Articles tagged with Molecules
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
Researchers develop substrate design strategy to selectively promote benzidine-type sigmatropic rearrangement of nitroarenes, enabling efficient synthesis of polyfunctionalized biaryls. The method achieves high yields without expensive transition-metal catalysts or complex prefunctionalization.
Researchers have developed a new methodology for selective molecular transformations of polycyclic aromatic hydrocarbons (PAHs), targeting the challenging L-region. This enables the creation of larger PAH structures and new nanographenes, increasing versatility in technological applications.
The North Carolina State University researchers successfully synthesized bacteriochlorophyll a , a photosynthetic pigment found in bacteria which absorbs infrared light. The strategy could be used to synthesize other photosynthetic macrocycles of interest, leading to increased exploration in energy sciences.
A team of chemists has found a simple way to attach the highly sought-after dichloromethyl group onto complex compounds using proline. This method enables the precise assembly of molecules with unparalleled purity and selectivity, simplifying the synthesis of complex drug compounds.
Researchers have discovered that native soil bacteria can degrade persistent pollutants like dioxins without genetic engineering. Using decoy molecules, the bacteria's natural enzymes are tricked into breaking down these toxic compounds.
A team of researchers from Pohang University of Science & Technology has identified the underlying cause of water's unique properties, solving a fundamental mystery in science. They have observed water's liquid-liquid critical point, which marks the transition from two distinct liquid states into a single supercritical liquid state.
Researchers developed a solvent-free method to transform biochar into a hydrophobic material that repels water and absorbs oil. The material, created through mechanochemical functionalization, was applied to hemp fibers, providing strong water repellent properties while allowing oil absorption.
A research team at Kumamoto University identified a plant-derived molecule, PGG, that breaks down transthyretin (TTR) amyloid linked to heart and nerve disorders. The study found PGG effectively disassembled amyloid fibrils without disrupting other types of protein aggregates.
Researchers at Goethe University used X-ray radiation to determine the spatial structure of formic acid, finding that its atoms oscillate slightly back and forth. This 'quantum trembling' causes the molecule to lose its symmetry and become effectively three-dimensional at almost every moment.
Researchers develop a synthetic compound that acts on all three stages of the disease cycle, eliminating parasites from human blood and liver, and preventing transmission to mosquitoes. The molecule has shown effectiveness against P. vivax and P. falciparum species.
Researchers have developed a method called PropMolFlow that can generate molecular candidates roughly 10 times faster than existing methods while maintaining accuracy. The breakthrough could lead to faster creation of pharmaceuticals, materials, and new technologies by specifying properties first and then finding structures.
Scientists at Northwestern University have determined the three-dimensional structures of rye pollen's cancer-fighting molecules, secalosides A and B. This breakthrough opens the door to exploring how these molecules interact with the immune system and could inspire new approaches to cancer therapy.
Researchers have combined molecular imprinting technology with biochar to create materials that can selectively target specific molecules, achieving high adsorption capacity and selectivity. These smart sorbents show promise for efficient pollution control in complex mixtures and at low concentrations.
A University of Houston chemist has received a nearly $2M grant to develop molecular blueprints for controlling how molecules change shape and reactivity upon absorbing light. This research could lead to breakthroughs in storing and using chemical energy, as well as designing materials that change when exposed to light.
A UCO study verifies acorns' high starch content, fatty acid profile similar to olive oil, and nutrient-rich compounds with antioxidant and anti-inflammatory activity. The research identifies diverse microbiomes associated with seeds influencing bitterness levels and paves the way for future domestication programs.
Researchers have developed a chemical compound that degrades beta-amyloid plaques, reducing symptoms of Alzheimer's disease. The compound was tested on rats and showed promising results, including reduced memory loss and improved spatial awareness.
Researchers developed a composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions to promote faster wound closure. The hydrogel demonstrated over 98% antibacterial efficacy and improved fibroblast and endothelial cell growth.
Researchers developed a new method to probe an atom's nucleus using its own electrons as messengers within a molecule. They measured the energy of electrons whizzing around a radium atom in a molecule, detecting a slight energy shift and analyzing it to sense the internal structure of the nucleus.
Researchers developed voltage-matrix nanopore profiling to accurately classify proteins in complex mixtures based on their electrical signatures. The method reveals molecular individuality and compositional differences without labeling or modifications, holding promise for disease diagnosis and real-world bioanalytical applications.
