Articles tagged with Mass Spectrometry
Researchers use matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to track injected collagen in the heart. The technique allows for precise detection of therapeutic peptides and their distribution in the myocardial infarct.
Researchers used wastewater samples from 25 treatment plants across 10 countries to track the popularity of new synthetic drugs. Synthetic cathinones, including eutylone and 3-MMC, were found to have high per capita levels in wastewater, with increased international presence reported between 2020-2021 New Year periods.
Researchers from Dalian Institute of Chemical Physics discovered triboionization in a discontinuous atmospheric pressure interface, enabling analytes to be detected without an extra ionization source. By adjusting the pinch valve frequency, signal intensity was improved by nearly 20 times.
A new approach has been developed to identify proteins affected by pollutants and chemicals, allowing for early detection of harmful biological effects. The method, called PISA, can be used to study the interactions between chemicals and proteins, revealing potential toxicity pathways.
A study by the Technical University of Munich discovered that pungent substances from chili, ginger, and pepper are transferred to breast milk after consumption. These substances can be detectable in breast milk for several hours, with maximum concentrations being 70- to 350-fold below the taste perception threshold of an adult.
Researchers trained an artificial intelligence algorithm to predict the next designer drugs before they are even on the market, allowing law enforcement agencies to identify and regulate new versions of dangerous psychoactive drugs. The model was tested against 196 new designer drugs and found nearly all were present in its generated set.
The £3.6 million equipment will enable researchers to measure trace levels of radioactive elements, particularly actinides, in samples from UK nuclear facilities and natural environments.
Researchers developed a new mass spectrometry technique to identify key protein features in cyanobacteria, enabling rapid detection of harmful species. This approach can be used to prevent blue-green algae blooms and detect toxic species, such as spirulina extracts.
A team of bioinformaticians at Friedrich Schiller University Jena developed a method to identify small active substance molecules using machine-learning methods. They successfully identified 11 new, previously unknown bile acids in mice using this approach.
Researchers developed a real-time measurement technique to detect algae health issues, detecting threats 37-76 hours earlier than traditional methods. This could save hundreds of millions of dollars in algae biomass losses and protect the world's most promising sustainable product source.
Researchers developed a new analytical technique to isolate and characterize individual organelles within cells, allowing for rapid chemical analysis. The study found heterogeneity among vesicle types, indicating the potential for earlier disease detection.
Researchers at Max Planck Institute found that early human groups in Europe endured cold climatic conditions for over 7,000 years. The team used archaeological materials to generate climatic data, revealing a higher degree of climate flexibility than previously believed.
A study published in Nature Communications reveals the mechanisms of SARS-CoV-2 proteolysis and identifies key cellular substrates with therapeutic potential. The research provides a powerful resource for developing targeted strategies to inhibit the virus, which has caused over 227 million infections and 4.6 million deaths worldwide.
Scientists at TUM and LSB developed a new methodology to quantify the flavor profile of cocoa samples. The method provides quantitative data on 66 taste-decisive substances using a single mass spectrometric platform, allowing analysis of 200 samples per week.
A randomized clinical trial found that yogurt containing Bifidobacterium lactis BB-12 protected against harmful changes in the gut microbiome after antibiotic administration. The study also showed that levels of beneficial short-chain fatty acid acetate returned to baseline within 30 days.
Researchers analyzed 8 popular plant-based burgers and found that some closely mimic the odor of real beef when cooking. The Beyond Burger from Beyond Meat came closest to replicating the hamburger aroma, but still differed significantly.
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
A recent study reveals enormous chemical complexity in commercial beers, tracing tens of thousands of different molecules. The diversity originates from raw materials, processing, and fermentation.
A team of researchers developed a high-throughput biochemical assay to assess small molecule impact on SARS-CoV-2 nonstructural protein 14, identifying potential inhibitors from FDA-approved drugs. The study aims to deliver therapeutics for the SARS-CoV-2 virus, targeting its critical methyltransferase activity.
Wayne State University has been awarded a $1.29 million NIH grant to purchase a new mass spectrometer for biomedical research, enhancing protein analysis and disease understanding. The instrument will also aid in training students and promoting local product development.
A new algorithm called MolDiscovery uses mass spectrometry data to predict the identity of unknown substances, helping scientists avoid rediscovering known compounds and save time and millions of dollars. The algorithm could accelerate the discovery of novel natural products that could lead to the development of new drugs.
