Articles tagged with Molecular Structure
A team of researchers has combined expansion microscopy and stimulated Raman scattering microscopy to create a new imaging technique called MAGNIFIERS. This allows for the high-resolution imaging of biomolecules, including proteins, lipids, and DNA, at the nanoscale.
Researchers at the Beckman Institute found a direct link between high-fat diets and heightened nitric oxide levels, which can lead to increased risk of inflammation and cancer development. The study used a molecular probe to visualize changes in the tumor microenvironment.
Scientists at UMass Amherst developed a new theory to predict how double-gyroid networks form in polymer superstructures. The theory reveals the hidden geometry allowing polymers to assume this complex shape.
Researchers determined the 3D structure of NTCP, a protein crucial for liver function and HBV/HDV infection. The study reveals two essential conformations: one 'open' pore for bile salt binding and a 'closed' conformation preventing virus recognition.
Researchers at Arizona State University have designed and constructed artificial membrane channels using DNA, allowing selective transport of ions, proteins, and cargo. The channels can be opened and closed with a lock and key mechanism, enabling diverse scientific domains such as biosensing and drug delivery applications.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
A cross-disciplinary team at the University of Illinois used automated synthesis to discover a new mechanism for high conductance in organic electronics applications. The technology rapidly scanned through a library of molecules and uncovered unexpectedly high conductance, dependent on concentration and surface adsorption.
Researchers aim to improve stability and efficiency of catalytic materials using quantum mechanics-based calculations and computational simulations. The goal is to create more effective catalysts that reduce pollution and energy consumption.
A new study reveals that two equal charges in enzymes do not repel each other, but instead attract, facilitating chemical reactions. The researchers used protein crystallography to obtain a structural snapshot of the substrate before the reaction and found an attractive interaction between the enzyme and substrate.
Researchers successfully synthesized a novel nitride with hexazine rings, a dianionic compound, for the first time in a laboratory experiment. The nitride remained stable under pressures as low as 20 GPa, paving the way for potential high-energy density materials.
Scientists at Stockholm University have revealed the structure of bismuth subsalicylate, a century-old pharmaceutical ingredient used to treat nausea and diarrhea. The discovery was made possible by advanced transmission electron microscopy techniques, which provided atomic resolution images of the molecule's molecular packing.
Researchers at George Washington University developed a novel tool to rapidly screen pesticides for safety and performance. The new approach can aid in the design of next-generation molecules to develop safer pesticides, with only 7% of analyzed compounds meeting safety criteria.
Researchers at Van Andel Institute have discovered a new, detailed molecular structure of PhyB, a vital photoreceptor in plants, which allows them to sense light and regulate their lifecycles. The findings may lead to breakthroughs in agricultural and bioengineering practices.
A team of scientists successfully investigated the electronic structure of tautomeric mixtures using inelastic X-ray scattering (RIXS) at BESSY II. They can now experimentally separate the signal of each individual molecule, providing detailed insight into their functionality and chemical properties.
Researchers have solved the full-length structure of a crucial signaling protein in cells, known as a Janus kinase. The breakthrough could lead to new and better drugs against certain cancers, allowing healthy versions of the proteins to keep performing their normal duties.
Researchers at Dalian Institute of Chemical Physics have developed a flexible soft-solid MOF composite membrane for efficient H2/CO2 separation. The membrane's unique structure, featuring quasi-vertically oriented solid particles, achieves better separation accuracy and robust anti-swelling capacity.
Researchers discovered two novel contractile injection systems (CISs) in cyanobacteria and a marine bacterium, revealing unique features and anchoring mechanisms. These systems provide insights into the evolutionary differences between various injection system classes.
Researchers at HKUST and UChicago have designed the basic elements needed for logic operations using liquid crystals, paving the way for novel computing methods. The team controlled topological defects to perform operations like amplification and switching, opening the door to potential applications in robotics and sensing.
Researchers have discovered the structure of C.difficile's protective armor, a chain-mail like layer that prevents molecules from entering the cell. This discovery opens the possibility of designing specific drugs to target the armor and kill the cell.
A recent study has shed light on the protein structure that helps bacteria pump toxic molecules out of their cells, contributing to drug resistance. The researchers found that as a pH change occurs, the protein's channel opens and closes in a specific way, allowing the transport of toxic compounds.
Researchers at the University of Eastern Finland used molecular modeling to investigate nano-plastic transport into cell membranes. The study found that some microplastics can passively penetrate the membrane, potentially causing adverse health effects.
