Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from UC Riverside developed a revolutionary imaging technology that compresses light into a nanometer-sized spot, allowing for unprecedented 6-nanometer color imaging of nanomaterials. This advance improves the study of unique properties and potential applications in electronics and other fields.
The new quantum microscope uses entangled photons to create interference patterns on the sample, reducing noise levels and increasing sensitivity by over 25%. This allows for high-resolution imaging of transparent cells without damaging them.
A team of scientists has developed a novel method to characterize microscope objectives without an aberration-less reference element, enabling error correction and precise data collection. Using nanoscale dipole scatterers, they create a nearly-perfect reference wave for measurement.
Researchers from The University of Tokyo Institute of Industrial Science used microscopy to examine surfactant onion layers, discovering they contain defects. Their findings are crucial for designing effective therapeutic carrier systems.
Researchers discovered that living cell interiors become softer and more fluid during mitosis, a process crucial for life. The findings could help ensure precise separation of cellular structures into daughter cells.
Optical coherence tomography (OCT) has significant growth potential across various medical applications, including cardiology and dermatology. Miniaturized OCT systems are expected to revolutionize healthcare with compact, mobile, and cost-effective devices.
Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.
A team developed a smart microscope that adapts to curved biological surfaces, reducing irradiation by up to 100 times. This breakthrough technology enables long-term imaging of fragile objects like embryos and organoids.
A new study from the University of Gothenburg introduces an AI-based method to develop faster, cheaper, and more reliable information about cells using microscopy. This approach eliminates the drawbacks of traditional fluorescence microscopy by providing accurate results without damaging cells or inhibiting processes.
La Trobe University researchers developed a smart microscope slide that can detect cancer cells using enhanced color contrast. The technology uses nanoscale modifications to distinguish cancer cells from normal tissue, making early diagnosis more efficient.
A team from The University of Tsukuba used microscopy techniques to analyze the microstructure of the ground beetle's wing casing, revealing a unique helical structure that creates optical effects. This finding has significant implications for the development of new biomimetic materials with enhanced performance.
GIST scientists utilized latest advances in single molecule detection to observe the enzymatic activity of gene repair. The study revealed that ExoIII has an affinity for damaged DNA sites, creating a gap that Pol I fills. Understanding this mechanism may lead to technologies for targeted gene repair and drug development.
A team of researchers from the Beckman Institute for Advanced Science and Technology has developed a fast, accurate, and cost-effective COVID-19 test. Using label-free microscopic imaging combined with artificial intelligence, they can detect and classify SARS-CoV-2 in under one minute.
The university will acquire an optical tweezer to study colloidal copolymer chains, protein binding strength and other phenomena. The instrument will be made available to Rice researchers and collaborators.
Researchers from DTU develop Fano laser, harnessing bound-state-in-the-continuum to improve coherence. This advancement enables ultrafast and low-noise nanolasers for high-speed computing and integrated photonics.
Researchers have developed a dye-free method to visualize blood flow in the brain, allowing for detailed mapping of small capillaries and assessing blood flow rates. The technique has potential applications in understanding cardiovascular diseases, tumor growth, and targeted drug delivery.
Researchers have developed DiLFM, a dictionary-learning-based light-field microscopy that improves noise resistance and reduces artifacts. The method combines sparse signal representation and dictionary patching to produce high-quality volumetric imaging.
Scientists detected electronic and optical interlayer resonances in bilayer graphene by twisting one layer 30 degrees, resulting in increased interlayer spacing that influences electron motion. This understanding could inform the design of future quantum technologies for more powerful computing and secure communication.
Researchers developed a colorization method via color transfer termed CFPM, significantly reducing reconstruction time by 2/3 without sacrificing precision. This technique enables high-throughput full-color imaging in digital pathology.
Scientists developed a label-free optical microscopy approach that can image deep brain cells with high resolution and minimal invasiveness. They used the 1700 nm water absorption window to visualize neuronal cell architecture across the entire depth of the mouse neocortex, revealing severe pathology in deep but not superficial cortex.
Researchers at UNIST developed a new optical microscope technology that can image deeper into biological tissues. By limiting the numerical aperture of incident wavefronts, they improved focus peak to background ratio and energy delivery throughput.
The new method uses a simple unit consisting of two rotating mirrors to form projections from multiple angles, bypassing the need to acquire image stacks. This allows for real-time imaging without physically moving the specimen or requiring expensive computer hardware.
