Articles tagged with Open Access
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Common genetic variations in nicotine receptors significantly increase the chance of life-long nicotine addiction among European American youth smokers. A study of 2,827 long-term smokers found that those who began smoking before age 17 with a high-risk haplotype had a 1.6- to 5-fold increased risk of heavy nicotine dependence.
The study reveals stark differences in antibiotic resistance between European countries, with major antibiotics being less effective in certain nations. Resistance to oxacillin and cephalosporins is of particular concern, suggesting the presence of MRSA in some countries.
Researchers from Harvard Medical School and Brandeis University used a full-genome RNAi screen to identify genes essential for brain development in neurons. The study revealed unexpected roles for genes involved in signaling, protein trafficking, and cytoskeletal proteins.
Researchers analyzed fecal samples from 25 chimpanzee communities and found a range of SFV infection rates from 44% to 100%. The study highlights the importance of understanding cross-species infections in primates and their potential impact on human health.
A recent study published in PLOS ONE found that a significant proportion of Chinese consumers admit to purchasing tiger products, despite widespread support for the country's ban on selling these products. The researchers also discovered that 71% of respondents preferred products made from wild tigers over those from farmed tigers.
Researchers found that administering a simple polymer, Polyethylene glycol, within four hours of a head injury can limit damage and improve behavioral tests in rats. The treatment is potentially feasible for victims of traumatic brain injury, especially when delivered at the scene of an accident.
A study published in Acta Veterinaria Scandinavica found that pigs fed three times a day gained more weight than those fed nine times, despite the natural feeding behavior of self-feeding and random spacing. The researchers suggest increased competition within groups may be a reason for the better outcome.
Research published in BMC Public Health found that schools with positive social environments and high-quality teacher relationships can significantly reduce student smoking. The study of over 5,000 Scottish students revealed that pupils from these schools were less likely to smoke.
A study published in BioMed Central's Journal of Inflammation found that pomegranate extract reduced the production of chemicals causing inflammation in rabbits. The findings suggest that pomegranate extract may provide relief from chronic inflammatory conditions in humans.
A recent study published in Globalization and Health reveals that fluoride toothpaste is prohibitively expensive for the world's poorest populations. The researchers found that as per capita income decreased, the proportion of income needed to purchase a year's supply of toothpaste increased, with the poorest being hardest hit.
Research in BMC Pharmacology disproves the false claims surrounding benfotiamine, a synthetic derivative of thiamine, and its supposed benefits. The study reveals that benfotiamine is not more physiologically active or easily absorbed by the body than other precursors.
Research published in BMC Public Health found that living near green spaces does not encourage people to engage in physical activities like walking or cycling. In fact, those with more green space nearby tend to walk and cycle less frequently due to convenience factors.
A new study published in PLoS Biology uses magnetoencephalography to record brain activity as humans detect target tones in a complex auditory scene. The researchers find that the awareness of these sounds correlates with activity in high-level auditory regions, not the initial cortical region where sound is processed. This novel study...
Researchers have discovered a family of transporters called NIPs that can move arsenite across plant cell membranes, reducing toxic arsenic content. The findings suggest that some NIPs can even clear cells of toxic arsenite, potentially enabling plant detoxification.
A study of Kenyan nomads found that an ADHD-associated gene variant is linked to better health in the nomadic population, but malnourishment in settled individuals. This suggests that behavior differences associated with ADHD may be more or less effective depending on the environment.
Research shows that ewes fed a diet enriched with polyunsaturated fats have a significantly higher chance of giving birth to male offspring. This finding suggests that dietary composition around conception can influence sex ratio in farm species.
A new study has provided genetic clues for dealing with soil pollution by using a systems toxicology approach to understand the impact of four soil contaminants on earthworm gene expression patterns. The research reveals subtle changes induced by toxic chemicals in earthworms, offering insights into monitoring and remediation of toxins.
A study published in Environmental Health found that drinking tap water disinfected by chlorine while pregnant may increase the risk of certain birth defects. Exposure to high levels of chlorination by-products was associated with a significant increased risk of ventricular septal defects, cleft palate, and anencephalus.
Researchers can now contribute to large-scale community protein annotation, enhancing comprehensive coverage of biomedical knowledge. WikiProteins combines existing authoritative databases with mined scientific papers, creating over one million concept clouds called 'Knowlets', which can be annotated by experts.
