Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new discovery enables researchers to directly visualize unlabeled nanoscale objects with deep sub-wavelength separations, advancing the field of optical microscopy. This breakthrough has significant implications for applications in semiconductor wafer inspection, nanoparticle sensing, material characterization, and biosensing.
Researchers developed a single-molecule orientation imaging approach to study amyloid proteins, revealing nanoscale differences in their structures. The method provides insights into the fundamental biological mechanisms of disease, potentially contributing to the development of effective therapeutics.
Researchers developed an ultra-high resolution imaging technique using Extreme Ultraviolet radiation, producing extraordinary detail compared to traditional light microscope images. The method has the potential to aid the analysis of neurodegenerative diseases like Alzheimer's disease.
Researchers at UNSW achieved unprecedented resolution capabilities in single-molecule microscopy to detect interactions between individual molecules within intact cells. Their self-aligning microscope smashed the limits of existing super-resolution microscopy technology by measuring distances between proteins with nanometre precision.
A recent study published in Science Advances has shed light on the molecular organization of synapses, revealing that glutamate receptors are directly connected to calcium channels and Munc-18-1. This new understanding could lead to a better comprehension of brain function and signal transmission.
Researchers developed a machine learning system that can automatically detect and label 2D materials in microscope images, reducing the time required for their development. The system was trained using labeled examples and achieved accuracy in under 200 milliseconds, enabling faster testing of new electronic devices.
Scientists at University of Göttingen produce new nanomaterial based on Egyptian blue pigment for near infrared spectroscopy and microscopy. The resulting nanosheets are stable, fluoresce brightly in the near infrared range, and enable clear resolution using modern microscopes.
Engineers at MIT developed a small, mirrored chip that helps produce dark-field images without expensive components. The chip can be added to standard microscopes or hand-held microscopes to visualize difficult-to-image biological organisms.
A new lensless on-chip microscopy platform developed at UConn removes traditional lenses to provide a fuller picture of tissue samples, leading to more accurate diagnoses. The platform uses ptychography and achieves an ultra-high Fresnel number, allowing for a 30 mm2 field of view and eliminating the need for cell staining.
Researchers at Tokyo University of Agriculture and Technology developed a new approach to detect crystallization signs without fluorescent labeling or tracking. They used particle image diffusometry to analyze microscopy movie data, revealing the collective motion of molecular clusters before nucleation.
Researchers developed a hybrid microscope that combines optical and infrared measurements with machine learning algorithms to create digital biopsies. The hybrid microscope closely correlates with traditional pathology techniques and outperforms state-of-the-art infrared microscopes in terms of resolution, consistency, and coverage.
Scientists studied the behavior of viscoelastic fluids interacting with tiny structures called cilia. They found that fluid elasticity drives patterned movement of cilia, but only under specific conditions. Future research aims to develop new biological models and understand the dynamic movements within cells.
A new photoacoustic microscopy system developed by researchers at Pohang University of Science & Technology (POSTECH) can image blood vessels with high resolution and speed. This system enables real-time monitoring of blood flow, which is significant for diagnosing and treating stroke and cardiovascular diseases.
Researchers from DUT and SUTD developed novel rhodamines to overcome fluorophore brightness limitations in SMLM, enabling clearer resolution and analysis of cellular structures. The new dyes show increased fluorescence brightness and 'photon budget', crucial for high-resolution imaging.
Researchers at KAUST have developed a novel method for quantitative phase and intensity imaging in microscopy, overcoming limitations of existing techniques. This new approach enables high-resolution images to be acquired quickly and accurately using affordable optics and common light sources.
Researchers at EPFL have found unexpected constraints on the achievable sensitivity of measurements, even with backaction-evading techniques. Tiny deviations in optical and mechanical frequencies can cause mechanical oscillations to amplify out of control, affecting quantum sensors and applications.
Researchers optimized DNA-PAINT for faster image acquisition using orthogonal DNA sequences, achieving sub-10nm spatial resolution and multiplexing capabilities. This improvement allows for biomedically relevant high-throughput studies, such as diagnostic applications.
Researchers have developed a fluorescent probe that can image electrical activity in multiple neurons simultaneously, enabling the visualization of brain circuits and their relation to behavior. This technique uses a voltage-sensing molecule to record electrical activity on a millisecond timescale, providing more informative measuremen...
Researchers from Bielefeld University have developed a faster method for super-resolution SR-SIM microscopy, allowing for real-time recording of cell movements and observations of small structures. This enables biologists to explore such structures in detail, particularly in the study of viral particles on their way through cells.
