Articles tagged with Optical Microscopy
A new type of optical manipulation has been developed, using laser light to pull macroscopic objects. The researchers designed a graphene-SiO composite structure specifically for laser pulling, which creates a reversed temperature difference when irradiated with a laser beam.
Researchers have developed a technique to record cellular events in a long protein chain, allowing them to reconstruct the timing of gene activation, response to drugs, and other processes. This method has potential applications in understanding memory formation, aging, and disease progression.
New expansion microscopy methods, dubbed Magnify, allow researchers to observe nanoscale biological structures with standard microscopes. The protocol retains biomolecules intact, enabling simultaneous imaging of proteins, lipids, and carbohydrates.
A new parallel peripheral-photoinhibition lithography system has been developed, enabling the fabrication of subdiffraction-limit features with high efficiency. The system uses two beams to excite and inhibit polymerization, allowing for nonperiodic and complex patterns to be printed simultaneously.
A new mesoscopic oblique plane microscopy method captures up to three times more resolvable image points than other similar systems, enabling whole-body volumetric recordings of neuronal activity and blood flow dynamics. The technique allows for single-cell tracking within the complete 3D circulation system for the first time.
Researchers developed a photon-efficient volumetric imaging method, laterally swept light-sheet microscopy (iLSLM), which improves axial resolution and optical sectioning while reducing photobleaching. iLSLM outperforms conventional methods like swept focus light-sheet microscopy in terms of resolution and photon efficiency.
A new analysis confirms that ancient Roman coins featuring the portrait of 'Sponsian' are genuine, suggesting he was a real leader who ruled Roman Dacia in the 260s CE. The study used advanced microscopy and spectroscopy techniques to analyze the coins and uncover evidence of their authenticity.
A gold coin long dismissed as a forgery appears to be authentic and depicts Emperor Sponsian, who ruled Roman Dacia during civil wars. The study used scientific analysis to confirm the coin's authenticity, shedding light on Sponsian's history.
Researchers studied diatom shells to understand how they perform photosynthesis in low-light conditions. They found that the frustule can contribute a 9.83% boost to photosynthesis, especially during transitions from high to low sunlight.
Researchers used a terahertz scanning probe microscope to investigate Methylammonium Lead Iodide perovskite, a potential alternative to silicon in solar cells. The team found significant variation in light scattering along grain boundaries, shedding light on the material's degradation issue.
Researchers develop hybrid brightfield-darkfield transport of intensity approach, expanding accessible sample spatial frequencies and achieving 5-fold resolution increase. This method enables precise detection and quantitative analysis of subcellular features in large-scale cell studies.
A team of scientists developed a new model to overcome optical measurement instruments' diffraction effects, enabling local improvement of lateral resolution and magnification enhancement. The model reliably reproduces measurement results and demonstrates the relative improvement of lateral resolution.
Researchers can now study microplankton at an individual level using holographic microscopy and AI, gaining a deeper understanding of their movement, growth, reproduction, and interactions. This breakthrough provides new insights into the ocean's oxygen production and carbon cycle.
Researchers from the University of Kassel developed an approach to extend the limits of interferometric topography measurements for optical resolution below small structures. Microsphere assistance enables fast and label-free imaging without requiring extensive sample preparation.
The Beckman Institute has established a new national collaborative Biomedical Technology Research Resource to develop label-free optical imaging technologies. The center aims to create optical and computational imaging technologies that can serve as a resource for clinicians and researchers.
A Cornell University researcher is using optical microscopy and other tools to map the brain's neural response to psychedelics. The study aims to develop fast-acting antidepressants and treatments for substance-use disorders and cluster headaches.
A team at KAUST has created an ultrathin dielectric metalens that improves focusing capabilities and can be scaled down for integration with photonics equipment. The metalens, designed from a custom array of TiO2 nanopillars atop a DBR, offers negligible intrinsic loss and easy fabrication.
Conscious perception of sound generates specific neuronal assemblies in the brain, differing from spontaneous brain activity. Under anesthesia, similar assemblies are present but lack sound-specificity, highlighting the importance of cortical creativity in sensory processing.
Physicists have introduced a new technique for 3D nanoscale elemental analysis using ion-electron microscope systems, improving resolution to 15 nanometres and detecting hard-to-characterise elements like hydrogen and lithium. This device can be retrofitted to existing focused ion beam systems, optimizing the characterisation workflow.
