Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Physicists from TU Dresden and JMU developed a novel approach to measure optical near-fields with significantly less effort. By using biomolecules as a transport system, they can slide extremely small optical nano-probes over a surface, circumventing the diffraction limit.
Researchers verify anomalous amplitude apodization for non-spherical particles, boosting microscope magnifying power and peak field intensity. This technique enhances imaging capabilities for biological molecules, viruses, and living cells.
Researchers have developed a new method for weighing single molecules using light scattering, enabling the measurement of mass with high accuracy. This breakthrough has potential applications in fields such as protein-protein interactions, drug discovery, and point-of-care diagnostics.
Scientists have developed a new microscope that can capture unprecedented 3-D detail of cells in their natural state, overcoming previous limitations. The technology combines adaptive optics and lattice light sheet microscopy to create high-resolution images of cellular dynamics.
The researchers developed a label-free multimodal microscopy platform that allows non-invasive study of cellular preparations. The platform enables the study of fine cellular processes, such as macrophage cells activation upon exposure to lipopolysaccharide (LPS), at single-cell level through phenotypic and molecular characterization.
The new TILT3D microscope produces clear 3-D images of structures and individual molecules within a cell, overcoming existing illumination techniques' limitations. Researchers can track the 3-D movement of molecules over time with high precision, enabling detailed studies of cellular structures.
A team of researchers has developed a technique that can perform both 3D super-resolution microscopy and fast 3D phase imaging in a single instrument, enabling high-time resolution visualization of living cells. This new platform, called PRISM, allows for direct visualization and analysis of subcellular structures without labeling.
Scientists use super-resolution microscopy to reveal the fine detail of red blood cells' cellular mesh underlying the cell membrane. They discover that the mesh is a triangular structure composed of proteins, allowing for flexibility and elasticity in squeezing through narrow capillaries.
Scientists from ITMO University developed a silicon-gold nanoparticle that acts as an effective source of white light when agitated by a pulse laser in IR band. This technology makes modern near-field microscopy cheaper and simpler, with potential applications in medicine.
Scientists have developed a new method for microscopy that surpasses the Abbe diffraction limit by utilizing chirped laser pulses and quantum dots. This breakthrough enables the imaging of biological samples at resolutions of 1/31 of the wavelength of light, opening up new possibilities for nanoscale analysis.
Physicists at the University of Basel developed an optical nanoscope that can image individual atoms and quantum dots with unprecedented resolution. The technique, which works with two-energy level systems, overcomes the wave nature of light limitations, releasing no heat in the process.
Researchers will test the quantum superposition principle (QSP) in a microscopic system, exploring its validity at larger scales. If successful, this could lead to robust quantum technology for daily applications, enabling faster data processing and transmission.
Scientists at NIST have developed a method to precisely control the depth of nanometer-scale structures using ion beams. This technique allows for the precise measurement of nanoparticle size and has potential applications in quality control, industrial production, and biomedical research.
A new microscope technology using ultraviolet light enables fast and accurate imaging of fresh tissue samples, revolutionizing pathology and medical research. This approach eliminates the need for time-consuming slide preparation and preserving tissue, making it an essential tool for improving patient care and research nationwide.
A new microscope, Firefly, has been developed to study brain activity and neurological disorders. With a 6-millimeter-diameter field of view, the microscope can image neural circuits containing hundreds of cells, allowing for the observation of electrical pulses traveling between neurons.
Researchers at UCLA developed a deep-learning-based technique to reconstruct holograms for microscopic images, producing better results than current methods. This approach could aid in diagnosing abnormalities in medical images and improve optical microscopy for medical diagnostics.
INRS professor Jinyang Liang has designed an ultrafast, highly sensitive imaging microscope to study living animals. The new technology bridges the gap between biomedical, physics, and engineering fields.
Scientists at the Marine Biological Laboratory developed a technique using mirrored cover slips to improve the speed and efficiency of light-sheet microscopy. The method doubles the speed of the microscope and markedly improves its efficiency, useful for imaging fast-moving biological processes.
Scientists from NIH and University of Chicago developed a new microscope that produces high-resolution images at high speed, improving efficiency and resolution. The use of mirrored coverslips allows for the capture of reflected images, removing unwanted background and increasing light collection.
Researchers at Goethe University Frankfurt have developed a new super-resolution optical microscopy technique that makes dimerization of membrane receptors visible. The study reveals ligand-specific receptor dimerization and improves our understanding of the decision between cell life or death.
