Articles tagged with Mass Spectrometry
Researchers have created a new technique to rapidly assess paracetamol levels from saliva using Mass Spectrometry technology. The Paper-Arrow Mass Spectrometry (PA-MS) test is non-invasive, fast, and cost-effective, with the potential to improve patient care and outcomes.
Archaeologists have discovered that early North Americans made needles from the bones of fur-bearers, including foxes, hares, and cats, which were likely used to create garments for warmth. The findings provide strong evidence for tailored garment production using bone needles and fur-bearing animal pelts.
A WVU research partnership with the DEA aims to improve fast and accurate identification of psychoactive substances like fentanyl. The Expert Algorithm for Substance Identification (EASI) will enable labs using different instruments to share data on chemical profiles, helping to identify drugs like fentanyl.
The study reveals large genomic differences between European aurochs, North Asian aurochs, and South Asian ancestor, with evidence of human intentional feeding and targeted domestication. The genome of the central European aurochs was fully decoded for the first time, providing insights into the history of wild cattle in Europe and Asia.
A new method allows direct access to specific bits in synthetic polymer data storage, enabling random access. The researchers encoded a sequence of ones and zeroes into a polymer chain, demonstrating the feasibility of storing and retrieving large amounts of data efficiently.
Researchers at Caltech have developed a new technique called 'fingerprint nanoelectromechanical mass spectrometry' that allows for the accurate measurement of individual protein masses. This breakthrough could pave the way to determining the complete proteome, providing insights into an organism's health and potential disease treatments.
Researchers have introduced Tune-IMS, a technique that improves the precision of isochronous mass spectrometry for measuring short-lived atomic nuclei. The method has been successfully tested on several nuclides and has shown higher precision than previous IMS methods.
Researchers at ETH Zurich have developed a method to study protein interactions using LiP mass spectrometry, identifying thousands of interaction interfaces between proteins. They found that stress situations alter around five dozen protein complexes and their interactions, with a key player being the SAGA complex.
The new funding supports the first-of-its-kind single-cell mass spectrometer in Maine and one of the first in the country. Researchers can now analyze proteins and metabolites from individual cells, providing unprecedented detail into disease mechanisms.
A new study in ACS Pharmacology & Translational Science investigates the molecular mechanisms behind Efavirenz's negative effects on brain function. The research reveals that the drug alters lipid metabolism and downregulates certain enzymes, which could lead to the development of new drugs to block its negative activity.
A new mass spectrometry technique from Brown University dramatically reduces sample loss, paving the way for more accurate and efficient protein analysis. The nanopore ion source transfers ions directly into the vacuum of a mass spectrometer, eliminating the need for drying and vacuum processes.
Researchers developed an algorithm to analyze peptides in infected wounds, revealing unique biomarkers that enable earlier and more accurate diagnoses. This breakthrough method uses mass spectrometry and machine learning to diagnose infections in just a few minutes.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
Researchers at TUM have mapped the interactions of 144 active substances with around 8,000 proteins using a new method called decryptE. This study could help identify previously unknown potential benefits of existing drugs and improve treatment outcomes for patients.
Researchers design Na0.6[Ni0.3Ru0.3Mn0.4]O2 and vacancy-introduced Na0.7[Ni0.2V0.1Ru0.3Mn0.4]O2 compounds to enhance sodium-ion battery performance. The V-NRM compound exhibits improved capacity and rate performance, with an additional short voltage plateau at 3.9V during charging.
A novel tool called BitterMasS harnesses mass spectrometry to predict bitterness without prior knowledge of chemical structures. The tool achieved remarkable precision and recall rates in internal and external tests, streamlining compound screening processes.
Han Xiao aims to develop cells that can biosynthesize and utilize non-canonical amino acids as in vivo sensors for enzymes involved in posttranslational modifications. This research could lead to new strategies in treating diseases by providing real-time insights into enzyme activities.
Researchers identify key proteins and signaling pathways for personalized treatment, enabling early detection of aggressive tumors. The study provides a crucial resource for developing new therapies and tests to guide treatment.
Scientists have developed a new method to detect antibiotics in finger sweat, showing high accuracy for tuberculosis treatment monitoring. The technique allows for less invasive testing, making it easier to monitor treatment and preventing drug-resistant TB.
