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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Chain length determines molecular colour

Researchers at ETH Zurich have developed an approach to generate a broad palette of colours by adjusting the chemical structure of molecules themselves. By varying the chain length of fluorescent organic polymers, they can produce polymers with different colours, including yellow, green, and blue.

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Sorting out nanodiamonds with fluorescent centers

Researchers at Hokkaido University have developed a technique to manipulate nanodiamonds with fluorescent centers using opposing lasers. This breakthrough enables the independent control of resonant and non-resonant nanodiamonds, which can be sorted based on their optical properties.

Recurrent neural network advances 3D fluorescence imaging

A new recurrent neural network framework enables fast and efficient 3D imaging of fluorescent samples, reducing scan times by ~30-fold. The approach uses few 2D images to reconstruct 3D images, mitigating photo-bleaching challenges in live sample experiments.

Complex fluid dynamics may explain hydroplaning

Scientists used laser imaging and fluorescent particles to study water flow in tire grooves, finding vortices and bubbles that can contribute to hydroplaning. The study's findings may help improve tread designs to counteract this phenomenon.

How photoblueing disturbs microscopy

Researchers discovered that photobleaching can transform fluorescent dyes into new molecules with altered fluorescence spectra, affecting microscopy results. Simple buffer additions can prevent or even exploit this effect for targeted tracking of specific particles.

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Comb of a lifetime: a new method for fluorescence microscopy

Scientists from Japan develop a novel approach to acquire fluorescence lifetime images without scanning, using optical frequency combs and high-speed single-point photodetectors. This method offers superior speed and high spatial resolution for simultaneous imaging of multiple samples.

Christmas trees can be green because of a photosynthetic short-cut

Researchers at Umeå University discovered a photosynthetic shortcut in pine trees that allows them to stay green year-round. This mechanism, called spill-over, enables the transfer of energy directly between photosystems I and II, protecting the plant from damage caused by excess light energy.

Inverted fluorescence

Researchers have discovered a new class of fluorescent dyes that can convert visible light into ultraviolet light, overcoming one of the biggest challenges to harnessing sunlight for energy. This breakthrough could enable more efficient solar-powered water splitting and other high-energy reactions.

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Quantum nanodiamonds may help detect disease earlier

A new study by UCL researchers used quantum sensing abilities of nanodiamonds to improve the sensitivity of paper-based diagnostic tests, enabling earlier detection of diseases such as HIV. The tests can detect lower viral loads and may be adapted for COVID-19 and other diseases.

Smart fluorescent molecular switches based on boron-based compounds

Scientists have created extremely stable fluorescent molecular switches that can be controlled electrochemically, using a particular redox active anion. These systems show large reversible fluorescence modulation and are soluble in many organic solvents, making them suitable for applications in biosensing, imaging, and drug delivery.

Getting the full scope

Researchers aim to understand how electrical stimulation affects glia and vasculature in the brain, with potential implications for treating neurological diseases. They'll use two-photon microscopy and optogenetics to investigate inner workings of the brain.

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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

What membrane can do in dealing with radiation

Researchers developed a novel γ-radiation intensity sensor using polymethylmethacrylate and polyvinyl chloride membranes. The sensor changes color in response to increasing radiation intensity, allowing for quick and easy measurement.

Fluorescence bioimaging

Researchers at the University of Notre Dame created a new class of near-infrared fluorescent dyes by introducing a voluminous shield to protect against photobleaching. The dye, called s775z, provided stable fluorescence and was quickly cleared from the body, making it suitable for biomedical imaging applications.

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Zoology: Biofluorescence may be widespread among amphibians

A study reveals biofluorescence is widespread among amphibians, including salamanders and frogs, which may aid in finding each other and avoiding predators. The phenomenon's mechanisms are linked to the presence of fluorescent proteins and compounds in skin, secretions, and bones.

Ghost imaging speeds up super-resolution microscopy

Researchers used ghost imaging to enhance the speed of super-resolution microscopy, achieving nano-scale resolution in just 10 image frames. The new approach resolves structures with spatial and temporal resolutions at which biological processes take place.