Researchers developed a novel, computer-based approach to study lipoprotein profiles and identify patients at risk for cardiovascular disease. By simulating every single lipoprotein in blood plasma, the model revealed possibly clinically-relevant abnormalities that would remain undetected by evaluating only LDL and HDL.
Researchers report transformation of y-larvae into a previously unseen parasitic form, challenging current understanding of crustacean taxonomy. The discovery highlights the potential ecological importance of adults in this enigmatic group.
US researchers have created living computers by genetically altering bacteria, solving the burnt pancake problem in a matter of flips. The breakthrough showcases computing in living cells, offering potential advantages over conventional computers, including parallel processing and self-repair mechanisms.
A new study found that only 113 articles about neglected tropical diseases were published in leading international media from 2003 to 2007. This lack of coverage is particularly concerning given the significant burden of NTDs on public health, including widespread illness, poverty, and suffering.
Researchers at the University of Akron discovered that temperature and humidity significantly impact a gecko's ability to stick to glass. The study revealed that under humid conditions, geckos can cling with twice the force as in dry conditions. Conversely, high temperatures reduce their adhesion, making humidity level less crucial.
The EPA dismissed Deborah Rice, a highly respected toxicologist, after the chemical industry complained about her views on deca's health hazards. Herbert Needleman argues that this trend is not new and unique, citing his own dismissal for speaking out on lead poisoning.
A study found that young Australian women would accept age-based chlamydia screening, but prefer it be offered universally, rather than based on their sexual history. The researchers suggest that detailed sexual history should not be required before testing women for chlamydia to improve screening rates and reduce stigma.
Malagasy mouse lemurs use advertising calls to attract mates of their own species, ignoring those of similar but different species. This unique communication method helps prevent hybridization and ensures genetic purity.
Researchers identified BILBO1 as crucial for Flagellar Pocket formation in trypanosomes. The protein is essential for the structure's functions, including endo- and exocytosis. Inhibition of BILBO1 function is fatal to the parasite.
Conservation efforts in Madagascar could avert catastrophic biodiversity loss with pro-active programs. The country harbors
A recent study found that coronary heart disease mortality rates among younger women under 50 are increasing despite overall declines since the 20th century. Factors such as high levels of smoking, obesity, and a lack of exercise may be contributing to this trend.
A new study found that young and homeless drug-users are more likely to exit treatment early, with nearly a quarter exiting within 30 days. Problem users who are younger, homeless, or not currently injecting face significant barriers in traditional drug services.
Research highlights a key role for general practitioners in providing long-term, individually formulated support schemes for families of suicide victims. The study found that post-suicidal reactions and impacts on daily living are still profoundly affecting families after the event.
A newly discovered arenavirus, Chapare virus, has been identified in a fatal hemorrhagic fever case in rural Bolivia. The virus produces clinical hemorrhagic symptoms similar to those associated with other New World arenaviruses, but genetically it is distinct from Junin, Machupo, Guanarito, and Sabia viruses.
A year-long pilot project trained barbers as peer educators to reach low-literacy rural communities in India, distributing educational materials and condoms. The program showed positive effects, including increased social recognition for women peer educators and a rise in customers among barber clients.
A new study published in PLoS Biology shows that gene-environment interactions play a crucial role in determining thousands of traits in yeast, with the environment having a bigger effect on regulated genes than direct mechanisms. The research reveals intriguing interactions between genetic and environmental factors.
Researchers found that large-scale plantations in tropical regions could sequester significant amounts of carbon, potentially offsetting up to 5-7% of global CO2 emissions. However, the effectiveness of these plantations is limited by social, economic, and institutional barriers, as well as uncertainties in land use.
New research reveals that nicotine reduces neutrophil ability to seek and destroy bacteria, contributing to increased susceptibility to infection in chronic tobacco users. The study also found that nicotine suppresses oxidative burst and increases matrix metalloproteinase-9 release, leading to impaired neutrophil function.
A new study found that doctors are dissatisfied with treating non-native patients due to cultural differences and language barriers. Over 2400 doctor questionnaires revealed that Turkish patients received lower-quality care, highlighting the need for improved communication and intercultural training.
Researchers found septic acute kidney injury (AKI) patients have higher acuity of illness, lower blood pressure, and worse pulmonary function compared to non-septic AKI. The study suggests septic AKI requires specific clinical interventions to reduce injury and promote kidney recovery.
Researchers found that rats use exploratory sniffing to discriminate odors quickly, with neural responses confirming minimal processing takes place in the olfactory bulb. The study suggests odorant identity may be encoded by sequence of responses rather than peak activation.
