Researchers at UCLA have developed a new method to bioprint miniature tumor organoids that can mimic the function and architecture of real tumors. This allows for the accurate measurement of individual organoids, enabling the identification of personalized treatments for people with rare or hard-to-treat cancers.
Researchers have developed a technology to grow genetically identical mini lungs on microchips, enabling high-throughput analysis of lung tissue infections and identification of candidate therapeutics. The platform can track thousands of lung buds at once, revolutionizing the study of respiratory diseases like COVID-19.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
The PARIS Test, a CLIA-certified drug sensitivity assay, uses patient-derived tumor organoids to screen an array of drugs and develop personalized treatment reports. Ibrutinib, a BTK inhibitor approved only for certain leukemias and lymphomas, was identified as the optimal treatment for a patient with ovarian cancer.
Scientists have developed a new method to genetically modify brain organoids, allowing for quick and effective analysis of gene function in early stages of brain development. This breakthrough enables comparative studies across primate species and simulates neurological diseases without animal experiments.
Researchers developed a biobank of head and neck cancer organoids to validate biomarkers and predict treatment responses. The study found that organoid responses matched patient outcomes, suggesting potential for personalized therapies.
Researchers create a human-brain-like environment to study microglia development and function for the first time in living human-derived tissue. The findings suggest that brain environment influences microglia development and function, particularly in diseases such as autism spectrum disorder and Alzheimer's disease.
Researchers have created a detailed map of human retinal organoid development, revealing information on cell types, proteins, and gene expression. The study uses advanced imaging techniques to visualize multiple proteins simultaneously and provides insights into retinal diseases such as retinitis pigmentosa.
Human brain organoids, grown in labs from stem cells, raise questions about personhood. Researchers propose a legal framework to understand their potential personhood and uses.
Researchers created organoids from patient tissues to test chemotherapy drugs and identified genetic signatures that predict treatment response, offering high accuracy in personalized drug screening. This breakthrough may help select effective drugs for individual patients, reducing trial and error.
Cincinnati Children's scientists have successfully grown functional human intestinal organoids that mimic key development stages of the human fetus. These lab-grown tissues accurately replicate the formation of specific cell types and tissue structures, providing a valuable resource for studying fetal intestine development and potentia...
Researchers used human liver organoids to study fibrolamellar carcinoma, a rare childhood liver cancer. They found that different genetic mutations underlie different degrees of aggressiveness in the tumors, and uncovered the probable cell-of-origin as hepatocytes.
A research team created the first human respiratory organoid culture system, enabling scientists to study COVID-19 and its variants. The study found that the BA.5 Omicron variant exhibits dramatically increased infectivity and replicative capacity in human nasal and airway organoids.
Researchers have developed a new technique to study the molecular causes of pediatric bipolar disorder by growing brain cells in the laboratory. The approach identified significant changes linked to the psychiatric condition, including a gene mutation that may be responsible for the disorder.
Scientists create B cell organoids to screen conjugate vaccine candidates, identifying antigen-specific antibodies with potential applications. The platform accelerates testing throughput, offering insights into the immune response to vaccines.
Researchers have developed an organoid-based method to assess the potency of glycoconjugate vaccines, speeding up the vaccine development process. This method uses tissue from a single mouse to create hundreds of immune organoids, allowing for the assessment of dozens or even hundreds of vaccine candidates in just four days.
Scientists at RIKEN have developed a new technique for creating complex 3D organoids using a cube-like structure made of hydrogels. This innovation enables researchers to control the environment around cells, allowing for the creation of tissues with faithful reproduction of asymmetric genetic expression. The technology has the potenti...
SourceRIKEN·JournalCommunications Biology·TypeExperimental study·DateApr 6, 2023
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
A UNIGE team created customizable treatments by testing drugs on artificial tumors derived from patients' cancer tissue. The approach opens the way for optimized and tailored therapies against various cancers and diseases.
The March special issue of SLAS Discovery introduces protocol articles highlighting detailed scientific methods and procedures in drug discovery. The issue covers topics such as 3D imaging, cancer treatments, and high-throughput screening, emphasizing transparency and rigor in research methodology.
