Articles tagged with Optical Microscopy
Researchers found specialized astrocytes in mouse brains that can repopulate damaged areas and rebuild cells. These 'regenerative' astrocytes send newly formed cell nuclei to the site of injury, knitting the network back together.
The COCOON Lab provides a coordinated suite of microscopes that work together to connect macro-scale observations to findings at the nanoscale. This allows researchers to study biological and industrial materials in unprecedented detail, from the macroscale down to the molecular scale.
Researchers developed a non-contact optical sensing strategy to detect ethanol molecules in air using light-field distortions and deep learning. The system employs a graphene-based Fresnel lens to focus light through interference, capturing minute changes in the focal spot formed by the lens.
A new design for microscopes and microscope lenses, called HySIL, addresses both problems by pairing a simple solid lens with a precisely matched immersion liquid. This enables inexpensive air lenses to deliver high-resolution images across centimeter-scale tissues.
Scientists have directly imaged the effect of short current pulses on skyrmions, finding that they break up into disordered patterns before re-forming in a predictable manner. This discovery opens up new possibilities for computing concepts like probabilistic computing.
Researchers at Max Planck Institute for the Science of Light create a 'map' of glycocalyx by mapping individual sugar structures using super-high-resolution microscopy technology. The results show that the spatial arrangement of sugar structures relates to cell physiological state, providing a structured display to the outside world.
Researchers at University of Witwatersrand and University of East Anglia have discovered a way to control light by exploiting its natural geometry. Light can develop chiral behavior, meaning it acts like left or right hand, while traveling freely through space, without mirrors or special materials.
Salk scientists and collaborators advance visualization technology using visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), reducing background fluorescence by up to a hundredfold. The new probe enables high spatial and temporal precision, allowing for real-time tracking of dynamic changes in living models.
Researchers at DZNE discovered complex, situation-dependent interactions between glioblastoma cells and microglia in the brain. The study found that microglial activity changes as tumors spread, influencing containment and spread of the disease.
Researchers developed MAPPI, a system that enables real-time visualization of how a plant's leaves, stem, and roots communicate with each other in response to environmental stress. The system reveals bi-directional communication between leaves and roots, overcoming limitations of traditional microscopy.
Researchers demonstrate polarization-based microscopy as a tool for EDS diagnosis, detecting structural signatures in unstained biopsy samples. The study identifies five parameters that can differentiate classical from hypermobile EDS, reflecting variations in collagen organization.
For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum and transition onto microtubule tracks inside living cells. The study reveals that the ER plays an active role in steering intracellular traffic.
A €150,000 ERC Proof of Concept Grant will help physicist Daqing Wang integrate his
A multidisciplinary team developed a dual-scale Capillary-Cell microscope to visualize tumor metabolism and vasculature dynamics. The platform revealed complex relationships between tumor vascular network and metabolic behavior, highlighting distinct adaptations based on local conditions.
Researchers at IIT develop optical microscopy technique that combines polarization and dark-field microscopy to observe cells with high contrast, preserving their natural conditions. The next step involves using AI to enrich images with molecular information related to diseases.
Researchers from the UJI Optics Group have developed a new method to correct image aberrations in single-pixel microscopy using a deformable lens. This approach combines an adaptive lens with a sensor-less method that evaluates image sharpness directly from the data, producing sharper images close to the physical resolution limit witho...
Researchers at the University of Tokyo have developed a new microscope that can detect signals over an intensity range 14 times wider than conventional microscopes, enabling label-free observations of cells and particles.
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization, overcoming phototoxicity and halo artifacts. ExAPC microscopy captures biomolecular condensate-like structures and cellular responses to drugs.
Scientists at Max Born Institute develop technique to generate µJ-level tunable few-fs UV pulses in VUV range. They successfully characterized few-fs pulses tuned between 160 and 190 nm using electron FROG, revealing pulse duration of 2-3 fs.
Scientists have successfully measured ultrafast electric fields using a diamond nonlinear probe, achieving femtosecond temporal and nanometer spatial resolution. This breakthrough enables the detection of local electric field dynamics near surfaces with unprecedented precision.
A new computational method, DIGIT, enables optical microscopes to resolve individual atoms and zero in on their exact locations in a crystal structure. This technique can help guide the design of quantum devices and provide insights into advanced materials.
