Articles tagged with Optical Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed an AI system to spot parasitic worm infections in children's stool samples using digital mobile microscopy. This innovation improves diagnosis in resource-limited settings where manual microscopy may miss light intensity infections.
Researchers have developed a new open-source algorithm called Conditional Variational Diffusion Model (CVDM) that improves the quality of images by reconstructing them from randomness. The CVDM is computationally less expensive than established diffusion models and can be easily adapted for various applications.
Researchers from Osaka University have developed a combined microscopy technique that captures the nanoscale behavior of azo-polymer films triggered by laser light. This allows for real-time observation with high spatiotemporal resolution, shedding light on the mechanism of light-driven deformation in these materials.
Scientists have developed a new technique called electron ptychography that boosts the resolution of electron microscopes using computation, allowing for record-breaking resolution without expensive aberration correctors. This breakthrough enables state-of-the-art resolution at a fraction of the cost, making microscopy more accessible.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Scientists use a special microscope to break up the bond between electrons and holes in semiconductors, revealing that hole interactions determine charge transfer processes. The findings have implications for future computer and photovoltaic technologies.
Researchers developed a compact microscope using a single photon avalanche diode array detector, enabling super-resolution imaging with improved signal-to-noise ratio and spatial resolution. The system also combines fluorescence lifetime measurements for enhanced structural specificity.
Using optical traps, researchers controlled bacterial aggregation and biofilm development, finding different types of lasers can stimulate or suppress growth. The study opens up possibilities for creating microscopic building materials from bacteria.
A new study by GIST researchers provides efficient hydrogen storage solutions using clathrate hydrates, overcoming limitations such as limited gas storage capacities and slow formation rates. The study offers crucial insights for developing clathrate hydrate-based technologies for carbon dioxide separation and hydrogen storage.
A team of researchers at Tohoku University has developed a novel visualization method to study the behavior of hydrogen atoms in alloys. They successfully filmed the flow of hydrogen atoms in pure nickel, revealing that they preferentially diffuse through grain boundaries with large geometric spaces.
Researchers at Purdue University developed a novel AI engine to control and optimize optical microscopes, enabling 3D ultrastructure visualization of the brain circuitry with nanometer resolution. This technology has the potential to shed light on human development and disease, particularly autism and Alzheimer's disease.
Researchers have developed a new form of microscopy that can probe details in an object's surface using evanescent waves. The technique, which detects radiation emitted by the object itself, has been used to examine thermally excited evanescent waves in dielectric materials with nanoscale precision.
Researchers at Purdue University propose using vanadium oxides to create neuromorphic computing hardware that mimics brain behavior. This breakthrough aims to improve energy efficiency and computational performance in AI systems.
Scientists have developed a way to regulate gene expression in organoids using optogenetics, enabling the observation of cell behavior and development patterns. This breakthrough allows for more accurate reproduction of tissue processes in the petri dish.
The Marine Biological Laboratory (MBL) has been awarded $4.3 million by the Massachusetts Life Sciences Center to expand its imaging capabilities. The grant will support the procurement of two state-of-the-art microscopes that can perform advanced imaging techniques, including 2D and 3D reconstruction from electron and light microscopy.
Micro4PAP, a fast-scan Brillouin Microscope, allows for non-destructive, label- and contact-free imaging of biological samples. The device enables sub-millisecond acquisition time, suitable for in-vivo measurements in living cells, promoting early disease detection and diagnosis.
The research team created a multi-spectral, super-low-dose photoacoustic microscopy system with improved sensitivity, enabling new applications and clinical translation. The system achieved up to capillary-level or sub-cellular resolution at greater depths than traditional optical microscopy methods.
Researchers at Shanghai Jiao Tong University have developed a new scattering matrix method that can sculpt light output with minimal optimization time. The method offers unparalleled nonlinear scattered light control, enabling high-resolution scanning microscopy and particle trapping through dense, scattering media.
A research team at USTC realized single-pixel imaging of single living cells using 3D light-field illumination, achieving a resolution of up to 2.7 μm laterally and 37 μm axially. This breakthrough enables volumetric imaging of microscopic objects with high-performance 3D SPI.
The new microscope uses structured illumination and optical fibers to achieve fast super-resolution imaging over a wide field of view, enabling the study of individual cell responses to various drugs. The system can image multiple cells simultaneously with high resolution, providing statistical information about cell response.
