Articles tagged with Cell Models
Researchers developed a new 3D organoid model that replicates the unique disease process of autosomal recessive polycystic kidney disease (APRKD). The model identified potential therapeutic targets, including FOS and RAC1, and showed therapeutic effects with FDA-approved drugs.
Researchers developed a machine learning algorithm that can generate a continuous 3D model of cells from a partial set of 2D images. The neural field network learns a mapping from spatial coordinates to physical quantities, allowing for smooth zooming and no pixelation.
A team of scientists from Ural Federal University has developed a complex mathematical model to understand the dynamics of nanoparticles and viruses in cells. The model reveals how viruses cluster inside endosomes and interact with cellular proteins, shedding light on their behavior and replication mechanisms. This breakthrough can hel...
Researchers are using in vitro skeletal muscle models to study Type 2 diabetes and its treatment. These models enable the exploration of disease characteristics and discovery of new medicines tailored to individual patients' muscles.
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
Researchers at KU Leuven have developed a new model of human extraembryonic mesoderm cells, which closely resemble their natural counterparts in early embryos. This breakthrough enables scientists to study processes previously inaccessible during development.
Researchers use human tissue models to study myocardial infarction, a leading cause of mortality worldwide. These models allow for early detection of discrepancies between animal and human responses, enabling faster and safer clinical trials.
Researchers at the University of Cambridge have successfully grown a model embryo with a brain, beating heart, and all other organs using mouse stem cells. This breakthrough could help understand why some pregnancies fail and develop a new approach for repairing synthetic human organs.
Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.
Researchers at Terasaki Institute create micro-organospheres for direct viral infection, immune cell penetration, and high-throughput therapeutic drug screening. The technology holds promise for personalized medicine, tumor therapy and rapid drug testing.
Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people, paving the way for new drug testing and treatments. The immune cell type created played a key role in infection, inflammation, and regeneration, but also served as a natural host for germs.
Researchers developed a high-throughput spheroid-based migration assay using tissue-mimicking ECM to accurately recreate cell migration. This new method enables studying of cell motility and cancer metastasis, potentially benefiting cancer research.
This special collection of articles explores the 'dark side' of Alzheimer's Disease, revealing new biomarkers for brain hyperexcitability and its impact on vigilance and sleep-wake cycle. The findings provide a foundation for an extended model to speed up research lines and discovery.
Researchers analyzed four pesticides' effects on earthworms and springtails in Northern, Central, and Southern Europe. They found varying risks depending on soil compartment and pesticide characteristics. The study highlights the need to consider regional variability when regulating agricultural practices.
A University of Arizona-led study uses bacteria to understand how natural patterns form through mechanical interactions. The findings suggest that just four different adhesive molecules are sufficient to create any possible tiling pattern, with implications for understanding complex multicellular life and creating biodegradable materials.
Researchers at Cedars-Sinai created complex computer models of individual brain cells using artificial intelligence. These models capture the electrical signals that neurons fire to communicate with each other, allowing researchers to replicate brain activity at the single-cell level.
Researchers at Kyoto University have developed a cancer therapy model that utilizes a protein degrading system to transiently degrade and reduce the PD-1 protein, which blocks immune function. This approach has shown high therapeutic efficacy in inhibiting cancer cell growth in mice.
Researchers at Moffitt Cancer Center used mathematical modeling to study the impact of tumor size, immune cell populations, and interactions on cancer treatment outcomes. The models predicted optimal therapeutic approaches for different types of therapies, including cytotoxic chemotherapy and immunotherapies.
Researchers identified CUDC907 as a dual phosphoinositide-3 kinase/histone deacetylase inhibitor that promotes apoptosis in NF2 schwannoma cells. The compound reduced viability and induced cell cycle arrest in human merlin deficient Schwann cell models.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A new study uses machine learning models to predict cancer patients' responses to immunotherapy based on their gut microbiome features. The research identifies common gut bacterial taxa associated with responders versus non-responders, providing a potential tool for distinguishing and predicting immunotherapy responders.
Biomedical engineers have created a novel 3D synthetic structure that mimics the extracellular matrix, guiding neural progenitor cells and promoting their differentiation. The results show promise for developing brain-healing treatments, including biogels that can repair and regrow brain tissue after a stroke or other trauma.
A team of scientists discovered a mathematical principle explaining how cells connect to form tissues and organs, shedding light on embryonic development and organ formation. The study found that epithelial cells can adopt complex three-dimensional shapes like scutoids, which determine cellular connectivity and tissue properties.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.
Researchers at MIT have created a new liver tissue model that identifies one molecule playing a key role in human liver regeneration. The study also reveals several other candidates that will be explored further to discover new human-specific pathways.
A new study published in ACS' Journal of Agricultural and Food Chemistry found that plant-based meat substitutes contain proteins that are not as easily absorbed by human cells. The researchers used a model meat alternative made from soy and wheat gluten, which was found to have lower peptide uptake than chicken meat.
Researchers at Nagoya University created a 3D model of the human genome structure, analyzing its dynamics and functions. The study provides new insights into chromatin distribution, cell division, and transcription regulation, shedding light on cellular processes and potential disease mechanisms.
Researchers developed a low-cost 3D model of the brain to study SARS-CoV-2's neurological effects. The adapted virus replicates 30 times more efficiently in astrocytes than neurons, highlighting the importance of these cells in central nervous system infection.
