Articles tagged with Molecular Structure
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The study reveals that the GABA transporter structure is facing the cytosol and bound to a GABA molecule, sodium, and chloride ions. This binding mechanism is crucial for understanding GABA recognition and release into neurons.
Researchers have developed a new material for single-molecule electronic switches, which can vary current at the nanoscale in response to external stimuli. The ladder-type molecular structure enhances stability and makes it promising for use in single-molecule electronics applications.
A team of chemists at UC Riverside has discovered that the distribution of a magnetic field is itself chiral, allowing for the rapid formation of chiral structures. This method has potential applications in sensing and anti-counterfeit technology, such as detecting chiral or achiral molecules linked to certain diseases.
Scientists have developed a method to engineer tubulins with precise post-translational modifications, revealing a new interplay between polyglutamylation and detyrosination. This breakthrough uncovers the tubulin code's connection to microtubule function and its regulation in cells.
A recent study by researchers at the University of Zurich found that the Notch signaling pathway plays a crucial role in shaping and varying tooth enamel. The team used genetically modified mouse models to analyze the effects of the Notch-ligands on teeth, revealing that their absence affected tooth morphology and enamel formation.
A Clemson team created a novel metal-organic framework with combined conduction pathways, outperforming traditional MOFs. This breakthrough could advance modern electronics and energy technologies.
Researchers at the University of Queensland have uncovered the atomic structure of the Langya virus, a highly infectious virus with pandemic potential. The study aims to develop broad-spectrum human vaccines and treatments for Henipaviruses, which cause severe disease and have the potential to get out of control.
Kolomeisky aims to develop analytical models that quantify the role of heterogeneity in chemical and biological processes. He plans to explore its impact on catalytic reactions, antimicrobial peptides and early cancer development.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
A new study has determined the atomic-level structure of a zinc-transporter protein, showing how it regulates zinc levels inside cells through a built-in sensor. The protein acts as a dimer, using feedback to control its activity based on zinc levels.
A new study reveals the molecular structure of UCP1, allowing scientists to develop therapeutics that activate it to burn excess calories. This breakthrough could combat obesity and related diseases like diabetes by activating brown fat tissue.
Researchers at the University of Adelaide have discovered a failed antibiotic that can effectively kill two of Australia's most problematic weeds, annual ryegrass and wild radish, without harming bacterial or human cells. This finding could lead to faster development of new weed killers, saving farmers billions of dollars each year.
Scientists at St Jude Children's Research Hospital have captured six cryo-EM structures of a key transporter involved in cancer and immunity, providing unprecedented insight into its function. The findings have significant implications for developing targeted therapies against cancer and autoimmune diseases.
Researchers at Aarhus University discover how the SUC transporter recognizes sucrose and uses acid to power its sugar delivery. This breakthrough sheds light on how plants defend themselves from pests and could lead to new ways of protecting plants from harmful bugs.
Researchers at Brookhaven Lab used pulse radiolysis to study a key class of water-splitting catalysts, revealing the direct involvement of ligands in the reaction mechanism. The team discovered that a hydride group jumped onto the Cp* ligand, proving its active role in the process.
A research team led by Professor Nicolas Doucet investigated the evolutionary conservation of molecular dynamics in enzymes. They found that specific atomic motions are conserved throughout evolution to preserve biological function.
Researchers at City University of Hong Kong have developed a multifunctional additive that improves the efficiency and stability of perovskite solar cells by modulating film growth. The additive reduces defects, leading to higher power conversion efficiency and lower energy loss.
Scientists studied water's interactions with cellulose, discovering it can form layered shells that control chemical reactions and physical properties of the material. The work aims to design better cellulose-based products using water's properties for applications like drug delivery and electronics.
Researchers propose a new bonding theory that illustrates how each boron atom satisfies the octet rule and how alternating σ bonds further stabilize the 2D sheet. The theory introduces a new form of resonance, allowing delocalization of σ electrons within the plane.
This study reconstructs Sessilida's phylogenetic tree using infraciliature and silverline system, establishing two new families. It challenges traditional morphology-based classification and provides insights into the origin and evolution of this group.
Researchers have elucidated the mechanism of CELSR cadherin dimerization, revealing a twisted cell-cell adhesion molecule complex structure. The extracellular domains of CELSR cadherins exhibited strand- and globule-like portions, which bound through strand-like structures in an antiparallel orientation.
