Articles tagged with Fluorescence Microscopy
Researchers at Nagoya University have developed a new photostable fluorescent dye, PhoxBright 430 (PB430), to visualize cellular ultrastructure. PB430 enables continuous STED imaging and can be used for multicolor imaging of biological structures.
Researchers used a new, non-destructive technology to access medieval texts hidden inside ancient bookbindings. By fusing visible hyperspectral and X-ray fluorescence imaging, they discovered sixth-century Roman Law code written in marginal comments.
A new nanoparticle 'buckyswitch' developed by Clemson researchers improves microscopic imaging resolution by allowing microscopes to capture images up to the terapixel level. This innovation overcomes the diffraction limit constraint and enables clearer visualization of small cellular structures.
Chulhong Kim, a POSTECH Associate Professor, has received the IEEE-EMBS Early Career Achievement Award for his contributions to biomedical imaging. His lab developed world-first photoacoustic gastro-intestinal tract imaging using organic agents.
Scientists at Goethe University Frankfurt have combined two advanced fluorescence microscopy techniques to observe cells with high-resolution imaging. The new technique, called csiLSFM, allows for three-dimensional insight into a cell's interior with sub-100nm resolution.
Researchers developed a dual-modality imaging technique using SPECT/CT and fluorescence to detect micrometastases in colorectal cancer. This approach can guide resection of tumor lesions and potentially improve prognosis for cancer patients.
Researchers have developed a new technique to track the movement of cancer cells using reversible, photo-luminescent carbon nanoparticles. The study demonstrates that these particles can be used for intracellular imaging and drug delivery tracking without photo-bleaching issues.
Researchers have developed an image analysis technique called Hyper-Spectral Phasor (HySP) that can track multiple molecules in living organisms, making it easier to diagnose diseases and identify therapeutic targets. The new technology uses cell phone images and is faster and less expensive than current methods.
Scientists have discovered metabolons, complex enzyme clusters, for the first time using molecular movie technology. This breakthrough reveals plants' secret medicinal toolbox and unlocks new possibilities for harnessing plant-based medicines.
Scientists have created peptide probes that attach to proteins with comparable efficiency to antibodies, improving image resolution. These probes can help shed light on protein layout and quantification, opening new possibilities for neurobiological research.
Scientists at MIT and Harvard University developed a new imaging technique called LASE microscopy, which uses tiny particles to create sharper images of deep tissue and cells. The particles emit laser light when stimulated by a laser beam, resulting in higher-resolution images.
Researchers at University of California San Diego developed a new form of multicolor electron microscopy allowing simultaneous visualization of multiple molecular species. This technique reveals details and processes not visible in grayscale images, providing new insights into cellular ultrastructure.
A study by Lund University researcher Pontus Nordenfelt reveals how cells move using integrins, actin, and an adaptor protein. The technique enables measuring mechanical force acting on integrins, which could lead to targeted drugs to strengthen the immune system against infections.
CAS researchers have developed a new monomer fluorescent protein, Skylan-NS, enabling substantial improvements in the speed, duration, and noninvasiveness of live-cell superresolution microscopy. The protein shows high photostability, cycle numbers and signal-to-noise ratio, making it suitable for live-cell SR imaging.
Scientists have developed a multi-view microscope that captures higher-resolution images of live cells and tissues without increasing radiation exposure. The new system uses computation to fuse images and achieve double the volumetric resolution of traditional methods.
Researchers developed a new method to capture three views simultaneously, producing more detailed perspectives of bacteria and living cells. The technique improved volumetric resolution by up to 235nm, doubling the resolution of traditional methods.
A new platform called spectroscopic photon localization microscopy (SPLM) increases the resolution of molecular imaging by fourfold, making it faster and simpler. This breakthrough can be applied to various fields like materials science and life sciences to study nanoscale environments.
Researchers have developed a method to observe nanometer-sized patterns of biomolecules such as proteins in an arrested but living state. This allows for the recording of molecular activity and interactions without causing cell death, revealing new insights into cellular behavior and processes.
Researchers have developed a spinach-like, nanoparticle juice that can help doctors get a better look at the human gastrointestinal tract. The drink, made from chlorophyll-based nanoparticles, has shown promise in improving imaging techniques such as photoacoustic and PET imaging.
Researchers at the University of Washington have developed a simple expansion microscopy technique to visualize cellular structures on conventional laboratory microscopes. This approach uses an expandable polymer and fluorescent dyes, enabling high-resolution images while maintaining excellent resolution.