Scientists at Osaka University successfully mapped the three-dimensional forces acting on quantum dots with unprecedented subnanometer resolution, opening up new avenues for nanotechnology and optical manipulation. This breakthrough could lead to advances in photocatalysts and optical tweezers.
A team of researchers built a high-resolution microscope using LEGO bricks and mobile phone parts, showing significant improvement in children's knowledge of microscopy. The study demonstrated that constructing the microscope themselves increased children's understanding of optical characteristics.
Scientists at Weill Cornell Medicine developed a computational technique that greatly increases the resolution of atomic force microscopy, revealing atomic-level details on proteins and biological structures. The new method allows researchers to study biological molecules under physiologically relevant conditions, providing high-resolu...
A novel calibration procedure developed by scientists enables precise super-resolution brain imaging at greater depth. The method corrects spherical aberration of the depletion beam, allowing for high-quality images of biological tissue.
University of Queensland researchers have created a quantum microscope that can see biological structures impossible to detect with traditional light-based microscopes. The device uses quantum entanglement to provide 35% improved clarity without destroying cells, enabling minute biological structure observation.
Electrical engineers at UC San Diego developed a technology that converts low-resolution light to high-resolution light, enabling ordinary microscopes to image living cells with a resolution of up to 40 nanometers. The technology uses a specially engineered material that shortens the wavelength of light as it illuminates the sample.
Kakshine is a new DNA fluorescent dye with unprecedented versatility, enabling super-resolution imaging of mitochondrial DNA in living cells and deep tissue imaging. Its applications include electrophoresis, quantitative PCR, and flow cytometry, making it a promising tool for DNA analysis.
Researchers at MIT have developed a technique for imaging biological samples with accuracy of 10 nanometers using an ordinary light microscope. The new hydrogel-based approach improves upon previous versions, enabling high-resolution images without expensive equipment.
Scientists have developed a new microscopy technique that can acquire 3D super-resolution images of subcellular structures deep inside biological tissue, including the brain. This breakthrough enables researchers to study subtle changes in neurons over time, during learning, or as a result of disease.
Researchers found Gazelle Malaria test to be highly sensitive and specific, missing only 4 cases of P. vivax infection per 100 people compared to RDTs which missed 16 cases. The test's portability, battery operation, and cold chain-free design make it a promising alternative for field conditions.
A team from UB developed a super-resolution optical chip-sized microscope based on 200 nm nanoLEDs. The new microscope allows real-time observation of viruses and cellular processes without current techniques' problems.
COSMIC, a multipurpose X-ray instrument at Berkeley Lab's Advanced Light Source, has made groundbreaking contributions in fields ranging from batteries to biominerals. It offers world-leading soft X-ray microscopy resolution below 10 nanometers and extreme chemical sensitivity.
Researchers discovered that photobleaching can transform fluorescent dyes into new molecules with altered fluorescence spectra, affecting microscopy results. Simple buffer additions can prevent or even exploit this effect for targeted tracking of specific particles.
Researchers developed a new AO module comprising two deformable phase plates, enabling direct integration with existing microscopes. The system successfully corrected sample-induced aberrations in synthetic samples, demonstrating improved image quality and doubling the aberration correction range.
Researchers from Kumamoto University have developed a highly sensitive method to evaluate cytoskeleton organization from microscopic images. The new technique uses computer simulations and image analysis to accurately measure bundle states, even in unclear images.
The article reviews the development of surgical microscopes, from their introduction in 1921 to the latest advancements. Advanced technologies such as augmented reality displays, hyperspectral imaging, and robotic visualization platforms are increasing the capabilities of surgical microscopes. These improvements enable better visualiza...
Researchers have developed a new method to enhance the sensitivity of quantitative phase imaging, enabling the observation of tiny particles in living cells without labels or stains. The technique, called ADRIFT-QPI, produces images with seven times greater sensitivity than traditional methods.
A team of researchers developed a novel microscope that can image through an intact mouse skull, resolving fine internal structures deep within living tissues. The reflection matrix microscope combines hardware and software-based adaptive optics to reconstruct object images without loss of spatial resolution.
The UC2 system allows users to produce a high-quality microscope at low cost, making it suitable for areas where conventional microscopes are not feasible. The open-source tool also enables researchers to share their knowledge and incorporate it into their work, promoting open science.
