Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at CU-Boulder have developed an ultrafast optical microscope that captures real-time, slow-motion movies of light interacting with electrons in nanomaterials. The technique enables the visualization of matter on its natural time and length scale.
A team at HZB has developed an alternative method for representing microstructures in polycrystalline materials, utilizing Raman microspectroscopy. This non-invasive technique allows for orientation distribution mapping without specimen preparation, enabling analysis under ambient conditions.
Researchers have developed a new method to calibrate high-tech microscopes, enabling the tracking of single molecules in 3D at the nanoscale. This breakthrough has exciting implications for understanding key biological processes such as signaling, cell division, and neuron communication.
A new hybrid optical microscope/mass spectrometry-based imaging system developed at ORNL provides sub-micron resolution for chemical analysis and differentiates between polymers and cells. The technology enhances understanding of material interactions, drug transport, disease progression, and response to treatment.
Researchers at Einstein and Berkeley will develop new instruments to image genes and proteins in living cells, enabling visualization of gene regulation processes. The grant aims to create powerful microscopes and fluorescent probes to reveal mechanisms controlling gene expression.
The IsoView light sheet microscope produces high-resolution images of entire organisms in all three dimensions at sub-second temporal resolution and sub-cellular spatial resolution. This breakthrough enables scientists to monitor brain activity, track cell movement, and study developmental processes with unprecedented clarity.
Researchers at EPFL have created a groundbreaking DNA stain called SiR-Hoechst, which enables the safe imaging of living cells for extended periods. This innovation allows biologists to track biological processes such as cell division in real-time, paving the way for further breakthroughs in bioimaging.
Researchers developed a novel approach using liquid crystals to detect neuro-degenerative diseases by detecting the protein fibers implicated in their development. The system shows extremely high sensitivity and could enable earlier detection at a lower cost.
Researchers have imaged ultraslow pulse propagation and backward propagating waves in deep subwavelength-scale thick slabs of boron nitride, a natural hyperbolic material. The study provides insights into the behavior of light inside these materials, laying the foundations for future nanophotonic devices.
A team of researchers has developed a novel optical technique to resolve individual components of spindle pole body (SPB) duplication in living yeast cells, uncovering surprising facts about this nanoscale process. The study reveals that SPB duplication begins near the end of mitosis and forms structures not previously seen.
Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have developed new imaging techniques that dramatically improve spatial resolution in living cells. The new methods offer extraordinary visual detail of structures inside cells with unprecedented clarity and speed.
Researchers at University of Illinois develop a data-based method to diagnose breast cancer using spatial light interference microscopy, promising fast and accurate results. The technique uses quantitative imaging parameters to analyze breast tissue lesions, overcoming limitations of manual inspection.
A new technology, SR-STORM, enables high-resolution imaging of multiple components and local chemical environments inside a cell. It allows scientists to examine cell structures and study diseases using unprecedented spectral and spatial resolution.
Scientists at HZDR and TU Dresden create compact camera that enables precise filming of dynamic processes at the nanometer scale. The instrument combines advantages of two methods, allowing high spatial and temporal resolution.
Scientists developed a technique to enhance nanoparticle signals using an optical microcavity, achieving near fundamental diffraction limit resolution. This enables the study of individual nanoparticles' optical properties, promising potential breakthroughs in biology, chemistry, and nanoscience.
Researchers at the Niels Bohr Institute have discovered a way to design nanowires for LEDs that use less energy and provide better light. By using X-ray microscopy, they can pinpoint the optimal structure of these tiny wires, leading to more efficient core/shell designs.
Researchers have developed a new microscope technique using holographic images and machine-learning software to identify bacterial species at the single bacterium level. The approach has shown high accuracy in distinguishing between pathogenic and non-pathogenic bacteria, promising to reduce treatment time and improve patient outcomes.
Researchers at Berkeley Lab develop CLAIRE, a technique for noninvasive nanoscale imaging of soft matter. This allows for high-resolution observation of dynamics behind nano-sized components in biomolecules, accelerating the development of technologies such as artificial photosynthesis and photovoltaic cells.
A team of MIT physicists has developed a laser-based technique to trap and freeze fermions in place, allowing for the simultaneous imaging of over 95% of potassium gas fermions. This breakthrough enhances our understanding of fermion behavior, particularly that of electrons.
Researchers at Texas A&M University demonstrate a bright, speckle-free strobe light source using random Raman lasing emission, enabling rapid imaging of microscopic forms of life. The new laser-like light source has a low level of spatial coherence and can produce high-speed images with improved quality.