Researchers have developed a new DNA nanotechnology-driven method called Light-Seq that enables the analysis of gene expression patterns in hard-to-access cells within intact tissues. This approach overcomes limitations of existing spatial transcriptomics methods, allowing for deeper understanding of disease mechanisms and biology.
The researchers used a 3D laser printing approach to create high-quality, complex polymer optical devices directly on the end of an optical fiber. The device turns normal laser light into a twisted Bessel beam with low diffraction and can be used for applications like STED microscopy and particle manipulation.
Researchers developed a metasurface device with three working modes, exploiting nanostructures to manipulate light and create holographic or structural-color nanoprinting images. The device offers two layers of security for anticounterfeiting measures, providing a simple yet effective approach to fight against counterfeiting.
Researchers at Universiteit van Amsterdam use fluorescence microscopy and specialized molecules to study the transition from static to dynamic friction. They find that a slip wave propagates from the edge towards the center of the contact area just before sliding occurs.
Researchers have developed a flexible endoscopic imaging probe using a bendable graded index (GRIN) lens, enabling 3D microscopic imaging of tissue. The new technology could shorten biopsy waiting times to minutes and enable real-time monitoring of tissue changes.
Researchers developed a new holographic microscope that can see through the intact skull and image the neural network of a living mouse brain with high resolution. The technology uses a wave correction algorithm to filter out multiple scattered light waves, allowing for sharper images.
Researchers found that developing sea anemones use hydraulic muscles to regulate body pressure and sculpt tissue. The more active larvae are, the longer they take to develop, suggesting a trade-off between movement and growth.
A novel 937-nm laser source has been developed for multiphoton microscopy, enabling deep tissue imaging at depths of over 600 µm with only 10 mW of power. This breakthrough technology offers a good balance between sensitivity, penetration depth, and imaging speed.
Researchers developed a high-resolution holographic endoscope system that can reconstruct microscopic images without attaching equipment to the fiber bundle. The new endoscope has a diameter of 350 μm and achieves spatial resolution of 850 nm, far smaller than the core size of optical fibers.
The report explores diffuse optical imaging methods applicable to noninvasive human studies, including near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). It introduces state-of-the-art technologies and software, exploring their impact on neuroscience and clinical applications.
A homemade microspectrometer invented by Dr. Jamie Laird enables scientists to image defects in perovskite solar cells, improving stability and efficiency. This innovative technique has the potential to revolutionize next-generation photovoltaics, including space missions.
Researchers at Texas A&M University created a device that harnesses quantum fluctuations to enhance spectroscopy results in Brillouin microscopy, increasing image clarity and accuracy. The new source significantly improves the signal-to-noise ratio, allowing for better visualization of biological structures and properties.
Customized fibers have been engineered to generate Bessel beams, opening up new applications in imaging and communications. The fibers use a technique called two-photon lithography to fabricate special beam-shaping elements, enabling the creation of compact Bessel beam generators.
A newly developed polarizer-embedded metalens microscope system achieves high-quality, wide-field imaging with a large depth-of-field, significantly expanding human eyesight to the microworld. The chip-scale device offers a thousand-fold reduction in volume and weight compared to traditional microscopes.
Researchers have developed a new method to generate flexible needle-shaped laser beams, extending the depth-of-focus for optical coherence tomography (OCT) imaging. This allows for improved lateral resolution, signal-to-noise ratio, contrast, and image quality over a long depth range.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A research team from Japan has developed a stable TERS system that enables characterization of defect analysis in large-sized WS2 layers at high pixel resolution. The team successfully imaged nanoscale defects over a period of 6 hours in a micrometer-sized WS2 film without significant signal loss.
Researchers from Politecnico di Milano have developed a programmable photonic processor that can separate and distinguish optical beams even if they are superimposed. This device allows for high-capacity wireless communication, with transmission rates of over 5000 GHz.
Researchers developed a novel frequency-domain method to selectively suppress background noise in STED microscopy, achieving higher spatial resolution and improved signal-to-noise ratio. The approach has potential applications in various dual-beam point-scanning techniques.
A research team developed a novel super-resolution microscopy technique combining metal-induced energy transfer and single-molecule localization microscopy. The method achieves isotropic three-dimensional imaging of sub-cellular structures, allowing for high-resolution analysis of protein complexes and organelles.
Researchers from Delft University of Technology demonstrate that iterative modulation enhanced single-molecule localization microscopy has fundamental limitations, predicting a maximum improvement of five times compared to standard techniques. The study provides a method for informed choices and sheds light on the underlying science.
