Articles tagged with Optical Microscopy
Researchers from Harvard University have demonstrated a laser with unprecedented detail, capable of resolving chemical composition of samples like cells. This device combines Quantum Cascade Lasers with optical antenna nanotechnology, enabling new ultrahigh spatial resolution microscopes for chemical imaging.
Researchers at the Max Planck Institute developed a technique called optical 3D far-field microscopy using photoswitchable rhodamine amides, allowing for highly resolved 3D images of transparent fluorescence-marked samples. The method can capture nanoscale resolution with good signal-to-noise ratio and relatively short exposure times.
Stefan Hell's STED microscope enables nanoscale imaging, achieving resolutions up to 10-12 times higher than the diffraction limit. This breakthrough allows for non-invasive imaging of cells' inner structures.
Researchers at NIST have devised a system for manipulating and positioning individual nanowires using optical microscopy and conventional photolithographic processing. They can fabricate sophisticated test structures to explore the properties of nanowires with high control, enabling the creation of elaborate structures for testing.
The Adaptive Scanning Optical Microscope (ASOM) eliminates traditional trade-offs between magnification and field of view, providing 40mm diameter field of view with consistent resolution. This technology enables faster imaging and reduces visual distortions.
Researchers created microscopic 'nanolamps' using electrospinning, a technique that produces extremely small fibers made of ruthenium and polyethylene oxide. The fibers emit orange light when excited by low voltage, making them useful for applications in sensing, microscopy, and flat-panel displays.
Virginia Tech researcher Yong Xu seeks to create an optical microscope that can image nanostructures at one nanometer resolution, a breakthrough in arranging atoms on the molecular scale. Observing the vacuum field at this resolution could help solve quantum electrodynamics' remaining mysteries.
Researchers at University of Sheffield have developed a new technique to enhance x-ray microscope images, enabling the capture of high-resolution 3D images of any molecular structure. They aim to develop the ultimate x-ray microscope with computer-aided image processing and potentially replace lenses with solid-state optical microscopes.
Researchers developed Interferometric Synthetic Aperture Microscopy, a novel technique that produces crisp three-dimensional images from out-of-focus data. This method can perform high-speed, micron-scale imaging without time-consuming processing or sectioning of tissue.
The Rensselaer Polytechnic Institute has licensed its Adaptive Scanning Optical Microscope (ASOM) technology to Thorlabs Inc. The ASOM enables the automation of challenging laboratory tasks, such as diagnosing cancer and discovering new drugs. It provides high-resolution images of large sample areas without sacrificing image quality.
Researchers have used a new type of light microscope to visualize the distribution of H2AX proteins in the cell nucleus, revealing clusters that direct DNA repair after damage. This discovery provides new insights into the complex process of gene repair and its relationship with other nuclear components.
A new scanning microscopy technique, SPIM, combines high spatial resolution with sensitivity to subtle electrical activity, enabling the visualization of both electronic and physical patterns in devices. The method has been successfully validated by comparing its images with atomic force microscopy scans.
A new 'superlens' has been integrated into a microscope to visualize two-dimensional objects, such as holes in gold films. This innovation increases the resolution beyond the wavelength of light, allowing for previously impossible imaging of ultra-small objects.
A new light microscope allows scientists to peer deep inside cells and study protein organization at a molecular level. This technology, called photoactivated localization microscopy (PALM), has the potential to unlock secrets of intracellular dynamics and provide new insights into cellular structures and proteins.
A new type of microscopy developed by Xiaowei Zhuang at Harvard University resolves objects as small as 20 nanometers, enabling the first ultra-resolution imaging of living biomolecules and cells. The technique, called stochastic optical reconstruction microscopy, uses glowing molecules to create high-resolution images in real-time.
Scientists have developed a new light microscope that can image cellular proteins with near-molecular resolution, surpassing conventional optical microscopes. This technique, called photoactivated localization microscopy (PALM), allows researchers to discriminate molecules separated by as little as two to 25 nanometers apart.
Researchers at Rice University have developed a method to visualize individual carbon nanotubes using standard optical microscopes and fluorescent dyes. The technique reveals the harmonic bending of nanotubes in liquids, providing insights into their behavior and potential applications in life sciences.
Scientists have visualized individual synaptic vesicles and proteins using Stimulated Emission Depletion (STED) microscopy, resolving the diffraction barrier. They found that synaptotagmin molecules remain together after fusion, enabling efficient neurotransmitter release.
A new nanoparticle sensor developed at the University of Rochester can detect individual flu viruses and particles, setting a high bar for detection techniques. Meanwhile, researchers from the University of Twente have found that thin grooves with sharp edges can speed up drying even in humid conditions.
Gold bowties may allow for the production of detailed images of proteins, DNA molecules, and synthetic nano-objects. The device amplifies near-infrared light into a concentrated speck of light, improving resolution by a factor of 10 compared to conventional microscopes.
Researchers at NIST found a significant difference between white light interferometric microscopes and phase shifting interferometers in measuring surface roughness, with discrepancies peaking at 100 nanometers. The study evaluated five instruments from three vendors and compared them to stylus profiling instruments.
Researchers at Max Planck Institute in Germany have developed Stimulated Emission Depletion (STED) microscopy, enabling resolutions of up to 16nm with conventional optics. This breakthrough surpasses the long-held resolution limit imposed by Abbe's law.
Researchers at NIST develop a novel optical imaging technique that uses structured illumination to reveal details as small as 40 nanometers. This breakthrough could transform chip-making and other industries by enabling the creation of nanometer-scale features.
The new SPIM microscope allows scientists to study live systems from multiple angles in real conditions, with minimal disruption. This enables the capture of high-quality images that would have been impossible with traditional microscopes.
Researchers developed a novel imaging process using neutrons, providing better resolution and penetration than visible light. The microscope has potential applications in biology, particularly with samples containing hydrogen.
PNNL scientists have found a new way to see beyond the 'diffraction limit' of optical microscopes, revealing the structure of DNA molecules. By combining FLIM with AFM techniques, they've produced sharp images of DNA and nanobeads.
The University of Toronto has developed technology using laser-sensitive dyes to foil document fraud, providing high data encryption and relatively low-cost production. This innovative approach could offer a speedy alternative to current security checks, enabling authorities to verify documents more efficiently.
Researchers at CU-Boulder created more efficient 'soft' x-ray light in the water-window region using a femtosecond laser, making it possible to build compact microscopes for biological imaging. This advance could visualize processes within living cells and understand how pharmaceuticals function.
Scientists have found that Bacillus spore size changes with environmental conditions, potentially allowing for rapid detection of anthrax. The discovery could enable a test to identify anthrax spores in seconds to minutes.
Researchers have developed the STED-4Pi-Microcope, which uses stimulated emission to narrow the focal spot of the fluorescence microscope, allowing for resolutions below 50 nm. This technique enables the imaging of features on a molecular level, advancing biological and medical research.
Researchers at the University of Michigan developed a new technique combining coherent nonlinear optical spectroscopy and near-field microscopy to detect quantum coherence in extended structures. This breakthrough enables sub-wavelength resolution, bringing nanotechnology closer to sophisticated devices.
Scientists at Max Planck Institute break Abbe's diffraction limit in focusing light microscopes using two laser beams and stimulated emission. The new microscope achieves sub-Abbe resolution, enabling imaging of intact transparent specimens in three dimensions.