Articles tagged with Optical Microscopy
Researchers used light sheet microscopy to visualize the inner structures of a living fungus, Sordaria macrospora, without damaging it. They achieved high-resolution images and 3D reconstructions using Bessel beams, which provided uniform illumination and minimized optical properties issues.
The new device, Bio-FlatScope, uses a custom algorithm to reconstruct images of micron-scale targets like cells and blood vessels inside the body. The light captured by Bio-FlatScope can be refocused after the fact to reveal 3D details, making it potentially valuable for detecting cancer or sepsis.
Researchers are developing a new SWIR surgical microscope system to detect and remove cholesteatomas, a type of chronic otitis media. The microscope uses short-wave infrared light to illuminate blood, bacterial biofilms, cartilage, and soft tissue, making them distinguishable from each other.
An international research team developed nanometric light modulators to study neuronal tissue in deep brain regions. The new approach enables the creation of minimally invasive neural probes that can be used to study specific brain diseases, including brain tumors and epilepsy.
Researchers from Washington University in St. Louis have discovered that the pore size of a battery separator plays a crucial role in determining the stability and safety of a battery. The study reveals that smaller pores can lead to localized metal ion penetration and increased risk of short circuits.
A team of Penn State researchers developed a transparent, biocompatible ultrasound transducer chip for easy cell culture and stimulation. The chip enables high-resolution imaging and reproducible results in stem cell, cancer, and neuroscience research.
Researchers developed a vortex microscope that captures detailed motion and rotation of molecules in liquid. The technique provides unprecedented insight into molecular dynamics, enabling the study of diseases like Alzheimer's.
A new microscope allows for real-time aberration-free dynamic speckle microscopy using compressed time-reversal matrix technology. This enables almost real-time volumetric adaptive optical imaging with reduced data acquisition time and improved lateral resolution.
Scientists successfully image a single ion in an ion trap system on nanosecond timescale, achieving resolution beyond 175 nm. The technique also demonstrates sub-10nm positioning accuracy and time resolution of 50 ns.
Researchers at NIST developed new standards and calibrations for optical microscopes, enabling accurate measurement of microdroplet volumes smaller than 100 trillionths of a liter. They combined microscopy with gravimetry to verify results, linking their findings to fundamental constants of nature.
A new device has been developed that converts sunlight into two promising sources of renewable fuels – ethylene and hydrogen. The researchers found that by optimizing the working conditions for cuprous oxide, a promising artificial photosynthesis material, they can create a more stable system.
A team from the University of Washington has developed a non-destructive 3D imaging method that can help doctors more accurately diagnose borderline cases of prostate cancer. The new approach uses 3D images to identify complex features in tissue samples, which can increase the likelihood of correctly predicting a cancer's aggressiveness.
Scientists at Chalmers University of Technology discovered a way to create a stable resonator using two parallel gold flakes in a salty aqueous solution. The structure can be manipulated and used as a chamber for investigating materials and their behavior, with potential applications in physics, biosensors, and nanorobotics.
Researchers from UC Riverside developed a revolutionary imaging technology that compresses light into a nanometer-sized spot, allowing for unprecedented 6-nanometer color imaging of nanomaterials. This advance improves the study of unique properties and potential applications in electronics and other fields.
The new quantum microscope uses entangled photons to create interference patterns on the sample, reducing noise levels and increasing sensitivity by over 25%. This allows for high-resolution imaging of transparent cells without damaging them.
A team of scientists has developed a novel method to characterize microscope objectives without an aberration-less reference element, enabling error correction and precise data collection. Using nanoscale dipole scatterers, they create a nearly-perfect reference wave for measurement.
Researchers from The University of Tokyo Institute of Industrial Science used microscopy to examine surfactant onion layers, discovering they contain defects. Their findings are crucial for designing effective therapeutic carrier systems.
Optical coherence tomography (OCT) has significant growth potential across various medical applications, including cardiology and dermatology. Miniaturized OCT systems are expected to revolutionize healthcare with compact, mobile, and cost-effective devices.
Researchers discovered that living cell interiors become softer and more fluid during mitosis, a process crucial for life. The findings could help ensure precise separation of cellular structures into daughter cells.
Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.
A team developed a smart microscope that adapts to curved biological surfaces, reducing irradiation by up to 100 times. This breakthrough technology enables long-term imaging of fragile objects like embryos and organoids.