Researchers developed a new enhanced DNA imaging technique that can probe individual DNA strands at the nanoscale, providing orientation information and rotational dynamics. The technique offers more detailed information than current methods, enabling monitoring of DNA conformation changes and interactions with proteins.
Researchers at Vienna University of Technology have developed a new method to distinguish real protein clusters from single blinking molecules in superresolution microscopy. The study reveals that many studied proteins do not form clusters as previously assumed, challenging the theory on protein distribution on cell membranes.
Researchers at Bielefeld University have developed an open source software solution to process raw data from ultra-high resolution fluorescence microscopy. This technology allows for the attainment of higher resolutions than physical limits, enabling the study of dynamic processes in living cells.
Researchers visualized the mechanism of cell polarity maintenance using a super-resolution microscope, revealing its relationship to exocytosis and microtubules. The study used a fungal model to clarify the behavior of polarity markers, shedding light on their role in site-specific growth and cell function.
The recipients are selected based on scientific merit and will present their research, receive a travel grant, and be recognized at a reception. The winners include students and postdoctoral fellows working on various topics such as membrane protein flux, mechanotransduction, and DNA binding regulation.
Researchers have discovered that yeast cells use a complex protein structure, called the polarity site, to detect scent gradients. This site moves along the membrane towards the strongest signal before creating a bulge in the cell to grow towards its source.
MIT researchers develop a low-cost biomedical imaging system using fluorescence lifetime imaging and Fourier transform analysis, enabling accuracy comparable to expensive lab equipment.
Researchers have invented a device that provides real-time augmented images under the microscope, allowing surgeons to clearly distinguish cancerous from healthy tissue. This technology can improve surgical accuracy and efficiency in brain cancer and aneurysm patients.
Scientists at ITbM developed a new fluorescent dye, C-Naphox, with enhanced photostability to enable continuous live cell imaging by STED microscopy. The dye has demonstrated extreme photoresistance and no significant toxicity towards cells, opening doors to real-time biological event observation for extended periods.
A low-cost, digital fluorescence microscope has been developed to diagnose diseases in rural areas by examining blood smears. The device can quantify white blood cell levels and differentiate between three types of cells, enabling accurate diagnoses with minimal infrastructure.
The new augmented microscopy technology overlays real and computer-generated images to help surgeons visualize blood flow, cancerous tissue, and anatomical structures more accurately. This innovation aims to improve the translation of research into clinical practice, particularly in neurosurgery and laser surgery.
Researchers at the Howard Hughes Medical Institute's Janelia Research Campus have developed new imaging techniques that dramatically improve spatial resolution in living cells. The new methods offer extraordinary visual detail of structures inside cells with unprecedented clarity and speed.
Scientists have developed nanoscale hybrid materials for noninvasive cancer diagnosis, offering improved image resolution and minimal toxicity. These hybrid materials combine strong fluorescence, high photostability, and great biocompatibility, making them promising for clinical bioimaging applications.
The hybrid scanner combines conventional MRI, hyperpolarized MRI, positron imaging, luminescence imaging, and fluorescence microscopy to provide high-resolution multimodal intra-vital imaging. This allows researchers to study tumor biology and develop targeted therapies by analyzing the co-registration of multiple imaging data lines.
Researchers at UCSB have developed a novel device that enables real-time observation of the forces involved in cell membrane hemifusion. By combining the Surface Forces Apparatus and fluorescence microscopy, they were able to visualize the rearrangement of lipid domains during this process.
Scientists have developed a new approach combining ptychographic X-ray imaging and fluorescence microscopy to study the role of trace elements in biological functions. This technique demonstrates unparalleled sensitivity for measuring trace element distribution in thicker specimens at cryogenic temperatures.
New review highlights advances in image-guided surgery using fluorescence imaging to improve cancer detection and patient survival. Innovative strategies in low-income countries, such as mosquito net repairs and task redistribution, offer lessons for high-income countries.
Defective cilia can lead to diseases such as blindness, infertility, and obesity. UGA researchers have made a breakthrough by imaging and measuring tubulin transport in cilia, revealing the mechanism behind their assembly.
University at Buffalo researchers have designed a nanoparticle that can be detected by six medical imaging techniques, including CT scanning, PET scanning, and photoacoustic imaging. This technology has the potential to provide doctors with clearer pictures of patients' organs and tissues, enabling faster diagnosis and treatment.
Researchers discovered that filopodia, finger-like structures on cell membranes, can extend, contract, and bend in dynamic movements. A twist-based mechanism involving the actin internal 'skeleton' enables these movements, allowing cells to interact with their environment.