Chinese team makes nanoscopy breakthrough

A Chinese research team has developed a new technique that enables super-resolution microscopy of living cells with unprecedented speeds and resolutions. The approach, which combines ghost imaging and compressive imaging, can capture processes in living cells on millisecond time-scales with spatial resolution of tens of nanometers.

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Sleep, wake, repeat: How do plants work on different time zones?

Research at Earlham Institute reveals that plant clocks oscillate faster as plants age, with wheat exhibiting more rapid oscillations under constant darkness. The study uses delayed fluorescence to measure daily patterns in crops, enabling breeders to select optimal clock rhythms for improved yields.

A late-night disco in the forest reveals tree performance

Researchers from the University of Helsinki developed a new method to measure chlorophyll fluorescence in trees, revealing information on plant performance and structure. The technique uses LED technology to light up the forest at night, allowing for easier interpretation of data.

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Researchers discover new charge transfer and separation process

Scientists have developed a new charge transfer and separation process called Twisted Intramolecular Charge Shuttle (TICS) that enables faster energy conversion in solar cells and photosynthesis. TICS molecules exhibit a bidirectional, role switching phenomenon, paving a new avenue for chemists to construct unique fluorescent probes.

Polymer reversibly glows white when stretched

Researchers developed a first-of-its-kind elastic polymer blend that displays white fluorescence when deformed and then goes dark after relaxing. The material's color can be tailored by using different fluorescent rings, enabling the creation of a white-light-emitting polymer.

Fluorescence discovered in tiny Brazilian frogs

Researchers found that tiny Brazilian frogs, called pumpkin toadlets, have fluorescent patterns on their backs and heads when exposed to UV light. These patterns are created by bony plates beneath a thin layer of skin, allowing the frog's skeleton to glow under UV illumination.

Tiny 'blinkers' enable simultaneous imaging of multiple biomolecules

Researchers have developed tiny 'blinkers' that can image single molecules of RNA or protein inside cells simultaneously, opening up new possibilities for diagnostics and treatments. The approach uses fluorescent probes that blink with variable duration and frequency to detect dozens of biomolecules at once.

Avoiding the crack of doom

Researchers at NIST have developed a new imaging technique that can observe the effects of strain at the single-molecule level, allowing for better design of composite materials. The technique uses super-resolution optical microscopy to track the alignment of molecules in response to applied force.

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New method uses fluorescence to identify disease-causing forms of proteins

Researchers developed a method using fluorescent compound AggTag to identify intermediate forms of proteins that misfold and aggregate in live cells, which are believed to contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. The method allows for simultaneous detection of multiple proteins with distinct colors.

Green fluorescence from reef-building corals attracts symbiotic algae

Researchers discovered that corals emit green fluorescence, attracting symbiotic dinoflagellates and potentially aiding coral recovery after bleaching. This biological signal enhances the chances of meeting new symbionts, suggesting a possible mechanism for corals to recover from heat stress-induced losses.

Corals light the way to a healthy partnership

Researchers discovered that corals use green fluorescent light to signal the presence of Symbiodinium, a type of mobile microalgae critical to the establishment of a healthy partnership. The study found that this 'positive phototaxis' mechanism enables corals to attract Symbiodinium, which provide essential nutrients via photosynthesis.

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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.

Burst of morning gene activity tells plants when to flower

A team of researchers discovered that flowering plants exhibit a morning peak of gene activity, contrary to the previously established evening peak theory. The study, conducted in natural environments, suggests that artificial growing conditions used in labs may have influenced earlier findings.

New patch boosts brightness in medical diagnostic tests

A new patch developed at Washington University in St. Louis increases fluorescence intensity by 100 times, making it easier to visualize and diagnose low-abundance analytes. The plasmonic patch is a cheap fix that can be applied to existing diagnostic tests without requiring any protocol changes.

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Bees love blue fluorescent light, and not just any wavelength will do

Researchers at Oregon State University discovered that bees are attracted to blue fluorescent light, particularly within a specific wavelength range of 430-480 nanometers. This finding has significant implications for bee population assessment and manipulation, such as attracting large numbers of bees for crop pollination.

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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

Operating on brain gliomas by detecting the 'glow'

A new surgical imaging instrument using Scanning Fiber Endoscope (SFE) technology has been developed to detect the fluorescent glow of malignant brain tumors. This allows neurosurgeons to visualize the tumor more accurately, enabling them to remove more tissue and potentially improve patient outcomes.