Researchers at the University of Stuttgart have developed a new method to detect tiny nanoplastic particles using an optical sieve, which is less expensive and faster than traditional methods. The test strip can be used to analyze environmental samples, blood or tissue for nanoplastic particles.
Cryo-optical microscopy captures high-resolution, quantitatively accurate snapshots of dynamic cellular processes at precisely selected timepoints. This technique enables the observation of transient biological events with unprecedented temporal accuracy.
Scientists at the Max Planck Institute for the Science of Light developed a new method to resolve specific sites within mechanosensitive protein PIEZO1 in its native cell membrane state. The technique, using cryogenic conditions and rapid freezing, sheds light on how the protein flexes and expands in response to mechanical stimuli.
A new microscopy technique allows scientists to observe active cells, even in the presence of diseases, and understand how drugs interact with living tissues. The technique has been made available to the scientific community as Open Science, enabling rapid dissemination and further innovation.
A new method using label-free optical microscopy and artificial intelligence effectively identifies disease phenotypes in pancreatic cancer. The approach achieved nearly 90% accuracy in predicting tissue phenotypes, demonstrating the promise of combining light-based imaging with AI for precision medicine.
Researchers at Aston University have developed a new class of ultralow loss optical microresonators that can be widely tunable and precisely controlled. The devices, formed at the intersection of two optical fibers, hold potential applications in communication, computing, sensing and more.
A new microscopy method, LICONN, developed by ISTA scientists and Google Research, can reconstruct mammalian brain tissue with all synaptic connections between neurons. This technique uses standard light microscopes and hydrogel to achieve high resolution and opens up possibilities for visualizing complex molecular machinery.
A novel cannula delivery system allows repeated, nondisruptive delivery of imaging agents to the mouse brain during long-term multiphoton microscopy. This innovation enhances longitudinal studies on brain function, disease progression, and potential treatments.
Researchers used video microscopy to explore extreme field sites on Earth, finding signs of microbial life in hot deserts, Arctic ice, and alkaline springs. The study highlights digital holographic microscopy as a tool for detecting life in space samples.
Scientists developed a method that harnesses chromatic aberration to produce high-quality images using a single exposure. The AI approach uses generative models to retrieve phase information from limited data input.
Researchers have made a breakthrough in creating artificial chiral-structural-color materials, exhibiting iridescent colors through microscopic structures that interact with light. The new discovery enables the creation of microdomes composed of widely available polymers that produce exceptional dissymmetry and polarization selectivity.
Researchers at TUM developed a new microscopy technique combining magnetic resonance spectroscopy with fluorescence microscopy, enabling high-resolution imaging of individual cells and structures down to the microscopic level. The technique has potential applications in cancer research, pharmaceuticals, and materials science.
A new hybrid microscope allows scientists to image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. This can reveal the real biology hidden from just a position change of a molecule alone.
Researchers have created a new imaging technique that uses the nanostructures found on butterfly wings to analyze cancerous tissues, providing a simpler and more accessible tool for cancer diagnosis. The method has shown comparable results to conventional staining methods and advanced imaging techniques, offering a stain-free alternative.
Researchers have made a significant leap forward in Brillouin microscopy, providing a 1,000-fold improvement in speed and throughput. The new technology enables full-field imaging with minimal light intensity, opening up new possibilities for life scientists.
Genoa Instruments has secured €1 million funding to expand its market presence, develop new products, and democratize access to super-resolution microscopy. The company aims to enable researchers and professionals worldwide to access cutting-edge imaging technology.
Ultrafast nano-spectroscopy and nano-imaging enable atomic-scale spatial and femtosecond-level temporal resolutions, allowing for the direct observation of fleeting quantum states and complex phenomena. This breakthrough permits real-time exploration of ultrafast interaction processes with unprecedented insights into material properties.
Researchers have developed an AI framework called XLuminA that autonomously discovers new experimental designs in microscopy. The framework performs optimizations 10,000 times faster than well-established methods, opening the path for exploring completely new territories in microscopy.
Researchers achieved control over competing reaction outcomes by selectively manipulating charge states and specific resonances through targeted energy injection. This breakthrough has profound implications for pharmaceutical research, potentially improving efficiency and sustainability.
