Articles tagged with Cell Models
A digital twin of the bladder has been developed to simulate normal and bladder outlet obstruction (BOO)-affected function. The model will help researchers better understand the connection between changes in BOO bladder wall structure and functionality, enabling them to develop new treatments and predict treatment success rates.
Göttingen University researchers develop mathematical model that shows small imbalances in mixture composition can amplify and control phase separation. This discovery offers a potential mechanism for regulating structure formation in living cells, with applications in fields such as market economies and ecological networks.
Researchers at MIT and partners have discovered that variations in lithium ion flow rates are correlated with differences in carbon coating thickness, which could lead to improved battery efficiency. This technique allows for the extraction of insights from nanoscale data, offering potential applications beyond battery technology.
Researchers from Shinshu University identified citrullination as a key mechanism in lung cancer metastasis. A novel CitFbg peptide was developed to block metastatic cell homing and reduce the risk of cancer spread.
The NSF Science and Technology Center for Quantitative Cell Biology will create whole-cell models to transform understanding of cell function. The center will use cutting-edge imaging and simulation tools, including Minecraft, to advance research into gene expression, metabolism, and division.
A new study published in eLife reveals the folding speed limit of helical membrane proteins using a robust single-molecule tweezer method. The findings provide unprecedented insights into structural states, kinetics, and energy barrier properties, offering valuable guidance for advancing pharmaceutical research and design.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
Researchers aim to identify genetic risk factors and mechanisms underlying virus-induced asthma, using artificial intelligence-based techniques and patient-derived models. The study may lead to personalized prevention campaigns and mechanism-targeted drugs.
A new study reveals that red blood cells can protect against myocardial infarction when exposed to oxygen deficiency, and this effect is enhanced by a nitrate-rich diet. The research provides hope for patients at risk of heart disease.
Researchers at Massachusetts General Hospital have developed a novel 3D human cellular model that mimics the intricate interactions between brain cells and immune invaders, providing insights into how immune cells contribute to Alzheimer's disease progression. The study identified specific types of immune cells called CT8+ T Cells surg...
A new immune-infiltrated human kidney organoid-on-chip model enables the assessment of on-target, off-tumor effects of immunotherapeutic T cell bispecific antibody drugs. The study's findings provide important insights into which cells are targeted by a given TCB and what, if any, off-target damage arises.
Researchers have found that a genetic risk factor for schizophrenia, 3q29 deletion syndrome, impairs mitochondrial function in brain cells. This impairment contributes to the development of schizophrenia and has implications for understanding the neurobiology of the disease.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
A group of biologists and ethicists suggest adding clarity to ongoing research using embryo models to refine the legal definition of human embryos. They propose a new definition that focuses on what an embryo can become rather than how it came to be, allowing for improved evaluation of models and potential future recognition as embryos.
A team of researchers developed a computational simulation that explains key mechanism of DNA segregation, providing new insights into the distribution of genetic information during bacterial cell division. The study reveals fundamental biochemical principles relevant to synthetic biology and medical applications.
Researchers have found a promising new mechanism to target aggressive forms of prostate cancer, where the LSD1 protein is involved. By inhibiting LSD1, the tumor suppressor gene p53 can be reactivated, leading to suppression of tumor growth.
A panel of genetically diverse mice has been created to accurately model the variable human response to SARS-CoV-2 infection. The mice exhibit different levels of disease severity, ranging from asymptomatic to lethal, and can help scientists discover biomarkers of disease severity and evaluate countermeasures.
Scientists have created ultra-thin layers of human cells in tube-like structures using the RIFLE technique, enabling the development of lifelike tissue models. This innovation has significant implications for drug development and disease research, offering a more accurate alternative to animal models.
Researchers propose a novel theory of aging that suggests cell competition is a key factor in the process. The selective destruction theory (SDT) proposes a mechanism of aging that is independent of accumulating damage and consistent with epigenetic rejuvenation.
Researchers create accurate tumor models using 3D bioprinting and a bioink made from Laponite, improving bonding and cross-linking capabilities. The study shows that Laponite enhances biological signaling in the tumor microenvironment, increasing cell viability and promoting anti-tumor drug development.
A team of scientists has successfully elucidated the structure and function of LITE-1, a biomolecule used by Caenorhabditis elegans to detect danger. The researchers used artificial intelligence to predict the structure of LITE-1, which is a channel protein that forms a pore in the cell membrane allowing charged particles to pass through.
Researchers created a smart model system to visualize the gating of individual subunits in Kir2 potassium channels. The study reveals that each subunit gating transition leads to conductance level changes, suggesting all subunits must move together for a fully open channel.
A new complex-domain neural network enhances large-scale coherent imaging by exploiting latent coupling information between amplitude and phase components. The technique reduces exposure time and data volume significantly while maintaining high-quality reconstructions.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
Researchers from ISTA and NUS developed a new theoretical model to understand long-range cell-cell communication. The model reveals the interplay between mechanical forces and biochemical signals in cells, shedding light on complex biological phenomena. It has potential applications in wound healing and understanding tissue behavior.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
Scientists have created human brain organoids free of animal cells, which could greatly improve the study and treatment of neurodegenerative conditions. The novel method uses an engineered extracellular matrix to support stem cell growth, resulting in more accurate models of brain development.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Researchers investigated premature senescence in biliary atresia and assessed senotherapies. They found that human allogenic liver-derived progenitor cells reduced early markers of senescence and improved liver disease in a preclinical model, providing encouraging results for pediatric biliary cirrhosis treatment.