Researchers developed an optical sectioning–3D reconstruction method using compound fluorescence light microscopes to image plant cells without damaging them. This approach allows for bulk processing of samples, clear imaging months after collection, and higher resolution than SEM.
KAIST researchers create a novel technique for precisely tracking the 3D positions of optically trapped particles with complicated geometry. The Optical Diffraction Tomography (ODT) method measures 3D images in high speed, enabling the visualization and analysis of particles in various fields.
Researchers have developed a new approach to sharpen nanoscale microscopy by precisely determining the light source's location, overcoming diffraction limit challenges. This innovation enables super-resolution imaging with accuracy, correcting for image-dipole distortions and improving spatial resolution.
A new compound based on rare earth ions has been developed to measure oxygen concentrations in living tissue with high precision. The compound works by emitting coloured light that varies in colour with the amount of oxygen present, making it possible to measure oxygen using optical microscopes already present in hospitals.
NYU's Materials Research Science and Engineering Center (MRSEC) received a six-year, $14.4 million NSF grant to expand its research and exploration of fundamental organizing principles of matter. The Center aims to create new materials with unique properties and advance technology sectors.
Researchers from Ohio State University and the University of Georgia collaborate to visualize cellular processes at a nanometer scale. The QSTORM project aims to enhance microscopy resolution for sub-cellular imaging, enabling scientists to make molecular movies of muscle contraction.
Researchers used microscopic fossils to date sedimentary layers and shed light on the origin of the Canary Islands. The study supports the mantle plume model, suggesting oceanic volcanoes formed from an anomalously hot plume of molten rock from the Earth's mantle.
Researchers discover cluttered jumble of randomly oriented nanocrystallites at interface, impeding charge-carrier mobility and device performance. A novel microscopy technique reveals the role of solution-processing methods in creating optimal film structures.
Researchers from UCLA have created a device that can accurately detect cancer and cell abnormalities like pathology lab microscopes. The lens-free microscope uses holograms to create 3D images, making it easier to spot any issues.
The new lattice light sheet microscope collects high-resolution images rapidly, minimizing damage to cells. It enables biologists to visualize the three-dimensional activity of molecules, cells, and embryos in fine detail.
Scientists at USC have developed CALM technology, allowing for high-resolution imaging of single molecules in living animals. The technique revealed that dystrophin regulates calcium channel fluctuations in muscle cells, leading to impaired muscle activity in muscular dystrophy patients.
Researchers at Berkeley Lab set a new record for X-ray microscopy, achieving resolutions of five nanometers using soft X-rays and ptychography. This breakthrough enables the visualization of chemical phase transformations and mechanical consequences at the nanoscale.
Scientists are developing new technologies at the atomic scale to create ultra-low-power electronics. This breakthrough has the potential to revolutionize the electronic industry, enabling smaller, more efficient devices that can be powered by longer-lasting batteries.
The HZB team has developed novel 3D X-ray optics, enabling sharper imaging with improved resolution. The new optics capture more light and can be stacked on top of each other to achieve even better results.
Scientists have developed a new imaging system that reveals neural activity throughout the brains of living animals in 3-D. The technique allows for simultaneous imaging of every neuron in the worm Caenorhabditis elegans and the entire brain of a zebrafish larva, providing a more complete picture of nervous system activity.
Researchers have developed a new process to create high-quality lenses at a low cost, making them suitable for various applications including disease detection, scientific research, and education. The lenses were created using a simple method involving the hanging and curing of droplets of transparent silicone polymer.
The Biotechnology and Biological Sciences Research Council (BBSRC) is investing £10M in advanced scientific research instruments. This funding supports world-leading research in various fields, including plant biology, microscopy, and protein interactions.
Researchers at Berkeley Lab have developed a technique to image individual carbon nanotubes, allowing for the characterization of their electronic and optical properties. This breakthrough enables the identification of specific species of nanotubes in functional devices, crucial for advancing nanotube technology.
Researchers have developed two new microscopes that capture fast-moving cells in 3-D and reduce light exposure to preserve cell health. The iSIM microscope enables real-time super resolution imaging of small structures at high speed.
Researchers have developed a new Spinning Disk Statistical Imaging (SDSI) system that allows for deeper imaging of cellular structures, including viruses and parts of the nucleus. The technique combines super-resolution microscopy with fluorescent probes to produce high-speed focused images.
Researchers at MIT have developed a new concept for a microscope that uses neutrons to create high-resolution images, enabling the probing of internal structures in metal objects and biological materials. The device could improve existing neutron imaging systems by a factor of 50, allowing for sharper images and smaller instruments.
