Researchers at UC Davis have developed SparkMaster2, an open-source software that analyzes normal and abnormal calcium activity in human cells. The tool can identify calcium sparks associated with irregular heartbeats, or arrhythmia, enabling better understanding of the underlying biology.
SourceUniversity of California - Davis Health·JournalCirculation Research·TypeData/statistical analysis·DateSep 1, 2023
Imperial researchers have imaged Piezo1 channels in human cells and organs, revealing their role in regulating blood pressure, respiration, bladder control, and the immune system. This breakthrough could lead to a better understanding of their role in fundamental physiological processes and potentially new drug targets for diseases.
SourceImperial College London·JournalNature Communications·TypeExperimental study·DateAug 21, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new nano-sized force sensor developed by Tampere University researchers allows for the measurement of intracellular forces and mechanical strains. This technology has great potential for studying cancer cells and understanding cellular mechanics.
SourceTampere University·JournalNature Communications·DateAug 21, 2023
Researchers used DNA-PAINT to study base-stacking interactions in DNA strands, finding that adding one more interaction increases stability by up to 250 times. This information allowed them to design a highly efficient three-armed DNA nanostructure with potential biomedical applications.
SourceIndian Institute of Science (IISc)·JournalNature Nanotechnology·DateAug 17, 2023
The new microscope uses structured illumination and optical fibers to achieve fast super-resolution imaging over a wide field of view, enabling the study of individual cell responses to various drugs. The system can image multiple cells simultaneously with high resolution, providing statistical information about cell response.
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at Emory University have discovered a new paradigm for understanding how actin filaments are formed and fine-tuned in cells. They found that three proteins - formin, twinfilin, and capping protein - work together to regulate the activity of actin filaments, allowing for more precise control of cellular movement.
SourceEmory University·JournalNature Communications·TypeImaging analysis·DateJul 20, 2023
Lead-free Cs3MnBr5 anti-perovskite nanocrystals embedded in glass matrices enable tunable emission and ultra-stable X-ray imaging. The results achieve exceptional X-ray detection limits, spatial resolutions, and dose irradiation stability.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateJul 10, 2023
Researchers created a new method, RESORT, to image and analyze living systems in unprecedented detail. The technique combines benefits of super-resolution fluorescence and vibrational imaging, allowing for high spatial resolution and analysis of complex interactions.
SourceUniversity of Tokyo·JournalScience Advances·TypeExperimental study·DateJun 16, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers found that coronaviruses, like SARS-CoV-2, bind to individual monomeric ACE2 receptors on host cells, rather than forming dimers or oligomers. This interaction is sufficient for infection and contributes to the virus's high infectiousness.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateJun 12, 2023
Researchers developed a new spectropolarimetric imaging technique called DIP-SP, which integrates a passive polarization modulator into an imaging spectrometer. This approach enables high-dimensional information capture from incomplete measurements and significantly improves image quality.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics Nexus·DateJun 12, 2023
Researchers developed a novel endoscopic imaging system with a bioinspired sensor that can detect multiple fluorescent probes, enabling more accurate fluorescence-guided cancer surgery. The system showed improved spatial resolution and sensitivity in detecting tumors, paving the way for the adoption of multi-tracer FGS.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateMay 26, 2023
Researchers found that cells store extra 'skin' in folds and bumps on their surface to rapidly deploy temporary protrusions. This allows cells to move safely while maintaining cell volume and membrane integrity.
SourceCell Press·JournalBiophysical Journal·TypeExperimental study·DateMay 18, 2023
Researchers have created a detailed map of human retinal organoid development, revealing information on cell types, proteins, and gene expression. The study uses advanced imaging techniques to visualize multiple proteins simultaneously and provides insights into retinal diseases such as retinitis pigmentosa.
SourceETH Zurich·JournalNature Biotechnology·DateMay 8, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
Researchers have discovered that nuclear pore IDPs form a dynamic barrier that allows essential cellular factors to pass while blocking viruses and pathogens. The team used synthetic biology, multidimensional fluorescence microscopy, and computer-based simulations to study IDPs in living cells.
SourceMax-Planck-Gesellschaft·JournalNature·TypeComputational simulation/modeling·DateMay 2, 2023
Researchers used microscopy techniques to study polyfluorene chains and found that intra-chain aggregation causes green emission, which disappears when the chain unfolds. The team also discovered a novel optomechanical force acting on some chains, originating from van der Waals interactions and excitonic coupling.