Researchers developed an innovative optical tool, the Schistoscope, to capture microscopy images of urine samples for efficient detection of Schistosoma haematobium eggs. A two-stage diagnostic framework using deep learning accurately identified and counted eggs in field settings with high sensitivity, specificity, and precision.
Scientists have studied the internal parts of spider silk using an optical microscope without cutting it open. The analysis revealed that the fiber consists of at least two outer layers of lipids and numerous fibrils running in a straight, tightly packed arrangement. Understanding how to create such strong fibers is crucial for produci...
Researchers created a new method, RESORT, to image and analyze living systems in unprecedented detail. The technique combines benefits of super-resolution fluorescence and vibrational imaging, allowing for high spatial resolution and analysis of complex interactions.
Researchers at Ulsan National Institute of Science and Technology have made a breakthrough in creating ultra-photostable avalanching nanoparticles that can perform unlimited photoswitching. This achievement has significant implications for fields like optical probes, 3D optical memory, and super-resolution microscopy.
A team of scientists has developed an automated algorithm to reconstruct the shape of each neuron inside a light microscopy image using deep learning. This breakthrough addresses the challenge of generalizing algorithms across diverse species, brain locations, developmental stages, and microscopy image sets.
A new study from Duke University identifies 1,500 genes essential for invasive cell behavior in C. elegans worms. The researchers created a 'parts list' of these genes and proteins, which may help identify effective ways to stop cancer's spread.
Researchers at Caltech have developed a technique that uses quantum entanglement to create biphotons, which can be used to image cells with a resolution twice that of traditional microscopes. By harnessing the properties of quantum entanglement, scientists can now visualize tiny structures within living cells with unprecedented precision.
Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.
Scientists create a simple approach to fabricating highly precise 3D aperiodic photonic volume elements (APVEs) for various applications. The method uses direct laser writing to arrange voxels of specific refractive indices in glass, enabling the precise control of light flow and achieving record-high diffraction efficiency.
Researchers at Brown University developed a new microscopy technique using blue light to measure electrons in semiconductors and other nanoscale materials. This breakthrough enables the study of critical components that can help power devices like mobile phones and laptops.
Scientists at TUM create genetic reporter proteins that can be resolved by electron microscopy, unveiling invisible cellular structures and processes. The discovery enables further research into disease mechanisms and potential therapeutic cell production.
Researchers at Duke University have successfully improved the resolution of Magnetic Resonance Imaging (MRI), capturing images of a mouse brain with unprecedented sharpness. The breakthrough allows for the visualization of microscopic details within the brain, enabling new insights into neurodegenerative diseases such as Alzheimer's an...
A new CLEM approach uses small gold nanoparticles as single probes visible in both LM and EM with high contrast and photostability. This method detects individual nanoparticles with nanometric precision, enabling accurate correlative microscopy workflows without the need for unstable fluorophores or additional fiducial markers.
Researchers uncover how HIV enters human bodies via dendritic cells using Siglec-1 membrane protein; formation of nanoclusters enhances capture, leading to virus compartment formation. Understanding this process can aid in developing effective treatments for HIV/AIDS.
This technology uses light and sound to create images of the inside of the body. The research team developed a novel method that eliminates the need for ultrasonic transducers, allowing for non-contact photoacoustic signal detection and improved sensitivity. The technique has great application potential in various biomedical research.
Researchers have developed a novel imaging method to detect gold nanoparticles in woodlice, allowing for the study of metal toxicity and its impact on the environment. This technique enables scientists to precisely pinpoint the fate of individual gold nanoparticles in complex biological systems.
A new type of meta-optics, developed at Harvard, has been successfully tested at Graz University of Technology, allowing the observation of ultra-fast physical processes. The lens uses extreme ultraviolet radiation to track charge carriers in space and time, enabling optimization of modern transistors and optoelectronic circuits.
Researchers have developed a new type of microscope objective inspired by the eyes of scallops, which can capture images in various immersion media, including liquids. This innovative approach uses a mirror instead of lenses and has been shown to provide excellent image quality in homogeneous fluids as well as in air.
Researchers have identified properties like curl shape, coils, and cuticle layers that can help distinguish between curly, kinky, wavy, and straight hair. These findings aim to provide a more precise and quantitative classification system for haircare products.
Researchers utilize liquid crystal droplets to visualize electric field distribution within microelectrodes, revealing rotational and translational behaviors under applied voltage. The technique provides high spatial resolution and detection accuracy, enabling defect location analysis.
