Articles tagged with Electron Microscopy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study published in Nature Communications reveals chemical heterogeneities in Apollo 17 sample troctolite 76535, indicating an early rapid cooling of the Moon. This finding challenges previous estimates of a 100-million-year cooling duration and supports initial rapid cooling of magmas within the lunar crust.
The study found that certain grain boundaries in strontium titanate exhibit enhanced thermal expansion, leading to potential material failures. This discovery highlights the importance of grain boundaries in material properties and has implications for selecting suitable materials for various applications.
Cryo-EM study reveals details of DNA repair mechanism translesion synthesis (TLS), allowing cells to survive with mutations. Key protein complex Pol K - PCNA interaction modulated by ubiquitination facilitates recruitment of TLS polymerase to damage sites.
Researchers have uncovered how a viral RNA changes shape to hijack host proteins, revealing the role of cryogenic electron microscopy in making this discovery possible. The study highlights the emerging power of cryo-EM to visualize multifunctional dynamic RNA structures.
Researchers from the University of Chicago used cryo-electron microscopy to study protein degradation in yeast, describing the structure of a key enzyme involved in ubiquitination. The study provides new insights into the process and its potential role in human diseases such as aging and neurodegeneration.
Researchers have used advanced microscopy to study the ultrastructure of huntingtin inclusions, revealing different mechanisms of aggregation that lead to distinct biochemical properties. The findings suggest targeting inclusion growth as a potential therapeutic strategy for slowing Huntington's disease progression.
A team of researchers from the University of Münster has identified a second barrier in the fly brain, formed by glial cells that regulate molecule distribution. The discovery is essential for understanding nervous system functioning and may have implications for human neural health.
Researchers have discovered that genes regulating synaptic connections between cells are active in specific parts of the digestive chambers of freshwater sponges. This finding suggests that these cells may be evolutionary precursors for the first animal brains, providing insight into the evolution of brain function.
Researchers at Arizona State University have refined cryogenic electron microscopy to produce more accurate structures of biological samples. The new method uses a statistical approach to model transitory structures, which can play a vital role in biological processes.
Researchers from Germany, Sweden, and China have discovered braided structures of nanoscale skyrmions in alloys of iron and germanium, offering new insights into their properties and potential uses. These complex shapes stabilize the magnetic structures, making them interesting for applications in information processing.
A new machine learning algorithm has enabled researchers to automatically identify and map the inner structures of cells, including organelles, with unprecedented precision. By processing tens of thousands of high-resolution images, scientists have gained insights into how these structures interact and are arranged within the cell.
Researchers have observed for the first time how silicon anodes degrade in lithium-ion batteries due to swelling and electrolyte infiltration. This degradation leads to reduced battery capacity and charging speed, but scientists are exploring ways to protect silicon from these effects.
A team from The University of Tsukuba used microscopy techniques to analyze the microstructure of the ground beetle's wing casing, revealing a unique helical structure that creates optical effects. This finding has significant implications for the development of new biomimetic materials with enhanced performance.
A team of researchers from the Beckman Institute for Advanced Science and Technology has developed a fast, accurate, and cost-effective COVID-19 test. Using label-free microscopic imaging combined with artificial intelligence, they can detect and classify SARS-CoV-2 in under one minute.
Scientists have developed a powerful new imaging strategy capable of visualizing the fine, ultrastructural changes to dendritic spines during structural plasticity. They found that the postsynaptic density region underwent significant growth and reorganization on a rapid timescale.
Researchers at the University of Konstanz have discovered that MXenes can be switched repeatedly between a flat and a rippled shape by applying femtosecond laser pulses. This discovery could lead to improved energy storage capacity, enhanced catalytic or antibiotic activity, and new applications in sensing and active plasmonic devices.
A new study suggests that existing drugs for multiple sclerosis may not be effective due to toxic blood leaks in the brain. Researchers have identified a promising alternative treatment option that could improve myelin repair, even in the presence of these harmful elements.
A novel method for imaging vibrations and movements of atoms in catalysts has been developed by a collaboration of internationally leading researchers. The new analytical method reveals a dynamic behavior of the atoms, contrary to the long-held expectation that atoms in nanoparticles are static during observations.
Scientists discovered a new mitochondrial recycling pathway that may help prevent Parkinson's disease. The study, published in Science Advances, reveals that genes associated with Parkinson's disease play key roles in this process and that disruptions can contribute to neurodegeneration.