A recent study found that nutrient levels in broccoli and kale microgreens differ significantly depending on the growing environment. Researchers measured polyphenols and glucosinolates in microgreens grown under different conditions, revealing varying levels of antioxidant- and anticancer-related compounds.
A team of researchers from Skoltech and universities developed a neural network-based solution for automated recognition of chemical formulas on research paper scans. The algorithm combines molecules, functional groups, fonts, styles, and printing defects to mimic existing molecular template depiction styles.
Scientists at Stanford University and SLAC National Accelerator Laboratory have created a molecular cage to study the structure of KIX, a protein used by AML cancer cells. The technique has successfully imaged KIX with cryo-EM, revealing new insights into its function and potential targets for therapy.
A Japanese research team successfully estimated the bending energy of disiloxane molecules with state-of-the-art quantum Monte Carlo method, overcoming previous simulation challenges. The method's self-healing property reduced basis-set dependence and bias, enabling accurate results without dependence on parameter choices.
Researchers used energy dispersive diffraction to create high-resolution 3D maps of bioapatite arrangements within shark centra, revealing key structures and their functions. The study provides insights into the structure-function relationship of the shark skeleton and could be applied to other organisms.
Researchers at MIT have developed a new material that is stronger than steel and as light as plastic, with potential applications in car parts, cell phones, bridges, and other structures. The material, called polyaramide, self-assembles into sheets and has unique properties, including high elastic modulus and impermeability to gases.
Researchers have developed conducting systems that control electron spin and transmit a spin current over long distances without ultra-cold temperatures. This breakthrough enables the creation of new technologies for encoding and transmitting information at room temperature.
Researchers have developed an ultrasensitive bioelectronic tongue that mimics human taste buds to measure sweetness. The device responds to sweet-tasting compounds at the 0.1 femtomolar level, making it a powerful tool for industries such as healthcare and food.
Researchers at the University of Oklahoma have developed a molecular framework that solves the challenge of predicting peptide structures. The framework bridges experimental and computer sciences, enabling the use of machine learning and artificial intelligence to model peptide structures for materials engineering.
Researchers from Tokyo Tech created hybrid ferritin nanocages with histidine residues, achieving 1.5 times higher metal ion uptake and improved catalytic efficiency for alcohol production. The new cages show promising potential as viable catalysts in the chemical industry.
The study reveals that Omicron's spike protein mutations increase its binding affinity to human cells and evade antibodies, contributing to its increased transmissibility. The researchers aim to develop more effective treatments against Omicron and related variants using this knowledge.
Researchers develop small-molecule serial femtosecond crystallography, enabling precise analysis of complex materials. The technique reveals accurate atomic structures of previously unsolvable compounds.
Scientists have developed a new technique called small-molecule serial femtosecond X-ray crystallography (smSFX) that can reveal the structures of not-so-neat-and-tidy materials. This method uses an exceptional X-ray laser and custom-built image processing algorithms to diffract individual granules of powders, providing a precise sharp...
Researchers have successfully integrated the shape-shifting molecule bullvalene into a coordination cage, restricting its fluctuating behavior and enabling controlled molecular recognition. This breakthrough could lead to the development of responsive materials with fast adaptation capabilities.
Biologists at the University of Leeds created high-resolution images of the foot-and-mouth disease virus, revealing fibril structures that play a key role in replication. These findings could lead to new antiviral treatments for diseases caused by the virus.
Researchers from Japan Advanced Institute of Science and Technology have identified a new crystal structure for hydrogen at low temperatures near 0 K and high pressures. The team used supercomputer simulations and data science to generate several candidate patterns, which were then validated through high-resolution simulations.
Researchers from Tokyo University of Science developed a high-quality crystalline interface using quasi-homo-epitaxial growth, which eliminated mobility issues and enabled spontaneous electron transfer. This breakthrough could lead to highly efficient flexible solar cells and wearable electronic devices.
Researchers have created a powerful DNA-peptide hybrid that could lead to advancements in nanotechnology and the study of Alzheimer's disease. The new structure combines three-stranded DNA and peptide structures, overcoming the challenge of chirality between these biomolecules.
Scientists have successfully engineered protein needles that can self-assemble into lattice structures and ordered monomeric states. The study's findings provide insights into protein-protein interactions and could lead to the development of biocompatible materials and targeted drug transports.