Researchers at Chalmers University of Technology have developed a groundbreaking microscopy technique that allows for the study of proteins, DNA, and other biological particles in their natural state. This innovation enables earlier detection of promising drug candidates and provides valuable insights into cell communication processes.
A new EU project, DeLIVERY, aims to develop a microscopy system for liver cells to test tolerability of drug interactions. The system will enable researchers to observe how liver cells react to different medications, dosages, and combinations, potentially leading to improved patient safety.
A HKUST research team developed a microscope combining 3PM with adaptive optics, achieving high-resolution imaging of neuronal structures in mouse cortices up to 750µm below the skull. This technology holds great potential to advance in-vivo imaging techniques and facilitate study of living brain.
The new technique, 3D optical coherence refraction tomography (3D OCRT), produces highly detailed images revealing features difficult to observe with traditional OCT. It has the potential for biomedical research and eventually more accurate medical diagnostic imaging.
Researchers at the Lew lab have created a novel hardware and algorithm that enables visualization of cell membranes and molecular motions in six dimensions. This breakthrough allows for the observation of 3D structures with additional information on molecular orientation, providing new insights into biological systems.
Biomedical engineers at Duke University have created a method to scan and image the blood flow and oxygen levels inside a mouse brain in real-time. The new imaging approach breaks long-standing speed and resolution barriers, enabling researchers to uncover insights into neurovascular diseases like stroke, dementia, and acute brain injury.
A team of researchers has combined expansion microscopy and stimulated Raman scattering microscopy to create a new imaging technique called MAGNIFIERS. This allows for the high-resolution imaging of biomolecules, including proteins, lipids, and DNA, at the nanoscale.
Researchers developed a self-alignment attention-guided deep learning architecture to improve resolution and speed in label-free nonlinear optical microscopes. The technique achieved high-quality reconstruction with significant speed-ups and spatial resolution enhancements.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
A new measurement and imaging approach resolves nanostructures smaller than the diffraction limit without dyes or labels, using polarization and angle-resolved images of transmitted light. The method measures particle size and position with high accuracy, closing the gap between conventional microscopes and super-resolution techniques.
Researchers at Gwangju Institute of Science and Technology (GIST) have developed a new technique to easily visualize viruses using an optical microscope, called the Gires-Tournois immunoassay platform. The platform uses 'slow light' technology to detect coronavirus particles by slowing down light that gets reflected around them.
Researchers developed a new framework to extract meaningful vectorial metrics from Mueller matrix elements, providing insights into exotic material characterization and precise cancer boundary detection. The framework establishes a universal metric for calculating different physical properties of target objects.
Researchers at the University of Illinois created quantum dots to visualize macrophages in fat tissue, shedding light on chronic inflammation's role in diseases. The new technology enables accurate cell counting and tracking over time, offering a potential diagnostic tool for insulin resistance and metabolic syndrome.
Researchers used light sheet microscopy to visualize the inner structures of a living fungus, Sordaria macrospora, without damaging it. They achieved high-resolution images and 3D reconstructions using Bessel beams, which provided uniform illumination and minimized optical properties issues.
The new device, Bio-FlatScope, uses a custom algorithm to reconstruct images of micron-scale targets like cells and blood vessels inside the body. The light captured by Bio-FlatScope can be refocused after the fact to reveal 3D details, making it potentially valuable for detecting cancer or sepsis.
Researchers are developing a new SWIR surgical microscope system to detect and remove cholesteatomas, a type of chronic otitis media. The microscope uses short-wave infrared light to illuminate blood, bacterial biofilms, cartilage, and soft tissue, making them distinguishable from each other.
An international research team developed nanometric light modulators to study neuronal tissue in deep brain regions. The new approach enables the creation of minimally invasive neural probes that can be used to study specific brain diseases, including brain tumors and epilepsy.
Researchers from Washington University in St. Louis have discovered that the pore size of a battery separator plays a crucial role in determining the stability and safety of a battery. The study reveals that smaller pores can lead to localized metal ion penetration and increased risk of short circuits.
A team of Penn State researchers developed a transparent, biocompatible ultrasound transducer chip for easy cell culture and stimulation. The chip enables high-resolution imaging and reproducible results in stem cell, cancer, and neuroscience research.
Researchers developed a vortex microscope that captures detailed motion and rotation of molecules in liquid. The technique provides unprecedented insight into molecular dynamics, enabling the study of diseases like Alzheimer's.