Researchers from Kyoto University developed a microchip using human iPS cells to measure transport capacity of membrane proteins, potentially giving test animals respite. The model simulates glucose reabsorption and drug excretion in renal proximal tubules, enabling patient-specific disease modeling and personalized medicine studies.
Researchers at the University of Cambridge have developed a stem cell-derived model of the human embryo, allowing for the experimental modeling of embryonic development during the second week of pregnancy. This breakthrough could help understand why and how pregnancies fail, and potentially lead to new treatments for genetic disorders.
Researchers at DTU Health Tech created a multi-levelled scaffold that enables near-perfect bone healing in just eight weeks, without using growth factors or endocrine factors and cells. The scaffold combines essential bone minerals with mechanical properties matching human bone compressive strength.
A groundbreaking model of human embryonic development has been created, offering a unique look at the molecular and cellular processes that occur during gastrulation stages. The model includes both embryonic and extraembryonic components, allowing researchers to study their interaction and potential new insights into pregnancy failures...
Researchers applied sparse identification and latent variables (SINDy) to analyze experimental CAR T-cell killing assay data for glioblastoma cancer cells. The study aimed to extend the CARRGO model by capturing more precise interactions between CAR T-cells and glioma cells.
Researchers at MD Anderson Cancer Center have engineered a new model of aggressive renal cell carcinoma, highlighting molecular targets and genomic events that trigger chromosomal instability. The loss of interferon receptor genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability.
Scientists at Doshisha University develop a novel method to produce cell-sized microgel structures that can encapsulate and store DNA molecules. The study reveals the potential applications of these microgels in biomedical research, including confining and transporting large biomolecules.
A study by John Innes Centre researchers has revealed how plants avoid cracking under stress by using a growth hormone called brassinosteroid to loosen the straitjacket effect on their skin. The findings, published in Science, have implications for our understanding of plant development and potentially improve crop yields.
Researchers used a stem cell model to study the effects of Alzheimer's disease-associated mutations on early human brain development, finding that mutant spheres were larger and contained fewer mature neurons. The study highlights the need for tailored therapies and paves the way for studying Alzheimer's in its early stages.
A preclinical study has uncovered the role of Y chromosome gene KDM5D in regulating anti-tumor immune responses and promoting metastasis in male patients with KRAS-mutated colorectal cancer. The study reveals that mutant KRAS drives upregulation of KDM5D, leading to reduced cell adhesion and immune recognition by the immune system.
Researchers developed Precious1GPT, a multimodal transformer-based approach for aging clock development and feature importance analysis. The model utilizes methylation and transcriptomic data to predict biological age and identify disease-related genes, providing a pathway for therapeutic drug discovery.
A UMass Amherst biostatistician is developing statistical tools to better predict breast cancer survival rates and survival time after recurrence. The methods, funded by an NIH grant, will also have a broad application for other chronic diseases, such as those involving hormones and biomarkers.
Researchers created a detailed 3D image of the synapse, a key juncture in neuronal communication. The model reveals the precise geometry of interactions between individual cells, which may hold the key to understanding neurodegenerative diseases.
Researchers have identified LP-284 as a novel acylfulvene compound with anti-tumor activity against non-Hodgkin's lymphoma. The compound exerts nanomolar potency in 15 NHL cell lines and prolongs survival of mantle cell lymphoma xenograft mice, making it a potential therapeutic option for patients with HR or TC-NER deficiency.
Researchers at Texas Biomedical Research Institute have developed a new cell culture model to generate human alveolar macrophages, the most critical immune cells in the lungs. This model allows for easier and inexpensive investigation of lung inflammatory diseases and testing of new therapies.
A unique microcircuit in fruit flies' visual system transforms a single type of neuronal input to compute direction selectivity, with no inhibitory neurons present. The discovery reveals a striking example of the multilayered mechanisms of inhibition and excitation in the brain.
Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.
A new computer-modeling system, scDesign3, has been developed to generate realistic synthetic data for analyzing genetic makeup of cells. The system can help researchers evaluate and validate computational methods for tasks such as gene expression analysis and cell trajectory modeling.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
Researchers have developed a non-invasive technique using laser speckle imaging to visualize microvasculature in donor hearts and detect abnormal blood flow. The method enables precise visualization of blood circulation, potentially identifying hearts suitable for transplantation.
Researchers at Cedars-Sinai created computational models to bridge the gap between
Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
Researchers found that participants with lower written health literacy experienced longer delays in initiating postoperative radiation therapy. The study controlled for demographic and clinical factors, highlighting the importance of health literacy in cancer care.
Scientists from Centre for Ocular Research & Education (CORE) unveiled multiple advancements in 3D printing, accelerating development of drug delivery systems, biodegradable contact lenses, and pharmaceuticals. CORE's innovations include a novel method to fabricate PDMS microfluidic chips with high throughput.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
Researchers at Kyoto University have discovered a genetic mutation that causes lethal arrhythmia in humans. The study found that a novel variant of the CALM2 gene produces robust arrhythmogenicity in human-induced pluripotent stem cell-derived cardiomyocytes.
Researchers have identified a new cell state in embryonic airway development, which may lead to new approaches for treating chronic respiratory diseases. The discovery highlights the crucial role of cellular heterogeneity in shaping airway biology.
Researchers generated a POLDIP2 knockout ARPE-19 cell line and found reduced mitochondrial superoxide levels, consistent with upregulated SOD2. The study demonstrates a potential role of POLDIP2 in regulating oxidative stress in AMD.
A team of investigators created embryo-like structures from monkey embryonic stem cells and transferred them into female monkeys, which implanted and elicited a hormonal response similar to pregnancy. The study provides new tools and perspectives for exploring primate embryos and reproductive medical health.