A new study reveals that flexibility in peptides used to treat Type 2 diabetes may be key to their effectiveness. The research found that a peptide called GLP-1 can switch between two shapes, maximizing its potency and activating insulin release from the pancreas.
Researchers at Lawrence Berkeley National Laboratory developed a method to stabilize graphene nanoribbons and directly measure their unique magnetic properties. By substituting nitrogen atoms along the zigzag edges, they can discretely tune the local electronic structure without disrupting the magnetic properties.
Researchers have designed porous, carbon-based crystals that can stretch to more than twice their length, making them suitable for nanofiltration and pollutant removal. By adding 'soft joints' into the crystal's scaffold, they can be disrupted by specific chemicals, causing the crystal to expand and contract rapidly.
Heidelberg researchers have created a rapid process for 3D imaging of cells using soft X-ray tomography, enabling high-resolution images in just five to ten minutes. This technology provides valuable insights into viral diseases and their impact on infected cells.
A team of researchers used CARS microscopy to analyze the fat arrangement in foie gras and duck pâté. They found that foie gras had a harder, more brittle texture due to its irregularly shaped fat network. The study provides new insights into the relationship between microstructure and food texture.
Recent study uses advanced spectroscopy techniques to observe water molecules in superconcentrated salt solutions and identifies heterogeneity in solvation structure. This finding explains the unexpected fast lithium-ion transport in highly viscous electrolytes.
Researchers create large molecular rings that self-assemble into a sheet-like structure on surfaces, allowing for adjustable mesh size and attachment of bulky molecules. This technology has the potential to enable novel catalysts and measure nanomechanical properties of proteins.
Researchers have uncovered how a viral RNA changes shape to hijack host proteins, revealing the role of cryogenic electron microscopy in making this discovery possible. The study highlights the emerging power of cryo-EM to visualize multifunctional dynamic RNA structures.
Scientists designed a precursor compound with a single conjugated polymer chain and then formed a second rail through a zipper reaction to create a molecular ladder. The ladder has two tracks of conjugated polymers, allowing energy to move along the molecule in space.
A Rice University undergraduate student and her mentor have synthesized the first molecule found in poppies, setigerumine I, using a three-step process at room temperature. The environmentally friendly method produced 20 milligrams of the rare extract, which could be a potential precursor for non-addictive painkillers.
Researchers trained an artificial intelligence algorithm to predict the next designer drugs before they are even on the market, allowing law enforcement agencies to identify and regulate new versions of dangerous psychoactive drugs. The model was tested against 196 new designer drugs and found nearly all were present in its generated set.
Researchers have successfully imaged the spin of an individual molecule using electron spin resonance in a scanning tunneling microscope. This achievement allows for precise control of spin states and investigation of magnetic interactions between molecules.
Researchers at Korea Maritime & Ocean University have discovered a novel compound, β-HQ clathrates, that can capture both carbon dioxide and nitrous oxide in the atmosphere. The discovery provides valuable insights into the kinetics of trapping these greenhouse gases, which could lead to the development of new gas capture technologies.
Researchers from Tokyo Tech have developed a long DNA molecule-based junction that shows remarkable conductivity and self-restoring ability under electrical failure. The 'zipper' configuration allows for high electron transport and reveals delocalized ς-electrons moving freely within the molecule.
A UCLA-led research team directly observes how atoms are packed in samples of amorphous materials using 3D imaging. They found that the most commonly seen arrangement is groups of seven, with five in one central layer, leading to a network structure with shared edges.
A team of bioinformaticians at Friedrich Schiller University Jena developed a method to identify small active substance molecules using machine-learning methods. They successfully identified 11 new, previously unknown bile acids in mice using this approach.
Researchers at Arizona State University have refined cryogenic electron microscopy to produce more accurate structures of biological samples. The new method uses a statistical approach to model transitory structures, which can play a vital role in biological processes.
Researchers from Shibaura Institute of Technology synthesized atropisomeric N-aryl quinazoline-4-thiones, showing unprecedented isotopic atropisomerism due to rotational restriction around an N-Ar bond. The findings support the formation of diastereomers and have potential applications in pharmaceuticals.
The study models biomolecular condensates using oil droplets and polymer mesh, revealing temperature modulation's impact on droplet growth and size distribution. The results provide insights into the formation of microscopic patterns in biological systems.
Scientists use specific self-assembling peptides to organize silica nanoparticles into larger structures, demonstrating a new approach to self-assembly. The researchers' method enables the creation of novel materials with various applications, including drug delivery systems and nanocatalysts.