Articles tagged with Nanoparticles
Researchers have developed a 'double-punch' approach to treating brain cancer using light-activated nanoparticles that enable precise imaging during surgery and targeted phototherapy after surgery. The platform has shown promising results in mouse models, achieving 100% survival rate at 60 days.
Researchers at Kyushu University found that microwave heating creates high-temperature regions on nickel nanoparticles, accelerating hydrogen production and paving the way for low-carbon chemical manufacturing. The study showed a six-fold increase in hydrogen production compared to conventional heating.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
A multidisciplinary team of Penn researchers has developed a platform that delivers a combination of cancer-fighting therapies to treat oral squamous cell carcinoma. The findings show that the platform significantly reduces tumor burden and extends survival in aggressive, p53-therapy-resistant cancer models.
A new method for three-dimensional visualization of nanoplastic distribution in the neonatal mouse brain has been established, revealing particle-size-dependent biodistribution patterns. The study found that smaller particles (50 nm) were widely distributed throughout the brain, while larger particles (500 nm) showed weaker accumulation.
A UTEP researcher has developed a simple, low-dose leaf spray that can substantially reverse the damage caused by salty soil on tomato plants. The treatment pairs manganese oxide nanoparticles with chitosan and has been shown to increase shoot weight, root growth, and antioxidant enzyme activity in stressed plants.
A team of researchers at Ohio State University has identified a noncoding RNA that binds to ATP, which could lead to the development of new therapeutic nanomaterials. The discovery builds on previous work and follows up with an investigation into the mechanism of how this RNA binds to ATP.
A research team has overcome two major hurdles for photo thermal therapy, a less invasive treatment option than surgery and radiation. They created a new biodegradable protein called IDP1 that helps nanoparticles avoid immune detection, and developed an ultra-thin endoscope to deliver laser light directly into tumors.
Researchers developed a nanoparticle system that uses cancer cells' own copper resources to activate cuproptosis, eliminating tumor cells while protecting healthy tissue. The targeted nanoparticles showed enhanced cellular uptake and were more lethal to breast cancer cells than non-targeted versions.
Researchers developed nanoparticles that retain their protective coating in normal tissue but shed it upon reaching tumor tissue, releasing anticancer drugs. This technology reduces systemic side effects and enhances treatment efficacy.
Researchers from Tokyo Metropolitan University introduced ultra-fine bubbles into ink droplets, demonstrating their ability to modify ink drying patterns. The team's discovery holds promise for the printing of microdevices, where additives can negatively affect properties of ink deposits.
Researchers developed antifungal nanoparticles from human immune cells that target Candida albicans, reducing fungal growth and improving survival rates in mice. The nanodiscs physically damage fungal cells and boost the body's natural immune defenses.
Researchers developed an AI approach that identifies nanoparticle morphology using data from standard NTA measurements, achieving high classification accuracies. The method integrates two types of information and performs multi-class classification with stable performance even at reduced data amounts.
Physicists at UTEP have discovered a new type of manganese ferrite nanoparticle that can deliver targeted heat treatment to tumors, potentially improving cancer therapies. The nanoparticles were found to produce a stronger heating response than other materials, making them a promising building block for future treatments.
Researchers develop a new strategy to control electronic and magnetic properties of oxide thin films through nanoparticle exsolution, resulting in giant insulator-to-metal transition and room-temperature superparamagnetism
Researchers developed a silver nanoparticle-based technology to precisely cut and join DNA at targeted sites, increasing assembly efficiency by 2-5 times. The process uses chemical reactions instead of restriction enzymes, resulting in higher DNA recovery rates and improved joining efficiencies.
Researchers at the University of São Paulo have developed nanoparticles that deliver therapeutic RNA molecules directly to skin cells, silencing genes responsible for chronic inflammation. This precision nanomedicine approach holds promise for treating complex diseases like psoriasis and vitiligo.
A deep learning model combines knowledge from different catalyst families to identify a top-performing green hydrogen catalyst. The AI correctly predicted the activity ranking of 12 tested catalysts within a previously unexplored material family.
A team of researchers from the University of Michigan and other institutions developed a quantitative measure to quantify complexity in nanomaterials. The metric enables engineers to design materials with unique properties not seen in natural or existing man-made materials.
Researchers have created a new molecule that stabilizes gold nanoparticles, preserving their shape and enhancing photothermal therapy's effectiveness. This breakthrough aims to control the function of these particles during medical treatments like cancer therapy.
Researchers at The University of Osaka developed a strategy to make nanoparticle aggregates thermoplastic by introducing ions at interfaces. This allows for the creation of high-strength and low-expansion materials suitable for various applications. The study paves the way for diverse systems, including graphene oxide and cellulose nan...
Researchers develop hemoglobin-based nanoparticles to deliver tigecycline directly to Klebsiella pneumoniae infection sites, improving survival rates and reducing bacterial burden. The novel strategy overcomes dose-limiting toxicity and enhances pharmacokinetics of the antibiotic.
Researchers have developed nanoparticles that sequentially disable the cancer cell's drug-expulsion mechanism and then release anticancer drugs, combined with photothermal therapy. This approach overcomes multidrug resistance and achieves complete tumor elimination in a mouse model, with no detectable toxicity to normal tissues.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
Researchers at Stanford University have developed a non-invasive method to deliver light to specific locations in the body using nanomaterials and ultrasound waves. This technique provides a potential roadmap for easier, less invasive light-based treatments, with applications in biology, medicine, and gene editing.
A new imaging strategy combines dissolvable microneedles with a methylene blue-based nanoparticle tracer to produce clearer images of lymphatic vessels and nodes. The system also reveals segmental contractions linked to lymphatic pumping, opening a path toward more refined visualization and functional assessment.
