Articles tagged with Fluorescence
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers summarize recent progress of organic RTP materials with long lifetime, large Stokes shift, stimuli-responsiveness and potential applications in display, environmental detection and bioimaging. Challenges to overcome include achieving high quantum yield, short lifetime and rich luminous colors.
Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.
Researchers have found a way to increase the efficiency of fluorescence in phosphole-based compounds by modifying them with sulfonyl isocyanates. This modification method has been shown to significantly enhance the optical properties of these substances, making them suitable for use as efficient dyes or markers.
A Pitt lab discovery sheds light on how a specific mutation in the lsr2 gene helps bacteria resist phage infection. The team developed new tools to visualize phages attacking bacteria, revealing critical insights into the mechanisms of phage resistance.
Researchers have developed a novel fluorescence recognition method for detecting D-glucose in water, showing excellent D-glucose chiral selectivity. The system consists of cyclodextrin and monoboronic acid-based receptor complexes, which can detect glucose concentrations with low limits of detection.
Scientists at IISc develop neuromorphic camera that uses machine learning to pinpoint objects smaller than 50 nanometers in size, enabling nanoscale precision in biological processes, chemistry, and physics. The technique combines optical microscopy with the neuromorphic camera and machine learning algorithms.
Scientists have developed a technique to detect RNA structures in live cells, shedding light on the role of G-quadruplexes in neurodegenerative diseases. The method uses fluorescent spectroscopy and resolves existing limitations in studying these structures in real-time.
A new biopsy procedure is developed with a multispectral confocal endomicroscope to aid in lung tissue imaging. The system allows for simultaneous imaging of multiple fluorescent dyes, enabling unique identification and spectral unmixing.
Researchers at Rice University have developed a new fluorescent dye that can cross the blood-brain barrier, allowing for noninvasive brain imaging and differentiation between healthy tissue and tumor cells. The dye's long-lasting fluorescence enables stable imaging over extended periods.
Researchers used machine learning to create molecule chains that display designated colors in response to different stimuli, such as light, chemicals, and energy. This breakthrough enables faster and more efficient data storage and security applications.
KAUST researchers have designed and built novel organic scintillator materials for detecting X-rays at low doses, overcoming stability issues with existing ceramic or perovskite materials. The new approach uses heavy atoms to improve X-ray absorption capability and exciton utilization efficiency.
Researchers at ETH Zurich developed novel fluorescent dyes with modular structures, producing a wide color palette. The dyes have potential applications in security ink, solar power plants, and organic light-emitting diodes.
Researchers have developed a new spectroscopy technique called filament- and plasma-grating-induced breakdown spectroscopy (F-GIBS), which improves the sensitivity of trace metal detection in liquid samples. The technique uses fluid jets to analyze aqueous solutions and achieves high precision by avoiding detrimental influences of liqu...
Researchers at Hokkaido University identify a nerve pathway in the brain stem involved in processing rewarding and distressing stimuli, opposing a previously identified pathway. This finding could lead to developing drug treatments for mental disorders like addiction and major depression.
A team of researchers from Lithuania has developed organic dyes showing a particularly long afterglow after being excited by light. The new material exhibits persistent thermally activated delayed fluorescence and long phosphorescence at room temperature, enabling color-tunable room-temperature organic afterglow.
Researchers from Osaka University developed a new fluorescent sensor system to visualize N-cadherin-mediated interactions between living cells. The INCIDER system enables accurate tracking of temporal changes in these interactions, with a fluorescence signal 70 times stronger than existing methods.
A new portable device can detect the low-intensity light emission from healthy plants, allowing researchers to measure their health and sustainability. This technology can help assess the impact of CO2 emissions, greenhouse gases, and extreme weather events on plant stress and inform strategies for sustainable agriculture.
Researchers designed a small fluorescent protein that emits and absorbs light in the near-infrared spectrum, allowing for deeper and clearer biomedical images. The protein's ability to penetrate tissue enables the capture of detailed images of complex structures and cells.
Osaka University researchers have synthesized a fluorescent protein with the shortest emission wavelength to date, enabling the simultaneous tracking of multiple processes in cells. The new protein, Sumire, exhibits improved brightness and stability compared to existing fluorophores.
Scientists have successfully created two types of light-driven molecular motors that can both rotate and fluoresce in the same molecule. This achievement demonstrates that these motors can be designed to control various functions using light energy, paving the way for potential applications in biomedical imaging and cellular processes.