Researchers introduce a new approach for megapixel-scale fluorescence microscopy through complex scattering media, resolving high-resolution images without requiring specialized equipment. This technique efficiently corrects distortions caused by light scattering, enabling clear imaging of dense targets.
A new computational model called Multi-Stage Residual-BCR Net (m-rBCR) uses a unique frequency representation to solve deconvolution tasks with fewer parameters and faster processing times. The model demonstrates high performance on various microscopy datasets, outperforming traditional methods.
Researchers at Tokyo University of Science have successfully captured viral infection process under a light microscope using the giant Mimivirus. The footage showcases the proliferation of the virus and its release from cells, highlighting its biological significance in ecosystems.
A new type of cationic epoxy photoresist exhibits greater sensitivity to two-photon laser exposure, enabling fast writing speeds and fine features. The material was developed by a research team led by Professor Cuifang Kuang, who achieved lithography speeds of 100 mm/s and resolution of 170 nm.
Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.
Researchers used x-ray microtomography to discover and describe 12 new weevil species from Japan, Malaysia, Vietnam, and Taiwan. The technique revealed significant morphological differences between species, which cannot be easily observed using other methods.
Researchers introduce a novel computational holography-based method for high-resolution, non-invasive imaging through highly scattering media. The technique drastically reduces measurements required and corrects over 190,000 scattered modes using just 25 holographic frames.
Scientists have developed MINFLUX microscopy to measure distances within biomolecules, down to one nanometer, and with Ångström precision. This allows for the detection of different conformations of individual proteins and the observation of their interactions.
Researchers successfully visualized tiny magnetic regions, known as magnetic domains, in a specialized quantum material using nonreciprocal directional dichroism. They also manipulated these regions by applying an electric field, offering new insights into the complex behavior of magnetic materials at the quantum level.
A new microscope-integrated OCT system has been developed to identify tumor margins during brain surgery, providing high-resolution images of subsurface anatomy. The system has shown promising results in clinical studies, with the potential to improve outcomes for neurosurgery procedures.
A new smartphone-based digital holographic microscope enables precise 3D measurements and has potential applications in medical diagnostics, education, and resource-limited settings. The portable device uses a simple optical system created with a 3D printer and calculates reconstructions based on a smartphone.
Researchers at the University of Arizona developed a transmission electron microscope with attosecond temporal resolution, allowing scientists to observe electron motion in real-time. This breakthrough enables studies of ultrafast processes at the atomic level, paving the way for advancements in physics and chemistry.
A new study enables the reconfiguration of nanoparticles, a step toward smart materials and coatings. The approach combines electron microscopy, computer simulations, and microscopic channels, allowing researchers to watch how nanoparticles react to changes in their environment.
Researchers developed DeepLens design method based on curriculum learning to optimize complex lens designs. The approach considers key parameters like resolution, aperture, and field of view, providing optimal solutions without human intervention.
Researchers at the University of Göttingen developed a new approach to analyze cell properties, using random fluctuating movement of microscopic particles. The method, called mean back relaxation (MBR), can distinguish between active processes and temperature-dependent processes.
Researchers used optical metabolic imaging to study the effects of Toxoplasma gondii infection on host cells. They found that infected cells became more oxidized and had changes in glucose and lactate levels, highlighting the parasite's impact on metabolism.
The Marine Biological Laboratory has introduced two new microscopes for biological and biomedical research, providing a valuable resource for scientists and students. The instruments enable correlative imaging, allowing researchers to confirm results in different ways, and are expected to influence further development of advanced imagi...
Researchers at Caltech have developed a new microscopy technique called APIC that can produce clear, high-resolution images covering large fields of view without the need for iterative trial-and-error methods. This breakthrough eliminates guesswork and allows for faster, more accurate image acquisition.
A new microscope developed by Rockefeller University's Alipasha Vaziri and team captures broad swaths of brain activity with unprecedented resolution. The lightweight microscope, weighing only a US penny, images the mouse brain across a 3.6 x 3.6 mm field of view with 4 μm lateral resolution.
Researchers at HHMI's Janelia Research Campus have adapted a phase diversity method from astronomy to microscopy, generating clearer images of thick biological samples. The new method is faster and cheaper to implement than current techniques, making adaptive optics more accessible to biologists.