Scientists have characterized lipid nanoparticles' internal shape and structure, which correlates with how well they deliver therapeutic cargo. The research provides a blueprint for engineering more effective RNA therapies by matching LNP designs to specific therapies and tissues.
Regional mesylate anticoagulation in centrifugation artificial liver support systems is safe for liver failure patients at risk of bleeding. Adjusting the mesylate dose based on pre-R and pre-MA enhances safety.
Researchers developed a microfluidic device to alleviate limitations of conventional blood-filtering machines used in treating hyperleukocytosis in children. The new device separates blood cells by size without platelet loss or adverse effects, enabling safe leukapheresis procedures.
Researchers at NTU Singapore have created a chip that can directly isolate blood plasma from a tube of blood in just 30 minutes, removing over 99.9% of blood cells and platelets. The device, called ExoArc, enables high-quality plasma for disease screening and research, improving diagnosis accuracy and reducing waiting times.
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A new method, EPISENS-S, has been developed to measure SARS-CoV-2 in wastewater with high sensitivity. This allows for the estimation of COVID-19 prevalence, including asymptomatic cases. The method was found to be approximately 100 times more sensitive than existing methods.
A new method has been developed using a microchip device that sorts sperm based on their swimming potential, allowing for faster and cheaper selection of viable sperm. This technology may improve IVF success rates, especially in women under 35 who have low chances of successful fertilization.
Researchers studied knotted steel chains in a viscous fluid, reproducing Kelvin's vortex atoms. The chains formed stable, toroidal structures with intertwined loops that swirled around each other.
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