Articles tagged with Electron Microscopy
Researchers discover how S1P molecules are released from SPNS2 protein via small cavities, enabling potential treatment for inflammatory diseases. The study provides a foundation for designing future drugs targeting the protein.
The UK Centre for Multimodal Correlative Microscopy and Spectroscopy (CoreMiS) will enable researchers to analyze environmental samples with unprecedented detail. CoreMiS has already been used to study ancient artifacts, detect pollutants in drinking water, and investigate antimicrobial resistance.
Researchers have discovered nitrogen-bearing biorelevant molecules, including amino acids and nucleobases, in the Winchcombe meteorite. These findings suggest that the meteorite may have delivered crucial organic molecules to early Earth, potentially influencing the origin of life.
Research reveals that a small subset of bacterial cells produces deadly toxins while sacrificing themselves for the benefit of their comrades. The bacteria use a temperature-sensitive genetic switch to synchronize toxin production with cell enlargement, ensuring an efficient strategy for infection.
Researchers at TU Graz have made a breakthrough in manufacturing complex, free-standing 3D nanoarchitectures with precise shapes and sizes. They achieved this by precisely simulating the required optical properties in advance and completely removing chemical impurities, enabling new optical effects and application concepts.
Focused ion beam technology has numerous applications in material processing, microelectronics, and life sciences. The instrument uses a finely focused ion beam for nanoscale analysis, prototype creation, and material modification.
Researchers at ISTA investigated the crucial set of synapses between neurons within the cerebellum, uncovering details of their function and development. The study used advanced techniques to look at the inhibitory synapses in great detail, revealing how they delicately influence the cell's signal output.
Scientists have made significant progress in understanding ultrafast electron dynamics by tracking the motion of electrons released from zinc oxide crystals using laser pulses. The research team combined photoemission electron microscopy and attosecond physics technology to achieve temporal accuracy, enabling them to study the interact...
Researchers have developed a new technique to understand the relationship between atomic structure and electric polarization in 2D van der Waals ferroelectric materials. This discovery is expected to revolutionize domain engineering in these materials, positioning them as fundamental building blocks for advanced devices.
The Marine Biological Laboratory (MBL) has been awarded $4.3 million by the Massachusetts Life Sciences Center to expand its imaging capabilities. The grant will support the procurement of two state-of-the-art microscopes that can perform advanced imaging techniques, including 2D and 3D reconstruction from electron and light microscopy.
Researchers have developed a new microscopy technique using STED technology to visualize individual fibers in amyloid plaques, providing higher resolution than conventional light microscopy. This breakthrough allows for better understanding of the structure and morphology of Aβ aggregates and their role in Alzheimer's disease progression.
Researchers at City University of Hong Kong successfully morphed all-inorganic perovskites into various shapes at room temperature without compromising their functional properties. The findings demonstrate the potential of these semiconductors for next-generation deformable electronics and energy systems.
A new study explores how alpha-synuclein disrupts metabolic processes in neurons. Researchers used NanoSIMS imaging techniques to visualize isotopic variations and found changes in carbon turnover, suggesting increased metabolic demands on affected cells.
Researchers created a new method, RESORT, to image and analyze living systems in unprecedented detail. The technique combines benefits of super-resolution fluorescence and vibrational imaging, allowing for high spatial resolution and analysis of complex interactions.
Researchers have revealed key atomic structures of actin filament ends using cryo-electron microscopy. The study provides fundamental insights into the mechanism behind actin filament polarity, shedding light on disorders such as muscle weakness and heart problems.
Researchers at Ulsan National Institute of Science and Technology have made a breakthrough in creating ultra-photostable avalanching nanoparticles that can perform unlimited photoswitching. This achievement has significant implications for fields like optical probes, 3D optical memory, and super-resolution microscopy.
Researchers have developed TomoTwin, an AI-based software that accurately identifies and localizes proteins in cells using electron cryo-tomography. This innovation expands the potential of cryo-ET to decipher biomolecule functions and unveil disease origins.
Researchers developed a new surface coating technology that significantly increases electron emission in materials, improving production of high-efficiency electron sources. This breakthrough is expected to enhance performances in electron microscopes and synchrotron radiation facilities.
