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iPS cells from dish to freezer and back

Researchers at Kobe University developed a method to preserve iPS cells directly in their culture dishes using D-proline as a cryoprotectant. This allows for easy automation of the process, reducing costs and increasing efficiency in regenerative medicine and drug discovery research. The breakthrough enables the direct freezing, thawin...

SourceKobe University·JournalBiochemical Engineering Journal·TypeExperimental study·DateDec 18, 2025
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Integrated analysis of serum and fecal metabolites reveals the role of bile acid metabolism in drug-induced liver injury: Implications for diagnostic and prognostic biomarkers

Researchers identified bile acid metabolites as potential biomarkers for diagnosing and predicting drug-induced liver injury (DILI). Chenodeoxycholic acid and deoxycholic acid were found to distinguish DILI patients from healthy individuals, exhibiting predictive potential for chronicity.

SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Hepatology·DateAug 20, 2025

Serum-free cultures help transplanted MSCs improve efficacy

Researchers developed a serum-free culture for mesenchymal stem cells (MSCs), increasing cellular growth and enhancing specific differentiation capacities. This breakthrough enables the use of 'off-the-shelf' serum-free media, promoting greater control over cell fate regulation and tissue engineering applications.

SourceCell Transplantation Center of Excellence for Aging and Brain Repair·JournalCell Medicine·DateJun 28, 2011