Researchers developed an antibody cocktail effective against a Hendra virus variant, neutralizing its ability to mutate and evade recognition. The combination of four antibodies leaves the virus with minimal ability to further evolve, providing significant protection against this global biosecurity threat.
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
A team of researchers at Georgia Tech has developed a custom-built microscope that can reconstruct comprehensive 3D representations with a single camera image. This allows for quantitative analysis of organoids and provides insights into tissue development, drug interaction, and cellular behavior.
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
Researchers created a zebrafish model to study Bloom syndrome, uncovering similarities and species-specific novelties. The study found reduced fertility and shorter lifespan in mutant zebrafish, which are entirely male.
Researchers found that jellyfish's stinging cells evolved by repurposing a neuron inherited from a pre-cnidarian ancestor. This discovery provides insights into the emergence of new cell types and the evolution of biodiversity, suggesting that co-option of ancestral cell types was an important source for new cell functions.
A University of Washington model found that the body's ability to create cloned immune cells falls significantly with age, leading to increased susceptibility to COVID-19 in the elderly. The study suggests that genetic limits on cell division may play a role in the devastating effects of COVID-19 on older adults.
Researchers developed a droplet-based microfluidic technology to produce micro-organospheres from cancer patient biopsies within an hour. These miniature tumors retain the original microenvironment and can be used for testing many drug conditions, showing almost perfect correlation with actual clinical treatment outcomes.
Researchers at NC State University have created a stem cell-derived model that sheds light on the effect of dopamine on gene activity in neurons, revealing gene desensitization in human cells. The study provides a blueprint for future research into the relationship between dopamine and addiction.
Researchers from Columbia University have developed a plug-and-play multi-organ chip, customized to the patient, consisting of engineered human heart, bone, liver, and skin linked by vascular flow. The model allows for long-term studies and can be optimized for personalized therapy optimization in cancer and systemic diseases.
A team of scientists has developed a solution to accurately simulate how the atmosphere works by linking large- and small-scale simulations. This helps model winds, transport of pollutants, climate projections, and weather forecasts with greater accuracy.
Researchers at KU Leuven and UHasselt have created a 3D model with human dental stem cells that can produce enamel components, paving the way for biological dental enamel repair. This natural alternative has the potential to reduce risk of tooth necrosis and improve patient outcomes.
A study by Tokyo University of Science researchers has demonstrated that a computationally-light model can simulate complex brain cell responses, including periodic and quasi-periodic responses. The Izhikevich neuron model was found to be capable of reproducing both types of responses at lower computational cost.
Researchers developed a virus that infects cancer cells, killing them while sending signals to nearby uninfected cells for viral attack. This approach shrinks tumors and enhances cancer-killing efficacy in various models, including pancreatic and ovarian cancers.
Researchers developed an AI model to predict side effects from new combination therapies by analyzing over 15 million records of adverse events. The model can recognize patterns between drugs and their side effects, enabling the prediction of adverse events for individual therapy profiles.
A new phenomenon was discovered where increased pressure leads to a sudden burst of rapid and coordinated cellular motion, spraying outwards from the tumour. This fluid-like pushing mechanism can kill cancer cells but also enables them to survive and multiply in new environments.
UNIGE researchers developed a new approach combining genetics and cell biology experiments with physical modelling to simulate protein gradients. Their innovative model can explain complex mechanisms and be adapted to other biology systems.
Researchers created a new device called the lymphangion-chip, which models a section of a lymph vessel and can recreate conditions such as lymphedema. This innovation could lead to better understanding of mechanical forces regulating lymphatic physiology and pathophysiology.
Researchers discovered a new human embryonic stem cell population that closely resembles the 8-cell embryo stage, allowing them to map key genomic changes during early development. This model will help advance knowledge of genome activation errors in developmental disorders and embryo loss.
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Researchers at Baylor College of Medicine developed a human nose organoid model that replicates the complex interactions between human cells and viruses. The model showed divergent responses to SARS-CoV-2 and RSV infection, providing insights into disease progression and potential new therapies.
Researchers developed a new cell model of the olfactory mucosa, which is impaired in patients with Alzheimer's disease. The study provides new insights into the disease pathophysiology, including the potential role of viral infections and air pollutants in brain function.
A team of scientists has developed a three-dimensional airway model made from patient-derived stem cells to study COVID-19 infection. The model replicates the initial stages of infection and can be used to test potential antiviral drugs, with results showing that multi-ciliated airway cells are the primary entry point for the virus.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
Researchers at Rosalind Franklin University have identified a new therapeutic approach for treating cystic fibrosis. The treatment uses antisense oligonucleotides to restore CFTR function by removing stop mutations. This strategy has shown promise in treating CF patients with class I mutations and similar types of mutations.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
Scientists have built a three-dimensional model of a living minimal cell, which mirrors its behavior and allows for the prediction of how it functions. The model reveals key insights into how cells balance their metabolism, genetic processes, and growth.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
Researchers at Cedars-Sinai have identified opportunities to use microgravity in space for large-scale stem cell production, disease modeling, and biofabrication. This could lead to breakthroughs in regenerative medicine and the development of new treatments.
A team of researchers found a connection between energy production and Alzheimer's disease in zebrafish with mutated genes. They discovered that Alzheimer's disease affects the use of oxygen within cells to produce energy, leading to severe deficiency in brain function.