A team of researchers at the University of Connecticut created freeform illuminators that enable flexible illumination design and calibration using a blood-coated sensor. The newly developed technology simplifies microscopy experiments by reducing size, increasing density, and adjusting angle of illumination.
Researchers have created wearable microscopes to produce high-definition, real-time images of mouse spinal cord activity across previously inaccessible regions. This technology enables unprecedented insight into the neural basis of sensations and movement in healthy and disease contexts.
Researchers have successfully applied speckle illumination to photoacoustic microscopy, reducing tissue damage and improving image reconstruction. The technique harnesses the power of structured illumination methods initially developed for optical microscopy, allowing for more efficient imaging with acoustic detection.
Molecular biologist Shixin Liu is recognized for developing cutting-edge biophysical tools to visualize and understand biomolecular machines. His work aims to establish a quantitative input-output relationship between environmental stimuli and gene expression profiles.
Researchers developed an efficient algorithm that combines classical and quantum correlation functions to improve super-resolution microscopy. The algorithm, called 'super deconvolution imaging,' results in increased spatial frequency content, reduced mean squared errors, and faster imaging speeds.
Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.
Researchers have developed AI-based virtual staining technology to digitally generate histological stains, eliminating labor-intensive preparation steps, lengthy turnaround time, high costs, and inconsistent outcomes. This emerging field has the potential to improve diagnosis accuracy and speed patient outcomes.
Researchers developed a new label-free UV microscopy technique that provides superior contrast for cellular-scale biological research. The method uses c-band ultra-violet (UVC) light to enhance image contrast and extract quantitative information from biological samples.
Researchers discovered that woodcock tail feathers reflect up to 55% of light, 30% more than any other bird feather, due to their unique structure and arrangement. This enhanced reflectance allows them to attract attention in dimly lit environments.
Researchers at University of Gothenburg developed AI method using graph theory and neural networks to analyze cell movement, enabling better understanding of biological processes and development of new medical technologies. The method can reconstruct cell paths and test medication effectiveness as potential cancer treatments.
Researchers have developed a gold nanoparticle probe to detect porcine epidemic diarrhoea virus (PEDV), a devastating disease causing severe diarrhoea and high death rates. The new tool promises fast, affordable diagnosis on-site, critical for preventing future outbreaks and protecting the industry from economic losses.
The Chan Zuckerberg Initiative grant will support advanced imaging training for over 2,000 scientists through a combination of hands-on events and online resources. Array tomography, an imaging technique that offers higher resolution and detailed molecular labeling, will be a key focus of the project.
Researchers developed BrightEyes-TTM, an open-source stopwatch to study molecular interactions inside living cells. The platform records the lifetime of fluorescent molecules, providing insights into cellular structure and function.
Researchers report the discovery of photonic hopfions, a new family of 3D topological solitons with freely tunable textures and numbers. These structures exhibit robust topological protection, making them suitable for applications in optical communications, quantum technologies, and metrology.
A new type of optical manipulation has been developed, using laser light to pull macroscopic objects. The researchers designed a graphene-SiO composite structure specifically for laser pulling, which creates a reversed temperature difference when irradiated with a laser beam.
Researchers have developed a technique to record cellular events in a long protein chain, allowing them to reconstruct the timing of gene activation, response to drugs, and other processes. This method has potential applications in understanding memory formation, aging, and disease progression.
New expansion microscopy methods, dubbed Magnify, allow researchers to observe nanoscale biological structures with standard microscopes. The protocol retains biomolecules intact, enabling simultaneous imaging of proteins, lipids, and carbohydrates.
A new parallel peripheral-photoinhibition lithography system has been developed, enabling the fabrication of subdiffraction-limit features with high efficiency. The system uses two beams to excite and inhibit polymerization, allowing for nonperiodic and complex patterns to be printed simultaneously.
A new mesoscopic oblique plane microscopy method captures up to three times more resolvable image points than other similar systems, enabling whole-body volumetric recordings of neuronal activity and blood flow dynamics. The technique allows for single-cell tracking within the complete 3D circulation system for the first time.
Researchers developed a photon-efficient volumetric imaging method, laterally swept light-sheet microscopy (iLSLM), which improves axial resolution and optical sectioning while reducing photobleaching. iLSLM outperforms conventional methods like swept focus light-sheet microscopy in terms of resolution and photon efficiency.