Articles tagged with Organoids
Scientists have mapped the complete trajectory of placental development, shedding light on why pregnancy disorders occur. The study reveals new information on cell communication and trophoblast development, providing a better understanding of the process.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
Researchers at UCLA successfully used base editing to correct a mutation causing rare immune deficiency CD3 delta SCID. The treatment corrected an average of 71% of patient stem cells and allowed them to produce fully functional T cells, suggesting long-term persistence of corrected blood stem cells.
Researchers have developed a new type of computer using human brain cells, which could lead to significant advances in computing speed and data efficiency. The technology uses small clusters of brain cells grown from stem cells and aims to increase the number of neurons to surpass electronic computers.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers create lab-grown brain organoids as biological hardware to drive computing forward. These three-dimensional cultures can process information faster and more efficiently than current silicon computers.
Researchers at Johns Hopkins University are developing 'organoid intelligence' using human brain cells, which could exponentially expand computing capabilities and solve energy consumption issues. The technology has the potential to revolutionize drug testing research for neurodevelopmental disorders and neurodegeneration.
Researchers created human organoid models of fatty liver disease to shed light on drug responses and disease biology. The models identified a common mechanism for effective drugs that block lipid generation from sugars, suggesting personalized medicine applications.
Scientists at the Wyss Institute and Gameto develop a living, fully human ovarian organoid that supports egg cell maturation and secretes sex hormones. This technology enables the study of human ovarian biology without tissue from patients and could lead to new treatments for infertility and ovarian cancer.
Researchers successfully transplanted human brain organoids into adult rat brains and observed functional integration, including response to visual stimulation. The study demonstrates potential for neural tissues to rebuild injured brain areas.
Researchers generated cochlear avatars from stem cells, recreating hair cell function and transmitting electrical signals. This breakthrough enables the investigation of sensorineural hearing loss mechanisms and potential treatments.
Engineers create OCTOPUS device to grow organs-in-a-dish, achieving higher levels of maturity than traditional methods. The device allows for more mature organs with complex cell relationships, providing valuable tools for studying human organ development.
Researchers discovered that sugar plays a key role in the formation of fluid-filled cysts associated with polycystic kidney disease (PKD). By understanding this process, they identified a potential new approach to treating PKD, focusing on blocking sugar absorption in the kidneys.
Researchers have successfully grown retinal cells from stem cells that can connect with neighboring cells and transmit sensory information like healthy ones. The breakthrough could lead to human clinical trials to treat degenerative eye disorders such as retinitis pigmentosa and age-related macular degeneration.
Researchers have successfully demonstrated that human brain organoids implanted in mice can establish functional connectivity and respond to external sensory stimuli, including visual cues. The breakthrough uses a combination of transparent graphene microelectrode arrays and two-photon imaging, enabling real-time observation of neural ...
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
Researchers at UNSW Sydney have successfully induced a gastrulation-like event in human pluripotent stem cells, mimicking the early stages of embryonic development. This breakthrough could lead to new approaches for studying human development and creating personalized body tissue or organs using hydrogel materials.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers identify an off-patent liver disease drug that can prevent SARS-CoV-2 entry into cells, potentially offering protection against future variants. The study used a unique combination of 'mini-organs', animal studies, and human subjects to demonstrate the drug's effectiveness.
A new study by researchers at the Swiss Institute of Allergy and Asthma Research found that commercial dishwashers' rinse agents can damage the gut's epithelial barrier, leading to chronic diseases. The study used human intestinal organoids and analyzed the effect of detergents and rinse aids on gut cells.
Johns Hopkins researchers have developed a three-dimensional organoid model derived from human tissue to study gastroesophageal junction (GEJ) cancer. The dual knockout of genes in the model has identified key biological targets for treating GEJ cancers with existing drugs.
A team of engineers at UC Santa Cruz has developed an automated system for growing cerebral organoids, miniature models of brain tissue grown from stem cells. The new method, called Autoculture, precisely delivers nutrients to individual organoids, optimizing growth and reducing cellular stress.
