Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Beckman Institute developed a fast, non-invasive 3D microscopy method that visualizes E. coli sub-cellular structure in three dimensions without disturbing the specimen or using fluorescence or contrast agents.
Researchers developed a new microscope that uses X-ray excited luminescence microscopy to image material properties. The technique combines optical microscopy's spatial resolution with synchrotron radiation's element and magnetic specificity, enabling the imaging of features as small as one micron.
A new imaging technology captures unprecedented speed and precision of embryogenesis, enabling quantitative analyses of developmental processes. The SiMView light sheet microscope allows users to track each cell in an embryo as it takes shape over hours or days.
Researchers developed a computational technique to correct aberrations in optical tomography, enabling faster, less expensive and higher resolution tissue imaging. The technique was demonstrated using gel-based phantoms and rat lung tissue, resulting in sharp points and clearer tissue structures.
Researchers have developed a new approach using compressed sensing to resolve cellular features an order of magnitude smaller than before. This allows for the study of dynamic processes in live cells with seconds or even sub-second temporal resolution.
Scientists at the University of Sheffield have developed a new method, called electron ptychography, to form high-resolution images without lenses. This approach enables imaging at sub-atomic scale and has no fundamental experimental boundaries.
Researchers at Max Planck Institute have recorded detailed live images inside the brain of a living mouse using STED microscopy, making minute structures visible for the first time. This breakthrough could help decipher fundamental processes in the brain and shed light on illnesses caused by synapse malfunction.
The Focus Issue on Digital Holography and 3-D Imaging presents recent breakthroughs in digital holography, enabling non-invasive biomedical imaging and applications in structural analysis. Novel techniques such as compressive holography and lens-free tomographic microscopy are showcased, advancing 3-D display technologies.
Researchers at Princeton University discovered that blocking small holes in a metal film enhances light transmission by up to 70%. The technique challenges common assumptions in optics and could have significant implications for ultrasensitive detectors. Further investigation is needed to apply this finding to various applications.
Scientists have developed a technique using scanning transmission electron microscopy (STEM) to view proteins tagged with gold nanoparticles in whole, intact cells. This method offers ten times better resolution than optical microscopes and could help study cancer processes and understand how viruses hijack healthy cells.
A team of researchers transformed everyday iPhones into medical-quality imaging and chemical detection devices, enabling doctors to diagnose blood diseases in developing nations. The modified phones can perform detailed microscopy and spectroscopy, transmitting real-time data for further analysis and diagnosis.
The University of Alberta's Virtual Reflected-Light Microscopy (VRLM) technology enables geoscientists to analyze ancient sea creatures and date rocks with unprecedented detail. This innovation accelerates species identification of microfossils, used to determine rock age and explore energy resources.
Researchers at Imperial College London and the University of Oxford used 'optical' laser tweezers and a super-resolution microscope to observe the inner workings of white blood cells, including Natural Killer cells. The study provides new insights into how these cells deliver deadly enzyme-filled granules to kill diseased tissue.
Researchers have developed a compact, lightweight microscope that uses holograms instead of lenses for dual-mode imaging. The device is portable, inexpensive, and can be used for field diagnostics in developing countries, testing of water quality, and food contamination.
A research team from Yale University has successfully achieved two-color stimulated emission depletion (STED) microscopy in living cells, overcoming previous challenges in labeling target proteins. The breakthrough enables resolutions of 78 nanometers and 82 nanometers for sequential scans of two proteins in living cells.
Researchers at MIT have developed a new high-speed 3D imaging system based on optical coherence tomography (OCT) technology, enabling real-time visualization of microscopic features in the esophagus and colon. The system promises to improve cancer screening by detecting pre-cancerous changes and guiding endoscopic therapies.
Researchers at UCLA have created a lens-free optical microscope that can produce high-resolution 3D images of microscopic objects. The system uses tomography and digital sensor arrays to capture detailed sub-cellular structures without using a lens.
UCSD scientists create a new type of genetic tag visible under an electron microscope, allowing for detailed, three-dimensional images of individual cells. The modified protein, dubbed miniSOG, produces abundant singlet oxygen when exposed to blue light, enabling its visualization.
Scientists at UCSD and colleagues create a new type of genetic tag visible under electron microscopy, enabling detailed three-dimensional images of individual cells. The breakthrough enhances electron microscopy capabilities, allowing researchers to visualize proteins in unprecedented detail.
A new super-resolution microscopy technique reveals changes in protein concentration on human immune cells exposed to E.coli and Y.pestis toxins. This work provides insight into why some bacteria can evade the immune system.
