Articles tagged with Optical Microscopy
A new microscopy technique developed by NIST researchers uses cathodoluminescence to image nanoscale features with high resolution. The technique combines the benefits of optical and scanning electron microscopes, evading traditional limitations such as diffraction and sample preparation requirements.
Visikol, a polychlorinated alcohol mixture, effectively clears organisms for viewing under microscopes without the need for federal regulation. Developed as a replacement for chloral hydrate, it offers safety and cost benefits while maintaining high-quality microscopic images.
Researchers at Purdue University have developed a new super-resolution optical microscopy technique that can image synthetic nanostructures and molecules without the need for fluorescent dyes. The technique, called saturated transient absorption microscopy (STAM), uses a trio of laser beams to selectively illuminate molecules, allowing...
Researchers at Berkeley Lab's Advanced Light Source are transforming X-ray microscopy into a widely available form of high-resolution imaging. State-of-the-art instruments can create three-dimensional images with elemental and/or chemical sensitivity, allowing for unprecedented insights into biological systems.
Researchers used a super-resolution microscope to study protein distribution in human T-cells, revealing the dynamic opening and closing process of kinase molecules. This discovery could provide insights into immune disorders and cancer by understanding how signaling processes are controlled.
Researchers from China have devised a universal method using just an optical microscope to measure graphene and other two-dimensional materials' thickness. The technique exploits the reflected light's red, green, and blue components, increasing contrast with sample thickness.
A team of scientists has developed integrated arrays of optical vortex beams on a silicon chip, which can be used to transmit multiple streams of information. This breakthrough could enable the creation of compact and high-density devices for applications such as sensing and microscopic particle manipulation.
Researchers have developed a digital microscope that creates high-resolution images at fast speeds, enabling scientists to study biological processes like cell activity in greater detail. The new device uses a programmable micromirror system to reject unwanted light and improve image quality.
A team of Italian researchers has developed a new microscopy technique called confocal light sheet microscopy (CLSM) that improves the resolution and contrast of images of the brain's neural pathways. CLSM enables scientists to obtain high-resolution views of tissue samples with a resolution of a few microns and faster acquisition time.
Researchers developed nano-FTIR, combining s-SNOM and FTIR spectroscopy for nanoscale chemical identification and mapping. The technique offers high sensitivity and resolution, making it a unique tool for polymer chemistry, biomedicine, and pharmaceutical industry.
Researchers have developed materials and nanofabrication techniques to build miniaturized components for medical diagnostics, sensors, and other applications. These miniaturized components can perform rapid analysis with small sample volumes.
Researchers have developed a new fluorescent labeling strategy that enables the examination of bacterial biofilm structure, leading to potential drug targets. The study has provided new insights into the development of complex structures and may pave the way for new approaches to fighting infectious disease.
A Griffith University research team has successfully photographed the shadow of a single atom for the first time. The achievement is made possible by a super high-resolution microscope that allows the creation of a darker image, enabling its capture. This technology has far-reaching implications for quantum computing and biomicroscopy.
Researchers at Beckman Institute developed a fast, non-invasive 3D microscopy method that visualizes E. coli sub-cellular structure in three dimensions without disturbing the specimen or using fluorescence or contrast agents.
Researchers developed a new microscope that uses X-ray excited luminescence microscopy to image material properties. The technique combines optical microscopy's spatial resolution with synchrotron radiation's element and magnetic specificity, enabling the imaging of features as small as one micron.
A new imaging technology captures unprecedented speed and precision of embryogenesis, enabling quantitative analyses of developmental processes. The SiMView light sheet microscope allows users to track each cell in an embryo as it takes shape over hours or days.
Researchers developed a computational technique to correct aberrations in optical tomography, enabling faster, less expensive and higher resolution tissue imaging. The technique was demonstrated using gel-based phantoms and rat lung tissue, resulting in sharp points and clearer tissue structures.
Researchers have developed a new approach using compressed sensing to resolve cellular features an order of magnitude smaller than before. This allows for the study of dynamic processes in live cells with seconds or even sub-second temporal resolution.
Scientists at the University of Sheffield have developed a new method, called electron ptychography, to form high-resolution images without lenses. This approach enables imaging at sub-atomic scale and has no fundamental experimental boundaries.
Researchers at Max Planck Institute have recorded detailed live images inside the brain of a living mouse using STED microscopy, making minute structures visible for the first time. This breakthrough could help decipher fundamental processes in the brain and shed light on illnesses caused by synapse malfunction.
