Articles tagged with Mass Spectrometry
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Utrecht University found an extremely broad variety of autoantibodies in RA patients, contradicting previous assumptions about the disease. The study suggests that targeting the malfunctioning filtering mechanism may be a better approach to treat RA.
A new study published in Clinical Chemistry and Laboratory Medicine reveals that smartphone swabs can successfully detect drugs on phone surfaces. The method, which uses dry swabs, identified MDMA, cocaine, and THC as the most common substances, with other drugs including ketamine, LSD, and heroin also detected.
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
Researchers at the University of Texas at Arlington have developed a method to determine the clinical potency of psilocybin and psilocin in Psilocybe cubensis mushrooms. This technique uses liquid chromatography with tandem mass spectrometry, allowing for accurate extraction and measurement of the strength of the mushrooms.
Researchers used mass spectrometry imaging and single-cell metabolomics with deep learning to create 3D molecular maps of the brain, enabling a better understanding of chemical interactions within brain tissue. This breakthrough could help address currently intractable neurological diseases.
Scientists created an AF4-ICP-MS system to analyze cytotoxicity of silica nanoparticles in human hepatoma cells, revealing smaller particles exhibited higher toxicity. The study provides insights into nanoparticle exposure risks and potential health damage.
A new research effort, led by University of Oklahoma's Zhibo Yang and San Diego State University's Laura-Isobel McCall, aims to investigate the role of bystander cells in infectious diseases. By examining metabolism changes in non-infected cells near infected cells, researchers hope to gain insights into possible disease progression.
MIT researchers successfully produced a miniaturized quadrupole filter using additive manufacturing, achieving precision comparable to commercial-grade filters at a fraction of the cost and weight. This breakthrough enables the development of portable mass spectrometers for rapid chemical analysis in remote settings.
A new algorithm, SIMSEF, significantly speeds up and simplifies the identification of chemicals in tissues, enabling researchers to confidently recognize and visualize their distribution in organs. This development has great implications for medical diagnosis and treatment outcomes.
Researchers at the University of Gothenburg have developed a way to distinguish different types of structural changes in glycan molecules linked to various cancers. The AI-enhanced method uses mass spectrometry to identify patterns in data sets, providing a precise answer to what will change for a specific disease.
Scientists developed a high-throughput method to study oxidized lipids in ALS. Analysis of blood plasma from rats with ALS revealed 17 oxylipin alterations associated with oxidative stress and inflammation. Oxylipins may serve as biomarkers for monitoring disease progression.
Researchers developed a more efficient way to find emerging designer drugs in urine samples, uncovering new synthetic opioids, benzodiazepines, and stimulants that evaded initial screening. The approach can support public health and safety by enabling swift identification of new substances.
The study found that Ryugu and CIs share a common genetic heritage, but the asteroid's Cr isotopes exhibit anomalies that could be caused by water-driven processes. These anomalies are thought to have arisen from the physicochemical fractionation of presolar nanoparticles and secondary minerals.
Scientists analyzed body fluids from firefighters after rigorous training to understand the effects of intense physical exercise on the body. They found a decrease in inflammatory signals, which can improve breathing, but also increase vulnerability to viral respiratory infections.
Using 'aggressive' fragments of molecular ions, researchers created a new compound by incorporating unreactive nitrogen into a substance. This method could open up new possibilities for applications such as microchip production and solar cells.
Researchers from Helmholtz-Zentrum Dresden-Rossendorf are studying near-Earth cosmic explosions to understand their potential impact on the Earth's biosphere. They found that ejected debris can reach our solar system, with some isotopes, such as iron-60 and plutonium-244, potentially coming from supernovae or other galactic events.
Researchers have pinpointed the emergence of muddy flavors in farmed fish by measuring the concentration of geosmin and other compounds. The study highlights the importance of water quality management to prevent the production of off-flavor compounds, which can impact aquaculture industry revenue and sustainability.
A new study reveals the critical importance of post-transcriptional processes in regulating circadian rhythms and their impact on sleep. Researchers identified a structure in the circadian mRNA Period2 that alters the amplitude of circadian rhythms and disrupts sleep patterns, particularly during transitions between light and dark.