The new microscope allows researchers to study the dynamic inner lives of living cells without damaging them. It uses a combination of structured illumination and two-photon microscopy to create high-resolution, three-dimensional images of cellular landmarks.
Researchers have developed an iPad application for optical tweezers, overcoming limitations of computer mouse control. The multi-touch-based app allows for clear representation of particle systems and offers various techniques for movement.
Scientists have developed a microscope that can see objects as small as 50 nanometres, beyond the theoretical limit of optical microscopy. This breakthrough enables potential examination of human cells and live viruses for the first time, revolutionizing cell study and biomedicine.
Researchers have developed a new strategy to improve microscopy by following the astronomers' guide star technique, allowing for sharper images of biological samples. This method uses adaptive optics and two-photon fluorescence microscopy to correct for light waves hitting cells in different directions.
The team aims to create images revealing micro- and macroscopic matter with improved clarity, surpassing traditional microscopy resolution by 10-fold. This enables scientists to study living tissue in its natural state without sample manipulation.
Mark Bates has been awarded the GE & Science Prize for Young Life Scientists for his novel research on high-resolution imaging of biological cells and tissues. His technique, known as stochastic optical reconstruction microscopy, enables researchers to see previously hidden aspects of life with unprecedented detail.
Researchers at Harvard University have created a new type of biomedical imaging that can capture 'video' of blood cells squeezing through capillaries. The technique, based on stimulated Raman scattering (SRS), makes label-free chemical movies with streaming footage at the subcellular level.
Researchers have developed a technique that corrects a trick of the light, enabling the use of optical microscopy to image objects or distances with resolutions as small as 0.5 nanometers, revolutionizing biology. This breakthrough allows for accurate measurements of protein structures and molecular organization in biological samples.
The UCLA engineer's telemedicine invention uses a lensless cellphone microscope to detect sub-cellular elements and has the potential to revolutionize healthcare in developing countries. With its ability to be miniaturized, inexpensive, and easy to use, this technology aims to bridge the gaps left by inadequate healthcare infrastructure.
A new instrument, Centrifuge Force Microscope (CFM), uses centrifugal force to manipulate molecules, offering a low-cost and simple approach to single-molecule manipulation. This technique enables researchers to study the interactions of thousands of molecules simultaneously.
Researchers at Berkeley Lab's ALS beamline 9.0.1 developed a method to image whole yeast cells with soft X-rays, achieving a resolution of 11-13 nanometers. This breakthrough enables the possibility of full 3D tomography of whole cells at equivalent resolution.
The UCLA engineer has created a miniature microscope, the world's smallest and lightest for telemedicine applications. The lensless microscope can deliver health care in resource-limited settings by analyzing blood samples or fluids instantly.
Scientists at Arizona State University have developed a new imaging technology that can detect tiny particles of explosives, proteins, and heavy metals. This technique combines optical microscopy with electrochemical detection to provide a detailed map of the surface under study.
Researchers found that the ridges form from cutin polyester, not from underlying surfaces. The discovery could lead to enhanced pollination success and production of polyesters or related chemicals by genetically manipulating plants or microbes.
A team of Harvard chemists has developed a new microscopic technique that allows researchers to identify previously unseen molecules in living organisms. The room-temperature technique uses stimulated emission to generate images of non-fluorescent molecules, offering broad applications in biomedical imaging and research.
Researchers create a holographic microscope that records three-dimensional movies of microscopic systems like biological molecules. The technique uses a collimated laser beam to generate and record images, providing detailed information about the object's size, composition, and position.
Researchers at Vanderbilt University have developed the world's smallest periscope, allowing for multi-vantage-point imaging of cells and micro-organisms. This technology enables scientists to study dynamic processes within cells in three dimensions, providing a high resolution form of microscopy.
Scientists have developed a new imaging technology that produces the best three-dimensional resolution ever seen with an optical microscope, allowing them to pinpoint fluorescent labels in all three dimensions. This breakthrough will help reveal how biomolecules organize themselves into cellular structures and signaling complexes.
Scientists have successfully resolved features of cells as small as 20-30 nanometers using Stochastic Optical Reconstruction Microscopy (STORM), a new 'super-resolution' fluorescence microscopy technique. This breakthrough allows for the visualization of cellular structures at the level where they work.
A new NIST technique uses an optical microscope to quickly analyze nanoscale dimensions with high sensitivity. The 'Through-focus Scanning Optical Microscope' (TSOM) method has potential applications in nanomanufacturing, semiconductor process control, and biotechnology.
Caltech bioengineers create a super-compact high-resolution microscope, small enough to fit on a finger tip, operating without lenses. The optofluidic microscope can be used in the field to analyze blood samples and mass-produced for $10.