Researchers used novel biomolecular methods to analyze fossil bone fragments at the Smithsonian Museum, revealing excellent preservation of collagen proteins that can provide a molecular barcode for identification. The study provides new insights into the mysterious disappearance of North America's large mammals 50,000 years ago.
A new surgical platform using mass spectrometry identifies key gene mutations in brain cancer, including IDH mutations, during surgery. This allows for rapid diagnosis, prognosis, and tumor resection to improve patient outcomes.
Researchers at China Institute of Atomic Energy have developed a more sensitive method to detect iron-60 in lunar samples, allowing for deeper understanding of cosmic events. The new technique has improved detection sensitivity better than 4.3 × 10−14 and potentially reaching 2.5 × 10−15.
Researchers at Utrecht University found an extremely broad variety of autoantibodies in RA patients, contradicting previous assumptions about the disease. The study suggests that targeting the malfunctioning filtering mechanism may be a better approach to treat RA.
A new study published in Clinical Chemistry and Laboratory Medicine reveals that smartphone swabs can successfully detect drugs on phone surfaces. The method, which uses dry swabs, identified MDMA, cocaine, and THC as the most common substances, with other drugs including ketamine, LSD, and heroin also detected.
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
Researchers at the University of Texas at Arlington have developed a method to determine the clinical potency of psilocybin and psilocin in Psilocybe cubensis mushrooms. This technique uses liquid chromatography with tandem mass spectrometry, allowing for accurate extraction and measurement of the strength of the mushrooms.
Researchers used mass spectrometry imaging and single-cell metabolomics with deep learning to create 3D molecular maps of the brain, enabling a better understanding of chemical interactions within brain tissue. This breakthrough could help address currently intractable neurological diseases.
Scientists created an AF4-ICP-MS system to analyze cytotoxicity of silica nanoparticles in human hepatoma cells, revealing smaller particles exhibited higher toxicity. The study provides insights into nanoparticle exposure risks and potential health damage.
A new research effort, led by University of Oklahoma's Zhibo Yang and San Diego State University's Laura-Isobel McCall, aims to investigate the role of bystander cells in infectious diseases. By examining metabolism changes in non-infected cells near infected cells, researchers hope to gain insights into possible disease progression.
MIT researchers successfully produced a miniaturized quadrupole filter using additive manufacturing, achieving precision comparable to commercial-grade filters at a fraction of the cost and weight. This breakthrough enables the development of portable mass spectrometers for rapid chemical analysis in remote settings.
Researchers at the University of Gothenburg have developed a way to distinguish different types of structural changes in glycan molecules linked to various cancers. The AI-enhanced method uses mass spectrometry to identify patterns in data sets, providing a precise answer to what will change for a specific disease.
A new algorithm, SIMSEF, significantly speeds up and simplifies the identification of chemicals in tissues, enabling researchers to confidently recognize and visualize their distribution in organs. This development has great implications for medical diagnosis and treatment outcomes.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
Researchers developed a more efficient way to find emerging designer drugs in urine samples, uncovering new synthetic opioids, benzodiazepines, and stimulants that evaded initial screening. The approach can support public health and safety by enabling swift identification of new substances.
The study found that Ryugu and CIs share a common genetic heritage, but the asteroid's Cr isotopes exhibit anomalies that could be caused by water-driven processes. These anomalies are thought to have arisen from the physicochemical fractionation of presolar nanoparticles and secondary minerals.
Scientists analyzed body fluids from firefighters after rigorous training to understand the effects of intense physical exercise on the body. They found a decrease in inflammatory signals, which can improve breathing, but also increase vulnerability to viral respiratory infections.
Using 'aggressive' fragments of molecular ions, researchers created a new compound by incorporating unreactive nitrogen into a substance. This method could open up new possibilities for applications such as microchip production and solar cells.
Researchers from Helmholtz-Zentrum Dresden-Rossendorf are studying near-Earth cosmic explosions to understand their potential impact on the Earth's biosphere. They found that ejected debris can reach our solar system, with some isotopes, such as iron-60 and plutonium-244, potentially coming from supernovae or other galactic events.
