Kinase Assays | Topics

Homogeneous BTK occupancy assay

The new assay enables simultaneous measurement of tirabrutinib bound and total BTK levels, reducing sample requirements. It uses full-length purified recombinant human BTK protein and PBMCs derived from healthy volunteers and patients with CLL, demonstrating its utility for pharmacodynamic assessments.

FDA-approved ALK IHC CDx superior to another IHC assay for patient selection

A recent study published in Journal of Thoracic Oncology found that the FDA-approved VENTANA anti-ALK(D5F3)CDx assay is superior to the 5A4 IHC assay for selecting patients with non-small cell lung cancer eligible for ALK tyrosine kinase inhibitor treatment.

Study of key enzyme sheds new light on programmed cell death and may lead to new drugs for reducing the severity of stroke

Scientists have determined the three-dimensional structure of Death Associated Protein Kinase (DAPK) and created a quantitative assay to measure its activity. This breakthrough may lead to new drugs that can reduce cell damage following brain injuries and strokes.