Researchers at Göttingen University have found fluorescent color patterns in fossils from the Triassic period, making them the oldest of their kind. The study reveals a surprising variety of stripes, zigzags, and flame patterns, similar to those of modern seashells.
Researchers developed a low-cost, simple imaging system using tumor-targeting fluorescent molecules to determine tumor depth. The portable system provides quantitative information about the depth of tumor cells in the body, helping surgeons remove healthy tissue around tumors for better outcomes.
A team of researchers at Nagoya University has developed a novel tissue-mimicking phantom using konjac, enabling surgeons to practice fluorescence-guided cancer surgery. The model's use of indocyanine green and konjac jelly makes it suitable for training with electrocautery, promoting safer and more reliable surgical techniques.
A team of researchers led by Prof. Shinya Hosokawa analyzed the atomic configurations of Pd42.5Ni7.5Cu30P20, a champion bulk metallic glass, and found its characteristic configurations that lead to its excellent glass-forming ability.
A novel 937-nm laser source has been developed for multiphoton microscopy, enabling deep tissue imaging at depths of over 600 µm with only 10 mW of power. This breakthrough technology offers a good balance between sensitivity, penetration depth, and imaging speed.
Researchers at Rice University have created a new optical tool called homo-FRET that allows them to observe the real-time activity of two-component systems in bacteria. This breakthrough enables scientists to study the behavior of deadly pathogens and antibiotic-resistant bacteria, shedding light on their mechanisms and potential targe...
Researchers developed a non-invasive ocular imaging method to detect flavoprotein fluorescence in the eye, indicating mitochondrial oxidative stress. This technique may predict glaucoma progression earlier than current methods, with similar sensitivity to visual field changes.
Researchers have developed a genetically encoded fluorescent nanothermometer that measures temperature gradients within human cells at unprecedented precision. This technology has the potential to test long-contentious medical hypotheses and inspire drug development.
A Tel Aviv University study reveals that corals' fluorescence serves as a lure for plankton, which are then consumed by predators like corals. The researchers found that green-fluorescent corals were 25% more preyed upon than yellow-fluorescent ones.
Researchers developed a novel frequency-domain method to selectively suppress background noise in STED microscopy, achieving higher spatial resolution and improved signal-to-noise ratio. The approach has potential applications in various dual-beam point-scanning techniques.
Scientists construct figure-eight-shaped machines with rotary motors and polymer chains to enable measurement of mechanical work and forces. The machines twist and untwist like whirligig toys, exerting similar torque to the enzyme that produces ATP.
Researchers at Massachusetts General Hospital developed scission-accelerated fluorophore exchange (SAFE) to visualize molecules in living cells without disrupting normal physiological processes. The method uses immunofluorescence tags and fast chemical reactions to remove tags, creating a multi-color movie-like continuous stream of ima...
A new sensor technology allows for real-time monitoring of lactate levels in the brain, providing insights into energy metabolism and potential applications in cancer detection. The sensors corrected for hemodynamic artifacts using MRI-informed corrections enable accurate cell-specific lactate level recordings.
A new fluorescent probe can detect T cells involved in attacking tumors and monitoring treatment effectiveness. The technology could help clinicians develop personalized therapies and clear cancers faster without potential side effects.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
A novel technology has been developed for fast and reliable detection of SARS-CoV-2 in saliva samples using a flow virometer that utilizes fluorescent light markers. The device achieved high sensitivity and specificity in a blind test on over 50 patients, outperforming commercial antigen tests.
Researchers have discovered two new and unusual species of diatoms that fix nitrogen, a critical process supporting productivity in nutrient-poor open ocean waters. These diatoms harbor symbiotic cyanobacteria that convert dissolved nitrogen gas into ammonia, enabling them to thrive in nutrient-poor conditions.
Researchers have designed a nanoparticle system that can deliver fluorescent dyes to diagnose and treat pancreatic cancer tumors. The system overcomes the challenge of reaching cells deep within dense tumor masses, enabling detailed images of tumor structures and potentially targeted therapies.
A team of researchers at Rice University has developed a new method to detect tiny cracks in concrete using silicon fluorescence. The technique involves applying a thin coat of opaque paint to the concrete and shining near-infrared light on it, revealing even the smallest microcracks.
A new method combines computational ghost imaging and x-ray fluorescence to create high-resolution chemical element maps. This approach eliminates lenses, reducing scanning time and improving spatial resolution, making it useful for biomedicine, materials science, art analysis, and industrial inspection.
