Articles tagged with Mass Spectrometry
A team of researchers developed a high-throughput biochemical assay to assess small molecule impact on SARS-CoV-2 nonstructural protein 14, identifying potential inhibitors from FDA-approved drugs. The study aims to deliver therapeutics for the SARS-CoV-2 virus, targeting its critical methyltransferase activity.
Wayne State University has been awarded a $1.29 million NIH grant to purchase a new mass spectrometer for biomedical research, enhancing protein analysis and disease understanding. The instrument will also aid in training students and promoting local product development.
A new algorithm called MolDiscovery uses mass spectrometry data to predict the identity of unknown substances, helping scientists avoid rediscovering known compounds and save time and millions of dollars. The algorithm could accelerate the discovery of novel natural products that could lead to the development of new drugs.
Researchers at Martin-Luther-University Halle-Wittenberg studied protein interactions in synaptic vesicles, uncovering how they mesh like cogs in a clockwork mechanism. This understanding helps recognize and understand malfunctions that could trigger diseases such as Alzheimer's.
Researchers developed a handheld MasSpec Pen to identify common types of meat and fish within 15 seconds, with 100% accuracy. The device uses molecular components to verify meat sources, eliminating the need for sample preparation steps.
Researchers developed a mass spectrometry-based technique to measure thousands of proteins in blood plasma in just a few minutes. The new technology identified previously unknown proteins associated with disease severity, including those involved in the immune response to pathogens.
Researchers propose a new Mass Spectrometry Imaging (MSI) method that uses the theory of human color perception to create more interpretable images. The approach preserves borders and gradients, enabling better analysis of molecular distributions in tissues.
Scientists at Kanazawa University developed a new method to study the neutralization of excess charges during mass spectrometry, which can lead to more accurate results. The team used a combination of continuum and molecular dynamics simulations to model the effect of adding molecules of the opposite charge to neutralize excess charge.
Researchers at the Beckman Institute created a subspace mass spectrometry imaging approach to accelerate data acquisition without sacrificing quality. This technique can detect biomolecules across a wide range of sizes and has implications for analytical chemistry, clinical studies, and neurochemical research.
A new machine learning model has been developed to help characterize compounds in the development of new drugs. The model uses tandem mass spectrometry and is based on a small amount of positive and negative training data, making it useful for automating characterization of compounds by chemists.
The October edition of SLAS Discovery features a critical review of mass spectrometry applied to imaging in drug discovery, highlighting its potential for pharmacokinetic and pharmacodynamic measurements. The issue also includes original research articles on various topics in life sciences discovery and technology.
A team of scientists has identified a collective signature of proteins and metabolites that can predict who is at highest risk of dying from the infection. The biomarkers, including lower levels of glycosylated fetuin A and higher levels of serum protein carbamylation, were associated with death due to Staphylococcus aureus bacteremia.
Researchers have developed a method to use face masks to collect compounds in exhaled breath aerosols for analysis, enabling large-scale screening for disease biomarkers. The new technique uses a fiber inserted into an N95 face mask to concentrate molecules, allowing for more efficient identification through mass spectrometry.
Researchers at Martin Luther University Halle-Wittenberg have developed a novel mass spectrometry-based test that can detect small amounts of SARS-CoV-2 in highly diluted gargle samples. The test is highly specific for the virus and can be used in early stages of the disease when many viruses are present.
Researchers used imaging mass spectrometry and immunohistochemistry to identify novel lipid and protein tumor markers for head and neck squamous cell carcinoma. These markers, including S100A8 and S100A9, show promise as potential diagnostic tools and may provide insights into the pathophysiology of HNSCC.
The study reveals that medieval glass production in Spain predates Islamic influence by more than 50 years. Glass fragments from the Rabad of Šaqunda date back to the 8th century and show evidence of local lead production using nearby ore deposits.
Researchers at NJIT have developed a new coulometric mass spectrometric approach to quantify proteins, which could aid in discovering new therapeutic antibodies or biomarkers. The method is faster and more efficient than current methods, requiring less time-consuming preparation of synthesized standard material.
This article reviews the state-of-the-art analytical strategies for studying protein arginine methylation using mass spectrometry. The authors discuss the latest studies on profiling protein-methylation events, implementing biochemical methods, computational analysis tools, and the heavy methyl SILAC strategy.
Researchers at the University of Illinois have developed a high-throughput screening tool to rapidly profile medium-chain fatty acids produced in yeast. They identified seven new genetically engineered mutants that produce higher levels of those fatty acids, which are crucial components of biodiesel and other industrial chemicals.