Researchers have developed custom-built microscopes called mesoSPIMs, which can image the minute detail of brain tissue down to individual neurons. These new microscopes provide new insights into brain and spinal cord organization, enabling researchers to investigate neuronal networks involved in cognition, pleasure, or drug addiction.
A new interferometric single-molecule localization microscopy, called Repetitive Optical Selective Exposure (ROSE), has been developed to improve the precision of nanostructure imaging. ROSE achieves a two-fold improvement in localization precision compared to conventional methods.
Researchers at the University of Münster have developed a new technique that combines two methods to improve the spatial resolution of mass spectrometry imaging. This allows for better understanding of disease processes and potential new strategies for treating them. The technology uses dual-beam laser mass spectrometry, enabling the s...
A team of scientists at EPFL developed an algorithm that can estimate a microscope's resolution from a single image, boosting image quality and enabling optimized imaging conditions. The algorithm has been made available as an open-source plugin, allowing researchers to directly obtain the estimate and optimize their microscopes.
Researchers at Macquarie University have created a simple method to bypass diffraction limitations using standard optical imaging tools, enabling everyday bio-imaging techniques. The uSEE approach improves resolution by reducing illumination intensity, making it suitable for any biological lab with minimal extra cost.
Researchers successfully recorded sequences of up to 1,000 sharp images of live mitochondria at 1.5 frames per second using STED microscopy. By exploiting the probabilistic nature of photobleaching, scientists can distinguish between different regions of the cell and achieve unprecedented resolution.
Researchers have invented a new type of microscopy called 'DNA microscopy' that can image cells at the genomic level. This technique uses DNA bar codes to pinpoint molecules' relative positions within a sample, allowing scientists to build a picture of cells and amass enormous amounts of genomic information.
DNA microscopy enables spatially mapping genetic material without optical equipment, allowing researchers to track molecular positions and variations. The technique has potential applications in understanding biological processes, cancer, and immune system development.
Researchers at Carnegie Mellon University have developed a method combining expansion microscopy with virtual reality to visualize and analyze cell structures. This innovation allows for better understanding of infectious and autoimmune diseases, enabling the development of disease diagnostics and prevention methods.
Engineers at the University of California, Riverside, have developed a new technology that tunnels light into the quantum realm with unprecedented efficiency. The device integrates a glass optical fiber with a silver nanowire condenser to squeeze visible light to the tip of the condenser and interact with molecules locally.
Researchers at NIST developed a method to measure magnetic properties of nanoparticles by rapidly enlarging magnetic bubbles, revealing the orientation of individual nanoparticle poles. This technique enables fast and economical measurement of magnetic stability for various medical and environmental applications.
Researchers have discovered a new substance that can form during the oriented attachment (OA) process of crystal growth, which may deepen our understanding of crystal formation mechanisms. The discovery was made using state-of-the-art experimental methods and theoretical calculations.
Researchers from Tomsk Polytechnic University proposed a new configuration for nanoscopes that uses special diffraction gratings with gold plates, allowing for accelerated image generation without losing magnification power. The study's results are published in Annalen der Physik and show improvements in resolution up to 0.3 λ.
Researchers at Harvard University have developed a new tool that records and controls neural activity in real-time using genetically encoded voltage indicators. This breakthrough enables the study of complex behaviors and neural interactions with unprecedented clarity.
A new, portable 3D printed microscope provides high-resolution images of cells, potentially detecting diseases like diabetes and malaria. The instrument uses digital holographic microscopy with super-resolution techniques to achieve twice the resolution of traditional systems.
Researchers develop new microscope, SCATTIRSTORM, to study cellulase and plant cell wall dynamics for more efficient biofuel production. The microscope enables high temporal resolution and spatial resolution, allowing for detailed understanding of enzyme activity.
Researchers at the University of Houston are developing a new imaging technology that can simultaneously capture structural and molecular changes in embryos during critical periods of development. This breakthrough could lead to improved early detection and prevention of birth defects with long-term chronic conditions.
Researchers at University of California, Irvine, have produced the first images of a molecule's normal modes of vibration using light focused down to an atom's size. This breakthrough enables direct visualization of individual atoms vibrating within a molecule.
Researchers have developed a new way to visualize nano objects using superlenses and titanium oxynitride films, achieving spatial resolutions of 8 nm and 80 nm. This breakthrough enables non-destructive analysis and 3D visualization without the need for fluorescent labels.
A portable scientific microscope nicknamed Flamingo will make its way from Madison to Boston for collaboration and research. The project aims to democratize expensive high-end microscopy, bringing it cost-free to campuses and labs where access may be scarce.
