Nanoparticles
Articles tagged with Nanoparticles
A precision nanoparticle strategy to combat multidrug-resistant pneumonia
Researchers develop hemoglobin-based nanoparticles to deliver tigecycline directly to Klebsiella pneumoniae infection sites, improving survival rates and reducing bacterial burden. The novel strategy overcomes dose-limiting toxicity and enhances pharmacokinetics of the antibiotic.
Nanoparticles overcome drug-resistant cancer via sequential drug release and photothermal therapy
Brain Health emergency: Microplastic burden in the human brain now linked to stroke and dementia, with apheresis emerging as the first plausible removal pathway
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Promising new technique uses nanoparticles to detect pancreatic cancer
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
Twisted nanoparticles sorted by light
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
Scientists explore whether plastic particles could be linked to significant rises in liver disease
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
A painless, high-precision imaging platform brings lymphatic function into view
A new imaging strategy combines dissolvable microneedles with a methylene blue-based nanoparticle tracer to produce clearer images of lymphatic vessels and nodes. The system also reveals segmental contractions linked to lymphatic pumping, opening a path toward more refined visualization and functional assessment.
Researchers use ultrasound to create light inside the body
Researchers at Stanford University have developed a non-invasive method to deliver light to specific locations in the body using nanomaterials and ultrasound waves. This technique provides a potential roadmap for easier, less invasive light-based treatments, with applications in biology, medicine, and gene editing.
Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Researchers have developed a new CAR T therapy that targets tumor-supporting cells in pancreatic cancer, paving the way for a potentially safer and more effective treatment. The therapy uses lipid nanoparticles to deliver CAR instructions directly to patient T cells, resulting in higher expression rates and improved efficacy compared t...
New lipid nanoparticle design improves precision of mRNA vaccine delivery
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
Engineered lipid nanoparticles reprogram immune metabolism for better mRNA vaccines
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Johns Hopkins scientists engineer nanoparticles able to seek and destroy diseased immune cells
Researchers engineered nanoparticles that can educate the immune system to find and destroy disease-causing cells throughout the body. The nanoparticles were successful in depleting and destroying diseased immune cells in mice, with 95% of target B cells depleted in circulating blood within 24 hours.
New robotic microfluidic platform brings ai to lipid nanoparticle design
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Fe₃O₄@mPEG-Ag nanoparticles: a new frontier in combating antibiotic resistance
Researchers introduce Fe₃O₄@mPEG-Ag nanoparticles as a non-antibiotic strategy to combat drug-resistant bacteria. The novel nanomaterial demonstrates strong antibacterial activity against clinically relevant multidrug-resistant strains.
RCSI researchers develop RNA-activated implant to stimulate nerve regrowth after spinal cord injury
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
Antioxidants may protect male fertility during chemotherapy, study suggests
A recent study suggests that combining melatonin with zinc oxide nanoparticles can improve hormone levels and reduce oxidative stress in male rats treated with cyclophosphamide, a chemotherapy drug known to damage rapidly dividing cells. The combination of these antioxidants improved sperm-producing cell preservation and reduced reprod...
Killing cancer cells with RNA therapeutics
In a mouse study, researchers successfully used RNA micelles to shrink metastasized tumors in lungs by delivering chemotherapy drugs and an RNA molecule that blocks cancer survival. The treatment significantly reduced tumor growth and improved outcomes for mice with colorectal cancer lung metastasis.
BBB-crossing ionizable upconversion nanoparticles for synergistic therapy of carbapenem-resistant central nervous system infection
Researchers developed a novel nanoparticle system to cross the BBB, target infection sites, and release antibacterial agents locally. This strategy effectively disrupts biofilms, eliminates drug-resistant bacteria, and reduces neuroinflammation.
Sequestered in immune cells, barium titanate nanoparticles stimulated by ultrasound launch inflammatory response
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
Snowflakes just got metal: Researchers discover emergence phenomenon in metal nanocrystals
A team of researchers at Northern Arizona University discovered that fabricated gold, copper and iron nanocrystals exhibit pentagonal constructs resembling natural snowflakes, governed by emergence dynamics. This phenomenon holds key findings for controlling nanomaterial synthesis and advancing the field.
Cornell-developed particles supercharge cancer immunotherapy
A new study reveals that Cornell prime dots, ultrasmall fluorescent particles, can reprogram the tumor microenvironment to make it more responsive to treatment. The nanoparticles induce anti-tumor effects by stimulating innate immune responses and reprogramming key immune cells.
Cornell-developed particles supercharge cancer immunotherapy
Researchers found that Cornell prime dots can reprogram the tumor microenvironment, transforming melanoma and other aggressive solid tumors into responsive ones. The particles stimulate innate immune responses, halt cancer cell proliferation, reduce immune suppression, and repurpose key immune cells to attack cancer more effectively.
Scientists identify the key forces that shape the environmental fate of iron nanoparticles
Scientists have identified two key forces that shape iron nanoparticles' stability in environments, including aggregation and phase transformation. Understanding these processes can improve strategies for managing water quality and contaminant transport.