Researchers have pinpointed the emergence of muddy flavors in farmed fish by measuring the concentration of geosmin and other compounds. The study highlights the importance of water quality management to prevent the production of off-flavor compounds, which can impact aquaculture industry revenue and sustainability.
A new study reveals the critical importance of post-transcriptional processes in regulating circadian rhythms and their impact on sleep. Researchers identified a structure in the circadian mRNA Period2 that alters the amplitude of circadian rhythms and disrupts sleep patterns, particularly during transitions between light and dark.
University of Liverpool researchers develop a new material that captures coronavirus particles with minimal impact on breathability, increasing efficiency by approximately 93%. The new material has the potential to be used in various applications, including face masks and air filters.
Scientists have discovered a simple test for signs of past or present life on other planets, using artificial intelligence to distinguish between biological and abiotic samples with high accuracy. The method has the potential to revolutionize the search for extraterrestrial life and deepen our understanding of Earth's earliest life.
A Japanese research team used advanced analytical techniques to study the electrochemical phenomena in aqueous potassium-ion batteries. They found that solid-electrolyte interphases form a passivating layer, suppressing hydrogen evolution and improving stability.
A new study found that whole milk plain yogurt prevented almost all of the volatile compounds responsible for garlic's pungent scent. The researchers suggest high-protein foods may one day be formulated specifically to fight garlic breath. Yogurt's proteins were effective at trapping garlic odors, making it a potential solution.
Researchers developed methods to predict CCS values using machine learning and computer models, offering a faster alternative to experimental determination. The study's findings provide a foundation for measurements using portable ion mobility spectrometers in the future.
The MasSpec Pen, a handheld probe technology, discriminates between thyroid, parathyroid, and lymph node tissues using metabolite analysis. It achieves over 90% accuracy in real-time tissue identification, reducing surgical time and complications.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed a new method for detecting SARS-CoV-2 using MALDI-TOF mass spectrometry, which takes just two hours from swab to result. The approach can also detect other pathogens and is more flexible than existing PCR tests.
A team of researchers has determined that microplastic particles are present in the marine atmosphere, even in remote parts of the world. The study found that different types of plastics, including polyester and polyethylene terephthalate, were detected in air samples collected from various sites along the Norwegian coast.
Scientists created a unique data process that provides valuable insights into how drugs are processed in the body and their impact on biochemical responses. The approach reveals detailed maps of drug transformation and allows for simultaneous discovery of fate and effects.
Researchers analyze ancient documents to shed light on the health of Vlad III, the legendary inspiration behind Count Dracula. The study reveals potential signs of respiratory problems and a condition that could have caused him to cry blood.
Research reveals Kama'ehu volcano in Hawaii has erupted five times in the past 150 years. The new study uses mass spectrometry to measure radium-226 in lava samples, revealing a frequency of eruptions around 30 years. This slower rate is linked to sluggish mantle upwelling on the margin of the Hawaiian plume.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
A team of researchers led by Laura-Isobel McCall and Zhibo Yang is using single-cell mass spectrometry to investigate the role of intracellular drug concentration in antimicrobial treatment failure.
Researchers from Osaka University identified ten blood proteins associated with mortality in severe burns, including HBA1, TTR, and SERPINF2. These proteins may serve as targets for developing new treatment methods for burns, offering a promising direction for future research.
Prof. Chilai Chen's team successfully tested the first deep-sea mass spectrometer of China in the deep sea. This technology enables real-time detection of dissolved gases, shedding light on marine biogeochemical cycles, biodiversity, and global climate change.
A new study using mass spectrometry analyzed hand scent compounds from 60 individuals and achieved a 96.67% accuracy rate in predicting sex. The analysis can be used to uncover details about a potential perpetrator, such as age and racial or ethnic group, when other evidence is lacking.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Scientists at PNNL are developing a new way to identify unknown chemical compounds using high-resolution instruments, gaining important information faster and more accurately. The technique applies to ions, making them easier to control and detect using mass spectrometry.
Researchers developed a mass spectrometry method to analyze molecular glues and assess their relative strengths. The technique enables the elucidation of mechanisms through which these molecules stabilize protein interactions.
Researchers developed an AI-powered mass spectrometric technique to determine a polymer's monomeric sequence. This breakthrough may lead to improved materials performance and tackle plastic recycling issues.