Researchers at Skoltech have discovered structures called apical bulkheads in liver cells that are responsible for the narrow shape of bile canaliculi. The discovery reveals a key role for the Rab35 protein in regulating hepatocyte lumina formation and suggests potential avenues for medical applications in fatty liver disease and fibrosis
A recent study published in Science has detailed the structure of a critical enzyme, ExoN, that allows the coronavirus SARS-CoV-2 to resist nucleoside antiviral treatments. Understanding this enzyme's structure may lead to the development of new methods for deactivating it and improving existing treatments for COVID-19 patients.
Researchers at Graz University of Technology have demonstrated the absorption of energy from laser light by free electrons in a liquid for the first time. This breakthrough opens new doors for ultra-fast electron microscopy, crucial for investigating smallest objects at fastest time scales.
Scientists have imaged an entire mouse brain at the microscopic to macroscopic level using a new micro-CT approach. This technique bridges the resolution gap between MRI and electron microscopy, enabling the connection of biomarkers across multiple scales and improving image resolution.
Scientists from the University of Tsukuba directly observed electron dynamics in organic film OLEDs, revealing a previously unknown feature of exciton decay. The study's findings may contribute to the development of more efficient OLED-based products.
A team of biologists identified a family of algae as a living missing link in the microscopic domain. The discovery sheds new light on the evolution of these organisms and clarifies their evolutionary history.
Electrical engineers at UC San Diego developed a technology that converts low-resolution light to high-resolution light, enabling ordinary microscopes to image living cells with a resolution of up to 40 nanometers. The technology uses a specially engineered material that shortens the wavelength of light as it illuminates the sample.
Researchers captured the internal motor structure of Mycoplasma mobile, revealing an internal chain structure causing the external appendage structure to move in a specific direction. The study provides insight into the gliding motion mechanism and could lead to understanding human replications of it.
Researchers at Max Planck Florida Institute for Neuroscience used machine learning to develop Gold Digger software that can accurately identify gold particles bound to specific proteins of interest. The software uses a deep learning approach to distinguish gold particles from shadow artifacts with near-human level accuracy.
Scientists at the University of Groningen found that oxygen atoms migrating through a hafnium-based capacitor create spontaneous polarization, enabling ferroelectric properties. This discovery paves the way for new materials with potential applications in nanometre-sized memory and logic devices.
The 'Compact Cell-Imaging Device' project aims to advance research into viral diseases by developing a miniaturized soft X-ray approach. This method allows for three-dimensional imaging of intact cells and can reveal changes induced by viral infections, making it an attractive tool for studying SARS-CoV-2.
Researchers at MIT have developed a technique for imaging biological samples with accuracy of 10 nanometers using an ordinary light microscope. The new hydrogel-based approach improves upon previous versions, enabling high-resolution images without expensive equipment.
Researchers at Lawrence Berkeley National Laboratory have discovered that gold atoms undergo rapid, reversible nucleation processes before forming stable crystals. Using advanced electron microscopy, they observed individual atoms falling apart and reorganizing multiple times before establishing a stable nucleus.
Researchers from CNRS and universities in France and Austria develop new imaging technique to visualize electromagnetic fields surrounding nanocrystals. This breakthrough enables precise targeting of heat transfers and better understanding of materials properties.
A new method developed by Salk researchers enables scientists to improve microscope image quality using artificial intelligence and artificially degraded images. The 'crappifier' tool can help democratize microscopy, making it accessible to those without powerful microscopes.
Researchers at the University of Utah have developed a new technique to analyze magnetofossils, which can reveal information about past climates. The method uses FORC measurements to identify giant magnetofossils, allowing scientists to study ocean responses to past climate changes.
Researchers at the University of Zurich discovered that the size of connections between nerve cells determines their signaling strength. By measuring synaptic currents and analyzing synapse structure, they found a direct correlation between synapse size and signal strength.
Scientists have identified diverse types of patterns on the surface of solidified metal alloys, including stripes, curved fibers, and dot arrays. These findings challenge existing understanding of liquid metal alloys and their phase transition processes.
The new technique allows researchers to study whole neural circuits in high detail and at scale. They used it to create a comprehensive map of neuronal circuits that control motor function in fruit flies, discovering new sensory neurons.
An interdisciplinary team of scientists has developed a novel approach to measure the activity and strength of individual synapses that drive a neuron's response. They found that strong synapses do not have strict relationships with neuron responses, but rather are influenced by the total number of activated synapses.
Researchers have developed a new technique to analyze the properties of individual cobalt oxide particles, enabling more efficient catalysts for hydrogen production. The method allows for the selection of particles under an electron microscope and their placement on a nanoelectrode for electrochemical analysis.
Researchers at FAU have achieved a record resolution of 7 nanometres in X-ray microscopy, allowing for direct imaging of nanostructures. This breakthrough enables significant advances in research into nanostructures, solar cells, and magnetic data storage.
