Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
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Researchers have identified new biomarkers to detect non-small cell lung cancer in its early stages through a blood test, offering improved survival chances. The approach can also identify potential drug resistance, allowing clinicians to choose alternative treatment options.
Researchers have discovered a new type of triterpenes in fungi that don't require squalene, overturning current knowledge and offering a new approach to pharmaceutical science. This breakthrough opens up possibilities for creating more valuable compounds with anti-inflammatory, anti-cancer, and other properties.
A study published in Current Biology found that people share similar odour preferences regardless of cultural background. The researchers discovered that the structure of the odour molecule determines whether a smell is considered pleasant or not.
UC Riverside scientists developed a technique to map tryptophan production, opening the door to new treatment drugs. By understanding how bacteria make tryptophan, researchers can create enzymes that shut down this process, killing invasive bacterial cells without affecting human cells.
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Scientists at the University of Missouri study photodissociation reactions on the quantum level, revealing strong quantum effects that challenge classical 'billiard-ball' models. The research could lead to a better understanding of atmospheric chemistry and develop new theoretical frameworks.
In 2021, researchers made notable discoveries, such as the identification of pain-causing proteins in snake venom and the development of bite-sized protein structures that can be felt with the tongue. The year also saw significant progress in plastics recycling and molecular editing, which holds promise for medicinal chemists.
Scientists devised a method to analyze the NPC directly inside cells, capturing its true size and structure. The results showed that the pore had a wider central channel than previously thought, emphasizing the importance of analyzing complex molecules in their native environments.