The Focus Issue on Digital Holography and 3-D Imaging presents recent breakthroughs in digital holography, enabling non-invasive biomedical imaging and applications in structural analysis. Novel techniques such as compressive holography and lens-free tomographic microscopy are showcased, advancing 3-D display technologies.
Researchers at Princeton University discovered that blocking small holes in a metal film enhances light transmission by up to 70%. The technique challenges common assumptions in optics and could have significant implications for ultrasensitive detectors. Further investigation is needed to apply this finding to various applications.
Scientists have developed a technique using scanning transmission electron microscopy (STEM) to view proteins tagged with gold nanoparticles in whole, intact cells. This method offers ten times better resolution than optical microscopes and could help study cancer processes and understand how viruses hijack healthy cells.
A team of researchers transformed everyday iPhones into medical-quality imaging and chemical detection devices, enabling doctors to diagnose blood diseases in developing nations. The modified phones can perform detailed microscopy and spectroscopy, transmitting real-time data for further analysis and diagnosis.
The University of Alberta's Virtual Reflected-Light Microscopy (VRLM) technology enables geoscientists to analyze ancient sea creatures and date rocks with unprecedented detail. This innovation accelerates species identification of microfossils, used to determine rock age and explore energy resources.
Researchers at Imperial College London and the University of Oxford used 'optical' laser tweezers and a super-resolution microscope to observe the inner workings of white blood cells, including Natural Killer cells. The study provides new insights into how these cells deliver deadly enzyme-filled granules to kill diseased tissue.
Researchers have developed a compact, lightweight microscope that uses holograms instead of lenses for dual-mode imaging. The device is portable, inexpensive, and can be used for field diagnostics in developing countries, testing of water quality, and food contamination.
A research team from Yale University has successfully achieved two-color stimulated emission depletion (STED) microscopy in living cells, overcoming previous challenges in labeling target proteins. The breakthrough enables resolutions of 78 nanometers and 82 nanometers for sequential scans of two proteins in living cells.
Researchers at MIT have developed a new high-speed 3D imaging system based on optical coherence tomography (OCT) technology, enabling real-time visualization of microscopic features in the esophagus and colon. The system promises to improve cancer screening by detecting pre-cancerous changes and guiding endoscopic therapies.
Researchers at UCLA have created a lens-free optical microscope that can produce high-resolution 3D images of microscopic objects. The system uses tomography and digital sensor arrays to capture detailed sub-cellular structures without using a lens.
UCSD scientists create a new type of genetic tag visible under an electron microscope, allowing for detailed, three-dimensional images of individual cells. The modified protein, dubbed miniSOG, produces abundant singlet oxygen when exposed to blue light, enabling its visualization.
Scientists at UCSD and colleagues create a new type of genetic tag visible under electron microscopy, enabling detailed three-dimensional images of individual cells. The breakthrough enhances electron microscopy capabilities, allowing researchers to visualize proteins in unprecedented detail.
A new super-resolution microscopy technique reveals changes in protein concentration on human immune cells exposed to E.coli and Y.pestis toxins. This work provides insight into why some bacteria can evade the immune system.
The new microscope allows researchers to study the dynamic inner lives of living cells without damaging them. It uses a combination of structured illumination and two-photon microscopy to create high-resolution, three-dimensional images of cellular landmarks.
Researchers have developed an iPad application for optical tweezers, overcoming limitations of computer mouse control. The multi-touch-based app allows for clear representation of particle systems and offers various techniques for movement.
Scientists have developed a microscope that can see objects as small as 50 nanometres, beyond the theoretical limit of optical microscopy. This breakthrough enables potential examination of human cells and live viruses for the first time, revolutionizing cell study and biomedicine.
Researchers have developed a new strategy to improve microscopy by following the astronomers' guide star technique, allowing for sharper images of biological samples. This method uses adaptive optics and two-photon fluorescence microscopy to correct for light waves hitting cells in different directions.
The team aims to create images revealing micro- and macroscopic matter with improved clarity, surpassing traditional microscopy resolution by 10-fold. This enables scientists to study living tissue in its natural state without sample manipulation.
Mark Bates has been awarded the GE & Science Prize for Young Life Scientists for his novel research on high-resolution imaging of biological cells and tissues. His technique, known as stochastic optical reconstruction microscopy, enables researchers to see previously hidden aspects of life with unprecedented detail.
Researchers at Harvard University have created a new type of biomedical imaging that can capture 'video' of blood cells squeezing through capillaries. The technique, based on stimulated Raman scattering (SRS), makes label-free chemical movies with streaming footage at the subcellular level.