A new study from the University of Gothenburg introduces an AI-based method to develop faster, cheaper, and more reliable information about cells using microscopy. This approach eliminates the drawbacks of traditional fluorescence microscopy by providing accurate results without damaging cells or inhibiting processes.
La Trobe University researchers developed a smart microscope slide that can detect cancer cells using enhanced color contrast. The technology uses nanoscale modifications to distinguish cancer cells from normal tissue, making early diagnosis more efficient.
A team from The University of Tsukuba used microscopy techniques to analyze the microstructure of the ground beetle's wing casing, revealing a unique helical structure that creates optical effects. This finding has significant implications for the development of new biomimetic materials with enhanced performance.
GIST scientists utilized latest advances in single molecule detection to observe the enzymatic activity of gene repair. The study revealed that ExoIII has an affinity for damaged DNA sites, creating a gap that Pol I fills. Understanding this mechanism may lead to technologies for targeted gene repair and drug development.
A team of researchers from the Beckman Institute for Advanced Science and Technology has developed a fast, accurate, and cost-effective COVID-19 test. Using label-free microscopic imaging combined with artificial intelligence, they can detect and classify SARS-CoV-2 in under one minute.
The university will acquire an optical tweezer to study colloidal copolymer chains, protein binding strength and other phenomena. The instrument will be made available to Rice researchers and collaborators.
Researchers from DTU develop Fano laser, harnessing bound-state-in-the-continuum to improve coherence. This advancement enables ultrafast and low-noise nanolasers for high-speed computing and integrated photonics.
Researchers have developed a dye-free method to visualize blood flow in the brain, allowing for detailed mapping of small capillaries and assessing blood flow rates. The technique has potential applications in understanding cardiovascular diseases, tumor growth, and targeted drug delivery.
Researchers have developed DiLFM, a dictionary-learning-based light-field microscopy that improves noise resistance and reduces artifacts. The method combines sparse signal representation and dictionary patching to produce high-quality volumetric imaging.
Scientists detected electronic and optical interlayer resonances in bilayer graphene by twisting one layer 30 degrees, resulting in increased interlayer spacing that influences electron motion. This understanding could inform the design of future quantum technologies for more powerful computing and secure communication.
Researchers developed a colorization method via color transfer termed CFPM, significantly reducing reconstruction time by 2/3 without sacrificing precision. This technique enables high-throughput full-color imaging in digital pathology.
Scientists developed a label-free optical microscopy approach that can image deep brain cells with high resolution and minimal invasiveness. They used the 1700 nm water absorption window to visualize neuronal cell architecture across the entire depth of the mouse neocortex, revealing severe pathology in deep but not superficial cortex.
Researchers at UNIST developed a new optical microscope technology that can image deeper into biological tissues. By limiting the numerical aperture of incident wavefronts, they improved focus peak to background ratio and energy delivery throughput.
The new method uses a simple unit consisting of two rotating mirrors to form projections from multiple angles, bypassing the need to acquire image stacks. This allows for real-time imaging without physically moving the specimen or requiring expensive computer hardware.
Scientists at Osaka University successfully mapped the three-dimensional forces acting on quantum dots with unprecedented subnanometer resolution, opening up new avenues for nanotechnology and optical manipulation. This breakthrough could lead to advances in photocatalysts and optical tweezers.
A team of researchers built a high-resolution microscope using LEGO bricks and mobile phone parts, showing significant improvement in children's knowledge of microscopy. The study demonstrated that constructing the microscope themselves increased children's understanding of optical characteristics.
Scientists at Weill Cornell Medicine developed a computational technique that greatly increases the resolution of atomic force microscopy, revealing atomic-level details on proteins and biological structures. The new method allows researchers to study biological molecules under physiologically relevant conditions, providing high-resolu...
A novel calibration procedure developed by scientists enables precise super-resolution brain imaging at greater depth. The method corrects spherical aberration of the depletion beam, allowing for high-quality images of biological tissue.
University of Queensland researchers have created a quantum microscope that can see biological structures impossible to detect with traditional light-based microscopes. The device uses quantum entanglement to provide 35% improved clarity without destroying cells, enabling minute biological structure observation.
Electrical engineers at UC San Diego developed a technology that converts low-resolution light to high-resolution light, enabling ordinary microscopes to image living cells with a resolution of up to 40 nanometers. The technology uses a specially engineered material that shortens the wavelength of light as it illuminates the sample.