Scientists make dark exciton states shine, unlocking new frontiers for nanotechnology
A research team at CUNY and UT Austin discovered a way to control dark excitons, highly promising for quantum information and advanced photonic applications. They amplified light emission by 300,000 times, making them visible and controllable.
The Institute of Advanced Materials at the Universitat Jaume I promotes research into next-generation neuromorphic computing
Researchers at the Institute of Advanced Materials aim to develop sustainable, high-performance lead-free memristors for neuromorphic computing. The MemSusPer project seeks to improve perovskite layer properties and test new materials for enhanced electrical conductivity.
New nanoparticle therapy shrinks pancreatic tumors and extends survival in preclinical study
A new study found that magnetoelectric nanoparticles can locate and destroy pancreatic tumors in preclinical models, reducing tumor size by one-third and extending survival time. The treatment uses no drugs or invasive procedures, instead guiding the nanoparticles to the tumor site using a small magnet and activating them with an MRI s...
Researchers at MIT develop new nanoparticles that stimulate the immune system to attack ovarian tumors
MIT researchers have developed new nanoparticles that deliver the immune-stimulating molecule IL-12 directly to ovarian tumors, eliciting a strong response and clearing tumors in over 80% of mice. This treatment combines with checkpoint inhibitors to launch an attack on cancer cells without causing side effects.
Researcher improves century-old equation to predict movement of dangerous air pollutants.
A new method developed at the University of Warwick offers a simple way to calculate how irregularly shaped nanoparticles move through air. The study reworks a 100-year-old formula to bridge a key gap in aerosol science, providing accurate predictions for particles of any shape.
Nanoparticle blueprints reveal path to smarter medicines
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
Nano-biochar helps rice roots turn silver ions into less toxic nanoparticles
Researchers discovered that nano-biochar acts as an electron shuttle, transforming silver ions into metallic nanoparticles in rice roots. The process reduces the toxicity of silver ions while promoting their formation and accumulation inside plant cells.
Pottery-inspired method stencils nanoparticles for building advanced materials
A new technique allows engineers to more precisely place patches on microscopic building blocks, controlling their assembly into designer structures. This stenciling method provides a quantum leap in control over the building blocks' designs, enabling the creation of sophisticated materials from nanoparticles.
Chemicals might be hitching a ride on nanoplastics to enter your skin
Scientists have found that environmental coatings on microscopic plastic particles can bypass some skin cells' defenses, allowing them to stay inside the body longer. This highlights the importance of studying the interaction between nanoplastics and human skin, as well as the potential health risks associated with these tiny particles.
Treating liver disease with microscopic nanoparticles
Researchers have developed microscopic nanoparticles that can seek out and attach to damaged liver cells, helping to stop disease progression. The nanoparticles are engineered to recognize and selectively bind to a protein found only on Kupffer cells in the liver, promoting anti-inflammatory behavior and delivering medicine directly to...
Cracking the code of 2D materials: Why clean transfers matter as much as testing
The review highlights the importance of clean transfers in 2D material research, emphasizing that it can make or break an experiment. The authors propose a unified approach to transfer methods, synthesis, and testing to improve reproducibility and reliability.
Human Organ Chip technology sets stage for pan-influenza A CRISPR RNA therapies
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Atom-scale stencil patterns help nanoparticles take new shapes and learn new tricks
Researchers have developed atomic-level precision patterning on nanoparticle surfaces using stencils, creating 'patchy nanoparticles' with various shapes and functions. The technique allows for large-scale production of batched particles with intricate designs, enabling the creation of novel materials and metamaterials.
UMass Amherst researchers create nanoparticle vaccine that prevents cancer in mice
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Protein nanorings designed to detect and neutralize SARS-CoV2 virus
Researchers have generated a new ring-shaped protein nanomaterial capable of strongly binding to and neutralizing the SARS-CoV2 virus. The system can integrate therapeutic and diagnostic capabilities and be adapted to combat other viruses.
Scientists reverse Alzheimer’s in mice using nanoparticles
Researchers developed a nanotechnology strategy that reverses Alzheimer's disease by targeting the blood-brain barrier and restoring its natural waste-clearing pathway. The therapy achieved a significant reduction in amyloid-β levels and improved cognitive function in mouse models, showing promise for treating dementia.
Hanbat National University researchers present new technique to boost solid oxide fuel cell performance
Hanbat National University researchers have developed a new method for enhancing the performance of solid oxide fuel cells by inducing cobalt exsolution in high-temperature oxidizing atmospheres. This process results in improved electrochemical properties and higher oxygen reduction reaction activity, making it a promising direction fo...
How metals, organics, and microbes shape iron nanoparticles in nature
Researchers explain how iron nanoparticles form in water or on minerals, organic matter, and microbial biofilms, influencing ecosystem health and pollutant movement. Organic molecules and microbes also play major roles in nanoparticle growth and transformation.
Steel making could get a makeover
Researchers at the University of Minnesota have developed a new method for producing iron that eliminates CO2 emissions and can be performed at room temperature. The process uses hydrogen gas plasma to strip oxygen from iron ore, producing pure iron and water vapor.