Researchers successfully applied reinforcement learning to protein design, creating proteins with improved antibody generation and accurate nano-structures. The approach may lead to more potent vaccines and novel applications in regenerative medicine.
Researchers at Tohoku University developed a method for creating molecular robots using artificial multicellular-like bodies made of phospholipids and synthetic surfactants. The technique allows for the assembly of micron-sized compartments that can combine to form heterogeneous structures with multiple functionalities.
Researchers at Argonne National Laboratory and University of Chicago developed a hybrid simulation process using IBM quantum computers to solve electronic structure problems. The new method uses classical processing to mitigate noise generated by the quantum computer, paving the way for future improvements.
Researchers at Hokkaido University and Kyushu University have developed a technique to synthesize potential molecular switches from anthraquinodimethanes (AQDs), a group of overcrowded organic molecules. The synthesized derivatives can stably form twisted and folded isomers, as well as other isomeric forms, in different solvents.
Researchers from Japan have synthesized two di-superatomic molecules composed of Ag and evaluated the factors involved in their formation. The study found that a twist between the two icosahedral structures stabilizes the nanocluster by shortening the distance between them. Additionally, the presence of Pd and Pt central atoms was foun...
Researchers developed a method to characterize nanomaterials using sequential infiltration synthesis in nanostructured polymers. This technique allows for the creation of extremely small structures on semiconductor surfaces, enabling further miniaturization of next-generation microelectronic components.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have identified seven types of zirconium metal clusters found in MOFs and fourteen potential new metal building blocks. This discovery provides a crucial clue to accelerate the development of carbon-neutral porous materials.
Researchers have overcome a significant barrier to using 2D materials by designing covalent organic frameworks that retain their mechanical properties even when stacked into multiple layers. This breakthrough has the potential to revolutionize various applications, including filtration and battery technology.
A global analysis of coronavirus protein research found that countries with larger economies generated more 3D structure determinations for the protein components of coronaviruses. However, there were many outliers, with some advanced and prosperous countries publishing few or no structures, while others strongly affected by COVID-19 p...
A massive supercomplex in mitochondria comprising all four respiratory complexes induces a membrane curvature necessary for proper mitochondrial function. The supercomplex assembly actively contributes to the shaping of the macroscopic architecture of mitochondria.
A new method to regulate singlet fission (SF) in chromophores enables the design of SF-based materials with enhanced energy conversion. Pressure-based control strategy opens doors to novel, tunable SF materials.
The study resolves a long-standing question about the structure of respiratory supercomplexes in unicellular eukaryotic organisms. Complex II is found to be part of the supercomplex in these organisms, optimizing ATP formation and revealing a surprising variety in supercomplex construction.
Cooperative transitions occur when molecules shift their structure in synchrony, like a row of dominoes flowing seamlessly to the floor. The collaborative method is fast, energy-efficient, and easily reversible, helping living systems operate quickly and efficiently.
Soil bacteria have been used to produce prodrugs by selectively epoxidating indole and indene. This breakthrough enables the sustainable biocatalysis of active pharmaceutical ingredients with high purity.
Scientists at the University of Missouri have developed a novel method to detect food adulteration using nuclear magnetic resonance (NMR) spectroscopy. The technique can identify vegetable oil adulterants in hard cheese products with high accuracy, leading to improved consumer safety and product authenticity.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
BasePairPuzzle is a new DNA molecular model that accurately represents intermolecular interactions, including hydrogen bonds. Students can visualize and experience the sensation of molecules interacting with each other using this innovative 3D-printed model.
Scientists at University of Warwick and Politecnico di Milano developed a tool to regulate bacterial electric signals with light, opening new avenues for understanding antimicrobial resistance. This technology could help explain how some bacteria survive antibiotic exposure.
Researchers at KAUST have developed a rapid and sensitive soil moisture sensor using metal-organic frameworks (MOFs) to optimize water usage in agriculture. The MOF-based sensor shows high sensitivity and selectivity for water even in the presence of metal ions, enabling precise irrigation management.
The study uses artificial intelligence to generate new molecules with optimized properties, applicable to various industries. The method enables finding Pareto-optimal solutions, leading to more efficient materials for optoelectronics, solar energy, and other fields.