The new technology can reliably distinguish between cancerous and healthy liver tissue, aiding diagnosis and potentially reducing errors in biopsies. The researchers plan to continue measuring fluorescence lifetime parameters in patients with different types of tumors to generate real-time diagnostic classifiers.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
The study uses a new barcode system to track complex signaling activities in cancer cells and identify key protein interactions. The technique enables real-time analysis and synchronization of protein activity over time.
The FDA has approved Cytalux, which enables surgeons to identify and remove cancerous lesions with greater precision. In a Phase 3 study, nearly 27% of women with confirmed ovarian cancer found at least one undetected lesion during surgery.
A SUTD-led study develops brighter, more sensitive fluorophores by suppressing twisted intramolecular charge transfer (TICT) and enhancing photon-induced electron transfer (PET). The research provides design guidelines for dye chemists to rationally tune TICT, PET, and other mechanisms for a wide range of applications.
Researchers have designed a digital camera-based system that can accurately detect jaundice in newborns within one second, sending diagnoses to carers via SMS. The system uses image processing techniques to detect bilirubin levels, triggering blue LED phototherapy and treatment.
Researchers developed a color-changing indicator that detects rising levels of alkaline phosphatase, forecasting phytoplankton growth and impending algal blooms. The portable system reliably detected enzyme activity using smartphone scanning apps, potentially enabling real-time field monitoring and prediction.
Researchers have synthesized a novel organic peroxide mechanophore that releases fluorescence in response to mechanical stress. The compound, bis(9-methylphenyl-9-fluorenyl) peroxide (BMPF), was incorporated into a polymer network and found to retain its ability to release a fluorescent molecule when subjected to grinding or compression.
A new study from the University of Gothenburg introduces an AI-based method to develop faster, cheaper, and more reliable information about cells using microscopy. This approach eliminates the drawbacks of traditional fluorescence microscopy by providing accurate results without damaging cells or inhibiting processes.
Scientists have developed a synthetic fibre that guides molecular movement fueled by light over long distances, paving the way for new sustainable energy sources and applications in medicine and chemical tasks. The system emulates cellular fibres, allowing for controlled transport of molecules using light as energy.
Researchers at the University of Georgia have found that pocket gophers are biofluorescent, emitting a colored glow when illuminated with ultraviolet light. The phenomenon has been documented in flying squirrels and opossums before, but this is the first time it has been observed in pocket gophers.
Researchers developed a new phosphorescent material inspired by wood's natural ability to faintly glow, using lignin trapped within a 3D polymer network. The material glows visibly for around one second and has potential applications in medical imaging, optical sensing, and textile industry.
Chlorophyll fluorescence tracks photosynthesis rate, providing an 'optical window' for monitoring plant health. Recent advances enable estimation and imaging of SIF at ecosystem scales, paving the way for applications in precision agriculture and ecology.
Researchers have successfully synthesized AIE-active nanoparticles in a single step, producing fluorescent sensors that can detect nitroaromatic compounds with high sensitivity. The novel solid-state sensors show quenching of fluorescence emission on contact with PA, enabling fast and accurate detection of explosives.
Researchers at UBCO have developed a data processing technique that expands the effectiveness of fluorescence-based water quality monitoring. This approach addresses the challenge of source-specific models by mapping similarities between water sources, enabling real-time detection of hydrocarbons and pesticides in water.
Researchers developed a novel immunosensor called BRET Q-body, which works on the bioluminescence resonance energy transfer principle. The sensor detects antigens by inducing fluorescence through an enzyme-luminescent substrate reaction, allowing for simple and accurate immunoassay tests.
Researchers found a correlation between heat stress, sun-induced fluorescence, and grain quality, affecting soybean crop yield. The technique may help identify more heat-resistant crops and aid farmers in selecting suitable crops for the U.S. Corn Belt.
Kakshine is a new DNA fluorescent dye with unprecedented versatility, enabling super-resolution imaging of mitochondrial DNA in living cells and deep tissue imaging. Its applications include electrophoresis, quantitative PCR, and flow cytometry, making it a promising tool for DNA analysis.
Researchers demonstrate simultaneous imaging of up to 6 subcellular targets with low crosstalks and high temporal resolutions. They achieve full-frame high sensitivities in quantifying mitochondrial matrix pH and intracellular macromolecular crowding.
Osaka University researchers used a photostabilizer to modulate fluorescence blinking in biochemical assays, allowing for the detection of a cancer RNA biomarker at ultralow concentrations. The technique increases fluorescence and eliminates blinking, providing a clear means to diagnose diseases in early stages.