A Harvard team has developed a new microscopy method using DNA nanotechnology to overcome the diffraction limit and visualize tiny molecules in cells. The method, called DNA-PAINT, creates 'imager strands' that bind to target molecules, making them appear to blink and enabling sharper images than traditional methods.
Scientists at Queen Mary University of London developed a new technique to measure electrical activity in synapses, enabling three-dimensional visualisation of neuronal networks. This breakthrough opens a new window into understanding brain function at the nanometre scale.
Researchers at the University of Warwick have developed a way to control the speed and direction of motion of microscopic structures in water using chemotaxis. By adding a chemical catalyst, they can propel matchstick particles towards a specific location, demonstrating a versatile method for directing colloidal motion.
Arizona State University researchers have received a $1.6 million grant to develop advanced microscopy methods that can capture molecular-scale phenomena in living systems. The technique, called plasmonic resonance, allows for the imaging of proteins and other molecules within cells with enhanced contrast and temporal resolution.
Researchers create a method to convert conventional microscopes into high-resolution imaging systems that outperform standard microscopes. The new system combines the field-of-view advantage of a 2X lens with the resolution advantage of a 20X lens, producing images with 100 times more information.
A new microscopy technique called Through-Focus Scanning Optical Microscopy (TSOM) can detect tiny differences in the three-dimensional shapes of circuit components. This enables the semiconductor industry to improve chips for the next decade or more by measuring features as small as 10 nanometers across.
A new microscopy technique developed by NIST researchers uses cathodoluminescence to image nanoscale features with high resolution. The technique combines the benefits of optical and scanning electron microscopes, evading traditional limitations such as diffraction and sample preparation requirements.
Visikol, a polychlorinated alcohol mixture, effectively clears organisms for viewing under microscopes without the need for federal regulation. Developed as a replacement for chloral hydrate, it offers safety and cost benefits while maintaining high-quality microscopic images.
Researchers at Purdue University have developed a new super-resolution optical microscopy technique that can image synthetic nanostructures and molecules without the need for fluorescent dyes. The technique, called saturated transient absorption microscopy (STAM), uses a trio of laser beams to selectively illuminate molecules, allowing...
Researchers at Berkeley Lab's Advanced Light Source are transforming X-ray microscopy into a widely available form of high-resolution imaging. State-of-the-art instruments can create three-dimensional images with elemental and/or chemical sensitivity, allowing for unprecedented insights into biological systems.
Researchers used a super-resolution microscope to study protein distribution in human T-cells, revealing the dynamic opening and closing process of kinase molecules. This discovery could provide insights into immune disorders and cancer by understanding how signaling processes are controlled.
Researchers from China have devised a universal method using just an optical microscope to measure graphene and other two-dimensional materials' thickness. The technique exploits the reflected light's red, green, and blue components, increasing contrast with sample thickness.
A team of scientists has developed integrated arrays of optical vortex beams on a silicon chip, which can be used to transmit multiple streams of information. This breakthrough could enable the creation of compact and high-density devices for applications such as sensing and microscopic particle manipulation.
Researchers have developed a digital microscope that creates high-resolution images at fast speeds, enabling scientists to study biological processes like cell activity in greater detail. The new device uses a programmable micromirror system to reject unwanted light and improve image quality.
A team of Italian researchers has developed a new microscopy technique called confocal light sheet microscopy (CLSM) that improves the resolution and contrast of images of the brain's neural pathways. CLSM enables scientists to obtain high-resolution views of tissue samples with a resolution of a few microns and faster acquisition time.
Researchers developed nano-FTIR, combining s-SNOM and FTIR spectroscopy for nanoscale chemical identification and mapping. The technique offers high sensitivity and resolution, making it a unique tool for polymer chemistry, biomedicine, and pharmaceutical industry.
Researchers have developed materials and nanofabrication techniques to build miniaturized components for medical diagnostics, sensors, and other applications. These miniaturized components can perform rapid analysis with small sample volumes.
Researchers have developed a new fluorescent labeling strategy that enables the examination of bacterial biofilm structure, leading to potential drug targets. The study has provided new insights into the development of complex structures and may pave the way for new approaches to fighting infectious disease.
A Griffith University research team has successfully photographed the shadow of a single atom for the first time. The achievement is made possible by a super high-resolution microscope that allows the creation of a darker image, enabling its capture. This technology has far-reaching implications for quantum computing and biomicroscopy.