Researchers found that methane, ethane, and hydrogen cyanide can interact in ways previously thought impossible, expanding our understanding of chemistry before life emerged. This discovery has implications for the origin of life on Earth and may shed light on similar conditions in other cold environments in space.
Researchers from The University of Osaka develop a groundbreaking synthetic method to incorporate boron-rich carboranes into aromatic compounds, eliminating complex steps and hazardous conditions. This 'dump-and-stir' technique enables large-scale production using inexpensive aryl bromides and chlorides.
Researchers have created a novel strategy using a polycationic long-chain molecule to develop stable and efficient zinc-iodine batteries. This breakthrough addresses challenges including zinc dendrite formation and corrosion, paving the way for next-generation energy storage technologies.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
The global market for AI in pharmaceuticals is projected to reach $13.4 billion by 2035, driven by Insilico Medicine's innovative use of generative AI. The company will share its achievements at a satellite forum during BIOHK2025, showcasing significant efficiency boosts compared to traditional methods.
Researchers at Max Planck Institute successfully couple spatially separated molecules via a modified vacuum field in an optical microresonator. This breakthrough enables the creation of synthetic states of coupled molecules, with potential applications in quantum technology and information processing.
Researchers have found a way to rearrange atoms in a new generation of malaria drugs to make them more soluble, maintaining their effectiveness against drug-resistant parasites. This breakthrough could lead to an effective successor to artemisinin-based combination therapy.
Scientists at UC Riverside successfully measured the electric dipole moment of aluminum monochloride, a crucial diatomic molecule. The precise measurement will aid in quantum technologies, astrophysics, and planetary science.
The new device, nicknamed ABLE, uses a natural process to condense airborne biomarkers into water droplets, allowing for accurate detection at low concentrations. This technology has immediate applications in hospitals and neonatal units, offering a less invasive alternative to blood draws.
A team of Cambridge chemists has developed a powerful new method for adding single carbon atoms to molecules more easily, offering a simple one-step approach. This technique targets alkenes, common in everyday products, and allows for the introduction of functional groups, enabling further versatility in molecule design.
Scientists have designed human-made molecules that self-assemble into stacked rings, allowing charge and energy to circulate freely, echoing photosynthesis. This breakthrough could lead to improved energy generation and advanced electronics.
Researchers at UCSF have successfully engineered a shapeshifting protein that can change shape in response to signals, potentially leading to breakthroughs in medicine, agriculture, and environmental applications. This achievement marks the first step towards creating stable yet dynamic proteins using AI-augmented protein engineering.
Dr Constantine Evans, a Maynooth University researcher, has won the Robert Dirks Molecular Programming Prize for his work on molecular self-assembly and its applications in biological systems. His research continues to make important strides in the scientific community.
A study found that spending on GLP-1 RAs increased from 2018 to 2023, with the largest growth rate between 2022 and 2023. The total spending on these medications exceeded $71 billion.
Researchers at Durham University have successfully demonstrated long-lasting quantum entanglement between molecules, a key capability for next-generation quantum technology. The team achieved exceptionally high entanglement fidelity, reaching levels over 92%, enabling precision measurements in quantum sensing and simulating complex qua...
Researchers reaffirm collective bond theory, demonstrating its stability through computational tools. The LiCF3 molecule's unique arrangement challenges traditional understanding of chemical bonds.
Recent research at Shinshu University explores how molecular structure and geometry influence light emission in aggregation-induced emission molecules. The study reveals that changes in molecular shape affect emission behavior in both solution and solid states, enabling innovations in material design and energy interactions.
Researchers from Bar-Ilan University have uncovered a previously unknown phenomenon that enables precise control over molecular patterns on liquid droplet surfaces. The discovery, which involves a transformation between two types of structural defects, has broad implications for technologies such as vaccine design and nanoengineering.
A new AI method developed by Swedish researchers can identify toxic substances based on their chemical structure, potentially replacing animal testing. The method has been shown to be more accurate and broadly applicable than existing computational tools, offering a promising alternative for environmental research and authorities.
Researchers have identified a novel protein FOXF1 that stabilizes blood vessels inside lung tumors, decreasing intertumoral hypoxia and preventing lung cancer metastases. Increasing levels of FOXF1 or FZD4 shows promise to improve therapeutic outcomes in lung cancer patients.