A groundbreaking tool, LipidCreator, has been developed to efficiently analyze specific lipid groups and signal molecules, accelerating the discovery of biomarkers for diseases. This software enables scientists to quantify 60 lipid classes and their signaling molecules in larger studies than previously possible.
Scientists developed a new method to simplify the search for traces of medicines and sports doping drugs in human biological samples. By analyzing the chemical composition of a substance with reduced search space, the method helps detect illicit substances more efficiently.
A new technology developed at Northwestern University offers precise measurements of proteins down to their atoms, enabling better understanding of disease and the design of vaccines. This approach, called individual ion mass spectrometry, can determine the exact mass of a huge range of intact proteins.
The DIASyM research cluster will use state-of-the-art mass spectrometry to analyze blood parameters of patients with heart failure and compare them to healthy individuals. This will help identify biomarkers and understand the interactions between biological processes, leading to new approaches for diagnosis, therapy, and prevention.
Chemists at Iowa State University have developed a technique to analyze the degradation of unsaturated fatty oils in fingerprints, potentially allowing them to be used as a tool to determine their age. The method uses mass spectrometry imaging and has shown promising results, with individual differences in fingerprint aging detected.
SPion technology enables scientists to conduct accurate molecular profiling of living tissue without disruption, addressing limitations of traditional ex vivo techniques. This breakthrough innovation is expected to revolutionize health and biological sciences, including cancer surgery, by providing real-time tissue biopsy results.
The MSTARS consortium aims to further develop mass spectrometry technology for clinical application and detection of treatment resistance in various diseases. By combining expertise in mass spectrometry, patient care, and data analysis, the team hopes to improve precision medicine and tailor treatments to individual patients.
Researchers have developed a technique to create high-resolution images of biological samples, revealing new molecules and their spatial distribution. The technique uses a powerful mass spectrometer to produce detailed visuals of the molecular makeup of animal tissue.
Researchers are designing a toilet that can analyze urine for biomarkers of various human conditions, such as cancer and diabetes. The technology has the potential to provide early warning systems for viral or bacterial outbreaks and track medication effectiveness in older adults.
A team of WVU chemists has created a new molecular research tool that simplifies experiments in mass spectrometry, enabling non-invasive analysis of biological systems. The instrument, developed by Assistant Professor Peng Li, uses a vibrating sharp-edge spray ionization device to collect and ionize samples on the spot.
Researchers at the University of Münster have developed a new technique that combines two methods to improve the spatial resolution of mass spectrometry imaging. This allows for better understanding of disease processes and potential new strategies for treating them. The technology uses dual-beam laser mass spectrometry, enabling the s...
Scientists from Skoltech identified substances with antiviral activity in humic substances extracted from brown coal, highlighting the potential of natural compounds for creating new drugs. The study's results show that flavonoids and polyphenols may be responsible for virucidal activity.
Tohoku University researchers have developed a technique that improves on current photoluminescence spectroscopy techniques, allowing for the measurement of larger semiconducting crystals. The new approach uses a hollow sphere to minimize photon loss and test internal quantum efficiency, a key property of semiconductors.
Researchers developed a novel laser-based measurement device to quantify rare CO2 variants, enabling accurate tracking of Earth's temperature. This breakthrough technology surpasses mass spectrometry in precision and can significantly shorten measurement times.
Researchers have uncovered details of microalgae's light-harvesting system, which is up to 95% efficient, using advanced mass spectrometry techniques. This breakthrough could lead to the development of more efficient organic solar panels, increasing energy efficiency and reducing environmental impact.
Scientists have developed a novel strategy to extract and analyze membrane proteins, which are critical targets for therapy. Azo, a photocleavable surfactant, enables effective mass spectrometry analysis of whole proteins, opening up new opportunities to study membrane proteins.
Researchers developed a computational mass-spectrometry system that identified thousands of plant metabolites, including previously unknown compounds with medicinal properties. The new method provides 10 times the coverage of previous methods and has applications in drug discovery and understanding plant physiology.
Catherine Costello has made a lasting impact in proteomics with her groundbreaking research on biologically important polymers and their structures. She is the author of over 375 scientific papers and has received numerous awards for her contributions to mass spectrometry.
Researchers at University of Groningen developed nanopores that can measure peptide mass, offering a cheap and portable solution for proteomics research. The smallest pores produced have a resolution of around 40 Dalton, allowing for the identification of peptides with varying chemical compositions.
Researchers at Xiamen University have created a device that enables the direct detection and mapping of chemicals inside biological cells. This breakthrough technique, called near-field desorption postionization time-of-flight mass spectrometer (NDPI-TOFMS), overcomes challenges in high-resolution imaging and provides undistorted chemi...