University of Liverpool researchers develop a new material that captures coronavirus particles with minimal impact on breathability, increasing efficiency by approximately 93%. The new material has the potential to be used in various applications, including face masks and air filters.
Scientists have discovered a simple test for signs of past or present life on other planets, using artificial intelligence to distinguish between biological and abiotic samples with high accuracy. The method has the potential to revolutionize the search for extraterrestrial life and deepen our understanding of Earth's earliest life.
A Japanese research team used advanced analytical techniques to study the electrochemical phenomena in aqueous potassium-ion batteries. They found that solid-electrolyte interphases form a passivating layer, suppressing hydrogen evolution and improving stability.
A new study found that whole milk plain yogurt prevented almost all of the volatile compounds responsible for garlic's pungent scent. The researchers suggest high-protein foods may one day be formulated specifically to fight garlic breath. Yogurt's proteins were effective at trapping garlic odors, making it a potential solution.
Researchers developed methods to predict CCS values using machine learning and computer models, offering a faster alternative to experimental determination. The study's findings provide a foundation for measurements using portable ion mobility spectrometers in the future.
The MasSpec Pen, a handheld probe technology, discriminates between thyroid, parathyroid, and lymph node tissues using metabolite analysis. It achieves over 90% accuracy in real-time tissue identification, reducing surgical time and complications.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed a new method for detecting SARS-CoV-2 using MALDI-TOF mass spectrometry, which takes just two hours from swab to result. The approach can also detect other pathogens and is more flexible than existing PCR tests.
A team of researchers has determined that microplastic particles are present in the marine atmosphere, even in remote parts of the world. The study found that different types of plastics, including polyester and polyethylene terephthalate, were detected in air samples collected from various sites along the Norwegian coast.
Scientists created a unique data process that provides valuable insights into how drugs are processed in the body and their impact on biochemical responses. The approach reveals detailed maps of drug transformation and allows for simultaneous discovery of fate and effects.
Researchers analyze ancient documents to shed light on the health of Vlad III, the legendary inspiration behind Count Dracula. The study reveals potential signs of respiratory problems and a condition that could have caused him to cry blood.
Research reveals Kama'ehu volcano in Hawaii has erupted five times in the past 150 years. The new study uses mass spectrometry to measure radium-226 in lava samples, revealing a frequency of eruptions around 30 years. This slower rate is linked to sluggish mantle upwelling on the margin of the Hawaiian plume.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
A team of researchers led by Laura-Isobel McCall and Zhibo Yang is using single-cell mass spectrometry to investigate the role of intracellular drug concentration in antimicrobial treatment failure.
Researchers from Osaka University identified ten blood proteins associated with mortality in severe burns, including HBA1, TTR, and SERPINF2. These proteins may serve as targets for developing new treatment methods for burns, offering a promising direction for future research.
Prof. Chilai Chen's team successfully tested the first deep-sea mass spectrometer of China in the deep sea. This technology enables real-time detection of dissolved gases, shedding light on marine biogeochemical cycles, biodiversity, and global climate change.
A new study using mass spectrometry analyzed hand scent compounds from 60 individuals and achieved a 96.67% accuracy rate in predicting sex. The analysis can be used to uncover details about a potential perpetrator, such as age and racial or ethnic group, when other evidence is lacking.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
Scientists at PNNL are developing a new way to identify unknown chemical compounds using high-resolution instruments, gaining important information faster and more accurately. The technique applies to ions, making them easier to control and detect using mass spectrometry.
Researchers developed a mass spectrometry method to analyze molecular glues and assess their relative strengths. The technique enables the elucidation of mechanisms through which these molecules stabilize protein interactions.
Researchers developed an AI-powered mass spectrometric technique to determine a polymer's monomeric sequence. This breakthrough may lead to improved materials performance and tackle plastic recycling issues.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Researchers develop a technique to visualize carnitine distribution in muscle fiber cells, finding higher concentrations in slow-type fibers. The study reveals rapid transport of carnitine into muscle cells during contraction, shedding light on metabolic processes and potential therapeutic applications.
