Articles tagged with Mass Spectrometry
Physicists have developed two novel principles for optical spectroscopy, allowing for the direct observation of excitation-excitation interactions and energy transport in systems. This breakthrough enables the study of dynamic properties such as energy transport in natural light-harvesting systems and artificial dye aggregates.
Benjamin A.Garcia, a renowned biochemist at the University of Pennsylvania School of Medicine, has been awarded the Biemann Medal for his groundbreaking work in mass spectrometry analysis techniques. His research focuses on detecting proteins and biomarkers to study disease mechanisms and develop targeted therapies.
Researchers have used mass spectrometry to study proteins expressed by human cancer cells, identifying new potential therapeutic options for patients with exhausted clinical options. The advance allows for the quantitation of thousands of tumour proteins over several hours.
Researchers at Princeton University have improved a proteomics method to accurately count proteins in cells under different circumstances. The new approach, TMTc+, uses a combination of cell sample preparation and computer algorithm changes to provide superior measurement accuracy and precision compared to existing methods.
A Brazilian team developed a platform that combines mass spectrometry with AI to diagnose viral, bacterial, fungal, and genetic diseases. The method shows high accuracy in detecting Zika infection even after the acute phase.
Scientists used mass spectrometry to analyze proteins in beer at three stages of production, revealing over 200 unique proteins from barley and yeast. The study aims to understand how these proteins control beer's properties and potentially improve brewing techniques.
Researchers at University of Waterloo develop coated blade-spray mass spectrometry for rapid on-site screening of athletes' blood and urine samples, reducing analysis time to 55 seconds and cost to a few dollars per sample. The technology aims to prevent cheating by providing continuous monitoring.
Scientists discovered that specific metabolites in blue crab urine suppress mud crab foraging by 60% and 67%, respectively. This finding has significant implications for understanding chemically mediated interactions in marine ecosystems.
Researchers at UNICAMP developed a new method to increase the resolution of proteomic analysis by mass spectrometry, identifying 10,390 proteins expressed in oligodendrocytes. This improved resolution enables the study of previously undetectable proteins, potentially leading to novel therapeutic approaches for schizophrenia.
Researchers developed a high-resolution mass spectrometry imaging system capable of analyzing live biological samples at a resolution of several micrometers. The system uses femtosecond lasers and plasma jets to ionize biomolecules, allowing for accurate analysis without chemical pretreatment.
A team of scientists and archaeologists has discovered a 15,000-year-old Natufian site in Jordan that pushes back the timeline for permanent settlement in the region. The site's early dates suggest that hunter-gatherers were more versatile than previously thought and had multiple pathways to agriculture.
This special issue highlights innovations in MALDI mass spectrometry for characterizing proteomes, detecting analytes, and screening non-covalent binding of small molecules to target proteins. MALDI imaging is used to study diseases and therapeutics, including the distribution of glycosphingolipids in a Gaucher Disease model mouse brain.
Scientists successfully read several bytes of data stored on a molecular scale using synthetic polymers, setting a new benchmark for data storage. The breakthrough enables the use of polymers in hard drives to reduce size by 100 times.
Researchers at Brigham Young University have developed a miniaturized mass spectrometer capable of analyzing chemicals with high sensitivity. This portable device has significant implications for applications such as detecting chemical weapons, explosives in airports, and forensic investigations.
ASU scientists develop technique using zircon crystals to trace pulses of heat inside a volcano, which may help better predict risk. The new findings suggest that heat pulses before an eruption both begin and end more abruptly than previously thought.
Researchers at Louisiana State University have developed a portable system for capturing and analyzing biomolecules from fingermarks, including DNA and explosives. The technique uses infrared laser ablation to lift molecules off surfaces without destroying them.
A NASA scientist is developing an instrument to search for signs of life on Jupiter's moon Europa, leveraging experience from building a Mars instrument. The Ocean Worlds investigation will analyze molecular biosignatures in surface and subsurface samples.
A new mass spectrometry-based screening method enables quick turnaround of drug screens and can be used in emergency rooms to detect lethal compounds. The low-cost cartridges are estimated to cost less than $10 each, making them accessible to health facilities of any size.
The petitSat mission aims to study the link between plasma enhancements and Medium-Scale Traveling Ionospheric Disturbances (MSTIDs) in Earth's ionosphere. The satellite will measure plasma densities and ion distributions using two instruments, providing valuable insights into the transmission of GPS and radar signals.
Saiful Chowdhury, UTA assistant professor, develops new mass spectrometry techniques to identify prenylated proteins linked to cancer, aging, and genetic disorders. His work may lead to more efficient analysis of modified proteins and improved understanding of cancer mechanisms.
