Articles tagged with Biomaterials
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
A Carnegie Mellon University-led team is developing a bioelectronic implant called ROGUE that can produce a year's supply of treatment for chronic diseases like Type 2 diabetes and obesity. The device will offer continuous, adjustable therapy deployment via a minimally invasive procedure.
Researchers found significant challenges in spider silk production, including scale-up issues and toxicity concerns. The study highlights potential host organisms for producing spider silk, such as microbes and bacteria, to address these challenges.
Researchers developed a novel approach to optimizing siRNA-loaded lipid nanoparticles using NMR-based molecular-level characterization. Pre-mixed LNPs exhibit superior gene-silencing effects due to a stacked bilayer structure that enhances gene silencing.
Researchers are working on a new method for preserving microbial samples using microfluidics, biomaterials, and protein engineering. The goal is to improve biosurveillance and protect soldiers and civilians from infectious diseases.
A team from the University of Michigan School of Dentistry has patented a new regenerative bone graft material that can regenerate about eight times more bone than existing scaffolds. The breakthrough could transform bone grafts for millions of people who require them, reducing costs and complications associated with traditional methods.
Researchers at Kyushu University developed a new organic thermoelectric device that can generate power from ambient temperature. The device, composed of copper phthalocyanine and fullerenes, achieved an open-circuit voltage of 384 mV and a short-circuit current density of 1.1 μA/cm².
The researchers synthesized supramolecular polymers with the ability to form larger complexes in response to external stimuli, which may shed light on biomolecular self-assembly and other ‘smart’ materials. The resulting shape of the assemblies can be controlled based on the concentration of a specific additive.
The Journal of Bioresources and Bioproducts is a leading open access journal fostering transformative research on bioresource conversion into biomaterials, biochemicals, and bioenergy. The journal's eight thematic areas focus on cutting-edge topics in sustainable energy and materials science.
Researchers at PolyU have invented a unique fluidic processor called Connected Polyhedral Frames (CPFs), which enables reversible switching between liquid capture and release. CPFs offer a versatile platform for various applications, including controlled multidrug release, biomaterial encapsulation, and air conditioning.
Researchers at Singapore University of Technology and Design have developed a novel approach to metalworking using chitinous colloids and composites. By leveraging the affinity between chitin and metals, they created functional metallic structures without high temperatures or pressures.
Researchers developed an aspirin-containing hydrogel that mimics the nutrient-rich fluid between cells, accelerating healing of radiation-induced skin injuries in animal models. The new salve could provide rapid wound healing for humans with minimal side effects.
Researchers found that butterflies spin unique silk structures, including hook-and-loop fasteners and multi-strand safety tethers, to secure their chrysalises to branches. Despite being thinner and weaker than silkworm silk, these structures provide a stable anchor for the butterfly's transformation.
Researchers at Linköping University have created soft electrodes made of gold nanowires and silicone rubber, capable of stimulating nerve signals and capturing electrical signals. The material is expected to last for at least three years and has potential applications in medical devices.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
Researchers explore inkjet printing's potential for creating advanced biomaterials with controlled particulate distribution. The review highlights the technology's applications in tissue engineering, drug delivery systems, and bioelectronics.
A UVA research team has developed biomaterials with controlled mechanical properties matching those of various human tissues, representing a significant leap in bioprinting technologies. Their unique digital assembly of spherical particles (DASP) technique can deposit particles of biomaterial in a supporting matrix to build 3D structur...
A team of scientists at Harvard University developed a new RNA synthesis process that produces RNA with efficiencies comparable to current industry standards. The novel method can incorporate all common molecular modifications found in RNA drugs, expanding the RNA therapeutic design space.
The NTU team created a compact and flexible light-based sensing device, like a plaster, to provide highly accurate biomarker readings within minutes. The device detects glucose, lactate, and urea levels in sweat with ultra-high sensitivity and dynamic range.
Developed by University of Tsukuba researchers, the wearable patch accurately measures insensible perspiration, allowing for real-time hydration monitoring. The patch also detects variations in pH levels and chemical components, making it a promising tool for dehydration management, stress monitoring, and disease detection.