A portable holographic field microscope can rapidly identify diseased cells, including those infected with malaria. The device uses digital camera sensor technology and advanced algorithms to provide quick and accurate diagnosis, reducing the time and cost associated with traditional laboratory testing.
The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for developing cryo-electron microscopy. This technology allows researchers to freeze biomolecules mid-movement and define protein structures at atomic resolution.
The EU-funded DeLIVER project aims to understand how medical drugs affect the liver and how it changes with age, with researchers from 9 countries working together to develop minimally invasive procedures.
Scientists from ITMO University and Tampere University of Technology developed a new algorithm to increase the resolution of images obtained in lensless microscopes. The approach relies on diffraction patterns and computational methods, allowing for improved image quality without physical changes to the microscope.
Researchers have developed a new microscope technique that allows for the first time to produce 3D images of live embryos in cattle, enabling the selection of healthy embryos before in vitro fertilization. This breakthrough could significantly improve IVF success rates and reduce costs.
A new optical clearing technique allows researchers to study the 3D structure of blood clots, which could lead to a better understanding of heart attacks and stroke. The technique enables microscopic imaging up to 1 millimeter into a clot, providing insights into clot contraction and formation.
A new nanoparticle 'buckyswitch' developed by Clemson researchers improves microscopic imaging resolution by allowing microscopes to capture images up to the terapixel level. This innovation overcomes the diffraction limit constraint and enables clearer visualization of small cellular structures.
Researchers develop a new optical manipulation technique that can control the 3D motion of complex-shaped objects, including living cells. The technique uses 3D holographic microscopy to measure object shapes and calculates light shapes for stable trapping.
Scientists at Goethe University Frankfurt have combined two advanced fluorescence microscopy techniques to observe cells with high-resolution imaging. The new technique, called csiLSFM, allows for three-dimensional insight into a cell's interior with sub-100nm resolution.
Researchers from Osaka University developed an optical system for full-field X-ray microscopes that eliminates chromatic aberrations, allowing for the resolution of 50-nm features with high stability. The system, featuring two monolithic imaging mirrors, has been applied in spectromicroscopy experiments and shows promise for various ap...
Researchers at Bielefeld University and the University of Tromsø have developed a photonic chip that enables superresolution light microscopy with conventional microscopes. This breakthrough method produces images with a resolution of about 20 to 30 nanometres, ten times that of conventional light microscopy.
Hydrogels, jelly-like materials with water-based properties, require a better understanding of their structure and mechanical properties. Professor Ullal will use super-resolution microscopy techniques to characterize the structure of hydrogels and develop new materials.
Mini Das, assistant professor of physics at UH, aims to develop fast, low-radiation, high-resolution X-ray microscopy to study tissues and materials without slicing or killing samples. Her project will test new detecting methods, algorithms, and instrumentation.
MIT researchers have developed a way to make extremely high-resolution images of tissue samples, allowing scientists to see complex patterns in brain synapses and potentially map neural circuits. The new technique uses a tissue-expansion technique to boost resolution to about 25 nanometers.
Researchers developed a custom-built microscope to study living nerve synapses, resolving events in the synapse with high precision. They found that the active zone is more like a rain shower than a single jet, with about 10 locations reused too often and a limit to how quickly these sites can be reused.
Researchers have discovered a way to distinguish small or distant objects that normally blend into a single blur by utilizing the phase property of light. This method allows for increased resolution in microscopes and telescopes, with potential applications in observing binary stars and studying tiny structures.
A research group led by Prof. Dr. Benjamin Judkewitz is working on a new approach to overcome light scattering limitations in optical microscopy, enabling images of deeper tissue layers. The European Research Council has allocated €1.49 million over five years to fund this endeavor.
Researchers at the University of Chicago created a new tool to view the spectrum from specific structures within samples. The instrument, a spatially selective microscope, allows users to zero in on the spectrum from specific regions of interest and capture standard fluorescence images of the whole field of view.
Researchers use advanced microscope to observe thin water layers on ice, discovering they don't homogeneously wet the surface. This contradicts conventional wisdom and suggests a metastable transient state formed through vapor growth and sublimation.
Researchers developed an adaptive microscope that can analyze and optimize its settings in real-time, achieving five-fold improvements in resolution. This technology enables long-term imaging of entire embryos and has significant implications for high-throughput drug screens and biological modeling.