Researchers at the University of East Anglia have developed a novel mass spectrometry method to study iron-sulfur cluster proteins, which are crucial for various biological processes. The study successfully detects all reaction components simultaneously, providing detailed insights into their conversion process.
Researchers have developed a new experimental technique to take 3D images of molecules in action, combining two technologies to probe the structure and behavior of molecules. This tool enables experiments with larger molecules that were previously impossible, allowing for better understanding of quantum mechanics in complex systems.
Scientists at Lomonosov Moscow State University developed a new approach to monitor environmental status in Moscow, using gas chromatography-mass spectrometry analysis. The method detects novel pollutants and expands the list of hazardous substances, posing potential threats to human health and ecosystems.
Researchers at Australian National University have designed a portable device that uses MRI and mass spectrometry to analyze objects. The device, inspired by science fiction tools like the sonic screwdriver and tricorder, could revolutionize laboratory work and medical research.
Clint Alfaro has been honored with the Analytical and Bioanalytical Chemistry Best Paper Award for his research on using mass spectrometry to analyze kidney tissue from patients with renal cell carcinoma. The study demonstrated high sensitivity and specificity of touch-spray mass spectrometry in identifying cancerous tissue.
Researchers at Scripps Florida have developed a new protease tool to study protein structure and post-translational modifications, which can alter protein stability and function. The new tool helps shed light on these chemical changes and could lead to new tools for mass spectrometry.
Researchers developed a new method to identify antibiotics hidden in massive mass spectrometry datasets. By running data against a database of known antibiotics, they detected previously unknown compounds and discovered new variants of existing ones. This breakthrough aims to help combat antibiotic resistance.
The new facility will enable researchers to analyze individual molecule isotopes as fingerprints of biosphere, geosphere, hydrosphere and atmosphere processes. The stable isotope mass spectrometer systems will provide cutting-edge capabilities for studying ecology, environment and energy research.
A portable breathalyzer has been developed to diagnose diabetes noninvasively in offices. The device traps and analyzes acetone levels in exhaled breath, with accuracy matching mass spectrometry readings.
Researchers in Mainz develop a novel method to benchmark and improve the performance of protein measurement techniques, ensuring consistent results across various analysis software packages. This breakthrough enables widespread adoption of mass spectrometry-based quantitative proteomics for disease diagnosis and research.
A new device makes 2D mass spectrometry widely accessible, enabling researchers to produce data-driven results on protein molecules' function. This breakthrough could lead to a revolution in pharmaceutical and biomedical communities, producing quicker and better results.
Researchers from the Moscow Institute of Physics and Technology used mass spectrometry to identify components in an ancient bitumen sample from a 5th century BCE amphora. The analysis revealed a prolonged period of biodegradation due to bacterial activity, leading to increased oxygen content in the sample.
Robert Smith, a UM computer science assistant professor, was awarded a CAREER grant from the National Science Foundation to develop new analysis techniques for mass spectrometry. This advancement may lead to breakthroughs in fields like medical diagnostics, drug development, and research into Alzheimer's disease.
Researchers at Duke University have developed a new technology using coded apertures to improve the performance of mass spectrometers, enabling portable devices to detect environmental hazards in the field. The innovation could lead to miniaturized mass spectrometers for detecting trace amounts of methane and explosives.
A powerful new mass spectrometer has been made available to scientists worldwide to study molecular processes in the environment, biology and energy. The 21 Tesla Ultra-High-Resolution Mass Spectrometer can distinguish between molecules that differ by almost unimaginably small nuances.
Researchers have developed a compact and highly sensitive optical method for detecting radiocarbon dioxide concentration, enabling on-site carbon dating and greenhouse gas measurements. The SCAR instrument can deliver results in just two hours with lower cost and faster delivery time compared to traditional methods.
Volatile organic compounds protect plants from stress, attract insects for pollination and seed dispersal, and send warning signs to neighbor plants and animals. Plant VOC emissions contribute significantly to the atmosphere, emitting approximately 600 million tons of carbon annually.
Scientists have confirmed that blood vessel-like structures found in an 80 million-year-old hadrosaur fossil are original to the animal, not biofilm or contaminants. The discovery provides insight into how proteins can modify and change over millions of years.
Researchers developed a new method that identifies more proteins and peptides in mass spectrometry data, analyzing pairs of overlapping peptide spectra. The method improves performance by up to four-fold, overcoming the bottleneck created by vast amounts of raw data.
A new study reveals that gas chromatography mass spectrometry (GC-MS) fundamentally alters the samples it analyzes due to heat, affecting thousands of laboratories worldwide. The researchers used a data analysis platform to observe small molecules transforming and disappearing during an experiment meant to mimic the GC-MS process.