Researchers developed a flexible-yet-sturdy morphing structure inspired by the starfish skeleton with 4D morphing features. The structure exhibits self-locking, continuous bending, self-healing, and shape memory features, making it suitable for industry applications in robotics, aviation, and biomedical devices.
Researchers from Chiba University develop sustainable method for producing biodegradable polymers using cuttlefish ink melanin. Decomposition products are converted into polymeric materials with potential applications in circular economies.
Researchers develop mechanobiomaterials inspired by biomechanics to modulate biological responses with material-tissue mechanical interactions. This approach aims to create biomaterials that can adapt to changing mechanical environments in vivo, enhancing the body's regenerative potential and repairing various tissues.
Researchers have developed a biodegradable scaffold to facilitate bladder tissue growth, reducing complications associated with traditional augmentation procedures. An implantable sensor also enhances patient monitoring, paving the way for improved bladder surgery outcomes.
A new study published in GEN Biotechnology describes the establishment of a 3D hydrogel-based platform for producing functional T-cells from hematopoietic stem and progenitor cells. The platform was engineered with key thymic components to direct T-cell development, producing cytokine-producing T-cells.
Researchers at Wyss Institute develop subcutaneous scaffolds to restimulate CAR-T cells, increasing therapeutic efficacy in mice with aggressive blood tumors. The biomaterials increase CAR-T cell numbers and steer differentiation into tumor-killing T cells.
Researchers developed an antioxidant gel to preserve islet function after pancreas removal, significantly improving survival and preserving normal blood sugar levels in animals. The new approach could enable patients to live pain-free without complications of diabetes.
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
The new nanodevice shows significant efficacy against pathogenic microorganisms such as Escherichia coli, Staphylococcus aureus, and Candida albicans. It improves the efficacy of encapsulated cinnamaldehyde by up to 52-fold for E. coli and 60-fold for S. aureus.
Researchers at Rice University developed a new material that mimics skin elasticity and motion types while preserving signal strength in electronics. The material, made by embedding ceramic nanoparticles into an elastic polymer, stabilizes radio-frequency communication and minimizes energy loss.
Researchers at the University of East Anglia have developed a novel resin for 3D printing intraocular devices, offering unprecedented levels of customization and design precision. This innovation has potential to enhance eye care globally with tailored lenses, faster production, and cost reduction.
Researchers have developed a new paste substrate for cultivating mycelium leather, enabling faster growth and easier harvesting. The study found that this method produces thicker mycelial mats with improved yields, making it a promising sustainable alternative to traditional materials.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Researchers at ETH Zurich developed a protein gel that breaks down alcohol in the gastrointestinal tract, reducing blood alcohol levels and acetaldehyde production. The gel shows promising results in mice studies, demonstrating a lower alcohol level and therapeutic effect on liver damage and weight loss.
Researchers from Wyss Institute and Harvard University developed a biomaterial vaccine that enhances and sustains lymph node expansion, leading to more effective anti-tumor responses. The vaccine formulation, based on microscale mesoporous silica rods, reprograms antigen-presenting cells to orchestrate complex immune responses.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
Researchers at the University of Washington have solved a long-standing chemical mystery in organic electrochemical transistors (OECTs), which allow current to flow in devices like implantable biosensors. The study reveals that OECTs turn on via a two-step process, causing a lag, and off through a simpler one-step process.
Eric Markvicka is developing a manufacturing approach to produce novel liquid metal mixtures with enhanced properties, including thermal and electrical conductivity. These mixtures can be used in additive manufacturing and accelerate momentum toward 4D printing, enabling the creation of machines that mimic biological organisms.
Researchers will develop 'live' joints with biocompatible bone and cartilage grown from human cells, aiming to scale up the technology for commercial use. The project, valued at $47.7M, targets 40 patients within five years with knee replacements.
Jos Malda receives ERC grant to crack cartilage code and create regenerative treatments. By studying cartilage 'organ-on-a-chip' models and animal cartilages, researchers aim to recreate the intricate internal structure of cartilage.