The novel microscope combines high penetration power with spatial resolution, allowing for the detailed composition of semiconductor devices and cellular structures to be analyzed. This breakthrough technique has far-reaching implications for improving semiconductor production and life science microscopy.
Advances in super-resolution imaging technologies, such as STED, STORM, PALM, and structured illumination microscopy, have broken the diffraction limit of light, enabling the imaging of cellular structures as small as 50 nanometres. These techniques are driven by both biological and physical needs, inspiring new questions and discoveries.
Researchers at TU Delft have mapped the process of light passing through small holes, promising a significant improvement in Terahertz microscopy and microspectroscopy. The study confirms the Bouwkamp model and reveals that sufficient light can pass through even tiny holes, enabling measurements near the hole.
Magnet Lab researchers develop two new biosensors to monitor cellular dynamics and expand optical microscopy capabilities. The new technique enables the observation of two dynamic processes in a single cell for longer periods, speeding up experiments and advancing tumor and developmental biology research.
Scientists have developed a new technique to study neurons in three dimensions, allowing for faster analysis of neuronal activity and interactions. This breakthrough uses a fast-moving laser beam and multi-photon microscopy to provide a more detailed understanding of neuron function.
The University of Maryland researchers have developed a 2D invisibility cloak that refracts visible light around an object, making it invisible. The cloak is created using a thin, transparent acrylic plastic layer with a gold film and can be integrated into a conventional optical microscope to view nanoscale details.
A team of international researchers has observed the formation of metallic puddles in vanadium dioxide, leading to a better understanding of the Mott transition and its potential applications. The study uses near-field scanning optical microscopy to reveal new insights into superconductors and materials development.
Researchers at UCLA will use a new super-resolution stimulated emission depletion (STED) microscope to investigate molecular assemblies and biological processes, including chromatin structure and cell signaling. The instrument will also enable the development of new family of STED probes based on semiconductor nanocrystals.
Researchers from Harvard University have demonstrated a laser with unprecedented detail, capable of resolving chemical composition of samples like cells. This device combines Quantum Cascade Lasers with optical antenna nanotechnology, enabling new ultrahigh spatial resolution microscopes for chemical imaging.
Researchers at the Max Planck Institute developed a technique called optical 3D far-field microscopy using photoswitchable rhodamine amides, allowing for highly resolved 3D images of transparent fluorescence-marked samples. The method can capture nanoscale resolution with good signal-to-noise ratio and relatively short exposure times.
Stefan Hell's STED microscope enables nanoscale imaging, achieving resolutions up to 10-12 times higher than the diffraction limit. This breakthrough allows for non-invasive imaging of cells' inner structures.
Researchers at NIST have devised a system for manipulating and positioning individual nanowires using optical microscopy and conventional photolithographic processing. They can fabricate sophisticated test structures to explore the properties of nanowires with high control, enabling the creation of elaborate structures for testing.
The Adaptive Scanning Optical Microscope (ASOM) eliminates traditional trade-offs between magnification and field of view, providing 40mm diameter field of view with consistent resolution. This technology enables faster imaging and reduces visual distortions.
Researchers created microscopic 'nanolamps' using electrospinning, a technique that produces extremely small fibers made of ruthenium and polyethylene oxide. The fibers emit orange light when excited by low voltage, making them useful for applications in sensing, microscopy, and flat-panel displays.
Virginia Tech researcher Yong Xu seeks to create an optical microscope that can image nanostructures at one nanometer resolution, a breakthrough in arranging atoms on the molecular scale. Observing the vacuum field at this resolution could help solve quantum electrodynamics' remaining mysteries.
Researchers at University of Sheffield have developed a new technique to enhance x-ray microscope images, enabling the capture of high-resolution 3D images of any molecular structure. They aim to develop the ultimate x-ray microscope with computer-aided image processing and potentially replace lenses with solid-state optical microscopes.
Researchers developed Interferometric Synthetic Aperture Microscopy, a novel technique that produces crisp three-dimensional images from out-of-focus data. This method can perform high-speed, micron-scale imaging without time-consuming processing or sectioning of tissue.
The Rensselaer Polytechnic Institute has licensed its Adaptive Scanning Optical Microscope (ASOM) technology to Thorlabs Inc. The ASOM enables the automation of challenging laboratory tasks, such as diagnosing cancer and discovering new drugs. It provides high-resolution images of large sample areas without sacrificing image quality.
Researchers have used a new type of light microscope to visualize the distribution of H2AX proteins in the cell nucleus, revealing clusters that direct DNA repair after damage. This discovery provides new insights into the complex process of gene repair and its relationship with other nuclear components.