Research on engineered particles at the nanoscale. Covers hyperspectral imaging, nanoparticle cancer therapy, gene-editing delivery, and heat-beating materials.
MIT researchers developed a new technique to produce lipid nanoparticles with precise control over size and shape, accelerating the development of RNA and DNA therapeutics. The automated system can produce particles of varying sizes and shapes, enabling targeted delivery to specific organs and tissues.
Researchers at IIT have created nanoparticles that can heat up using infrared light, release antioxidant substances, and stimulate cells when activated by ultrasound. These multifunctional nanotubes have the potential to modulate cellular activity and be used in regenerative medicine and neurostimulation.
In vivo CAR-T therapy reduces manufacturing time and cost, enabling more accessible cancer immunotherapy. The strategy also enables superior self-renewal capacity and anti-tumor persistence.
Research found that small particles from activated carbon and biochar can transport particle-bound pollutants after filtration, affecting water treatment performance. Dissolved contaminants may be overlooked when particles are removed, leading to incomplete contaminant transport assessment.
Researchers developed a heat-venting ceramic metastructure with high terahertz shielding efficiency, combining material modification and structural design. The metastructure exhibited multifunctional characteristics, including hydrophobic and antifouling surfaces and excellent heat dissipation capabilities.
Researchers developed a redox-active ligand-stabilized LFP cathode integrating porphyrin molecules with nanoscale LFP, achieving high capacity and long-term stability. The cathode delivers approximately 260 mAh g−1 at 20 mA g−1 and retains 140 mAh g−1 at 2000 mA g−1, with nearly 100% Coulombic efficiency.
Researchers at Tohoku University have developed an ultrasound-based method to convert iron powder into magnetic oxide nanoparticles in hours, eliminating the need for chemical reagents. The process involves using ultrasound to activate the interface between metallic iron and water, resulting in the direct formation of nanoscale oxide p...
The SUNY Technology Accelerator Fund is providing grants to support research in AI, energy-efficient semiconductors, and non-invasive monitoring. Five campuses will receive funding for projects that could improve cancer diagnostics, circadian rhythm disorders, and burn diagnostics.
This technology delivers IL-10 mRNA to lung tissue, reducing inflammation and injury in acute lung injury and ARDS, while minimizing side effects. The lung-targeting lipid nanoparticles sustain therapeutic protein expression directly within lung tissue, reducing systemic exposure and improving treatment effectiveness.
By localizing peptides at the membrane interface or within the liposome interior, researchers can promote branched structures or spherical nanoparticles, respectively. This approach offers a new strategy for controlling nanoscale reaction environments in nanoparticle synthesis.
Researchers have developed a wide-field hyperspectral camera that captures real-time spectral changes from hundreds of nanoparticles simultaneously, revealing hidden heterogeneity in electrodeposition. The technique, called wide-field Fourier transform hyperspectral imaging, solves the throughput bottleneck in conventional dark-field s...
Researchers at the University of Massachusetts Amherst have been awarded $2.5 million to adapt their nanoparticle vaccine research to treat existing cancer. The prime-pull approach will deliver immune-activating medicines to both lymph nodes and tumors to create a robust immune response.
Researchers developed a bioinspired lipid nanoparticle that delivered gene-editing machinery to the liver, reducing low-density lipoprotein (LDL) cholesterol by over 20% and showing fewer signs of inflammation and toxicity. The nanoparticles also demonstrated positive effects on inflammation and healthy blood flow in cell experiments.
Researchers developed a purple fabric that reflects 87.6% of solar radiation and emits 96.4% of mid-infrared radiation, making it a highly effective cooling material. The fabric was tested in outdoor conditions and showed a significant cooling effect, making it suitable for people who spend long periods outdoors.
Researchers developed a hybrid nanoparticle that targets chronic wounds by reducing inflammation, oxidative stress, and promoting fibroblast migration. The treatment promotes full cell regeneration and near-complete closure of simulated lesions in 72 hours.
Researchers developed a method to inhibit lipid nanoparticle migration into the liver by coating hepatic sinusoidal walls with polyethylene glycol. This coating reduced liver accumulation by several dozen times and increased protein expression in the spleen, promoting safer nanomedicine with lower dosages.