Researchers at Georgia Institute of Technology developed a synthetic tumor model to understand the impact of microenvironment on targeted therapies for Activated B Cell-like Diffuse Large B cell lymphoma. The model showed promise in demonstrating how combining therapeutics can overcome tumor resistance to inhibitors.
Scientists have mapped the complete trajectory of placental development, shedding light on why pregnancy disorders occur. The study reveals new information on cell communication and trophoblast development, providing a better understanding of the process.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
Researchers at UCLA successfully used base editing to correct a mutation causing rare immune deficiency CD3 delta SCID. The treatment corrected an average of 71% of patient stem cells and allowed them to produce fully functional T cells, suggesting long-term persistence of corrected blood stem cells.
Researchers have developed a new type of computer using human brain cells, which could lead to significant advances in computing speed and data efficiency. The technology uses small clusters of brain cells grown from stem cells and aims to increase the number of neurons to surpass electronic computers.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
Researchers create lab-grown brain organoids as biological hardware to drive computing forward. These three-dimensional cultures can process information faster and more efficiently than current silicon computers.
Researchers at Johns Hopkins University are developing 'organoid intelligence' using human brain cells, which could exponentially expand computing capabilities and solve energy consumption issues. The technology has the potential to revolutionize drug testing research for neurodevelopmental disorders and neurodegeneration.
Researchers created human organoid models of fatty liver disease to shed light on drug responses and disease biology. The models identified a common mechanism for effective drugs that block lipid generation from sugars, suggesting personalized medicine applications.
Scientists at the Wyss Institute and Gameto develop a living, fully human ovarian organoid that supports egg cell maturation and secretes sex hormones. This technology enables the study of human ovarian biology without tissue from patients and could lead to new treatments for infertility and ovarian cancer.
Researchers successfully transplanted human brain organoids into adult rat brains and observed functional integration, including response to visual stimulation. The study demonstrates potential for neural tissues to rebuild injured brain areas.
Researchers generated cochlear avatars from stem cells, recreating hair cell function and transmitting electrical signals. This breakthrough enables the investigation of sensorineural hearing loss mechanisms and potential treatments.
Engineers create OCTOPUS device to grow organs-in-a-dish, achieving higher levels of maturity than traditional methods. The device allows for more mature organs with complex cell relationships, providing valuable tools for studying human organ development.
Researchers discovered that sugar plays a key role in the formation of fluid-filled cysts associated with polycystic kidney disease (PKD). By understanding this process, they identified a potential new approach to treating PKD, focusing on blocking sugar absorption in the kidneys.
Researchers have successfully grown retinal cells from stem cells that can connect with neighboring cells and transmit sensory information like healthy ones. The breakthrough could lead to human clinical trials to treat degenerative eye disorders such as retinitis pigmentosa and age-related macular degeneration.
Researchers have successfully demonstrated that human brain organoids implanted in mice can establish functional connectivity and respond to external sensory stimuli, including visual cues. The breakthrough uses a combination of transparent graphene microelectrode arrays and two-photon imaging, enabling real-time observation of neural ...
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
Researchers at UNSW Sydney have successfully induced a gastrulation-like event in human pluripotent stem cells, mimicking the early stages of embryonic development. This breakthrough could lead to new approaches for studying human development and creating personalized body tissue or organs using hydrogel materials.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers identify an off-patent liver disease drug that can prevent SARS-CoV-2 entry into cells, potentially offering protection against future variants. The study used a unique combination of 'mini-organs', animal studies, and human subjects to demonstrate the drug's effectiveness.
A new study by researchers at the Swiss Institute of Allergy and Asthma Research found that commercial dishwashers' rinse agents can damage the gut's epithelial barrier, leading to chronic diseases. The study used human intestinal organoids and analyzed the effect of detergents and rinse aids on gut cells.
Johns Hopkins researchers have developed a three-dimensional organoid model derived from human tissue to study gastroesophageal junction (GEJ) cancer. The dual knockout of genes in the model has identified key biological targets for treating GEJ cancers with existing drugs.