Researchers at RIKEN and Hiroshima University create technique to analyze metabolites, hormones, nutrients, and lipids in individual cells using nanospray tip and mass spectrometer. This breakthrough could speed up understanding of molecular distribution in time and space, transforming agricultural science.
A system developed at Oak Ridge National Laboratory can identify and characterize solid or liquid samples in seconds, providing a valuable tool for material science, forensics, pharmaceuticals, biology, and chemistry. The device is self-cleaning, requires no sample preparation, and is cost-effective.
Researchers have found that human irisin circulates in the blood at nanogram levels and increases during exercise. The discovery resolves a long-standing controversy over irisin's existence, with alternative start codons explaining its production in skeletal muscle cells.
Researchers at Carnegie Mellon University successfully separated and weighed a mixture of intact virus particles using matrix-assisted laser desorption ionization MS. This technique, called heavy ion mass spectrometry, allows for the analysis of viruses that are too large to be detected by standard instruments.
NASA has selected two Southwest Research Institute instruments, a mass spectrometer and ultraviolet spectrograph, to investigate Jupiter's fourth-largest moon, Europa. The mission will explore potential life in the outer solar system and study the moon's subsurface ocean.
Caltech scientists develop nanodevices that can measure the mass of individual molecules and reveal their three-dimensional spatial distribution, crucial for identifying large protein complexes. This technology enhances protein identification and analysis, improving odds in discovery mode.
A new mass spectrometry method developed by IUPUI chemist Nicholas Manicke can rapidly detect drugs and poisons in blood samples. The method, known as paper spray mass spectrometry, has potential use in various fields such as biomedical research, clinical testing, and forensic science.
Researchers at Helmholtz Zentrum München developed an approach to quantify gadolinium-based contrast agents in tissue using MALDI-MS imaging, correlating it with MRI images. This combination improves diagnostic value by detecting tissue-related kinetics of contrast agents used in myocardial infarction models.
Saiful Chowdhury's project aims to identify host-defense protein interactions networks using mass spectrometry-based chemical cross-linking technology. The research will help recognize protein-to-protein interactions and reduce data complexity in large-scale studies.
Researchers from Ohio State University discovered a layer within the Quelccaya Ice Cap containing lead and bearing the chemical signature of Potosi silver mines, providing the first detailed record of widespread human-produced air pollution in South America before the industrial revolution
Scientists at UT Arlington have developed a new method for detecting trace amounts of estrogen in small samples, improving research into cancer and other diseases. The new method is sensitive enough to detect estrogens at levels as low as 10 parts per trillion, making it applicable to human health, medicine, and environmental analysis.
Scientists have made the first definitive detection of organic molecules at Mars using NASA's Curiosity rover. The discovery suggests that ancient Martian environments may have provided a supply of reduced organic molecules for use as building blocks for life and an energy source.
Dr. Paul Mahaffy, a leading expert on Mars chemistry, received the John C. Lindsay Memorial Award for his groundbreaking work on the Curiosity Rover's Sample Analysis at Mars (SAM) Instrument Suite. The award honors his contributions to planetary science and exploration.
New research reveals how red tide's chemicals disable competitor algae without killing them, affecting nutrient cycling and primary production in the ocean. Red tide's chemical cues alter large-scale ecosystem processes.
Researchers at Purdue University developed a nanotube coating that significantly reduces the voltage required for mass spectrometers, allowing for miniaturization and increased portability. The technique simplifies analysis by nearly eliminating background noise, making it gentler on fragile molecules.
A robotic system enables scientists to analyze the chemical composition of irregularly shaped surfaces, simulating early Earth conditions on meteorites and rocks. This technology has potential applications in biomedical fields like dermatology, allowing researchers to probe lesions with high accuracy.
A new mass spectrometry-based technique provides high-throughput analysis of proteins like IGF1 at a rate of over 1,000 human samples per day. The method accurately characterizes protein structure and variants, offering a detailed portrait of protein information not available through traditional ELISA tests.
Immunologists have developed an improved mass spectrometric method for proteomic analyses, allowing for the identification and quantification of more proteins. The new technique, called ISOQuant, eliminates the need for labeling samples, enabling direct analysis of patient samples and specific immune cells.
The University of Colorado Boulder has been awarded a cooperative agreement worth up to $14.6 million from the Defense Advanced Research Projects Agency (DARPA) to develop a new technological system to rapidly determine how drugs and biological or chemical agents exert their effects on human cells. The Subcellular Pan-Omics for Advance...
Three mass spectrometers from NASA's Goddard Space Flight Center conducted simultaneous experiments on the moon and Mars to analyze atmospheric and rock samples. This milestone demonstrates the value of these instruments for understanding planetary environments.