Researchers from MPI-CBG and IMP define metrics for organ development, providing a framework to transform the field of organoids into an engineering discipline. They discover that tissue connectivity emerges from two processes: fusion of separate epithelia or self-fusion of a single epithelium.
A new study using human brain organoids reveals that prenatal alcohol exposure impairs brain cell development and functioning. The findings confirm the harm inflicted by alcohol on the developing fetus, with effects including faulty brain architecture and impaired electrical activity patterns.
Scientists have developed a new technology that captures the key features of human bone marrow, allowing for the screening of multiple anti-cancer drugs and testing personalized treatments. The 'bone marrows in a dish' can support the survival of cells from patients with blood malignancies
A team of scientists has made a breakthrough in growing stem cells and mini-brains from Sumatran rhino skin cells, which may help save the endangered species from extinction. The goal is to create sperm cells that can be used in artificial insemination, increasing the chances of successful breeding.
A team of Berlin scientists has successfully grown stem cells and mini-brains from Sumatran rhino skin cells, paving the way for potential use in assisted reproduction. The next step is to create sperm cells that may help save the critically endangered species from extinction.
Researchers generated induced pluripotent stem cells and cerebral organoids from the last male Malaysian Sumatran rhino, enabling study of brain development and potentially aiding in breeding program. The technology holds promise for fighting extinction of critically endangered species.
New insights into the processing of hormones in the human gut reveal dozens of peptides regulating appetite, bowel movement, and insulin secretion. By studying human intestinal organoids, researchers characterized potentially novel gut hormones, including glucagon, and explored its role in human physiology.
The HUSH complex is involved in normal brain development, neuronal individuality, and connectivity. The complex also regulates repetitive-like gene clusters, including protocadherin gene clusters, which are essential for neuron-to-neuron interactions.
Researchers used human brain organoids to show how SARS-CoV-2 infects and destroys synapses in cortical neurons. Sofosbuvir effectively inhibited viral replication and rescued impaired neurons, suggesting a potential treatment for Long COVID.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
Researchers from Yokohama National University successfully generated hair follicles in cultures using organoid cultures. The study demonstrates the potential of hair follicle organoids for understanding hair follicle development and regeneration, as well as evaluating drugs for treating hair loss disorders.
A new research method allows for a detailed examination of brain processes involved in neurological disorders by integrating human cortical organoids into developing rat brains. The study finds that transplanted organoids integrate into specific brain pathways, displaying functional connectivity.
A team of researchers at the University of Pittsburgh is using artificial intelligence to create more efficient and effective organoids. By designing and printing smarter cell structures that mimic human organs, they aim to reduce trial-and-error methods and costs, ultimately contributing to new methods in disease research and human he...
Researchers found positive correlations between lipoxin A4 and cognitive brain functions, as well as its potential to potentiate the endocannabinoid system. The study suggests that reducing levels of this substance may weaken the body's defenses against neurodegeneration.
Scientists have developed a new method to study human brain development by growing millimetre-sized three-dimensional tissues called organoids from pluripotent stem cells. The researchers characterized the cells in molecular-genetic terms, creating a kind of map showing the molecular fingerprint of each cell within the organoid.
Researchers have developed brain-like organoids that can be tested experimentally to uncover cellular and molecular causes of autism. The organoids, grown in a dish from human cells, self-organize into layers of cells reminiscent of the cerebral cortex, allowing scientists to study how complex neural structures arise.
Scientists have developed guidelines to produce high-quality, well-structured mini-brain organoids that accurately mimic human brain tissues. By using early-stage stem cells and specific molecules, researchers can overcome challenges in uniformity and structure, enabling studies of neurological development, disease, and therapies.
Researchers developed a new 3D organoid model that replicates the unique disease process of autosomal recessive polycystic kidney disease (APRKD). The model identified potential therapeutic targets, including FOS and RAC1, and showed therapeutic effects with FDA-approved drugs.