Ultrathin endoscope captures neurons firing deep in the brain

Scientists have created an ultra-thin fiber-based endoscope that can image neurons firing in living mice, offering new insights into brain function. The device is five times thinner than the smallest commercially available microendoscopes and allows for deeper brain imaging without damaging tissue.

Zoology: Luminescent lizards

Chameleons' bony tubercles on their heads emit blue fluorescent light when exposed to UV, creating distinct patterns that aid in species recognition. This phenomenon was previously unknown and is believed to play a role in mate attraction.

Tuning the wavelength of fluorescent carbon tubes

Researchers at Kyushu University developed a method to tune the fluorescence wavelength of carbon nanotubes by tethering organic molecules. This enables fine control over the emission wavelength, with potential applications in biomedical devices and bioimaging.

The electronic origins of fluorescence in carbon nanotubes

Researchers at Kyushu University used spectro-electrochemistry to investigate the frequency shifts in infrared fluorescence of modified carbon nanotubes. They found that the gaps between electron energy levels depend on the elements bonded to the exterior of the nanotubes.

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Bright and shining molecules for OLEDs and new drugs

A new technique for synthesizing thiophene derivatives has been developed, offering a convenient and effective two-step procedure. The compounds exhibit promising photophysical properties, including fluorescence, making them suitable for various applications, including OLEDs and potential biomedicine uses.

Tech increases microfluidic research data output 100-fold

North Carolina State University researchers have developed a novel microfluidic platform called NanoRobo, which can collect up to 30,000 spectrographic information points per day. This technology enables the rapid discovery and screening of colloidal semiconductor nanocrystals, such as perovskite quantum dots, used in LEDs.

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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.

Materials governed by light

Hybrid materials combining organic and inorganic components show promise for various applications, including optics and biomedicine. The materials display enhanced photophysical properties, such as anisotropic response to polarized light and artificial antenna effects.

Artificial fluorescent membrane lipid shows active role in living cells

Researchers at Osaka University developed artificial fluorescent membrane lipids that mimic sphingomyelin and interact with proteins, enabling the study of complex cellular processes. The findings reveal dynamic behavior of SMs associated with CD59 and plasma membranes, offering insights into modifying molecular interactions.

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Researchers shed new light on influenza detection

A new study by University of Notre Dame researchers has led to the development of a test kit for detecting influenza using fluorescent light. The test kit emits red fluorescence when exposed to infected patient samples, indicating the presence of the virus.

More exact, ethical method to tell the sex of baby chickens

Researchers have developed a non-destructive imaging technique to accurately determine the sex of baby chickens within four days of hatching, promising to reduce animal welfare concerns. The technique uses optical spectroscopy to identify gender-specific biochemical differences in embryonic blood, with an accuracy rate of 93%.

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Dipole orientation: New dimension in super-resolution microscopy

A new polarization-dipole azimuth-based super-resolution technique has been proposed, addressing a long-standing debate on the role of fluorescence polarization in super-resolution imaging. The technique uses SDOM technology to improve spatial resolution and detection accuracy, revealing interesting findings in biological samples.

New tool enables viewing spectrum from specific structures within samples

Researchers at the University of Chicago created a new tool to view the spectrum from specific structures within samples. The instrument, a spatially selective microscope, allows users to zero in on the spectrum from specific regions of interest and capture standard fluorescence images of the whole field of view.

Laser particles could provide sharper images of tissues

Scientists at MIT and Harvard University developed a new imaging technique called LASE microscopy, which uses tiny particles to create sharper images of deep tissue and cells. The particles emit laser light when stimulated by a laser beam, resulting in higher-resolution images.

Lighting type affects ground beef color

Researchers found that ground beef color fades quickly due to light exposure, but LED lights can slow down this process. The study showed that LED lighting retained a better red color on day 5 compared to fluorescent lighting.

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

New instrument could search for signatures of life on Mars

A new instrument prototype, BILI, uses fluorescence-based lidar to search for organic bio-signatures on Mars and other targets in the solar system. The instrument can scan terrain from a distance of several hundred meters, detecting small levels of complex organic materials in real-time.