Researchers at Martin-Luther-University Halle-Wittenberg studied protein interactions in synaptic vesicles, uncovering how they mesh like cogs in a clockwork mechanism. This understanding helps recognize and understand malfunctions that could trigger diseases such as Alzheimer's.
Researchers developed a handheld MasSpec Pen to identify common types of meat and fish within 15 seconds, with 100% accuracy. The device uses molecular components to verify meat sources, eliminating the need for sample preparation steps.
Researchers developed a mass spectrometry-based technique to measure thousands of proteins in blood plasma in just a few minutes. The new technology identified previously unknown proteins associated with disease severity, including those involved in the immune response to pathogens.
Researchers propose a new Mass Spectrometry Imaging (MSI) method that uses the theory of human color perception to create more interpretable images. The approach preserves borders and gradients, enabling better analysis of molecular distributions in tissues.
Scientists at Kanazawa University developed a new method to study the neutralization of excess charges during mass spectrometry, which can lead to more accurate results. The team used a combination of continuum and molecular dynamics simulations to model the effect of adding molecules of the opposite charge to neutralize excess charge.
Researchers at the Beckman Institute created a subspace mass spectrometry imaging approach to accelerate data acquisition without sacrificing quality. This technique can detect biomolecules across a wide range of sizes and has implications for analytical chemistry, clinical studies, and neurochemical research.
A new machine learning model has been developed to help characterize compounds in the development of new drugs. The model uses tandem mass spectrometry and is based on a small amount of positive and negative training data, making it useful for automating characterization of compounds by chemists.
The October edition of SLAS Discovery features a critical review of mass spectrometry applied to imaging in drug discovery, highlighting its potential for pharmacokinetic and pharmacodynamic measurements. The issue also includes original research articles on various topics in life sciences discovery and technology.
A team of scientists has identified a collective signature of proteins and metabolites that can predict who is at highest risk of dying from the infection. The biomarkers, including lower levels of glycosylated fetuin A and higher levels of serum protein carbamylation, were associated with death due to Staphylococcus aureus bacteremia.
Researchers have developed a method to use face masks to collect compounds in exhaled breath aerosols for analysis, enabling large-scale screening for disease biomarkers. The new technique uses a fiber inserted into an N95 face mask to concentrate molecules, allowing for more efficient identification through mass spectrometry.
Researchers at Martin Luther University Halle-Wittenberg have developed a novel mass spectrometry-based test that can detect small amounts of SARS-CoV-2 in highly diluted gargle samples. The test is highly specific for the virus and can be used in early stages of the disease when many viruses are present.
Researchers used imaging mass spectrometry and immunohistochemistry to identify novel lipid and protein tumor markers for head and neck squamous cell carcinoma. These markers, including S100A8 and S100A9, show promise as potential diagnostic tools and may provide insights into the pathophysiology of HNSCC.
The study reveals that medieval glass production in Spain predates Islamic influence by more than 50 years. Glass fragments from the Rabad of Šaqunda date back to the 8th century and show evidence of local lead production using nearby ore deposits.
Researchers at NJIT have developed a new coulometric mass spectrometric approach to quantify proteins, which could aid in discovering new therapeutic antibodies or biomarkers. The method is faster and more efficient than current methods, requiring less time-consuming preparation of synthesized standard material.
This article reviews the state-of-the-art analytical strategies for studying protein arginine methylation using mass spectrometry. The authors discuss the latest studies on profiling protein-methylation events, implementing biochemical methods, computational analysis tools, and the heavy methyl SILAC strategy.
Researchers at the University of Illinois have developed a high-throughput screening tool to rapidly profile medium-chain fatty acids produced in yeast. They identified seven new genetically engineered mutants that produce higher levels of those fatty acids, which are crucial components of biodiesel and other industrial chemicals.
A groundbreaking tool, LipidCreator, has been developed to efficiently analyze specific lipid groups and signal molecules, accelerating the discovery of biomarkers for diseases. This software enables scientists to quantify 60 lipid classes and their signaling molecules in larger studies than previously possible.
Scientists developed a new method to simplify the search for traces of medicines and sports doping drugs in human biological samples. By analyzing the chemical composition of a substance with reduced search space, the method helps detect illicit substances more efficiently.
A new technology developed at Northwestern University offers precise measurements of proteins down to their atoms, enabling better understanding of disease and the design of vaccines. This approach, called individual ion mass spectrometry, can determine the exact mass of a huge range of intact proteins.