Researchers developed Bright-field Holography to overcome limitations of holographic 3D imaging. The method combines the image contrast advantage of bright-field microscopy with the snapshot volumetric imaging capability of holography, allowing for rapid creation of images equivalent to those from a bright-field microscope.
A new microscope developed by Purdue University researchers uses phase-contrast microscopy to gather detailed information about molecules and membranes, enabling better testing of drugs and understanding of biological processes.
Researchers at PSI develop a new method that uses a small but efficient lens to create high-resolution images of X-ray microscopes, providing absorption and phase contrast information. This technique has the potential to reveal material properties and improve image quality for biological samples.
A new optical microscope system called SIFOM stimulates multiple cells simultaneously using holographic method and monitors cell activity using 3D measurements. The system has potential applications in reconstructing lost nerve pathways, constructing artificial neural networks, and developing food resources.
Researchers from Harvard John A. Paulson School of Engineering and Applied Sciences have developed a polarization-insensitive metalens using non-symmetric nanofins. This design doubles the efficiency of previous iterations and enables achromatic focusing across the visible spectrum.
Scientists have developed a new imaging technique that allows for rapid and detailed scanning of entire brains at the nanoscale. This breakthrough method, combined with the lattice light-sheet microscope, enables visualization of any desired protein and has the potential to revolutionize neuroscience research.
Researchers at the University of Geneva have developed a new technique called Ultrastructure Expansion Microscopy (U-ExM), which allows for the visualization of cellular structures and protein complexes at a nanoscale. This method enables the detection of biochemical modifications and mapping of large intracellular molecular complexes.
A new meta-surface technology has been developed to correct for chromatic aberrations across all kinds of lenses, from simple to complex. This innovation uses a single-layer surface of nanostructures and can be incorporated into commercial optical systems, improving performance while reducing complexity.
Researchers at NSLS-II have developed a TXM that can image samples in 3D faster than previously possible, reducing the time from over 10 minutes to just one minute. The new microscope enables scientists to visualize their samples much faster and collect more valuable data.
Physicists at Immanuel Kant Baltic Federal University developed a mini transfocator, a variable focus lens for compact and mobile optical systems. The new design offers submicron resolution and is ideal for studying biological samples under extreme conditions.
Researchers at Stanford University have developed a new technique to study individual nanoparticles undergoing photocatalytic reactions. The method, published in Nature Communications, uses a custom-designed specimen holder and mirrors to focus light onto the nanoparticle, allowing scientists to observe the reaction as it unfolds.
Scientists have developed a smart microscope that provides a 4D view of embryonic development in living mice. The microscope uses algorithms to track the embryo's position and size, creating high-resolution images of its development over a critical 48-hour window.
A new study reveals that kidney stones are built up in calcium-rich layers resembling mineralizations in nature. The research found that the stones partially dissolve and regrow again and again as they form, contradicting the widely held notion that they never dissolve.
Scientists have observed intersubband transitions in few-layer 2D materials using s-SNOM, revealing a new class of materials for infrared detection and emission. The study also shows potential for compact integration with Si CMOS.
Researchers at the University of Warwick have created a new tagging device called FerriTag that allows for the precise visualization of proteins within human cells. This breakthrough method eliminates the need for external tags, reducing cell damage and enabling more accurate studies on protein behavior.
The Flamingo project provides a portable and shareable light sheet microscope, addressing the challenges of accessing high-powered microscopy technologies. Labs can configure experiments remotely and mail the device to other labs for use, at no cost to users.
Researchers have devised a new method to measure free energy in microscopic systems, enabling the study of living systems and machine operation. The Relaxation Fluctuation Spectroscopy (ReFlucS) technique uses microscopy to track molecular motion, predicting system behavior without tracking individual atoms.
Researchers developed a new algorithm, GDP-ADMM, to further enhance the capabilities of SHARP in reconstructing high-resolution images from ptychographic datasets. The new framework takes advantage of state-of-the-art mathematical aspects to improve data acquisition and image resolution.
Researchers at Lehigh University have developed a new technique called peak force scattering-type scanning near-field optical microscopy (PF-SNOM) that reveals the 3D shape of polariton interaction around nanostructures with improved spatial resolution. The technique enables direct sectioning of vertical near-field signals for both thr...
Researchers at Tokyo Institute of Technology have created a micrometer-wide thermometer that can measure small and rapid temperature changes in real time. The device is sensitive to heat generated by optical and electron beams, enabling its use in various fields such as photo-thermal cancer treatment and advanced research on crystals.
Scientists combined two microscope technologies to create a microscope that offers unparalleled look at biological processes. The new microscope enables observation of rapidly moving objects about 10 times faster than other microscopes at similar resolution.