SourceTokyo Institute of Technology·JournalACS Nano·TypeExperimental study·DateApr 26, 2023
A new Raman probe, 9CN-JCR, has been developed for detecting multiple enzyme activities in heterogeneous biological tissues. The probe exhibits high sensitivity and multiplexing ability, making it a promising tool for cancer diagnosis and research.
SourceTokyo Institute of Technology·JournalJournal of the American Chemical Society·TypeExperimental study·DateApr 25, 2023
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
A new study reveals that different species of bacteria colonize specific areas on diatoms, reflecting their metabolic properties. The findings provide insight into the complex interactions between algae and bacteria in marine environments.
SourceUniversity of Oldenburg·JournalJournal of Phycology·TypeObservational study·DateApr 20, 2023
Scientists have developed a method to activate protein functions using brief flashes of light, enabling precise control over when and where chemical reactions occur. This technology has potential uses in tissue engineering, regenerative medicine, and understanding biological processes.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalNature Chemistry·TypeExperimental study·DateApr 17, 2023
Researchers develop a new technique to measure blood attenuation using a fluorophore-coated guidewire, improving the accuracy of near-infrared fluorescence in cardiovascular imaging. The method provides accurate information on vessel walls and outperforms existing correction methods.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateApr 13, 2023
Researchers have developed a multidisciplinary approach using a new microscope, artificial intelligence algorithm, and voltage indicators to better measure brain activity. The technique enables the imaging of up to 100 neurons at a time, far surpassing previous limits.
SourceBoston University·JournalNature Methods·TypeImaging analysis·DateMar 27, 2023
A new technique combines machine learning with short-wave infrared fluorescence imaging to detect precise tumor boundaries with higher accuracy than traditional methods. The approach achieved a remarkable per-pixel classification accuracy of 97.5 percent and demonstrated robustness against changes in imaging conditions.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·TypeExperimental study·DateMar 27, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers have developed a high-speed, 3D gigapixel microscope that stitches together dozens of cameras to capture life in unprecedented detail. The device enables the recording of differences in pitch and depth, allowing scientists to study zebrafish behavior and developmental biology without harming the animals.
SourceDuke University·JournalNature Photonics·TypeExperimental study·DateMar 20, 2023
Researchers have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond using the MINFLUX technique. This allows them to observe tiny movements of single proteins, including the stepping motion of kinesin-1 along microtubules while consuming ATP.
SourceMax-Planck-Gesellschaft·JournalScience·TypeExperimental study·DateMar 16, 2023
Molecular biologist Shixin Liu is recognized for developing cutting-edge biophysical tools to visualize and understand biomolecular machines. His work aims to establish a quantitative input-output relationship between environmental stimuli and gene expression profiles.
Researchers developed a new method combining pMINFLUX microscopy with graphene energy transfer, enabling axial precision of less than 3 angstroms. This allows for the study of molecular structures and dynamics at the nanoscale, fundamental for understanding cellular biomolecular reactions.
SourceLight Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS·JournalLight Science & Applications·DateMar 10, 2023
Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateMar 10, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A proof-of-principle study introduces a 'glowscope' - a $50 device that converts smartphones into fluorescence microscopes. The device allows for low-magnification imaging of cells, tissues, and organisms under fluorescent lighting.
SourceScientific Reports·JournalScientific Reports·DateMar 9, 2023
Researchers have designed a novel imaging and experimental preparation system to record the activity of the enteric nervous system in mice, providing new insights into the complex processes of digestion and waste elimination. The findings suggest that physical distention of the gut controls how the entire neural network is coordinated.
SourceUniversity of Calgary·JournalThe Journal of Physiology·TypeExperimental study·DateFeb 15, 2023
Scientists develop two-beam ultrafast laser scribing technology to fabricate ultrafine graphene patterns with sub-diffraction feature size. The technique overcomes the diffraction limit barrier, allowing for precise control over patterned structures.
SourceUltrafast Science·JournalUltrafast Science·TypeExperimental study·DateFeb 9, 2023
Researchers developed BrightEyes-TTM, an open-source stopwatch to study molecular interactions inside living cells. The platform records the lifetime of fluorescent molecules, providing insights into cellular structure and function.