Researchers utilized the Chemistry42 platform to generate novel molecular structures and identified a hit molecule for CDK20, a promising target for hepatocellular carcinoma. The platform's customizable reward function and generative models enabled efficient design and optimization of molecules.
Researchers at Universitat Autonoma de Barcelona solved the structure of a functional amyloid protein, hnRNPDL-2, which forms stable and non-toxic fibres in humans. The discovery changes the concept of disease origin and treatment, suggesting that molecules stabilising or facilitating fibre formation could be the key to therapy.
Researchers developed a machine learning model using advanced 2D chemical descriptors to predict highly selective asymmetric catalysts without quantum chemical computations. The model demonstrated high accuracy in predicting catalyst structures and selectivity, outperforming existing methods.
A new study analyzes the microstructure of eggshells from living and extinct flightless birds, shedding light on their evolutionary history. The research finds that wedge-like microstructures in rhea eggs evolved from ancient ancestors, while prism-like structures in ostrich and tinamous eggs likely developed independently.
The researchers aim to create a set of tools to help other chemists select and produce the right crystal structures for new drugs, potentially saving time and cost. By understanding how molecules crystallize, they hope to speed up the development process and lower costs.
Researchers have developed a chemical variation that significantly improves the stability of perovskite thin films in solar cells, achieving efficiencies of up to 24.6%. The new coating, b-pV2F, wraps around individual microcrystals like a soft shell, reducing thermal stress and increasing efficiency.
Researchers have discovered a new form of carbon, LOPC, which consists of 'broken C60 cages' connected by long-range periodicity. The formation of LOPC occurs under specific temperature and carbon/Li3N ratio conditions, and its characterization reveals unique electrical conductivity properties.
Researchers at Vienna University of Technology have explained the distribution of potassium ions on mica surfaces using an atomic force microscope in ultra-high vacuum. The study reveals tiny patterns of ion arrangement, which could improve electronic circuit performance and make mica a suitable insulator for 2D materials.
Researchers have used a technique called QCM-D to observe the interplay between hydration structures and ion configurations in layered materials. The study found that the hydration structure plays a crucial role in determining the material's ion-storage capacity, with flexible layers helping to stabilize the structure.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers at the University of California, Berkeley, have created a new type of 'chain mail' material called an infinite catenane, which can be synthesized in a single step. This material is flexible, strong, and resilient like chain mail, and has potential applications in airplanes, armor, and robotics.
Researchers from ETH Zurich elucidated the structure and function of tryptophan C-mannosyltransferase (CMT), a glycosyltransferase enzyme involved in C-mannosylation. The study reveals the enzyme's novel mechanism, enabling precise understanding of protein sequences and sugar substrates.
Researchers at Brookhaven National Laboratory have successfully discovered new materials using artificial intelligence and self-assembly. The AI-driven technique led to the discovery of three new nanostructures, expanding the scope of self-assembly's applications in microelectronics and catalysis.
Scientists successfully record phase distribution of electrons, unveiling detailed structure of its complex wavefunction. The method uses attosecond laser pulse to visualize electron wavefunction in a gas.
Researchers at EMBL Grenoble have discovered that THC inhibits the human enzyme autotaxin, which is involved in cancer, inflammation, and pulmonary fibrosis. This finding provides new molecular insights into the therapeutic effects of medical cannabis.
Researchers have developed novel organometallic molecular junctions that exhibit unprecedented thermoelectric performance, achieving a Seebeck coefficient of 73 μV/K. These results are promising for the development of nanoscale semiconductors and efficient thermoregulation.
Researchers at Hokkaido University have developed a new class of antibacterial compounds targeting MraY, effective against MRSA and VRE. The findings provide a promising lead for the development of more effective antibiotics against multidrug-resistant bacteria.
Researchers have gained a better understanding of the structures and functions of Andhra gene products, paving the way for custom phages for therapeutic applications. The high-resolution knowledge of the virus structure is crucial for developing targeted treatments against Staphylococcus epidermidis infections.
Researchers at Max Planck Institute developed a new model describing the autonomous remodeling of molecular structures. This concept sheds light on self-organization in living matter and could inspire engineering strategies for designing molecular robotic shape-shifters.