Researchers at Tokyo University of Science have discovered a novel gold-gallium-dysprosium quasicrystal that exhibits ferromagnetic properties, tunability and high phase purity. The discovery opens up new frontiers in magnetic materials science, with potential applications in spintronics and magnetic data storage.
The City University of Hong Kong has developed a novel electron microscope that combines scanning and transmission electron microscope modes in a compact format. The device can produce high-resolution images in five minutes, enabling the study of atom dynamics and beam-sensitive materials.
A new study reveals that different species of bacteria colonize specific areas on diatoms, reflecting their metabolic properties. The findings provide insight into the complex interactions between algae and bacteria in marine environments.
Scientists at TUM create genetic reporter proteins that can be resolved by electron microscopy, unveiling invisible cellular structures and processes. The discovery enables further research into disease mechanisms and potential therapeutic cell production.
Researchers at Salk Institute discover that dysfunctional mitochondria at synapses fail to meet energetic demand, supplying either too much or too little power and potentially causing working memory impairment with age. Adherence to the ultrastructural size principle is essential for avoiding cognitive decline in aging brains.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
Researchers developed MoBIE, a user-friendly tool for sharing and exploring large image data sets. The tool allows for visualization and analysis of huge amounts of data from hundreds of sources, making it easier for researchers to analyze and interpret microscopy data worldwide.
Researchers have observed exciton quasiparticles confined in atomically thin materials, opening paths to controlling excitons for quantum and optolectronic applications. Custom-built materials can now be designed to confine and manipulate excitons.
The São Paulo School of Advanced Science on Cryogenic Electron Microscopy will be held at the University of São Paulo from July 10-27, 2023. The event will cover theoretical and practical foundations of advanced CryoEM techniques, featuring renowned researchers and hands-on practical sessions.
Researchers have successfully uncovered the structure of a model bacterial phytochrome, revealing symmetrical and asymmetrical states in response to light. The study found that almost non-existent structural changes in regulatory domains can amplify biochemical effects elsewhere.
Researchers studied asteroid Ryugu's surface composition using X-ray Absorption Near Edge Spectroscopy and electron microscopy. They found dehydrated serpentine minerals and a water-rich interior, suggesting space weathering plays a key role in asteroid evolution.
Researchers used high-voltage electron microscopy to image frozen tokyovirus particles in detail, revealing a novel capsid protein network and scaffold protein component. The study provides new insights into the structure and function of giant viruses, which are larger than small bacteria.
Researchers at SLAC National Accelerator Laboratory and Stanford University have discovered the role of a tiny cellular machine called TRiC in directing protein folding, contradicting a 70-year-old theory. The study's findings have profound implications for treating diseases linked to protein misfolding, such as certain cancers and neu...
The study uses 3D electron microscopy and live cell imaging to observe molecular tethers between organelles. These dynamic structures are constantly binding and unbinding, altering contact site configuration in response to cellular changes.
Scientists at the University of Illinois have created a new strategy to build materials with unique properties by organizing nanoparticles into pinwheel shapes. The pinwheel lattice exhibits chirality, a property that can be seen in nature's examples such as DNA and human hands.
Researchers at Lehigh University have received a $1.2 million NSF grant to purchase a new plasma focused ion beam system for studying material deformation at the nanoscale. The system enables in situ mechanical testing and EBSD analysis, allowing for detailed study of microstructural elements and
Researchers have discovered that oligodendrocyte precursor cells (OPCs) play a crucial role in synaptic pruning, cleaning up unwanted connections between neurons. By analyzing a massive dataset of 3D brain cell structures, the team found OPCs digesting parts of neighboring neurons.
Scientists at Argonne National Laboratory have discovered tiny magnetic vortices called skyrmions that could store data in computers, promising 100-1000 times better energy efficiency than current memory. The team used AI and a high-power electron microscope to visualize and study the behavior of these micro-scale magnetic structures.
Engineers and chemists at the University of Illinois have combined electron microscopy and data mining to visualize chemical and physical alteration within ion batteries. The study reveals patterns of nucleation, growth, and coalescence that can inform the development of better rechargeable battery performance.
Researchers develop new technique to observe plasmons inside gold nanoparticles, revealing relaxation process with implications for energy conversion and development of light-harvesting materials. The ultrafast electron microscope enables analysis of ultrafast light-matter interactions at the nanoscale.