Researchers have developed a technique that corrects a trick of the light, enabling the use of optical microscopy to image objects or distances with resolutions as small as 0.5 nanometers, revolutionizing biology. This breakthrough allows for accurate measurements of protein structures and molecular organization in biological samples.
The UCLA engineer's telemedicine invention uses a lensless cellphone microscope to detect sub-cellular elements and has the potential to revolutionize healthcare in developing countries. With its ability to be miniaturized, inexpensive, and easy to use, this technology aims to bridge the gaps left by inadequate healthcare infrastructure.
A new instrument, Centrifuge Force Microscope (CFM), uses centrifugal force to manipulate molecules, offering a low-cost and simple approach to single-molecule manipulation. This technique enables researchers to study the interactions of thousands of molecules simultaneously.
Researchers at Berkeley Lab's ALS beamline 9.0.1 developed a method to image whole yeast cells with soft X-rays, achieving a resolution of 11-13 nanometers. This breakthrough enables the possibility of full 3D tomography of whole cells at equivalent resolution.
The UCLA engineer has created a miniature microscope, the world's smallest and lightest for telemedicine applications. The lensless microscope can deliver health care in resource-limited settings by analyzing blood samples or fluids instantly.
Scientists at Arizona State University have developed a new imaging technology that can detect tiny particles of explosives, proteins, and heavy metals. This technique combines optical microscopy with electrochemical detection to provide a detailed map of the surface under study.
Researchers found that the ridges form from cutin polyester, not from underlying surfaces. The discovery could lead to enhanced pollination success and production of polyesters or related chemicals by genetically manipulating plants or microbes.
A team of Harvard chemists has developed a new microscopic technique that allows researchers to identify previously unseen molecules in living organisms. The room-temperature technique uses stimulated emission to generate images of non-fluorescent molecules, offering broad applications in biomedical imaging and research.
Researchers create a holographic microscope that records three-dimensional movies of microscopic systems like biological molecules. The technique uses a collimated laser beam to generate and record images, providing detailed information about the object's size, composition, and position.
Researchers at Vanderbilt University have developed the world's smallest periscope, allowing for multi-vantage-point imaging of cells and micro-organisms. This technology enables scientists to study dynamic processes within cells in three dimensions, providing a high resolution form of microscopy.
Scientists have developed a new imaging technology that produces the best three-dimensional resolution ever seen with an optical microscope, allowing them to pinpoint fluorescent labels in all three dimensions. This breakthrough will help reveal how biomolecules organize themselves into cellular structures and signaling complexes.
Scientists have successfully resolved features of cells as small as 20-30 nanometers using Stochastic Optical Reconstruction Microscopy (STORM), a new 'super-resolution' fluorescence microscopy technique. This breakthrough allows for the visualization of cellular structures at the level where they work.
A new NIST technique uses an optical microscope to quickly analyze nanoscale dimensions with high sensitivity. The 'Through-focus Scanning Optical Microscope' (TSOM) method has potential applications in nanomanufacturing, semiconductor process control, and biotechnology.
Caltech bioengineers create a super-compact high-resolution microscope, small enough to fit on a finger tip, operating without lenses. The optofluidic microscope can be used in the field to analyze blood samples and mass-produced for $10.
The novel microscope combines high penetration power with spatial resolution, allowing for the detailed composition of semiconductor devices and cellular structures to be analyzed. This breakthrough technique has far-reaching implications for improving semiconductor production and life science microscopy.
Advances in super-resolution imaging technologies, such as STED, STORM, PALM, and structured illumination microscopy, have broken the diffraction limit of light, enabling the imaging of cellular structures as small as 50 nanometres. These techniques are driven by both biological and physical needs, inspiring new questions and discoveries.
Researchers at TU Delft have mapped the process of light passing through small holes, promising a significant improvement in Terahertz microscopy and microspectroscopy. The study confirms the Bouwkamp model and reveals that sufficient light can pass through even tiny holes, enabling measurements near the hole.
Magnet Lab researchers develop two new biosensors to monitor cellular dynamics and expand optical microscopy capabilities. The new technique enables the observation of two dynamic processes in a single cell for longer periods, speeding up experiments and advancing tumor and developmental biology research.
Scientists have developed a new technique to study neurons in three dimensions, allowing for faster analysis of neuronal activity and interactions. This breakthrough uses a fast-moving laser beam and multi-photon microscopy to provide a more detailed understanding of neuron function.
The University of Maryland researchers have developed a 2D invisibility cloak that refracts visible light around an object, making it invisible. The cloak is created using a thin, transparent acrylic plastic layer with a gold film and can be integrated into a conventional optical microscope to view nanoscale details.