Researchers at Stowers Institute for Medical Research have developed a precise model for the stinging organelle of the starlet sea anemone, revealing its complex architecture and firing mechanism. The findings could lead to beneficial applications in medicine, including microscopic therapeutic delivery devices.
Researchers used fluorescence microscopy to study clathrin-mediated endocytosis in living cells. They found evidence of three models of curvature initiation and discovered that short-lived events favored the constant-curvature model, while longer events preferred the flat-to-curved transition pathway.
A team of researchers at Georgia Tech has developed a custom-built microscope that can reconstruct comprehensive 3D representations with a single camera image. This allows for quantitative analysis of organoids and provides insights into tissue development, drug interaction, and cellular behavior.
A team of researchers has combined expansion microscopy and stimulated Raman scattering microscopy to create a new imaging technique called MAGNIFIERS. This allows for the high-resolution imaging of biomolecules, including proteins, lipids, and DNA, at the nanoscale.
A team of researchers has developed a novel method using infrared imaging to assess glymphatic function, which is crucial for understanding neurological conditions. The technique allows for the measurement of temporal dynamics of glymphatic functions and provides insights into brain fluid exchange and clearance.
A new measurement and imaging approach resolves nanostructures smaller than the diffraction limit without dyes or labels, using polarization and angle-resolved images of transmitted light. The method measures particle size and position with high accuracy, closing the gap between conventional microscopes and super-resolution techniques.
Researchers developed a novel algorithm, 'Joint Space and Frequency Reconstruction' (JSFR-SIM), to accelerate image reconstruction in optically sectioned superresolution structured illumination microscopy. The method achieves 80 times faster execution speed without compromising image quality.
Researchers at Martin Luther University Halle-Wittenberg create a new shape-stabilized phase change material that can absorb significantly more heat and is made of harmless substances. The material, which can be used as large panels integrated into walls, can store up to 24 times more heat than conventional concrete or wallboard.
A new technology called MediSCAPE has been developed by Columbia Engineers that can capture real-time cellular detail in living tissues. This allows doctors to make informed decisions about tumor removal without needing to remove tissue and wait for pathology results.
Researchers at the University of Illinois created quantum dots to visualize macrophages in fat tissue, shedding light on chronic inflammation's role in diseases. The new technology enables accurate cell counting and tracking over time, offering a potential diagnostic tool for insulin resistance and metabolic syndrome.
The new device, Bio-FlatScope, uses a custom algorithm to reconstruct images of micron-scale targets like cells and blood vessels inside the body. The light captured by Bio-FlatScope can be refocused after the fact to reveal 3D details, making it potentially valuable for detecting cancer or sepsis.
The researchers discovered two modes of transport that influence whether and how proteins attach themselves to a surface. The team found that rougher surfaces promote longer flights, while less hydrophobic surfaces facilitate quicker localized adsorption/desorption.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
Researchers discovered that Chaoborus larvae adjust their air-sacs' volume by changing the pH level, utilizing resilin's elastic properties. This unusual adaptation enables them to float neutrally buoyant in water.
A team of researchers at Rice University has developed a new method to detect tiny cracks in concrete using silicon fluorescence. The technique involves applying a thin coat of opaque paint to the concrete and shining near-infrared light on it, revealing even the smallest microcracks.
The new BD CellView Image Technology enables high-speed sorting of individual cells based on detailed microscopic analysis, accelerating discovery research in immunology, cell biology, and genomics. This technology has the potential to unlock new cell-based therapeutic discoveries and transform various fields of biomedical research.
A new method combines computational ghost imaging and x-ray fluorescence to create high-resolution chemical element maps. This approach eliminates lenses, reducing scanning time and improving spatial resolution, making it useful for biomedicine, materials science, art analysis, and industrial inspection.
A team from the University of Washington has developed a non-destructive 3D imaging method that can help doctors more accurately diagnose borderline cases of prostate cancer. The new approach uses 3D images to identify complex features in tissue samples, which can increase the likelihood of correctly predicting a cancer's aggressiveness.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
A SUTD-led study develops brighter, more sensitive fluorophores by suppressing twisted intramolecular charge transfer (TICT) and enhancing photon-induced electron transfer (PET). The research provides design guidelines for dye chemists to rationally tune TICT, PET, and other mechanisms for a wide range of applications.
Researchers have used advanced microscopy to study the ultrastructure of huntingtin inclusions, revealing different mechanisms of aggregation that lead to distinct biochemical properties. The findings suggest targeting inclusion growth as a potential therapeutic strategy for slowing Huntington's disease progression.