Researchers have developed a new CAR T therapy that targets tumor-supporting cells in pancreatic cancer, paving the way for a potentially safer and more effective treatment. The therapy uses lipid nanoparticles to deliver CAR instructions directly to patient T cells, resulting in higher expression rates and improved efficacy compared t...
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Researchers engineered nanoparticles that can educate the immune system to find and destroy disease-causing cells throughout the body. The nanoparticles were successful in depleting and destroying diseased immune cells in mice, with 95% of target B cells depleted in circulating blood within 24 hours.
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Researchers introduce Fe₃O₄@mPEG-Ag nanoparticles as a non-antibiotic strategy to combat drug-resistant bacteria. The novel nanomaterial demonstrates strong antibacterial activity against clinically relevant multidrug-resistant strains.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
A recent study suggests that combining melatonin with zinc oxide nanoparticles can improve hormone levels and reduce oxidative stress in male rats treated with cyclophosphamide, a chemotherapy drug known to damage rapidly dividing cells. The combination of these antioxidants improved sperm-producing cell preservation and reduced reprod...
In a mouse study, researchers successfully used RNA micelles to shrink metastasized tumors in lungs by delivering chemotherapy drugs and an RNA molecule that blocks cancer survival. The treatment significantly reduced tumor growth and improved outcomes for mice with colorectal cancer lung metastasis.
Researchers developed a novel nanoparticle system to cross the BBB, target infection sites, and release antibacterial agents locally. This strategy effectively disrupts biofilms, eliminates drug-resistant bacteria, and reduces neuroinflammation.
A team of researchers at Northern Arizona University discovered that fabricated gold, copper and iron nanocrystals exhibit pentagonal constructs resembling natural snowflakes, governed by emergence dynamics. This phenomenon holds key findings for controlling nanomaterial synthesis and advancing the field.
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
A new study reveals that Cornell prime dots, ultrasmall fluorescent particles, can reprogram the tumor microenvironment to make it more responsive to treatment. The nanoparticles induce anti-tumor effects by stimulating innate immune responses and reprogramming key immune cells.
Researchers found that Cornell prime dots can reprogram the tumor microenvironment, transforming melanoma and other aggressive solid tumors into responsive ones. The particles stimulate innate immune responses, halt cancer cell proliferation, reduce immune suppression, and repurpose key immune cells to attack cancer more effectively.
Scientists have identified two key forces that shape iron nanoparticles' stability in environments, including aggregation and phase transformation. Understanding these processes can improve strategies for managing water quality and contaminant transport.
A research team at CUNY and UT Austin discovered a way to control dark excitons, highly promising for quantum information and advanced photonic applications. They amplified light emission by 300,000 times, making them visible and controllable.
Researchers at the Institute of Advanced Materials aim to develop sustainable, high-performance lead-free memristors for neuromorphic computing. The MemSusPer project seeks to improve perovskite layer properties and test new materials for enhanced electrical conductivity.
A new study found that magnetoelectric nanoparticles can locate and destroy pancreatic tumors in preclinical models, reducing tumor size by one-third and extending survival time. The treatment uses no drugs or invasive procedures, instead guiding the nanoparticles to the tumor site using a small magnet and activating them with an MRI s...
MIT researchers have developed new nanoparticles that deliver the immune-stimulating molecule IL-12 directly to ovarian tumors, eliciting a strong response and clearing tumors in over 80% of mice. This treatment combines with checkpoint inhibitors to launch an attack on cancer cells without causing side effects.
A new method developed at the University of Warwick offers a simple way to calculate how irregularly shaped nanoparticles move through air. The study reworks a 100-year-old formula to bridge a key gap in aerosol science, providing accurate predictions for particles of any shape.
Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
Researchers discovered that nano-biochar acts as an electron shuttle, transforming silver ions into metallic nanoparticles in rice roots. The process reduces the toxicity of silver ions while promoting their formation and accumulation inside plant cells.
A new technique allows engineers to more precisely place patches on microscopic building blocks, controlling their assembly into designer structures. This stenciling method provides a quantum leap in control over the building blocks' designs, enabling the creation of sophisticated materials from nanoparticles.
Scientists have found that environmental coatings on microscopic plastic particles can bypass some skin cells' defenses, allowing them to stay inside the body longer. This highlights the importance of studying the interaction between nanoplastics and human skin, as well as the potential health risks associated with these tiny particles.
Researchers have developed microscopic nanoparticles that can seek out and attach to damaged liver cells, helping to stop disease progression. The nanoparticles are engineered to recognize and selectively bind to a protein found only on Kupffer cells in the liver, promoting anti-inflammatory behavior and delivering medicine directly to...
The review highlights the importance of clean transfers in 2D material research, emphasizing that it can make or break an experiment. The authors propose a unified approach to transfer methods, synthesis, and testing to improve reproducibility and reliability.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Researchers have developed atomic-level precision patterning on nanoparticle surfaces using stencils, creating 'patchy nanoparticles' with various shapes and functions. The technique allows for large-scale production of batched particles with intricate designs, enabling the creation of novel materials and metamaterials.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Researchers have generated a new ring-shaped protein nanomaterial capable of strongly binding to and neutralizing the SARS-CoV2 virus. The system can integrate therapeutic and diagnostic capabilities and be adapted to combat other viruses.
Researchers developed a nanotechnology strategy that reverses Alzheimer's disease by targeting the blood-brain barrier and restoring its natural waste-clearing pathway. The therapy achieved a significant reduction in amyloid-β levels and improved cognitive function in mouse models, showing promise for treating dementia.