The new 'smart' light-sheet microscope analyzes a specimen continuously and adjusts its settings to optimize image quality. Researchers achieved improvements in spatial resolution and signal strength by a factor of 2 to 5, making it easier to produce high-quality images of larger specimens.
The new CHIRPT microscope enables deep-tissue imaging in three dimensions with better depth of field than comparable techniques, reaching 600 frames per second. This allows for sharp, 3-D images of cells or tissue over a larger volume than conventional fluorescence microscopy methods.
A new measurement tool, developed by York University researchers, measures the spreading of liquid drops on surfaces. The study suggests that an advanced swimsuit could reduce fluid resistance underwater, potentially helping athletes achieve better times.
The new microscope tracks individual molecules' position and orientation in living cells, shedding light on cellular functions and forces. It detects nanoscale alignment of molecules required for cell movement and division.
Researchers at Bangor University have achieved a world first by using dragline silk from the golden web spider as an additional superlens to provide up to 2-3 times magnification. This innovation enables viewing of previously invisible structures, including nano-structures and biological micro-structures.
A team of neuroscientists and engineers will use a special microscope to reconnect neural communication between brain parts severed by injury or disease. If successful, this could improve conditions for those with Parkinson's, stroke, or neurological problems.
Scientists have created a new solid 3D superlens using nanobeads, enabling the view of previously invisible details on surfaces. The technology adds 5x magnification to existing microscopes, opening up new possibilities for biology and medicine.
Scientists have developed a multi-view microscope that captures higher-resolution images of live cells and tissues without increasing radiation exposure. The new system uses computation to fuse images and achieve double the volumetric resolution of traditional methods.
Researchers developed a new method to capture three views simultaneously, producing more detailed perspectives of bacteria and living cells. The technique improved volumetric resolution by up to 235nm, doubling the resolution of traditional methods.
Scientists from Russia and Australia have developed a simple new way to count microscopic particles in optical materials using laser diffraction. This method allows for the structure and shape of any optical material to be determined without expensive electron or atomic-force microscopy.
Scientists developed a new X-ray microscopy technique to image nanoscale changes in lithium-ion battery particles as they charge and discharge. The real-time images reveal non-uniform charging processes that curbs battery performance over time, offering insights to improve batteries for electric vehicles and smartphones.
Researchers have discovered that asymmetrical magnetic microbeads can be transformed into useful tools controlled by a changing external magnetic field. The Janus particles, inspired by the Roman god of two faces, exhibit unique behavior under oscillating fields, forming linear chains and expanding to create micro-muscles on a chip.
A new platform called spectroscopic photon localization microscopy (SPLM) increases the resolution of molecular imaging by fourfold, making it faster and simpler. This breakthrough can be applied to various fields like materials science and life sciences to study nanoscale environments.
A Harvard team has developed discrete molecular imaging (DMI), which enhances super-resolution microscopy with ultra-high resolution, enabling researchers to study molecular conformations and heterogeneities. The technology complements current structural biology methods, opening up new ways to analyze complex biological samples.
Researchers tested two portable handheld microscopes and found they could rule in infections, but the CellScope missed low-burden infections. The devices were effective in rural settings after minimal training of community laboratory technicians.
A novel on-chip microscope made from consumer electronics enables simultaneous measurement of nanometer-thick changes over a large volume in transparent objects. The device utilizes phase-shifting interferometry and offers unprecedented field-of-view and depth-of-field capabilities, making it suitable for point-of-care applications.
Scientists used X-rays to discover the microscopic structures on butterfly wings reflect light, creating brilliant colors. Researchers found photonic crystals with tiny crystal irregularities that enhance light-scattering properties.
Chinese researchers have developed a new in situ transmission electron microscopy (TEM) technique that offers powerful functionality to understand atomic-scale structure and its correlation with physical and chemical properties. The technique has potential applications in smart windows, energy management, and environmental protection.
Researchers at Colorado State University have developed a technique to simultaneously image with multiphoton fluorescence and second-harmonic generation, achieving nanoscale resolution. This breakthrough enables the observation of previously inaccessible structures in living tissue, opening up new avenues for biological research.
Researchers at ORNL have developed a new method that provides unprecedented detail on energy flow in nanometer scale, enabling the improvement of solar cells' performance. The technique uses femtosecond transient absorption microscopy to extract images with single-pixel precision.