Kakshine is a new DNA fluorescent dye with unprecedented versatility, enabling super-resolution imaging of mitochondrial DNA in living cells and deep tissue imaging. Its applications include electrophoresis, quantitative PCR, and flow cytometry, making it a promising tool for DNA analysis.
Researchers at MIT have developed a technique for imaging biological samples with accuracy of 10 nanometers using an ordinary light microscope. The new hydrogel-based approach improves upon previous versions, enabling high-resolution images without expensive equipment.
Scientists have developed a new microscopy technique that can acquire 3D super-resolution images of subcellular structures deep inside biological tissue, including the brain. This breakthrough enables researchers to study subtle changes in neurons over time, during learning, or as a result of disease.
Researchers found Gazelle Malaria test to be highly sensitive and specific, missing only 4 cases of P. vivax infection per 100 people compared to RDTs which missed 16 cases. The test's portability, battery operation, and cold chain-free design make it a promising alternative for field conditions.
A team from UB developed a super-resolution optical chip-sized microscope based on 200 nm nanoLEDs. The new microscope allows real-time observation of viruses and cellular processes without current techniques' problems.
COSMIC, a multipurpose X-ray instrument at Berkeley Lab's Advanced Light Source, has made groundbreaking contributions in fields ranging from batteries to biominerals. It offers world-leading soft X-ray microscopy resolution below 10 nanometers and extreme chemical sensitivity.
Researchers discovered that photobleaching can transform fluorescent dyes into new molecules with altered fluorescence spectra, affecting microscopy results. Simple buffer additions can prevent or even exploit this effect for targeted tracking of specific particles.
Researchers developed a new AO module comprising two deformable phase plates, enabling direct integration with existing microscopes. The system successfully corrected sample-induced aberrations in synthetic samples, demonstrating improved image quality and doubling the aberration correction range.
Researchers from Kumamoto University have developed a highly sensitive method to evaluate cytoskeleton organization from microscopic images. The new technique uses computer simulations and image analysis to accurately measure bundle states, even in unclear images.
The article reviews the development of surgical microscopes, from their introduction in 1921 to the latest advancements. Advanced technologies such as augmented reality displays, hyperspectral imaging, and robotic visualization platforms are increasing the capabilities of surgical microscopes. These improvements enable better visualiza...
Researchers have developed a new method to enhance the sensitivity of quantitative phase imaging, enabling the observation of tiny particles in living cells without labels or stains. The technique, called ADRIFT-QPI, produces images with seven times greater sensitivity than traditional methods.
A team of researchers developed a novel microscope that can image through an intact mouse skull, resolving fine internal structures deep within living tissues. The reflection matrix microscope combines hardware and software-based adaptive optics to reconstruct object images without loss of spatial resolution.
The UC2 system allows users to produce a high-quality microscope at low cost, making it suitable for areas where conventional microscopes are not feasible. The open-source tool also enables researchers to share their knowledge and incorporate it into their work, promoting open science.
Researchers at NSLS-II are building a quantum-enhanced x-ray microscope to image biomolecules like never before, enabling superior resolution without sacrificing dose. The facility's ultrabright light will be harnessed through ghost imaging techniques to preserve sensitive samples.
Dr. Jan Huisken, a renowned physicist and expert in multiscale imaging, joins the University of Göttingen's Cluster of Excellence MBExC with a five-year Alexander von Humboldt Professorship. He will contribute to research on electrically active heart and nerve cells, strengthening the cluster's interdisciplinary approach.
Researchers from the University of Illinois at Urbana-Champaign, Bar-Ilan University, and the University of Central Florida are collaborating on a $4.2 million grant-funded project to advance our understanding of DNA arrangement within cells in space and time. The goal is to shed light on the role of nuclear movement in gene expression...
The study compared survival rates in patients undergoing surgery for brain metastases with conventional white light microscopy versus 5-ALA fluorescence microscopy. The results showed no significant difference in local recurrence or mortality between the two groups, but radiotherapy was strongly associated with improved survival.
The new technique allows for simultaneous acquisition of images at different depths using a standard microscope, improving biological imaging applications. It utilizes a z-splitter prism to divide detected light, producing multiple high-resolution images on the same sensor without overlap.
A Polish-Israeli team has introduced a new method of super-resolution microscopy that, in theory, has no resolution limit. The technique, called SOFISM, uses naturally occurring fluctuations in emission intensity to enhance spatial resolution.