Researchers demonstrate a new x-ray microscopy technique called x-ray holographic nano-tomography (XNH) that can image large volumes of brain tissue at high resolutions. This technique, combined with artificial intelligence-driven image analysis, enables the comprehensive cataloging of neurons and tracing of individual neurons from mus...
Researchers developed a machine learning workflow to streamline the analysis of liquid-phase electron microscopy videos, enabling the extraction of valuable information from nanoparticle dynamics. The new technique has potential applications in medicine, energy, environmental sustainability, and biomaterials research.
Researchers at Texas A&M University have developed a new image processing technique that enhances the resolution of low-quality electron micrographs using deep neural networks. The method leverages pairs of low- and high-resolution images to train AI algorithms, allowing for detailed analysis without damaging specimen samples.
Researchers developed ultrathin 'smart nanosheets' that can capture protein complexes from mixtures, enabling faster and more accurate analysis with electron microscopy. This innovation can lead to better understanding of diseases and treatment with drugs.
Researchers at Martin-Luther-University Halle-Wittenberg have successfully determined the structure of ferritin using an affordable electron cryo-microscope, achieving resolutions comparable to expensive equipment. This method enables collaboration on structural analysis of samples with medical and biotechnological potential.
Scientists at TU Wien have developed a new method for simulating wear and friction on an atomic scale using supercomputers. This allows them to study the behavior of materials on a microscopic level, enabling the prediction of durability and safety in industrial applications.
A new super-resolution microscope reveals unprecedented detail of the centriole's twist, a nanoscale structure important for cell division. The technology could be used to study other cellular structures like mitochondria or viruses.
Researchers developed an ultra-high resolution imaging technique using Extreme Ultraviolet radiation, producing extraordinary detail compared to traditional light microscope images. The method has the potential to aid the analysis of neurodegenerative diseases like Alzheimer's disease.
A new lensless on-chip microscopy platform developed at UConn removes traditional lenses to provide a fuller picture of tissue samples, leading to more accurate diagnoses. The platform uses ptychography and achieves an ultra-high Fresnel number, allowing for a 30 mm2 field of view and eliminating the need for cell staining.
A recent study at BESSY II used X-ray microscopy to investigate how nanoparticles interact with cells. Researchers found that nanoparticles can change the number and type of cell organelles, such as increasing mitochondria and decreasing lipid droplets. This suggests that different nanoparticle coatings may have similar effects on cells.
Researchers developed Q-scores to assess true resolution at every point in cryo-EM maps, enabling accurate interpretation of atomic models. The approach validated on large molecules, achieving high-resolution maps close to 1.75 angstroms, and demonstrates improved confidence in molecular interpretations.
Researchers at Université libre de Bruxelles discover oldest known mushroom fossil, dating back 715-810 million years, using advanced molecular analysis techniques. The findings suggest that fungi played a crucial role in the colonization of Earth's surface around 500 million years ago.
A new microscopy technique, cryo-SR/EM, combines images from electron microscopes and super-resolution light microscopes to reveal the intricate 3D structure of cells. This allows researchers to study the relationships between cellular structures and their surroundings with unprecedented clarity.
A team of researchers, led by Uri Manor at the Salk Institute, used deep learning to develop a new approach for super-resolution microscopy. By training a neural network on high-resolution images, they were able to improve the resolution of microscope images, enabling better understanding of brain cells and their behavior.
Researchers at McMaster University developed a self-cleaning surface that can repel all forms of bacteria, preventing the transfer of antibiotic-resistant superbugs in medical settings. The treated material is also suitable for food packaging to prevent bacterial contamination, such as E. coli and Salmonella.
Researchers at Berkeley Lab successfully image the atomic structure of peptoid nanosheets using cryo-EM, a breakthrough that could advance applications such as synthetic antibodies and self-repairing membranes. The study demonstrates unprecedented atomic precision and paves the way for designing soft materials at the atomic scale.
New research published in PNAS finds the missing link between soft surface adhesion and the roughness of the hard surface it touches. The study reveals that small-scale roughness can create more surface area for soft materials to grip, explaining predicted adhesion behavior.
Scientists used X-ray microscopy to study the digestive process of malaria parasites, revealing that they store hemoglobin in their digestive vacuole. The parasites then crystallize toxic hemozoin molecules, which active compounds may prevent from forming by disrupting their detoxification process.
Researchers aim to leverage quantum dot technology to understand how living things conduct internal communications and send messages to other organisms. They will track the movement of extracellular vesicles and their cargo using quantum dots, which offer superior brightness and stability.