Researchers have developed a 'double-punch' approach to treating brain cancer using light-activated nanoparticles that enable precise imaging during surgery and targeted phototherapy after surgery. The platform has shown promising results in mouse models, achieving 100% survival rate at 60 days.
Researchers at Kyushu University found that microwave heating creates high-temperature regions on nickel nanoparticles, accelerating hydrogen production and paving the way for low-carbon chemical manufacturing. The study showed a six-fold increase in hydrogen production compared to conventional heating.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
A multidisciplinary team of Penn researchers has developed a platform that delivers a combination of cancer-fighting therapies to treat oral squamous cell carcinoma. The findings show that the platform significantly reduces tumor burden and extends survival in aggressive, p53-therapy-resistant cancer models.
A new method for three-dimensional visualization of nanoplastic distribution in the neonatal mouse brain has been established, revealing particle-size-dependent biodistribution patterns. The study found that smaller particles (50 nm) were widely distributed throughout the brain, while larger particles (500 nm) showed weaker accumulation.
A UTEP researcher has developed a simple, low-dose leaf spray that can substantially reverse the damage caused by salty soil on tomato plants. The treatment pairs manganese oxide nanoparticles with chitosan and has been shown to increase shoot weight, root growth, and antioxidant enzyme activity in stressed plants.
A team of researchers at Ohio State University has identified a noncoding RNA that binds to ATP, which could lead to the development of new therapeutic nanomaterials. The discovery builds on previous work and follows up with an investigation into the mechanism of how this RNA binds to ATP.
A research team has overcome two major hurdles for photo thermal therapy, a less invasive treatment option than surgery and radiation. They created a new biodegradable protein called IDP1 that helps nanoparticles avoid immune detection, and developed an ultra-thin endoscope to deliver laser light directly into tumors.
Researchers developed a nanoparticle system that uses cancer cells' own copper resources to activate cuproptosis, eliminating tumor cells while protecting healthy tissue. The targeted nanoparticles showed enhanced cellular uptake and were more lethal to breast cancer cells than non-targeted versions.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
Researchers from Tokyo Metropolitan University introduced ultra-fine bubbles into ink droplets, demonstrating their ability to modify ink drying patterns. The team's discovery holds promise for the printing of microdevices, where additives can negatively affect properties of ink deposits.
Researchers developed antifungal nanoparticles from human immune cells that target Candida albicans, reducing fungal growth and improving survival rates in mice. The nanodiscs physically damage fungal cells and boost the body's natural immune defenses.
Physicists at UTEP have discovered a new type of manganese ferrite nanoparticle that can deliver targeted heat treatment to tumors, potentially improving cancer therapies. The nanoparticles were found to produce a stronger heating response than other materials, making them a promising building block for future treatments.
Researchers developed an AI approach that identifies nanoparticle morphology using data from standard NTA measurements, achieving high classification accuracies. The method integrates two types of information and performs multi-class classification with stable performance even at reduced data amounts.
Researchers develop a new strategy to control electronic and magnetic properties of oxide thin films through nanoparticle exsolution, resulting in giant insulator-to-metal transition and room-temperature superparamagnetism
Researchers developed a silver nanoparticle-based technology to precisely cut and join DNA at targeted sites, increasing assembly efficiency by 2-5 times. The process uses chemical reactions instead of restriction enzymes, resulting in higher DNA recovery rates and improved joining efficiencies.
Researchers at the University of São Paulo have developed nanoparticles that deliver therapeutic RNA molecules directly to skin cells, silencing genes responsible for chronic inflammation. This precision nanomedicine approach holds promise for treating complex diseases like psoriasis and vitiligo.
A deep learning model combines knowledge from different catalyst families to identify a top-performing green hydrogen catalyst. The AI correctly predicted the activity ranking of 12 tested catalysts within a previously unexplored material family.
A team of researchers from the University of Michigan and other institutions developed a quantitative measure to quantify complexity in nanomaterials. The metric enables engineers to design materials with unique properties not seen in natural or existing man-made materials.