SourceIstituto Italiano di Tecnologia - IIT·JournalNature Communications·TypeExperimental study·DateJan 26, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A new biopsy procedure is developed with a multispectral confocal endomicroscope to aid in lung tissue imaging. The system allows for simultaneous imaging of multiple fluorescent dyes, enabling unique identification and spectral unmixing.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Optical Microsystems·DateJan 17, 2023
Researchers have developed an innovative amputated human limb model to evaluate molecularly targeted fluorescent probes for human tissues. The model allows for controlled testing of imaging agents with zero risk to patients, improving the accuracy and safety of surgical procedures.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateJan 6, 2023
Researchers from Osaka University developed a new fluorescent sensor system to visualize N-cadherin-mediated interactions between living cells. The INCIDER system enables accurate tracking of temporal changes in these interactions, with a fluorescence signal 70 times stronger than existing methods.
SourceOsaka University·JournalCommunications Biology·TypeImaging analysis·DateDec 15, 2022
A new mesoscopic oblique plane microscopy method captures up to three times more resolvable image points than other similar systems, enabling whole-body volumetric recordings of neuronal activity and blood flow dynamics. The technique allows for single-cell tracking within the complete 3D circulation system for the first time.
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers developed a photon-efficient volumetric imaging method, laterally swept light-sheet microscopy (iLSLM), which improves axial resolution and optical sectioning while reducing photobleaching. iLSLM outperforms conventional methods like swept focus light-sheet microscopy in terms of resolution and photon efficiency.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics Nexus·DateDec 5, 2022
Scientists have created a way to track brain diseases like depression, Alzheimer's, and strokes using fluorescent mouse blood. The method allows for months-long study of blood flow in the brain, providing new insights into disease progression and development.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell Reports·TypeExperimental study·DateNov 14, 2022
Researchers from the University of Kassel developed an approach to extend the limits of interferometric topography measurements for optical resolution below small structures. Microsphere assistance enables fast and label-free imaging without requiring extensive sample preparation.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Optical Microsystems·DateNov 1, 2022
Researchers used live fluorescence imaging experiments to uncover the mechanism behind cell volume regulation, revealing that WNK kinases activate the 'switch' through phase separation. This discovery has implications for human health, particularly in relation to kidney function and salt-sensitive hypertension.
A new genome imaging technique captures the structure of the human genome at unprecedented resolution, revealing how individual genes fold and work. This technique, called Modeling immuno-OligoSTORM (MiOS), combines high-resolution microscopy and advanced computational modeling to provide a detailed picture of gene shape and function.
SourceCenter for Genomic Regulation·JournalNature Structural & Molecular Biology·TypeExperimental study·DateOct 13, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers propose an optical imaging system for real-time hypoxia imaging in cancer treatment. The technique utilizes protoporphyrin IX to enhance contrast between tumors and healthy tissues, allowing for more effective surgical removal.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateOct 11, 2022
Researchers developed a low-cost, simple imaging system using tumor-targeting fluorescent molecules to determine tumor depth. The portable system provides quantitative information about the depth of tumor cells in the body, helping surgeons remove healthy tissue around tumors for better outcomes.
SourceOptica·JournalBiomedical Optics Express·DateOct 6, 2022
Researchers at Universiteit van Amsterdam use fluorescence microscopy and specialized molecules to study the transition from static to dynamic friction. They find that a slip wave propagates from the edge towards the center of the contact area just before sliding occurs.
SourceUniversiteit van Amsterdam·JournalThe Journal of Physical Chemistry Letters·DateSep 22, 2022
Researchers developed a new holographic microscope that can see through the intact skull and image the neural network of a living mouse brain with high resolution. The technology uses a wave correction algorithm to filter out multiple scattered light waves, allowing for sharper images.
SourceInstitute for Basic Science·TypeExperimental study·DateSep 16, 2022
Scientists at EPFL have created an intelligent microscope that uses artificial neural networks to automate image acquisition and reduce sample stress. The technique can capture more detailed images of bacterial division and mitochondrial constrictions, leading to a better understanding of these rare biological events.
SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Methods·TypeImaging analysis·DateSep 8, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers developed a novel way to visualize densely packed molecules using expansion microscopy, allowing for the first time their imaging. The technique enables visualization of nanostructures found in neurons and Alzheimer's-linked amyloid beta plaques.
SourceMassachusetts Institute of Technology·JournalNature Biomedical Engineering·DateAug 29, 2022
A team of researchers developed a deep learning pipeline to analyze vascular system images of plants with high accuracy. The pipeline can detect vascular bundles, identify specific zones, and perform statistical analysis of traits in different stem internodes. This study has the potential to improve crop resilience and food security.