The study investigates various biomaterials for bone defect repair, including autologous, allogeneic, and growth factor materials. These materials offer improved biocompatibility and strength, with potential solutions for enhancing soft tissue thickness.
Caterpillars of the Carolina sphinx moth have an extraordinary ability to instantly change their hemolymph's material properties, turning it into a viscoelastic fluid that helps stop bleeding. This discovery has potential applications for developing new drugs for humans to create fast-working thickeners of human blood.
A team of scientists from Pohang University of Science & Technology developed an artificial vitreous body based on alginate to treat retinal detachment. The hydrogel maintains vision post-surgery and regulates fluid dynamics within the eye, preventing recurrence and air bubble formation.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
Researchers have developed diverse nanoparticles for cancer therapy, including micelles, liposomes, and hybrid nanoparticles, which can overcome challenges and deliver drugs with enhanced targeting abilities.
Researchers at Brigham and Women's Hospital developed a sprayable adhesive hydrogel product to address GI wound management limitations. The material promotes rapid wound healing, provides tissue protection, and minimizes complications under harsh conditions.
Scientists create a hydrogel system that can remember its shape, allowing them to control cell adhesion behavior. The elastic modulus of the hydrogel is adjusted by compressing it into different thicknesses at high temperatures.
Researchers have developed a cost-effective method to create waterproof and grease-resistant paper coatings using extracellular polymeric substances (EPS) from anaerobic granular sludge. The study found that EPS derived from waste sludge can improve paper coating properties, including water/grease-proofing behaviour.
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
Researchers developed a scaffold with controlled pore sizes (200-700 microns) and shapes, using FDM printing technique. The results showed a favourable cellular response and mechanical properties, making it promising for bone defect regeneration.
Researchers developed protein-based microcapsules to enhance aptamer sensors, enabling direct detection of target molecules in biological samples. The system demonstrates robust protection against harmful proteins and simultaneous real-time sensing of multiple targets.
Researchers have created a new tool called epidecodeR to analyze epigenetic marks and predict their impact on gene activity. The tool can identify correlations between specific modifications and gene responses in various conditions, including cancer and neurological disorders.
A study by the University of Tsukuba found that keratin microsphere gel enhanced cell proliferation and gene expression related to hair growth. The gel's stimulatory impact on papilla cells was validated through genetic analysis, demonstrating its potential as a safe and effective hair growth agent.
A new roadmap has been published by IEEE EMBS, outlining five primary medical challenges that need to be addressed through advanced biomedical engineering approaches. The paper, written by 50 renowned researchers from 34 prestigious universities, aims to guide future research and funding for groundbreaking innovations.
Researchers at McGill University discovered a new mechanism for the attachment of avian eggshell membranes to their shells. This finding has significant implications for tissue engineering and biomaterial grafts, as well as reducing losses in the commercial egg and poultry industry.
Researchers created complex 3D structures that mimic bone microstructure using laser 3D printing and an alternate soaking process. The method supports the creation of bone grafts or artificial bone marrow, offering a potential solution to treating leukemia, lymphoma, and immune diseases.
Researchers at Chalmers University of Technology have developed a new, sustainable architectural material by 3D printing nanocellulose and algae. The material's use could significantly reduce energy consumption in construction, aligning with the European Green Deal's goals.
Princeton researchers create a system to control the growth of microtubule branches, enabling precise chemical transport and potential applications in soft robotics, new medicines, and biomolecular transport. The technique harnesses cellular scaffolding to build novel materials and technologies.
Researchers at RIKEN successfully spin artificial spider silk that closely matches natural production, mimicking the complex molecular structure of silk. The eco-friendly innovation has potential benefits for environment and biomedical fields.
Researchers developed a drinkable foam infused with carbon monoxide to enhance the effectiveness of autophagy inhibition in treating various cancers. The study showed significant reductions in tumor growth and progression in mice and human cancer cells, opening a promising new approach for therapies.