Researchers at the University of Illinois created a novel device using microscopic fluorescent diamonds to calibrate sensitive microscopy systems. The nanodiamonds' stability and longevity make them ideal as a 'first-aid kit' for microscopes, allowing for easy reuse and quality control.
Researchers have developed a novel data storage method using mixtures of fluorescent dyes, which can store binary information at high density with fast read/write speeds. The technique encodes sequences of 0s and 1s into dye molecules, allowing for the storage of digital information for thousands of years or longer.
A Harvard research team has created a new method of storing digital information using mixtures of fluorescent dyes, which can potentially store data for thousands of years or more. The technique uses inkjet printing and fluorescence microscopy to encode and decode binary messages in the dye molecules.
A new study from the University of Gothenburg introduces an AI-based method to develop faster, cheaper, and more reliable information about cells using microscopy. This approach eliminates the drawbacks of traditional fluorescence microscopy by providing accurate results without damaging cells or inhibiting processes.
Researchers developed a cost-effective protocol for plant sample preparation and visualization, eliminating the need for stains and dyes. The new method harnesses the natural autofluorescence of tissues in plants, allowing for rapid visualization of plant anatomy across diverse taxa.
Researchers at Texas Biomedical Research Institute developed 'reporter viruses' that allow for real-time tracking of SARS-CoV-2 spread in cells and animal models. This enables faster screening of potential anti-viral drugs, vaccines, and neutralizing antibodies.
Researchers at Umeå University developed a method to study specific cell types in human organs with high-resolution 3D imaging. This allows for the visualization of previously unrecognized alterations in organs like the pancreas, which can lead to improved understanding of disease conditions and treatment options.
Researchers from Nara Institute of Science and Technology developed a machine learning program that accurately predicts the location of proteins related to actin in cells. The program achieved a high degree of similarity with actual images, showing promise for future applications in cell analysis and artificial cell staining.
Researchers developed a topical fluorescent imaging agent targeting PARP1 enzyme in cervical cancer cells, enabling real-time detection with handheld microscopes. This non-invasive method could revolutionize cervical cancer screenings and biopsies, especially in low-resource areas.
Researchers developed a fluorescent probe that binds to activated platelets, enabling clinicians to proactively treat patients before clotting or scarring occurs. The tool uses intravascular catheter-based imaging and has the potential to optimize patient outcomes.
Researchers have developed a new technique called diffuse optical localization imaging (DOLI) that enables noninvasive imaging of the brain's microvasculature and neural activity at depths of up to 4 millimeters. This method uses the NIR-II window and is poised to bring new insight into how the brain works in health and disease.
Researchers have developed a new fluorescence microscopy technique that allows for high-resolution images of microcirculation in the brain without invasive surgical methods. This breakthrough has the potential to reveal new insights into neurological disorders and facilitate early detection and treatment.
Researchers have developed a novel super-resolution vibrational microscopy harnessing Stimulated Raman Excited Fluorescence (SREF) for ultrasensitive vibrational contrast. This technique enables all-far-field Raman spectroscopy with sensitivity down to single-molecule resolution.
Researchers developed a miniature light-sheet generator that can be implanted into a living animal's brain, enabling high-speed and high-contrast imaging of brain activity. The technology uses nanophotonic technology to create ultrathin silicon-based photonic neural probes that emit multiple addressable thin sheets of light.
A team of researchers from Shanghai Jiao Tong University has developed a new way to break the Abbe diffraction limit and realize subwavelength imaging in an all-optical manner. By utilizing nonlinear four-wave mixing, they create super-resolution through scattering of evanescent fields into the far field.
A new recurrent neural network framework enables fast and efficient 3D imaging of fluorescent samples, reducing scan times by ~30-fold. The approach uses few 2D images to reconstruct 3D images, mitigating photo-bleaching challenges in live sample experiments.
Researchers at FAU have uncovered the secret behind the Pazyryk carpet's vivid colors using high-resolution x-ray fluorescence microscopy. Fermenting sheep's wool before dyeing increases brilliance and longevity of the color.
Fermented wool retains its color without fading, a technique used by textile craftsmen in the Iron Age. The method involves fermenting wool and dyeing it with Turkey red, providing an insight into ancient textile production.
Researchers discovered that photobleaching can transform fluorescent dyes into new molecules with altered fluorescence spectra, affecting microscopy results. Simple buffer additions can prevent or even exploit this effect for targeted tracking of specific particles.
Researchers at Heidelberg University developed a novel fluorescence marker called RhoBAST to enable super-resolution RNA imaging in live cells. The method reveals details of subcellular structures and molecular interactions involving RNA, improving image resolution.