A new method has been developed to detect hydrogen cyanide (HCN) in exhaled breath, which is associated with Pseudomonas aeruginosa infection in cystic fibrosis patients. The flow-assisted photoionization mass spectrometry method enables real-time tracking of HCN concentrations, allowing for early screening and diagnosis.
A team of researchers conducted the largest proteomic study on yeast cells to gain a detailed picture of previously unknown gene functions. The study revealed general principles governing protein expression and identified thousands of proteins with their biophysical properties.
MIT researchers developed a miniature vacuum pump for portable mass spectrometers, overcoming design limitations of traditional pumps. The 3D-printed pump can create and maintain lower pressure vacuums, increasing the device's lifetime and enabling its use in remote locations and space exploration.
Conclusive evidence of chicken breeding in the Yayoi period of Japan has been discovered at the Karako-Kagi site. The study found that chickens were bred in the area during the middle Yayoi period, around 381-204 BCE, providing clear evidence that breeding occurred on the Japanese archipelago.
Researchers at Stanford University have developed a new tool to estimate long-term coastal cliff loss, finding that rates are similar to those over the past 2,000 years. The study's approach provides a relative assessment of driving factors behind cliff retreat over longer periods, with implications for managing coastal erosion.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Researchers from PSI deciphered the structure of an ion channel found in the eye while interacting with calmodulin, a protein that enables cell response to calcium fluctuations. This interaction is believed to be responsible for achieving remarkable sensitivity to dim light.
Researchers at Zurich University of Applied Sciences identified six compounds contributing to fermented coffee's unique flavor, including 2-methylpropanal, 3-methylbutanal, and ethyl 3-methylbutanoate. The study aims to standardize production methods and increase availability of this distinctive beverage.
Researchers have identified tens of thousands of molecular 'puzzle pieces' in two meteorites, including a larger amount of oxygen atoms than expected. This analysis provides a unique window into the origin of life itself and sheds light on the formation of the universe.
Researchers at Max Planck Institute developed an ammonia-based direct reduction process to produce sustainable iron and steel, overcoming logistics and energetic disadvantages of hydrogen. The process yields the same metallization degree as hydrogen-based reduction while forming nitrides that protect the sponge iron from corrosion.
A new study has created a comprehensive map of the human proteome, identifying over 1 million peptides from 17,717 different protein groups. The researchers also found that most alternative splicing detected at the RNA stage is also present in the proteins, validating long-held ideas about this process.
Researchers analysed wastewater from 10 cities to detect chemical and biological markers of health, including pesticides, pharmaceuticals and disease-causing viruses. The study found that analysing wastewater on a large scale could spot new outbreaks of diseases in communities early on.
Scientists have detected uracil and nicotinic acid in asteroid Ryugu samples collected by the Hayabusa2 spacecraft. The discovery suggests that important building blocks for life were created in space and delivered to Earth via meteorites, supporting current theories on the source of nucleobases.
Researchers have pushed single-atom vibrational spectroscopy to the level of chemical bonds, enabling precise measurements of point defects in graphene. The study found unique vibrational modes for two types of silicon point defects, with stronger signals for one defect configuration.
Researchers at the University of California - Riverside have discovered a way to deactivate mosquito sperm, preventing them from swimming to or fertilizing eggs. This breakthrough could help control populations of Culex mosquitoes that transmit infectious diseases like encephalitis and West Nile Virus.
A new study led by University of Maryland researchers found that melted meteorites have extremely low water content, ruling them out as the primary source of Earth's water. The team suggests that unmelted, or chondritic, meteorites may be responsible for delivering water to our planet.
A new generation of software, MZmine 3, enables scientists to analyze large volumes of data from mass spectrometry, tracing hundreds of thousands of chemical compounds. This breakthrough accelerates data processing and opens up opportunities for researchers to investigate disease causes and mechanisms.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
A University of Massachusetts Amherst epidemiologist is leading a team to better understand the effects of chronic stress on future health risks. They will examine metabolites in blood samples from a large, racially diverse population to identify potential biomarkers for heart disease, diabetes and cognitive decline.
Researchers at Osaka University found that male patients with COVID-19 have a faster loss of circulating Treg cells, leading to dysregulated antibody responses. Females, on the other hand, have higher levels of these cells, which may help protect them from infection.