A study published in BMC Veterinary Research found that lambs can contract scrapie, a fatal neurodegenerative disease, by consuming milk from infected ewes. The researchers detected the prion protein PrPd in intestinal tissues of both infected and control lambs, suggesting that the infectious agent can be shed and transmitted.
The new NIH policy requires all funded research articles to be made freely available in PubMedCentral within 12 months of publication. This move aims to increase public access to scientific literature and promote better use of the scientific literature through libraries like PMC.
A comprehensive study of the genetic basis of psoriasis has discovered seven new sites of common DNA variation that increase the risk of this skin condition. The variations were found to be strongly linked to psoriatic arthritis and other autoimmune disorders, paving the way for more targeted therapies.
Research published in BMC Complementary and Alternative Medicine suggests that the berries of Solanum villosum have potential for keeping mosquitoes at bay. The study found that S. villosum was particularly effective at eliminating Stegomyia aegypti larvae, which can spread diseases like dengue fever.
Researchers have isolated a new species of Leptospira, causing the disease leptospirosis, from domestic rats in the Peruvian Amazon. The discovery highlights the importance of region-specific Leptospira in diagnosis and reveals a higher incidence of leptospirosis than previously suspected.
Research published in BMC Neuroscience found that physical activity from juvenile age delays the onset of specific motor deficits in a mouse model of Huntington's disease. The study suggests that benefits stem from stimulation of neuronal receptors and other molecules that prolong normal function and delay motor deficits.
Researchers have identified neurons that form different spiral-shaped axons on the left and right sides of the brain, suggesting a possible explanation for brain asymmetry. The findings provide new insights into how the brain processes information and could lead to a better understanding of cognitive performance and social behavior.
A family-based study found a significant association between pesticide use, particularly herbicides and insecticides, and an increased risk of developing Parkinson's disease. The research team recruited 319 patients and over 200 relatives to analyze the relationship between pesticide exposure and Parkinson's disease development.
In Northern Vietnam, a significant disparity between reported and actual neonatal mortality rates has been discovered. The discrepancy highlights the need for robust health statistics to guide national and international health initiatives.
Researchers pooled data from 15 clinical trials to compare the efficacy of rectal artemisinins and conventional injectable antimalarials like quinine. Rectal artemisinins cleared malarial parasites more rapidly than quinine, suggesting they could be a lifesaving intervention in severe malaria cases.
Experts urge G8 leaders to establish a new fund to support neglected tropical diseases control and elimination. The proposed Global Fund could help scale up donated drug administration, leading to sustainable poverty reduction.
Researchers have developed an algorithm that can replicate the bat's ability to classify plants using echolocation. The study found that plant echoes are highly complex signals due to numerous reflections from leaves and branches.
A study published in Arthritis Research & Therapy found that a gluten-free vegan diet can lower cholesterol and oxidized LDL levels, while raising natural antibodies against phosphorylcholine in patients with rheumatoid arthritis. This may help protect against heart attacks and stroke.
A new essay proposes revising protected area categories to reflect biodiversity outcomes, with potential huge implications for preserving the earth's rapidly diminishing biodiversity. The change aims to make significant gains in biodiversity conservation and stanch species loss, habitat destruction, and ecosystem services degradation.
A review of published literature on women's expectations and experience of pain and pain relief in labour reveals a gap between expectations and reality. Most women underestimate the intensity of pain they will experience and may not be prepared for the possibility that they might need pain relief.
A study of Australian men's attitudes towards health reveals that they are not the disinterested pub-goers often stereotyped. Instead, they proactively monitor their health and seek medical attention only when necessary. The researchers identified four key factors influencing men's help-seeking decisions.
Inhalation of diesel exhaust induces stress response in brain activity, altering information processing. Researchers found that even short exposure can cause changes in brain waves, with effects lasting after subjects leave the room.
A recent study published in Substance Abuse Treatment, Prevention, and Policy found that parental monitoring in high school can reduce teenage drinking and have a protective effect on students' drinking in college. The research suggests that higher levels of parental supervision are associated with lower levels of high-school drinking,...
Researchers identified a hybrid gene in Asian monkeys that produces a protein capable of blocking HIV infection. This is the second time a similar TRIM5-CypA gene has been found in different monkey species, indicating convergent evolution.
A study of over 10,400 patients found no significant decrease in hospital mortality with intensive insulin therapy. In fact, mortality rates were higher in ICU patients with short stays.