Chemists develop new reactions using model systems and substrates to demonstrate versatility. A new computer-aided method reduces subjective bias by analyzing real pharmaceutical compounds' complexity and structural properties. This improves data quality and facilitates machine learning applications.
A blended antioxidant supplement improved spatial learning ability and short-term memory in supplement-treated aged mice. The discovery suggests that the supplements may also prevent age-related cognitive decline in humans and mitigate muscle frailty.
Researchers at the University of São Paulo have tested a synthetic molecule called AD-9308, which has shown potential in treating heart failure by activating the enzyme aldehyde dehydrogenase 2. The study found that the molecule improved mitochondrial filtration, eliminating cellular pollutants and boosting heart function by up to 40%.
The study successfully observed the chiro-optical effect at the nanoscale, demonstrating the ability to analyze the chiral structure of matter using light. Different images were obtained when illuminating with right- or left-circularly polarized light, clarifying that local handedness can be distinguished.
Rice University chemists have discovered that gold nanoparticles are synthesized from gold buckyballs, a finding that could revolutionize nanoparticle synthesis. This discovery was made by Matthew Jones and Liang Qiao, who found that the commonly used golden 'seed' particles were actually cousins of the original buckyballs.
Researchers at the University of Colorado Boulder have developed a new way to recycle polyethylene terephthalate (PET) plastic using electricity and chemical reactions. In small-scale lab experiments, PET was broken down into its basic building blocks, which can be recovered and potentially reused to make new plastic bottles.
Kolomeisky aims to develop analytical models that quantify the role of heterogeneity in chemical and biological processes. He plans to explore its impact on catalytic reactions, antimicrobial peptides and early cancer development.
A team of researchers from China and the UK has developed new ways to optimise the production of solar fuels by creating novel photocatalysts. These photocatalysts, such as titanium dioxide with boron nitride, can absorb more wavelengths of light and produce more hydrogen compared to traditional methods.
A team of Japanese researchers has successfully developed a recycling photoreactor that enables the synthesis of optically pure compounds with high yields, achieving an optical purity of 98-99%. The system uses a two-step rapid photoracemization process and can produce enantiomerically pure chiral sulfoxides in yields higher than 80%.
Three pre-clinical studies published in Journal of Pharmaceutical Analysis explore the molecular mechanisms underlying cardiovascular and neurological diseases, providing new avenues for therapeutic strategies.
Researchers at Durham University and the University of York have developed new concepts about the shape and dynamic nature of carbon-based molecules. They found that a simple rearrangement of a molecular cage structure can lead to inversion of mirror image forms, making carbon-centred chirality dynamic and responsive.
Researchers have observed steric effects, the interactions of molecules depending on their spatial orientation, in a chemical reaction involving non-polar molecules for the first time. This breakthrough opens the door to an entirely new way to control chemical reactions.
Researchers at UCSF's Cell Design Institute engineered cells with customized adhesion molecules to form complex multicellular ensembles in predictable ways. The discovery represents a major step toward building tissues and organs through regenerative medicine.
Researchers at UCSF discovered a small molecule called ISRIB that can reverse the neural and cognitive effects of concussion in mice, weeks after an injury occurred. The drug blocks the integrated stress response, which became chronically activated in damaged neurons, restoring normal spine dynamics and cognitive function.
A research group from Tokyo University of Science has discovered molecular features that govern the filling process at nanoscales, enabling finer resolutions in ultraviolet nanoimprint lithography. The findings provide valuable insights for guiding the selection and design of optimized resists for sub-10 nm resolution.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
Researchers have identified new biomarkers to detect non-small cell lung cancer in its early stages through a blood test, offering improved survival chances. The approach can also identify potential drug resistance, allowing clinicians to choose alternative treatment options.
Researchers have discovered a new type of triterpenes in fungi that don't require squalene, overturning current knowledge and offering a new approach to pharmaceutical science. This breakthrough opens up possibilities for creating more valuable compounds with anti-inflammatory, anti-cancer, and other properties.
A study published in Current Biology found that people share similar odour preferences regardless of cultural background. The researchers discovered that the structure of the odour molecule determines whether a smell is considered pleasant or not.
UC Riverside scientists developed a technique to map tryptophan production, opening the door to new treatment drugs. By understanding how bacteria make tryptophan, researchers can create enzymes that shut down this process, killing invasive bacterial cells without affecting human cells.