Researchers at NSLS-II are building a quantum-enhanced x-ray microscope to image biomolecules like never before, enabling superior resolution without sacrificing dose. The facility's ultrabright light will be harnessed through ghost imaging techniques to preserve sensitive samples.
Dr. Jan Huisken, a renowned physicist and expert in multiscale imaging, joins the University of Göttingen's Cluster of Excellence MBExC with a five-year Alexander von Humboldt Professorship. He will contribute to research on electrically active heart and nerve cells, strengthening the cluster's interdisciplinary approach.
Researchers from the University of Illinois at Urbana-Champaign, Bar-Ilan University, and the University of Central Florida are collaborating on a $4.2 million grant-funded project to advance our understanding of DNA arrangement within cells in space and time. The goal is to shed light on the role of nuclear movement in gene expression...
The study compared survival rates in patients undergoing surgery for brain metastases with conventional white light microscopy versus 5-ALA fluorescence microscopy. The results showed no significant difference in local recurrence or mortality between the two groups, but radiotherapy was strongly associated with improved survival.
The new technique allows for simultaneous acquisition of images at different depths using a standard microscope, improving biological imaging applications. It utilizes a z-splitter prism to divide detected light, producing multiple high-resolution images on the same sensor without overlap.
A Polish-Israeli team has introduced a new method of super-resolution microscopy that, in theory, has no resolution limit. The technique, called SOFISM, uses naturally occurring fluctuations in emission intensity to enhance spatial resolution.
Researchers at KAUST developed a cost-effective, ultrathin SRS lens using laser-based 3D printing, inspired by lighthouse design. The new lens rejects cross-phase modulation background signals, improving imaging efficiency for biological processes like cancer cell growth.
Researchers at Penn State develop a new type of imaging that uses reconfigurable particle-based masks to take multiple shots of an object, improving disease diagnosis and microscopy. The technology may also lead to thinner cellphone cameras by minimizing the space requirement.
A team of scientists has developed a novel optical design that enables fast imaging in 3D microscopy by converting lateral scanning into axial focusing. This technology accelerates axially swept light-sheet microscopy (ASLM) and raster scanning microscopes to multi-kHz rates, outperforming previous aberration-free focusing technologies.
Researchers create a new technique using luminescent DNA tools to visualize mechanical forces of cells at the molecular level. They discovered that platelets have a concentrated core of mechanical tension and a thin rim that continuously contracts, opening up new possibilities for studying blood clotting disorders.
Researchers from Osaka City University developed a microscope-based thermometer that uses quantum technology to detect temperature changes in live, microscopic animals. The thermometry algorithm successfully tracked temperature fluctuations in C. elegans nematode worms after inducing a fever by stimulating their mitochondria.
Researchers at ORNL developed a quantum microscope that measures signals with sensitivity better than classical limits, revealing fine details hidden by noise in microscopy signals. The approach uses squeezed light to reduce noise and achieve higher signal-to-noise ratios.
Researchers demonstrate that nanoscale infrared imaging can identify materials up to 100 nm below the surface. The technique distinguishes surface layers from subsurface layers, enabling direct identification without modeling.
Columbia engineers use sophisticated microscopy techniques to directly image localized states in 2D material, yielding single-photon emitters that can be tuned and controlled. This breakthrough enables the creation of quantum optical circuitry for future photonic applications.
Researchers have developed a new method to analyze microscopic samples without using external light, reducing interference and damage to living specimens. The 'glow in the dark' approach uses chemical stimuli to activate chemicals, enabling precise control over localized oxidative hotspots.
Researchers have developed a new laser-based microscope that can resolve the distribution of electrons in crystal lattices with unprecedented resolution. The technique, known as Light Picoscopy, uses powerful laser pulses to drive electrons into fast motion, allowing them to emit radiation that reveals their position within the crystal.
A custom light-sheet microscope enables gentle observation of corals and their polyps for eight hours at high resolution. This technology sheds light on coral bleaching and symbiotic relationships.
Researchers developed a smart lens that transmits light to correct optical aberrations, improving image quality in biological samples. The device can be easily installed on commercial microscopes, enabling advanced optical techniques like multiphoton microscopy.
Researchers developed a microscope to monitor wound healing without harming the subject. They studied mice with untreated wounds, placebo treatments, and different concentrations of treatment drugs to understand how topical drugs affect the skin.