Researchers used cryo-EM to obtain high-resolution images of actin filaments in three states, revealing the movement of hundreds of water molecules and their role in ATP hydrolysis. The study provides new insights into the assembly and aging of actin filaments, potentially leading to therapeutic applications.
Researchers at Kyushu University counted electric charges in individual platinum nanoparticles down to the electron level, revealing net charge with high precision. This breakthrough enables better understanding and development of catalysts for breaking down pollutants.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
Researchers developed a new method combining cryo-EM with iDPC-STEM, achieving sub-nanometer resolution for protein structures. This technique expands possibilities for structural analysis of heterogeneous and single-particle samples.
Researchers at HHMI's Janelia Research Campus have discovered a new type of synapse between neurons and their primary cilia, which allows for long-term changes in the cell's chromatin. This discovery could help scientists better understand how cells communicate and may lead to the development of more selective medications.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
Scientists from Göttingen and Lausanne successfully created electron-photon pairs in an electron microscope for the first time. This breakthrough enables researchers to harness free electrons and photons in a controlled manner.
A team of scientists from the University of Illinois Chicago discovered that hydrogen ions, not zinc, cause damage to manganese dioxide in rechargeable aqueous zinc-manganese batteries. This finding challenges existing knowledge about the charging mechanism and opens up new strategies for improving battery sustainability.
Researchers developed a new technique to track single blood stem cells in live organisms and describe their ultrastructure using electron microscopy. This allows for better understanding of cell-cell interactions and potential therapeutics for blood diseases and cancers.
Researchers discovered that CAMSAP2 proteins utilize phase separation to form an 'aster' structure, which then organizes into a microtubule network. This process is crucial for the formation of specialized cell shapes, such as those found in heart muscle and nerve cells.
Cannabis cells use a 'supercell' biofactory to create an efficient pipeline from raw materials to end products. The study reveals subcellular 'shipping routes' for THC and CBD production, enabling new paradigm for cannabinoid synthesis.
Researchers have made significant advancements in understanding the electronic structure of graphite, a crucial component in battery production. The study's findings highlight the importance of surface effects in bulk intrinsic electronic state measurements, revealing new insights into the material's electrical properties.
A new study reveals that the Hippo signaling pathway is responsible for forming the body axis in Hydra, a process also controlling tissue growth and morphogenesis. This breakthrough discovery sheds light on the evolutionary origins of the body axis in animals.
Researchers discovered a new prion structure using electron microscopy, revealing key similarities and differences between distinct strains. This finding could lead to better understanding of how shape variations affect disease outcomes.
Researchers at Stowers Institute for Medical Research have developed a precise model for the stinging organelle of the starlet sea anemone, revealing its complex architecture and firing mechanism. The findings could lead to beneficial applications in medicine, including microscopic therapeutic delivery devices.
Researchers have discovered a prominent network of silencing interneurons in the human cortex, which could be linked to enhanced working memory and reasoning abilities. This unique network relies on abundant connections between inhibitory interneurons and is distinct from those found in mice.
Scientists at the University of Vienna have successfully measured the migration of carbon atoms on graphene's surface using an indirect method. By heating the material and observing the effect on stability, they determined the energy barrier to be 0.33 electronvolts.
Researchers at USC Dornsife College of Letters, Arts and Sciences have elucidated the structure of a small protein carrying GABA into neurons using cryogenic electron microscopy. This breakthrough could lead to more effective drugs for conditions such as epilepsy, bipolar disorder, schizophrenia, Parkinson's disease, and autism spectru...
Researchers have developed an imaging technique to capture information about brain tissue at the subcellular level, combining seven methods to visualize neural networks and individual cells. This approach allows for a complete picture of brain structure and function, overcoming challenges of imaging tissues at different scales.
Scientists have observed the crystallization of nickel's two structural forms, cubic and hexagonal, in a liquid solution using liquid-phase electron microscopy. This breakthrough has significant implications for understanding nickel-based catalysts and their applications.
A UAB research team successfully monitored microplastic behavior in Drosophila larvae, revealing interactions with microbiota and intestinal barrier. The study confirms the fly's relevance as a model for studying nanoplastic effects on human health.
Researchers from Max Planck Institute have determined the 3D structural details of the human CCAN complex, highlighting its unique features and implications for interactions with centromere protein A. This discovery raises fundamental questions about creating artificial chromosomes.