Researchers have created a new molecule that stabilizes gold nanoparticles, preserving their shape and enhancing photothermal therapy's effectiveness. This breakthrough aims to control the function of these particles during medical treatments like cancer therapy.
Researchers at The University of Osaka developed a strategy to make nanoparticle aggregates thermoplastic by introducing ions at interfaces. This allows for the creation of high-strength and low-expansion materials suitable for various applications. The study paves the way for diverse systems, including graphene oxide and cellulose nan...
Researchers develop hemoglobin-based nanoparticles to deliver tigecycline directly to Klebsiella pneumoniae infection sites, improving survival rates and reducing bacterial burden. The novel strategy overcomes dose-limiting toxicity and enhances pharmacokinetics of the antibiotic.
Researchers have developed nanoparticles that sequentially disable the cancer cell's drug-expulsion mechanism and then release anticancer drugs, combined with photothermal therapy. This approach overcomes multidrug resistance and achieves complete tumor elimination in a mouse model, with no detectable toxicity to normal tissues.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
A new imaging strategy combines dissolvable microneedles with a methylene blue-based nanoparticle tracer to produce clearer images of lymphatic vessels and nodes. The system also reveals segmental contractions linked to lymphatic pumping, opening a path toward more refined visualization and functional assessment.
Researchers at Stanford University have developed a non-invasive method to deliver light to specific locations in the body using nanomaterials and ultrasound waves. This technique provides a potential roadmap for easier, less invasive light-based treatments, with applications in biology, medicine, and gene editing.
Researchers have developed a new CAR T therapy that targets tumor-supporting cells in pancreatic cancer, paving the way for a potentially safer and more effective treatment. The therapy uses lipid nanoparticles to deliver CAR instructions directly to patient T cells, resulting in higher expression rates and improved efficacy compared t...
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Researchers engineered nanoparticles that can educate the immune system to find and destroy disease-causing cells throughout the body. The nanoparticles were successful in depleting and destroying diseased immune cells in mice, with 95% of target B cells depleted in circulating blood within 24 hours.
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Researchers introduce Fe₃O₄@mPEG-Ag nanoparticles as a non-antibiotic strategy to combat drug-resistant bacteria. The novel nanomaterial demonstrates strong antibacterial activity against clinically relevant multidrug-resistant strains.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
A recent study suggests that combining melatonin with zinc oxide nanoparticles can improve hormone levels and reduce oxidative stress in male rats treated with cyclophosphamide, a chemotherapy drug known to damage rapidly dividing cells. The combination of these antioxidants improved sperm-producing cell preservation and reduced reprod...
In a mouse study, researchers successfully used RNA micelles to shrink metastasized tumors in lungs by delivering chemotherapy drugs and an RNA molecule that blocks cancer survival. The treatment significantly reduced tumor growth and improved outcomes for mice with colorectal cancer lung metastasis.
Researchers developed a novel nanoparticle system to cross the BBB, target infection sites, and release antibacterial agents locally. This strategy effectively disrupts biofilms, eliminates drug-resistant bacteria, and reduces neuroinflammation.
A team of researchers at Northern Arizona University discovered that fabricated gold, copper and iron nanocrystals exhibit pentagonal constructs resembling natural snowflakes, governed by emergence dynamics. This phenomenon holds key findings for controlling nanomaterial synthesis and advancing the field.
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
A new study reveals that Cornell prime dots, ultrasmall fluorescent particles, can reprogram the tumor microenvironment to make it more responsive to treatment. The nanoparticles induce anti-tumor effects by stimulating innate immune responses and reprogramming key immune cells.
Researchers found that Cornell prime dots can reprogram the tumor microenvironment, transforming melanoma and other aggressive solid tumors into responsive ones. The particles stimulate innate immune responses, halt cancer cell proliferation, reduce immune suppression, and repurpose key immune cells to attack cancer more effectively.
Scientists have identified two key forces that shape iron nanoparticles' stability in environments, including aggregation and phase transformation. Understanding these processes can improve strategies for managing water quality and contaminant transport.