A promising strategy for solvent‑regulated selective hydrogenation of 5‑hydroxymethylfurfural over porous carbon‑supported Ni‑ZnO nanoparticles
Scientists have developed a promising strategy for the selective hydrogenation of 5-hydroxymethylfurfural (HMF) using a porous carbon-supported Ni-ZnO nanoparticle catalyst. This breakthrough enables solvent-regulated selectivity and exceptional efficiency in producing valuable products such as BHMF and DMF.
From trash to treasure: Indonesian scientists turn plastic bags into glowing water sensors
Researchers from Universitas Gadjah Mada develop a breakthrough nanotechnology that converts plastic waste into glowing particles detecting toxic metals in drinking water with high precision and low cost. The innovation is a powerful step toward a circular economy, where waste becomes a resource for public health.
“Quantum squeezing” a nanoscale particle for the first time
Scientists have successfully demonstrated quantum squeezing of a nanoscale particle, achieving motion uncertainty smaller than quantum mechanical fluctuations. This achievement paves the way for basic research and applications like autonomous driving without GPS.
Prussian Blue breaks out of its cubic mold after 300 years
Researchers at Pohang University of Science & Technology have successfully synthesized Prussian Blue with an octahedral morphology by using a specialized solvent. The new crystal shape enhances electrochemical reactivity and stable performance in sodium-ion hybrid capacitors.
Soot's climate-altering properties change within hours of entering atmosphere
Researchers found that soot particles can transform their shape and behavior within hours of becoming airborne, altering their ability to warm or cool the atmosphere. This rapid transformation affects both soot's warming and cooling effects, as well as its lifetime.
Making the invisible visible: a new way to boost light emission at the nanoscale
Researchers discovered a new way to enhance light emission in nanoparticles, leading to the visualization of infrared radiation. The technique, which involves simultaneous excitation with two near-infrared beams, could have applications in microscopy and photonic technologies.
Chung-Ang University researchers reveal strange dynamics of nanoparticle growth and shrink
Researchers developed a new model and theory to explain nanoparticle growth dynamics, accounting for six essential characteristics of nanoparticle growth. The new theory provides fresh physical insights into the role of nanoparticle motion and configurational degeneracy on their nucleation and growth.
A nonsurgical path to treating pelvic organ prolapse
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
Ultrasound could deliver drugs with fewer side effects
Researchers at Stanford Medicine developed a non-invasive system that delivers drugs to specific regions of the body, reducing unwanted side effects. The system uses nanoparticles encapsulated in a sugar solution that responds to ultrasound stimulation, allowing for precise delivery of medication.
New book sheds light on synthesis and applications of advanced materials
The book sheds light on nanomaterials, metamaterials, and smart materials' synthesis, classification, and characterization techniques. It discusses size-dependent behavior, fabrication challenges, and interdisciplinary applications with practical implications for healthcare, energy, and electronics.
The future of ‘personalized’ cancer treatment: Antitumor mRNA-based vaccines
Researchers developed a neoAg mRNA-based vaccine that induces higher frequency of neoAg-specific cytotoxic T cells in mice, leading to tumor regression and eradication. The combination with anti-PD-1 therapy enhances antitumor efficacy, especially against peritoneal metastasis.
New study reveals simple peptides can mimic nature’s protein protection strategy
Researchers at CUNY ASRC Nanoscience reveal that extremely simple peptides can mimic a biological process that protects sensitive proteins from environmental stress. The findings offer a promising new approach to stabilizing biomolecules like vaccines and therapeutic proteins without refrigeration.
Nanodevice uses sound to sculpt light, paving the way for better displays and imaging
Researchers at Stanford University have developed a novel nanodevice that manipulates light using sound waves, enabling precise control over color and intensity. This breakthrough has significant implications for various fields, including computer displays, virtual reality, and optical communications.
Seeing urea in color: a new way to detect disease at a glance
A new biosensor has been developed to detect urea levels using visible color changes, offering a clear and multicolor visual cue across a wide concentration range. The sensor can detect urea down to 0.098 µM in solution and 0.2 µM in solid form, significantly outperforming traditional methods.
Titanium dioxide particles detected in milk, despite a ban on E171
A recent study detected titanium dioxide particles in 100% of animal milk samples and 83% of infant formulas, revealing widespread contamination. The findings suggest that infants' exposure to these particles does not end at birth, raising concerns over human and animal health.
Not just a messenger: Developing nano-sized delivery agents that also provide therapeutic treatment
Researchers at the University of Ottawa have made a breakthrough in developing nanoparticles that not only deliver drugs but also contribute to treatment. Their proof-of-concept study shows that particles can be armed with therapeutic potential, revolutionizing the field of nanomedicine.
Laser-generated nanoparticles promise cleaner, smarter artificial sensory systems
Laser-generated nanoparticles offer a cleaner, scalable alternative to traditional chemical synthesis methods for electronics applications. The method, called laser ablation in liquids, produces surfactant-free, highly pure metal-based nanoparticles with tailored surface properties.