Researchers developed a small, lightweight device that combines near-infrared fluorescent imaging to detect marked cancer cells with visible light reflectance imaging to see tissue contours. This technology enhances surgeons' ability to precisely remove tumors and minimize healthy tissue damage.
Researchers can conduct five different imaging studies in one scan with the Opti-SPECT/PET/CT system, providing comprehensive data on anatomy and physiological processes. The device allows for minimally invasive studies with a single dose of anesthesia, enabling scientists to develop new drug discovery methods.
Researchers at EPFL create two powerful probes for the imaging of cytoskeletal proteins with unprecedented resolution. These probes provide a significant improvement over existing techniques, enabling easier and higher quality imaging of cells with minimal toxicity.
A new high-throughput imaging method called CUBIC enables rapid whole-brain imaging at single-cell resolution, overcoming previous limitations. This allows for unprecedented insights into gene expression patterns and neural networks in the brain.
Columbia researchers have developed a novel method to image small biomolecules, such as drugs and nucleic acids, in living cells without disturbing their functions. By using stimulated Raman scattering microscopy with alkyne tags, they can obtain high detection specificity and sensitivity.
Researchers at ICFO have developed a framework to quantify photoactivation efficiency of fluorescent proteins, enabling accurate protein stoichiometry measurement. This breakthrough enhances our ability to study protein function and disease mechanisms.
The Biotechnology and Biological Sciences Research Council (BBSRC) is investing £10M in advanced scientific research instruments. This funding supports world-leading research in various fields, including plant biology, microscopy, and protein interactions.
Researchers have developed a new Spinning Disk Statistical Imaging (SDSI) system that allows for deeper imaging of cellular structures, including viruses and parts of the nucleus. The technique combines super-resolution microscopy with fluorescent probes to produce high-speed focused images.
Researchers developed a new microscopy method combining STED fluorescence microscopy with raster image correlation spectroscopy to track molecule movements in live cells. This allows for high-resolution analysis of biomolecular dynamics, enabling better understanding of cell membranes and protein interactions.
A new device allows cellphone cameras to take images from fluorescent microscopes and flow cytometers, enabling areas with limited resources to conduct tests such as checking for contaminated water and monitoring HIV positive patients. The device is expected to be helpful in resource-poor countries and fast-paced clinical environments.
Researchers developed a new method to study cellular transport dynamics, providing more comprehensive information than existing methods. The dispersion-relation fluorescence spectroscopy (DFS) approach labels molecules of interest, analyzing spontaneous fluorescence intensity fluctuations to quantify mass transport dynamics.
A new imaging technology captures unprecedented speed and precision of embryogenesis, enabling quantitative analyses of developmental processes. The SiMView light sheet microscope allows users to track each cell in an embryo as it takes shape over hours or days.
Researchers have developed a new approach using compressed sensing to resolve cellular features an order of magnitude smaller than before. This allows for the study of dynamic processes in live cells with seconds or even sub-second temporal resolution.
Researchers used single-molecule fluorescence microscopy to visualize myoV molecules walking along actin filaments in real-time. The study found that myoV can take multiple hand-over-hand steps without falling off its track, making it well-suited for intracellular cargo transport.
A team led by University of Miami professor Akira Chiba has developed a novel methodology to examine protein-protein interactions in the fruit fly, allowing for the creation of a point-by-point map of these interactions. This breakthrough uses custom-built 3D FLIM imaging technology to visualize protein associations in live cells.
A research team from Yale University has successfully achieved two-color stimulated emission depletion (STED) microscopy in living cells, overcoming previous challenges in labeling target proteins. The breakthrough enables resolutions of 78 nanometers and 82 nanometers for sequential scans of two proteins in living cells.
The new microscope combines light-sheet microscopy and single molecule spectroscopy to record fluorescence and take snapshots every millisecond. It allows scientists to observe and measure fast processes like molecular diffusion across entire samples.
Researchers use Photo Activated Localization Microscopy (PALM) to accurately count proteins on the cell surface, gaining insight into their interactions and evolution. This technique may help develop more effective drugs by understanding how cells react to external agents.
Researchers at Albert Einstein College of Medicine have developed a new fluorescent protein, iRFP, that allows for the non-invasive visualization of internal organs in live animals. The protein absorbs and emits light in the near-infrared spectrum, enabling clear imaging without radiation exposure or contrast agents.
Researchers developed alternative smear collection methods that are more convenient for patients, yet maintain the same level of accuracy for diagnosis. The findings suggest that a single patient visit could be sufficient to diagnose pulmonary tuberculosis, improving access to treatment, particularly in poor countries.