The DIASyM research cluster will use state-of-the-art mass spectrometry to analyze blood parameters of patients with heart failure and compare them to healthy individuals. This will help identify biomarkers and understand the interactions between biological processes, leading to new approaches for diagnosis, therapy, and prevention.
Chemists at Iowa State University have developed a technique to analyze the degradation of unsaturated fatty oils in fingerprints, potentially allowing them to be used as a tool to determine their age. The method uses mass spectrometry imaging and has shown promising results, with individual differences in fingerprint aging detected.
SPion technology enables scientists to conduct accurate molecular profiling of living tissue without disruption, addressing limitations of traditional ex vivo techniques. This breakthrough innovation is expected to revolutionize health and biological sciences, including cancer surgery, by providing real-time tissue biopsy results.
The MSTARS consortium aims to further develop mass spectrometry technology for clinical application and detection of treatment resistance in various diseases. By combining expertise in mass spectrometry, patient care, and data analysis, the team hopes to improve precision medicine and tailor treatments to individual patients.
Researchers have developed a technique to create high-resolution images of biological samples, revealing new molecules and their spatial distribution. The technique uses a powerful mass spectrometer to produce detailed visuals of the molecular makeup of animal tissue.
Researchers are designing a toilet that can analyze urine for biomarkers of various human conditions, such as cancer and diabetes. The technology has the potential to provide early warning systems for viral or bacterial outbreaks and track medication effectiveness in older adults.
A team of WVU chemists has created a new molecular research tool that simplifies experiments in mass spectrometry, enabling non-invasive analysis of biological systems. The instrument, developed by Assistant Professor Peng Li, uses a vibrating sharp-edge spray ionization device to collect and ionize samples on the spot.
Researchers at the University of Münster have developed a new technique that combines two methods to improve the spatial resolution of mass spectrometry imaging. This allows for better understanding of disease processes and potential new strategies for treating them. The technology uses dual-beam laser mass spectrometry, enabling the s...
Scientists from Skoltech identified substances with antiviral activity in humic substances extracted from brown coal, highlighting the potential of natural compounds for creating new drugs. The study's results show that flavonoids and polyphenols may be responsible for virucidal activity.
Tohoku University researchers have developed a technique that improves on current photoluminescence spectroscopy techniques, allowing for the measurement of larger semiconducting crystals. The new approach uses a hollow sphere to minimize photon loss and test internal quantum efficiency, a key property of semiconductors.
Researchers developed a novel laser-based measurement device to quantify rare CO2 variants, enabling accurate tracking of Earth's temperature. This breakthrough technology surpasses mass spectrometry in precision and can significantly shorten measurement times.
Researchers have uncovered details of microalgae's light-harvesting system, which is up to 95% efficient, using advanced mass spectrometry techniques. This breakthrough could lead to the development of more efficient organic solar panels, increasing energy efficiency and reducing environmental impact.
Scientists have developed a novel strategy to extract and analyze membrane proteins, which are critical targets for therapy. Azo, a photocleavable surfactant, enables effective mass spectrometry analysis of whole proteins, opening up new opportunities to study membrane proteins.
Researchers developed a computational mass-spectrometry system that identified thousands of plant metabolites, including previously unknown compounds with medicinal properties. The new method provides 10 times the coverage of previous methods and has applications in drug discovery and understanding plant physiology.
Catherine Costello has made a lasting impact in proteomics with her groundbreaking research on biologically important polymers and their structures. She is the author of over 375 scientific papers and has received numerous awards for her contributions to mass spectrometry.
Researchers at University of Groningen developed nanopores that can measure peptide mass, offering a cheap and portable solution for proteomics research. The smallest pores produced have a resolution of around 40 Dalton, allowing for the identification of peptides with varying chemical compositions.
Researchers at Xiamen University have created a device that enables the direct detection and mapping of chemicals inside biological cells. This breakthrough technique, called near-field desorption postionization time-of-flight mass spectrometer (NDPI-TOFMS), overcomes challenges in high-resolution imaging and provides undistorted chemi...
Scientists developed an electron microscopy technique to directly identify isotopes in amino acids at the nanoscale without damaging the samples. This allows for real-space observation of dynamic chemistry and creates a foundation for scientific discoveries.
Researchers from Skoltech and MIPT analyzed the protein and lipid composition of a Siberian mammoth bone, identifying 98 proteins and 73 lipids. The study provides insights into the mammoth's diet, health, and nervous system development, complementing paleogenomics and paleoproteomics.