Scientists are gaining a deeper understanding of extracellular vesicles (EVs), tiny particles that carry unique cargo from cells. EVs play a critical role in communication between cells, contributing to conditions like cancer and neurodegenerative diseases.
A new scanless high-speed holographic fluorescence microscopy system has been developed with submicron resolution, enabling 3D sensing of nanoparticles and color-multiplexed holographic fluorescence imaging. The system achieves measurements in less than 1 millisecond using digital holography and a phase modulator.
Scientists from Japan develop a novel approach to acquire fluorescence lifetime images without scanning, using optical frequency combs and high-speed single-point photodetectors. This method offers superior speed and high spatial resolution for simultaneous imaging of multiple samples.
Researchers have developed a novel synthetic aperture microscopy method using digital micromirror devices, achieving high spatial resolution and fast imaging speeds. The technique enables the observation of subcellular dynamics and nanometric structures without harming living cells.
Holographic fluorescence imaging combines sensitivity, resolution, and specificity to track individual particles in 3D. The technique uses lateral shearing-interferometry to access phase information of each photon, enabling single-molecule sensitivity.
Researchers from Kyushu University developed a technique that improves the resolution of fluorescence images of living cells using plasmonic metasurfaces. The metasurface, composed of self-assembled gold nanoparticles, enhances the focus of light-emitting molecules, resulting in high-resolution imaging capabilities.
Researchers have successfully raised funding for a project to develop a new super-resolution microscopy technique that can visualize individual synapse proteins with nanometer-scale resolution. The project combines expansion microscopy and single-molecule-sensitive super-resolution microscopy to achieve improved microscopic resolution.
The new technique allows for simultaneous acquisition of images at different depths using a standard microscope, improving biological imaging applications. It utilizes a z-splitter prism to divide detected light, producing multiple high-resolution images on the same sensor without overlap.
A Polish-Israeli team has introduced a new method of super-resolution microscopy that, in theory, has no resolution limit. The technique, called SOFISM, uses naturally occurring fluctuations in emission intensity to enhance spatial resolution.
Researchers at KAUST developed a cost-effective, ultrathin SRS lens using laser-based 3D printing, inspired by lighthouse design. The new lens rejects cross-phase modulation background signals, improving imaging efficiency for biological processes like cancer cell growth.
A new method for identifying sentinel lymph nodes (SLNs) in breast cancer uses photoacoustic microscopy and CD44 and SR-B1 dual-targeting nanoparticles. The technique distinguishes between metastatic SLNs and inflamed LNs, providing a potential solution for reducing complications during surgery.
Researchers from Osaka City University developed a microscope-based thermometer that uses quantum technology to detect temperature changes in live, microscopic animals. The thermometry algorithm successfully tracked temperature fluctuations in C. elegans nematode worms after inducing a fever by stimulating their mitochondria.
Researchers have developed a new method to analyze microscopic samples without using external light, reducing interference and damage to living specimens. The 'glow in the dark' approach uses chemical stimuli to activate chemicals, enabling precise control over localized oxidative hotspots.
Researchers have overcome the limitation of super-resolution microscopy by combining dSTORM and expansion microscopy, achieving a distance error reduction to just five nanometers. This enables fluorescence imaging with molecular resolution for the first time, allowing detailed insights into molecular function and architecture.
Researchers have developed new techniques that can significantly reduce the time needed to process complex images from cutting-edge microscopes. These methods use deconvolution algorithm modifications, parallelization, and neural networks to speed up processing time by several thousand-fold.
A new microscopy technique has pinpointed the locations of individual proteins within bacterial cells, revealing their precise positions and interactions. The technique, called CIASM, combines fluorescent imaging with cryogenic electron tomography to produce high-resolution images of molecules in their cellular neighborhoods.
Researchers developed a single-molecule orientation imaging approach to study amyloid proteins, revealing nanoscale differences in their structures. The method provides insights into the fundamental biological mechanisms of disease, potentially contributing to the development of effective therapeutics.
Researchers created a multimodal digital holographic microscope that can produce 3D fluorescence and phase images of living cells without scanning. This technology has the potential to increase our understanding of stem cell processes in plants and revolutionize biology.
Researchers have developed genetically-encoded X-ray-sensitive tags for site-specific labeling of protein-of-interest in mammalian cells. This enables endogenous labeling of diverse molecules and subcellular structures with an ultrahigh spatial resolution of ~30 nm. The high photostability of these tags allows long-term observation of ...