A team of engineers at UC Santa Cruz has developed an automated system for growing cerebral organoids, miniature models of brain tissue grown from stem cells. The new method, called Autoculture, precisely delivers nutrients to individual organoids, optimizing growth and reducing cellular stress.
Researchers from MPI-CBG and IMP define metrics for organ development, providing a framework to transform the field of organoids into an engineering discipline. They discover that tissue connectivity emerges from two processes: fusion of separate epithelia or self-fusion of a single epithelium.
A new study using human brain organoids reveals that prenatal alcohol exposure impairs brain cell development and functioning. The findings confirm the harm inflicted by alcohol on the developing fetus, with effects including faulty brain architecture and impaired electrical activity patterns.
Scientists have developed a new technology that captures the key features of human bone marrow, allowing for the screening of multiple anti-cancer drugs and testing personalized treatments. The 'bone marrows in a dish' can support the survival of cells from patients with blood malignancies
A team of scientists has made a breakthrough in growing stem cells and mini-brains from Sumatran rhino skin cells, which may help save the endangered species from extinction. The goal is to create sperm cells that can be used in artificial insemination, increasing the chances of successful breeding.
A team of Berlin scientists has successfully grown stem cells and mini-brains from Sumatran rhino skin cells, paving the way for potential use in assisted reproduction. The next step is to create sperm cells that may help save the critically endangered species from extinction.
Researchers generated induced pluripotent stem cells and cerebral organoids from the last male Malaysian Sumatran rhino, enabling study of brain development and potentially aiding in breeding program. The technology holds promise for fighting extinction of critically endangered species.
New insights into the processing of hormones in the human gut reveal dozens of peptides regulating appetite, bowel movement, and insulin secretion. By studying human intestinal organoids, researchers characterized potentially novel gut hormones, including glucagon, and explored its role in human physiology.
The HUSH complex is involved in normal brain development, neuronal individuality, and connectivity. The complex also regulates repetitive-like gene clusters, including protocadherin gene clusters, which are essential for neuron-to-neuron interactions.
Researchers used human brain organoids to show how SARS-CoV-2 infects and destroys synapses in cortical neurons. Sofosbuvir effectively inhibited viral replication and rescued impaired neurons, suggesting a potential treatment for Long COVID.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
Researchers from Yokohama National University successfully generated hair follicles in cultures using organoid cultures. The study demonstrates the potential of hair follicle organoids for understanding hair follicle development and regeneration, as well as evaluating drugs for treating hair loss disorders.
A new research method allows for a detailed examination of brain processes involved in neurological disorders by integrating human cortical organoids into developing rat brains. The study finds that transplanted organoids integrate into specific brain pathways, displaying functional connectivity.
A team of researchers at the University of Pittsburgh is using artificial intelligence to create more efficient and effective organoids. By designing and printing smarter cell structures that mimic human organs, they aim to reduce trial-and-error methods and costs, ultimately contributing to new methods in disease research and human he...
Researchers found positive correlations between lipoxin A4 and cognitive brain functions, as well as its potential to potentiate the endocannabinoid system. The study suggests that reducing levels of this substance may weaken the body's defenses against neurodegeneration.
Scientists have developed a new method to study human brain development by growing millimetre-sized three-dimensional tissues called organoids from pluripotent stem cells. The researchers characterized the cells in molecular-genetic terms, creating a kind of map showing the molecular fingerprint of each cell within the organoid.
Researchers have developed brain-like organoids that can be tested experimentally to uncover cellular and molecular causes of autism. The organoids, grown in a dish from human cells, self-organize into layers of cells reminiscent of the cerebral cortex, allowing scientists to study how complex neural structures arise.
Scientists have developed guidelines to produce high-quality, well-structured mini-brain organoids that accurately mimic human brain tissues. By using early-stage stem cells and specific molecules, researchers can overcome challenges in uniformity and structure, enabling studies of neurological development, disease, and therapies.