maps generated with cryo-electron microscopy, enabling researchers to determine atomic-level structural models. The algorithm enhances map resolution and visibility, particularly for complex biological molecules.
Researchers at UMD have developed a technique to determine the structures of large RNA molecules, enabling understanding of their shape and interactions with other molecules. This technology could lead to targeted RNA therapeutic treatments for diseases.
The structure of the mRNA initiation complex provides new insights into cancer and disease processes. The discovery proposes a model for how mRNA is pulled through the ribosome for scanning, revealing that start codons need to be sufficiently far from the front end of the mRNA.
A hemispherical vanadium oxide cluster cavity can stabilize a polarized Br2 molecule, enabling selective bromination of alkanes. The study reveals different product selectivity compared to the radical mechanism.
Research investigates cyclosporin variants for their potential in regulating mitochondrial activity, shedding light on the structure-activity relationship. The study's findings suggest that certain cycloprotein molecules may be useful in treating diseases related to mitochondrial dysfunction.
Scientists at the Weizmann Institute of Science have successfully self-synthesized and assembled a ribosome subunit on a surface chip. The discovery opens up new possibilities for designing and testing complex molecular structures, including potential applications in vaccine development and drug production.
Researchers found that molecule-plasmon coupling strength affects SEIRA spectral lineshapes, which are crucial for molecular detection. The study revealed how coupling distance, molecular density, and plasmon loss impact spectral profiles.
Researchers at Insilico Medicine developed a new AI model that combines generative biology and chemistry to generate novel molecular structures for a desired transcriptional response. The Bidirectional Adversarial Autoencoder can be used for virtual screening, discovering new molecular structures and predicting transcriptional responses.
Researchers from the University of Exeter's Living Systems Institute use light to monitor individual molecule structure and properties in real-time. The team temporarily bridges molecules together, allowing for crucial insight into their dynamics.
A new machine learning tool can calculate the energy required to assemble or pull apart a molecule with higher accuracy than conventional methods. The team's innovations made calculating a basic molecule's electronic structure simpler and faster.
Australian and US researchers used advanced computational methods to detect different structures of RNA, which until now could not be distinguished. The team discovered that changes in RNA structure influenced how the virus behaved, including which proteins it produced.
A new data-processing approach developed by researchers at the University of Michigan Life Sciences Institute offers a simpler path to analyzing cryo-electron microscopy data. The pipeline uses machine learning and connects various tools to streamline the process, making it more accessible to researchers from diverse backgrounds.
Researchers at Chiba University created a new type of helicoidal supramolecular polymer that changes its chemical structure in response to temperature. The polymer was formed by mixing two different monomers and exhibits a unique thermal response, collapsing rapidly at 45-50°C.
Researchers propose that modified nucleobases could have facilitated the emergence of rudimentary self-replicating systems by stabilizing short RNA molecule structures and providing catalytic activity. This could have increased the breadth of available functions for short RNAs.
Researchers at Helmholtz-Zentrum Berlin have decoded the 3D architecture of the SARS-CoV-2 main protease, providing concrete starting points for developing inhibitors. The analysis was conducted using high-intensity X-ray light from BESSY II.
Researchers develop peptoid-coated DNA origami that maintains structural integrity and functionality in different physiological environments, enabling potential use in delivering anti-cancer drugs and proteins. The method involves designing peptoids to stabilize DNA origami, with the brush-type architecture achieving optimal protection.
Researchers have used X-ray analysis to study lignin, a byproduct of paper production, and its potential as a sustainable raw material for manufacturing bioplastics. The study reveals that different lignin fractions can be engineered to have varying properties, such as hardness or softness, making them suitable for specific applications.
Researchers used new technology to analyze the self-assembling gateway structure within lithium-ion batteries, revealing its composition and chemical make-up. The study aims to create more energetic, longer-lasting, and safer batteries.
Researchers have identified a unique archaeal protein complex with a five-column tholos-like architecture, featuring a spacious center that can accommodate biomolecules. This discovery provides insight into the molecular evolution between archaeal and eukaryotic proteins.
The study suggests a fast and reliable method to determine the degradation behavior of complex biomacromolecules using Langmuir technique. The research paves the way for designing innovative, multifunctional polymers for regenerative medicine with improved performance in medical implants.
Researchers at SISSA developed a new method to characterize RNA's different configurations, combining experimental data and simulations to study dynamic molecular systems. The approach identifies dominant and minority structures, shedding light on the molecule's role in protein synthesis regulation.
Researchers developed a simplified NMR-based method to determine the atomic structure of natural products more accurately and efficiently. The new method enables chemists to analyze complex molecules with few hydrogen atoms, such as spiroepicoccin A isolated from marine microorganisms.
French researchers combine optical and electronic microscopy to observe axonal rings at the molecular scale. They discover that these rings are formed by long braided actin filaments, providing new understanding of axonal architecture.
Researchers at Nanyang Technological University have elucidated the structure of a key component of respiratory syncytial virus and human metapneumovirus, two closely related viruses causing severe respiratory diseases. The team's findings provide new targets for designing antiviral molecules.
A team of researchers at the University of Rome Tor Vergata has developed a novel approach to build and dismantle DNA nanostructures using antibodies. They engineered DNA bricks with recognition tags that assemble in the presence of specific antibodies, enabling the creation of intelligent nanostructures with potential applications in ...
A Northwestern University research team discovered similarities in RNA folding among riboswitches, which could impact the design of future RNA-specific therapeutics and synthetic biology tools. The findings could also inform efforts to treat diseases triggered by RNA-level misfolding.
Tetravinylallene, a highly unsaturated molecule with two adjacent double bonds, has been synthesized for the first time, offering a new approach to constructing complex molecular frameworks. Its symmetry enables chemists to perform multiple reactions in one step, making it a potent tool for synthesizing natural products and drugs.
Researchers at TU Dresden and Ulm University developed a new synthetic route to create crystalline 2D polymers with defined structures. The 2D polymers have promising properties for electronic components and systems, including superior charge transport and chemiresistivity.
A research team has found a way to overcome the limitations of graphene-based molecular devices, creating structures that are both electrically and mechanically stable at room temperature. The breakthrough, published in Nature Nanotechnology, uses a combination of covalent binding and large ۆ-conjugated head groups to achieve stability.