Scientists developed an electron microscopy technique to directly identify isotopes in amino acids at the nanoscale without damaging the samples. This allows for real-space observation of dynamic chemistry and creates a foundation for scientific discoveries.
Researchers from Skoltech and MIPT analyzed the protein and lipid composition of a Siberian mammoth bone, identifying 98 proteins and 73 lipids. The study provides insights into the mammoth's diet, health, and nervous system development, complementing paleogenomics and paleoproteomics.
Researchers have successfully developed an automatic suction device for Single-cell mass spectroscopy, enabling high efficiency and precision. The device uses cellular image analysis, confocal microscopy technology, and a software for one-click suction, achieving 22 samples per hour.
Researchers used mass spectrometry to analyze Zhu Ling's hair samples and establish a timeline of her thallium poisoning. The study found that Ling was exposed to multiple doses of thallium, with increasing frequency and concentration, over a period of four months.
Researchers are investigating the impact of prebiotics on immune system function in people with schizophrenia, focusing on the production of short chain fatty acids, particularly butyrate. The study aims to improve understanding of the brain-gut connection and potential treatments for cognitive impairments.
Researchers developed a new method to analyze cell membrane proteins directly, enabling new discoveries on protein function and behavior. This breakthrough could lead to better understanding of diseases such as cancer, metabolic disorders, and heart disease.
Scientists have gained new insights into dynamic structural changes in light-sensitive biomolecules, revealing a universal mechanism for the transformation from dark-adapted to light-adapted states. This discovery could advance applications in agriculture and optogenetics.
A new cloud-based analysis platform allows scientists to quantify molecules from biological samples and share their results publicly. The platform enables faster research and increased precision by identifying key fragments of molecules, benefiting fields like environmental sciences, pharmaceuticals, and sports medicine.
The grant enables researchers to detect and identify a wide range of molecules from diverse samples. The instrument will also support the university's goal of increasing participation by underrepresented groups in STEM education and research.
Researchers identify structure of ultra-long-chain lipid in tear film, which plays crucial role in vision. The finding may lead to improved treatments for dry eye by creating a better match with human tears.
Researchers have developed a molecular labeling method using polymers to identify biomedical implants, even after prolonged periods inside the living being. The technique uses mass spectrometry to decode the 'code' of the labels, enabling unambiguous identification and potential extension to other healthcare materials.
Physicists have developed two novel principles for optical spectroscopy, allowing for the direct observation of excitation-excitation interactions and energy transport in systems. This breakthrough enables the study of dynamic properties such as energy transport in natural light-harvesting systems and artificial dye aggregates.
Benjamin A.Garcia, a renowned biochemist at the University of Pennsylvania School of Medicine, has been awarded the Biemann Medal for his groundbreaking work in mass spectrometry analysis techniques. His research focuses on detecting proteins and biomarkers to study disease mechanisms and develop targeted therapies.
Researchers have used mass spectrometry to study proteins expressed by human cancer cells, identifying new potential therapeutic options for patients with exhausted clinical options. The advance allows for the quantitation of thousands of tumour proteins over several hours.
Researchers at Princeton University have improved a proteomics method to accurately count proteins in cells under different circumstances. The new approach, TMTc+, uses a combination of cell sample preparation and computer algorithm changes to provide superior measurement accuracy and precision compared to existing methods.
A Brazilian team developed a platform that combines mass spectrometry with AI to diagnose viral, bacterial, fungal, and genetic diseases. The method shows high accuracy in detecting Zika infection even after the acute phase.
Scientists used mass spectrometry to analyze proteins in beer at three stages of production, revealing over 200 unique proteins from barley and yeast. The study aims to understand how these proteins control beer's properties and potentially improve brewing techniques.
Researchers at University of Waterloo develop coated blade-spray mass spectrometry for rapid on-site screening of athletes' blood and urine samples, reducing analysis time to 55 seconds and cost to a few dollars per sample. The technology aims to prevent cheating by providing continuous monitoring.
Scientists discovered that specific metabolites in blue crab urine suppress mud crab foraging by 60% and 67%, respectively. This finding has significant implications for understanding chemically mediated interactions in marine ecosystems.
Researchers at UNICAMP developed a new method to increase the resolution of proteomic analysis by mass spectrometry, identifying 10,390 proteins expressed in oligodendrocytes. This improved resolution enables the study of previously undetectable proteins, potentially leading to novel therapeutic approaches for schizophrenia.
Researchers developed a high-resolution mass spectrometry imaging system capable of analyzing live biological samples at a resolution of several micrometers. The system uses femtosecond lasers and plasma jets to ionize biomolecules, allowing for accurate analysis without chemical pretreatment.