SourceCactus Communications·JournalThe Crop Journal·TypeExperimental study·DateAug 18, 2022
Researchers developed a novel method to visualize proteins secreted by cells with high resolution, using plasmonic-fluor technology. The FluoroDOT assay is versatile, low-cost and adaptable, providing a more comprehensive look at these proteins.
SourceWashington University in St. Louis·JournalCell Reports Methods·TypeExperimental study·DateAug 5, 2022
Researchers developed a non-invasive ocular imaging method to detect flavoprotein fluorescence in the eye, indicating mitochondrial oxidative stress. This technique may predict glaucoma progression earlier than current methods, with similar sensitivity to visual field changes.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalOphthalmology Glaucoma·TypeImaging analysis·DateAug 2, 2022
Researchers discovered that CAMSAP2 proteins utilize phase separation to form an 'aster' structure, which then organizes into a microtubule network. This process is crucial for the formation of specialized cell shapes, such as those found in heart muscle and nerve cells.
SourceKobe University·JournaleLife·TypeExperimental study·DateAug 2, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
SourceXi'an Jiaotong-Liverpool University·JournalACS Nano·TypeExperimental study·DateJul 20, 2022
Researchers developed a novel frequency-domain method to selectively suppress background noise in STED microscopy, achieving higher spatial resolution and improved signal-to-noise ratio. The approach has potential applications in various dual-beam point-scanning techniques.
SourceSPIE--International Society for Optics and Photonics·JournalAdvanced Photonics·DateJul 6, 2022
Researchers will develop and test new beacon molecules and imaging equipment to improve the detection and removal of non-small-cell lung cancers, aiming to reduce unnecessary tissue removal. The goal is to enhance surgical outcomes and improve patient care.
SourceUniversity of Pennsylvania School of Medicine·DateJun 28, 2022
The Biofinder instrument has successfully detected bio-residue in ancient fish fossils from the Green River formation, confirming that biological residues can survive millions of years. The device's capabilities make it an ideal tool for future NASA missions to detect signs of past life on other planetary bodies.
SourceUniversity of Hawaii at Manoa·JournalScientific Reports·TypeImaging analysis·DateJun 24, 2022
A research team developed a novel super-resolution microscopy technique combining metal-induced energy transfer and single-molecule localization microscopy. The method achieves isotropic three-dimensional imaging of sub-cellular structures, allowing for high-resolution analysis of protein complexes and organelles.
SourceUniversity of Göttingen·JournalScience Advances·TypeImaging analysis·DateJun 24, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers at Stowers Institute for Medical Research have developed a precise model for the stinging organelle of the starlet sea anemone, revealing its complex architecture and firing mechanism. The findings could lead to beneficial applications in medicine, including microscopic therapeutic delivery devices.
SourceStowers Institute for Medical Research·JournalNature Communications·TypeObservational study·DateJun 23, 2022
Researchers used fluorescence microscopy to study clathrin-mediated endocytosis in living cells. They found evidence of three models of curvature initiation and discovered that short-lived events favored the constant-curvature model, while longer events preferred the flat-to-curved transition pathway.
SourceUniversity of Alabama at Birmingham·JournalNature Communications·TypeExperimental study·DateJun 13, 2022
A team of researchers at Georgia Tech has developed a custom-built microscope that can reconstruct comprehensive 3D representations with a single camera image. This allows for quantitative analysis of organoids and provides insights into tissue development, drug interaction, and cellular behavior.
SourceGeorgia Institute of Technology·JournalBiosensors and Bioelectronics·TypeExperimental study·DateMay 26, 2022
A team of researchers has combined expansion microscopy and stimulated Raman scattering microscopy to create a new imaging technique called MAGNIFIERS. This allows for the high-resolution imaging of biomolecules, including proteins, lipids, and DNA, at the nanoscale.
SourceCarnegie Mellon University·JournalAdvanced Science·TypeExperimental study·DateMay 18, 2022
A team of researchers has developed a novel method using infrared imaging to assess glymphatic function, which is crucial for understanding neurological conditions. The technique allows for the measurement of temporal dynamics of glymphatic functions and provides insights into brain fluid exchange and clearance.
SourceSPIE--International Society for Optics and Photonics·JournalNeurophotonics·DateMay 17, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.